オオクボ タケシ大久保 武教授Takeshi OHKUBO
■研究者基本情報
経歴
■研究活動情報
受賞
- 2013年09月08日, The Journal of Poultry Science優秀論文賞, Detection of LeptinActivity in Living Cells Expressing Chicken Leptin Receptor and STAT3, 日本家禽学会
Hiromi Adachi;Daisuke Murase;Susumu Atomura;Takeshi Ohkubo - 2013年09月, 日本家禽学会賞, 日本家禽学会
- 2013年09月, The Journal of Poultry Science優秀論文賞, Detection of LeptinActivity in Living Cells Expressing Chicken Leptin Receptor and STAT3, 日本家禽学会
Hiromi Adachi;Daisuke Murase;Susumu Atomura and Takeshi Ohkubo
論文
- Genetic Analysis of HSP70 and HSF3 Polymorphisms and Their Associations with the Egg Production Traits of Bangladeshi Hilly Chickens.
Md Yousuf Ali; Shakila Faruque; Sadequllah Ahmadi; Takeshi Ohkubo, In warm environments, thermoregulation in poultry is controlled by heat shock protein 70 (HSP70), whose expression is controlled by heat shock factor 3 (HSF3). Although the association between genetic polymorphisms in these genes and thermotolerance as well as reproductive traits has been extensively studied in mammals, the association has not yet been studied in poultry. This study aimed to explore the relationship between single-nucleotide polymorphisms (SNPs) in these genes and the egg production traits of Bangladeshi hilly chickens. Sequencing and allele-specific PCR (AS-PCR) were used to detect new SNPs and perform genotyping. We identified two novel SNPs (G-399A and A-68G) in the 5'-flanking regions of HSP70 that were significantly associated with egg numbers (ENs) at 161-190 days and increased egg weight (EW) at 40 weeks of age. Furthermore, three SNPs in HSP70 (A258G, C276G and C1431A) and one SNP in HSF3 (A-1388G) were associated with EN at different ages. The haplotype and combined genotypic effects of these two genes were found to be associated with age at sexual maturity (ASM), EN, EW, and body weight at ASM. The identified SNPs and their corresponding haplotypes may be useful in selective breeding to enhance the productivity of chickens in warm environments.
Animals : an open access journal from MDPI, 2024年12月10日 - Molecular form identification of anterior pituitary gland-secreted prolactin in chicken
Kansaku N and Ohkubo T, Endocrine changes during bird reproduction are well documented. Prolactin (PRL) exhibits a strong relationship between incubation and broody behavior. The molecular forms of PRL in the anterior pituitary gland during the reproductive cycle have already been previously identified but not those in the secreted form. To identify the molecular forms of secreted PRL during the reproductive cycle, we thus monitored the physiological status and incubation behavior of 10 Silkie hens by a video recording system over 1-2 years. Nine out of ten mature hens exhibited incubation behavior multiple times during the experiment. Ten hens demonstrated two interesting features. In a typical clutch, hens spent 10-15 min in the nest to lay an egg. Once they spent over 1 h in the nest, the nest occupancy increased incrementally. This shift in the nest occupancy occurred 7-10 days before the incubation onset and was highly repeatable. Based on the behavior of the hens, we cultured the anterior pituitary gland during four stages (premature non-laying, laying, trans, and incubation) with physiological PRL-releasing factor, vasoactive intestinal peptide (VIP). Based on our two-dimensional protein analysis, glycosylated PRL (G-PRL) displayed several isoforms with varying isoelectric points (pI), whereas we could detect one primary signal for non-glycosylated PRL (NG-PRL). However, 3-4 NG-PRL isoforms were detected in the anterior pituitary gland. These results suggested that secreted PRL, especially from the trans and incubation stages, contains various isoforms and it is post-translationally glycosylated and phosphorylated., Elsevier
General and Comparative Endocrinology, 2024年01月, ［査読有り］ - 〔主要な業績〕Impact of in ovo leptin injection and dietary protein levels on ovarian growth markers and early folliculogenesis in post-hatch chicks (Gallus gallus domesticus)
Ahmadi S; Nemoto Y and Ohkubo T, 責任著者, MDPI
Biology, 2024年01月, ［査読有り］ - Regulation of prolactin release at the end stage of chicken embryogenesis
Kansaku N; Wakui S; Sasanami T; Ohkubo T
Journal of Poultry Science, 2022年10月, ［査読有り］ - 〔主要な業績〕Leptin promotes primordial follicle activation by regulating ovarian insulin-like growth factor system in chicken
Ahmadi S; Ohkubo T, 責任著者, Endocrine Society
Endocrinology, 2022年09月, ［査読有り］ - 〔主要な業績〕Leptin Modulates the mRNA Expression of Follicle Development Markers in Post-hatch Chicks in an Age-Dependent Manner.
Shaikat AH; Ochiai M; Sasaki A; Takeda M; Arima A and Ohkubo T, 責任著者, Frontiers
Frontiers in Physiology, 2021年07月, ［査読有り］ - Orexin system is expressed in avian liver and regulates hepatic lipogenesis via ERK1/2 activation.
Greene ES; Zampiga M; Sirri F; Ohkubo T; Dridi S
Scientific Reports, 2020年11月, ［査読有り］ - Determination of Polymorphisms in Pituitary Genes of the Native Afghani Naked Neck Chicken
Ahmadi S; Takeda M; Ohkubo T, 責任著者
Journal of poultry Science, 2019年10月, ［査読有り］ - Identification of hypothalamic genes in associating with food intake during incubation behavior in domestic chicken.
Takeda M; Ohkubo T, 責任著者
Animal Science Journal, 2019年09月, ［査読有り］ - AMP-activated protein kinase mediates the effect of leptin on avian autophagy in a tissue-specific manner
Alissa Piekarski; Gurueswar Nagarajan; Peter Ishola; Joshua Flees; Elizabeth S. Greene; Wayne J. Kuenzel; Takeshi Ohkubo; Helena Maier; Walter G. Bottje; Mark A. Cline; Sami Dridi, Frontiers Media S.A.
Frontiers in Physiology, 2018年05月15日, ［査読有り］ - Gene expression profiling in embryonic chicken ovary during asymmetric development
Amir Hossan Shaikat; Shoko Namekawa; Sadequllah Ahmadi; Misa Takeda; Takeshi Ohkubo, Blackwell Publishing
Animal Science Journal, 2018年04月01日, ［査読有り］ - Leptin activates chicken growth hormone promoter without chicken STAT3 in vitro
Murase D; Namekawa S; Ohkubo T, 責任著者
Comparative Biochemistry and Physiology Part B, 2016年01月, ［査読有り］ - Heat and oxidative stress alter the expression of orexin and its related receptors in avian liver cells
Greene E; Khaldi S; Ishola P; Bottje W; Ohkubo T; Anthony N; Dridi S
Comparative Biochemistry and Physiology Part A, 2016年01月, ［査読有り］ - 黒毛和種繁殖雌牛の成長ホルモン受容体遺伝子多型が子牛市場体重の直接および母性遺伝効果に及ぼす影響について
高橋和裕、木村 信熙、田中実、大久保武, ラスト(シニア)オーサー, 離乳前の子牛の発育は子牛自身の発育性と母牛の哺育能力に依存し，発育初期の子牛には母牛の哺育能力が非常に重要である．哺育能力に関与する遺伝子が判明されれば，子牛が生産された時点で遺伝的な能力を予測することが可能である．そこで本研究では成長ホルモン受容体遺伝子の肝臓特異的転写制御領域に存在するLINE-1In/Del多型と黒毛和種の直接および母性遺伝効果の育種価との関連性を検討した．直接および母性遺伝効果のそれぞれの育種価はLINE-1配列挿入遺伝子をホモに持つLL型の育種値が13.84kg，4.87kg，LINE-1配列挿入遺伝子と欠損遺伝子をそれぞれ持つLS型の育種値が11.18kg，2.10kg，LINE-1配列欠損遺伝子をホモに持つSS型の育種値が−0.29kg，−8.61kgであり，直接および母性遺伝効果の育種価はともにLL型とSS型，LS型とSS型の間には有意な差が認められた（P<0.01）．このことからGHR遺伝子のLINE-1In/Del多型は子牛自身の発育に関する直接遺伝効果ならびに繁殖雌牛の母性遺伝効果の選抜の一指標となる可能性が推察された．, Japanese Society of Animal Science
日本畜産学会報, 2015年, ［査読有り］ - Avian blood induced intranuclear translocation of STAT3 via the chicken leptin receptor
Takeshi Ohkubo; Kanako Hirota; Daisuke Murase; Hiromi Adachi; Tsutomu Nozawa-Takeda; Shoei Sugita
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY, 2014年08月, ［査読有り］ - Discovery of the elusive leptin in birds: identification of several 'missing links' in the evolution of leptin and its receptor.
Prokop JW; Schmidt C; Gasper D; Duff RJ; Milsted A; Ohkubo T; Ball HC; Shawkey MD; Mays HL Jr; Cogburn LA and Londraville RL
PLoS One, 2014年03月24日, ［査読有り］ - コレシストキニンA受容体遺伝子g.420 C > A 一塩基多型は比内鶏の発育を改善する
力丸宗弘、武田尚人、大久保武、高橋大希、小松恵、高橋秀彰, 我々は，既報において，発育が異なる比内鶏系統個体を交配し，作出したF2家系集団において，コレシストキニンA受容体遺伝子(CCKAR)の5'非翻訳領域の特定部位における一塩基多型(SNP，g. 420 C>A)とF2個体の発育形質との間に，有意な関連性を確認し，AアリルはCアリルよりも発育形質に対する効果が優れていることを報告した。本研究では，発育形質が改良されていない保存会系統の比内鶏を用いて，当該SNPによって比内鶏の発育が改善されるか検証を行った。比内鶏各個体における当該SNPの遺伝子型(A/A，A/C，C/C)を既報に従って，4週齢になる前に判定した後，4週齢から14週齢まで育雛ケージで飼育した。4週齢から14週齢まで，2週間おきに各個体の体重を測定し，2週間間隔の平均日増体重を算出した。また，2週おきに飼料摂取量を測定し，さらに平均日増体重と飼料摂取量から，飼料要求率を算出した。その結果，A/A型個体は他の遺伝子型個体より14週齢体重が有意に重く，平均日増体重も有意に優れていた。飼料摂取量では，遺伝子型間で有意差は認められなかった。飼料要求率では，4-10週齢において，A/A型個体がC/C型個体より有意に優れていたが，4-14週齢間では，各遺伝子型間に有意な差は認められなかった。以上の結果から，CCKAR遺伝子のg. 420 C>A SNPによって，比内鶏の発育が実際に改善されることが明らかになった。, 日本万国家禽学会
日本家禽学会誌, 2014年, ［査読有り］ - Inhibitory Mechanism of Signal Transduction through Chicken Leptin Receptor by Suppressor of Cytokine Signaling 3 (SOCS3)
Hiromi Adachi; Daisuke Murase; Takeshi Ohkubo
JOURNAL OF POULTRY SCIENCE, 2013年07月, ［査読有り］ - Detection of leptin activity in living cells expressing chicken leptin receptor and STAT3
Hiromi Adachi; Daisuke Murase and Takeshi Ohkubo, 責任著者
Journal of Poultry Science, 2012年01月20日, ［査読有り］ - Role of chicken Pit-1 isoforms in activating growth hormone gene.
Daisuke Murase; Shusuke Taniuchi; Sakae Takeuchi; Hiromi Adachi; Norio Kansaku; Katsuichiro Okazaki; Takeshi Ohkubo, 責任著者
General and Comparative Endocrinology, 2011年09月01日, ［査読有り］ - Central administration of metastin increases food intake through opioid neurons in chicks.
Kahn; M.S.I; Ohkubo; T.; Masuda; N.; Tachibana; T and Ueda; H.
Comparative Biochemistry and Physiology, Part A: Molecular & Integrative Physiology, 2009年, ［査読有り］ - 黒毛和種における成長ホルモン受容体多型と枝肉形質の遺伝的な能力の比較
高橋和裕; 木村 信熙; 田中実; 大久保武, 責任著者, 本研究では黒毛和種の成長ホルモン受容体（GHR）遺伝子のプロモーター領域に見いだされたLINE-1多型と黒毛和種肥育牛の枝肉形質との関連について香川県内で肥育された348頭の枝肉評価の成績を元に解析を行った．遺伝子頻度はLINE-1反復配列を有するL型0.529，LINE-1反復配列を欠失するS型0.471であった．遺伝子型と枝肉形質との関連については，胸最長筋面積およびバラ厚についてはL型ホモ（LL）がヘテロ型（LS）およびS型ホモ（SS）に対して有意に優れていた．また歩留基準値は，LLがSSに対して有意に高かった．しかしながら脂肪交雑基準は遺伝子型による差は認められなかった．以上の結果，黒毛和種のGHR遺伝子のLINE-1多型は黒毛和種の筋肉量と関連し，L型遺伝子の導入が肉量増加に有効であることが示唆された．, Japanese Society of Animal Science
日本畜産学会報, 2009年, ［査読有り］ - Chicken leptin receptor is functional in activating JAK-STAT pathway in vitro.
Adachi; H.; Takemoto; Y.; Bungo; T. and Ohkubo; T., 責任著者
Journal of Endocrinology, 2008年, ［査読有り］ - Molecular cloning of Pit-1 cDNA and genomic DNA of the domestic duck (Anas platyrhynchos).
Kansaku; N.; Ohkubo; T.; Guémené; D.; Kuhnlein; U.; and Zadworny; D.
Animal Science Journal, 2007年, ［査読有り］ - Existence of leptin receptor protein in chicken tissues: isolation of a monoclonal antibody against chicken leptin receptor.
Ohkubo; T.; Nishio; M.; Tsurudome; M.; Ito; M. and Ito; Y.:, 筆頭著者
General and Comparative Endocrinology, 2007年, ［査読有り］ - Structure and tissue distribution of cholecystokinin-1 receptor in chicken.
Ohkubo; T.; Shamoto; K. and Ogino; T.:, 筆頭著者
Journal of Poultry Science, 2007年, ［査読有り］ - Bos indicus type of growth hormone receptor gene is retained in Japanese Black cattle.
Ohkubo; T.; Yano; H.; Takahashi; S.; Takahashi; K.; Kimura; N. and Tanaka; M:, 筆頭著者
Journal of Animal Breeding and Genetics, 2006年, ［査読有り］ - Cloning of duck PRL cDNA and genomic DNA.
Kansaku; N.; Ohkubo; T.; Okabayashi; H.; Guémené; D.; Kuhnlein; U.; Zadworny; D. and Shimada; K.
General and Comparative Endocrinology, 2005年, ［査読有り］ - Comparison of mammalian prolactin-releasing peptide and Carassius RFamide for feeding behavior and prolactin secretion in chicks.
Tachibana; T.; Tsukada; A.; Fujimoto; M.; Takahashi; H.; Ohkubo; T.; Boswell; T. and Furuse; M.
General and Comparative Endocrinology, 2005年, ［査読有り］ - Characterization of structure and expression of the growth hormone receptor gene of the Japanese flounder (Paralichtys olivaceus).
Nakao; N.; Higashimoto; Y.; Ohkubo; T.; Yoshizato; H.; Nakai; N.; Nakashima; K. and Tanaka; M.
Journal of Endocrinology, 2004年, ［査読有り］ - Effect of central administration of prolactin-releasing peptide on feeding in chicks.
Tachibana; T.; Saito; S.; Tomonaga; S.; Takagi; T.; Saito; E.; Nakanishi; T.; Koutoku; T.; Tsukada; A.; Ohkubo; T.; Boswell; T. and Furuse; M.
Physiology & Behavior, 2004年, ［査読有り］ - cDNA cloning of chicken orexin receptor and tissue distribution: sexually dimorphic expression in chicken gonads.
Ohkubo; T.; Tsukada; A. and Shamoto; K., 筆頭著者
Journal of Molecular Endocrinology, 2003年, ［査読有り］ - Fasting differentially regulates expression of agouti-related peptide, pro-opiomelanocortin, prepro-orexin, and vasoactive intestinal polypeptide mRNAs in the hypothalamus of Japanese quail.
Phillips-Singh; D.; Li; Q.; Takeuchi; S.; Ohkubo; T.; Sharp; P.J. and Boswell; T.
Cell and Tissue Research, 2003年, ［査読有り］ - Up-regulated expression of a novel gene in activated human peripheral blood mononuclear cells that is a truncated paralog of the human system L-amino acid transporter 1.
Ito; M.; Takebayashi; S.-I.; Okumura; K.; Ohkubo; T.; Nishio; M.; Kawano; M.; Komada; H.; Ito; Y. and Tsurudome; M.
International Journal of Biochemistry and Cell Biology, 2002年, ［査読有り］ - Tryptophans 286 and 288 in the C-terminal region of protein B23.1 are important for its nucleolar localization.
Nishimura; Y.; Ohkubo; T.; Furuichi; Y. and Umekawa; H.
Bioscience, Biotechnology and Biochemistry, 2002年, ［査読有り］ - Molecular cloning of chicken prepro-orexin cDNA and preferential expression in the chicken hypothalamus.
Ohkubo; T.; Boswell; T. and Lumineau; S., 筆頭著者
Biochimica et Biophysica Acta, 2002年, ［査読有り］ - Structure and tissue distribution of prolactin receptor mRNA in Japanese flounder (Paralichtys olivaceus): conserved and preferential expression in osmoregulatory organs.
Higashimoto; Y.; Nakao; N.; Ohkubo; T.; Tanaka; M. and Nakashima; K.:
General and Comparative Endocrinology, 2001年, ［査読有り］ - Molecular cloning of chicken vasoactive intestinal polypeptide receptor complementary DNA, tissue distribution and chromosomal localization.
Kansaku; N.; Shimada; K.; Ohkubo; T.; Saito; N.; Suzuki; T.; Matsuda; Y. and Zadworny; D.
Biology of Reproduction, 2001年, ［査読有り］ - Structure and tissue distribution of chicken leptin receptor (cOb-R) mRNA.
Ohkubo; T.; Tanaka; M. and Nakashima; K., 筆頭著者
Biochimica et Biophysica Acta, 2000年, ［査読有り］ - Molecular cloning of the chicken prolactin gene and activation by Pit-1 and cAMP-induced factor in GH3 cells.
Ohkubo; T.; Tanaka; M. and Nakashima; K., 筆頭著者
General and Comparative Endocrinology, 2000年, ［査読有り］ - Two novel first exons in the prolactin receptor gene are transcribed in a tissue-specific and sexual maturation-dependent manner to encode multiple 5’-truncated transcripts in the testis of the chicken.
Tanaka, M; Yamamoto, I; Hayashida, Y; Nakao, N; Ohkubo, T; Wakita, M; Nakashima, K
Biochimica et Biophysica Acta, 2000年, ［査読有り］ - Effects of thyroid hormone on serum insulin-like growth factor binding proteins (IGFBPs) and IGFBP-2 mRNA expression in chickens.
Tsukada, A; Ohkubo, T; Tanaka, M; Nakashima, K; Wakita, M; Hoshino, S
Japanese Poultry Science, 1999年, ［査読有り］ - cDNA cloning and developmental alterations in gene expression of the two Pit-1/GHF-1 transcription factors in the chicken pituitary.
Tanaka; M.; Yamamoto; I.; Ohkubo; T.; Wakita; M.; Hoshino; S. and Nakashima; K.:
General and Comparative Endocrinology, 1999年, ［査読有り］ - Genetic mapping of the chicken prolactin receptor gene: a candidate gene for the control of broodiness.
Dunn; I.C.; McEwan; G.; Okhubo; T.; Sharp; P.J.; Paton; I.R. and Burt; D.W.
British Poultry Science, 1998年, ［査読有り］ - Prolactin receptor gene expression in the brain and peripheral tissues in broody and nonbroody breeds of domestic hen.
Ohkubo; T.; Tanaka; M.; Nakashima; K.; Talbot; R.T. and Sharp; P.J., 筆頭著者
General and Comparative Endocrinology, 1998年, ［査読有り］ - Relationship between prolactin receptor mRNA in the anterior pituitary gland and hypothalamus and reproductive state in male and female bantams (Gallus domesticus).
Ohkubo; T.; Tanaka; M.; Nakashima; K. and Sharp; P.J.:, 筆頭著者
General and Comparative Endocrinology, 1998年, ［査読有り］ - Cloning and expression of pigeon growth hormone receptor cDNA in COS-7 monkey kidney cells.
Ohkubo T.; Tsukada A.; Tanaka M. and Nakashima K.:, 筆頭著者
Comparative Biochemistry and Physiology, 1998年, ［査読有り］ - Tissue-specific regulation of growth hormone receptor and growth hormone binding protein gene expression during pregnancy and lactation in the rat.
Sakaguchi; K.; Tanaka; M.; Ohkubo; T.; Yoshizato; H.; Hanai; Y.; Fujikawa; T.; Kaneko; H. and Nakashima; K.:
Endocrine Journal, 1998年, ［査読有り］ - cDNA cloning and characterization of neuron-specific enolase from chicken.
Tanaka; M.; Taniguchi; T; Ohkubo; T. and Nakashima; K.
Biochimica et Biophysica Acta, 1998年, ［査読有り］ - Gene and cDNA structures of flounder insulin-like growth factor-I (IGF-I): Multiple mRNA species encode a single short mature IGF-I.
Tanaka; M.; Taniguchi; T.; Yamamoto; I.; Sakaguchi; K; Yoshizato; H.; Ohkubo; T. and Nakashima; K.
DNA and Cell Biology, 1998年, ［査読有り］ - Thyroid hormones are involved in insulin-like growth factor-I (IGF-I) production by stimulating hepatic growth hormone receptor (GHR) gene expression in the chicken.
Tsukada; A.; Ohkubo; T.; Sakaguchi; K.; Tanaka; M.; Nakashima; K.; Hayashida; Y.; Wakita; M. and Hoshino; S.
Growth Hormone and IGF Research, 1998年, ［査読有り］ - Structures of mollusc shell framework proteins.
Sudo; S.; Fujikawa; T.; Nagakura; T.; Ohkubo; T.; Sakaguchi; K.; Tanaka; M.; Nakashima; K. and Takahashi; T.:, Nature Publishing Group
Nature, 1997年, ［査読有り］ - Influence of recombinant chicken prolactin on thyroid hormone metabolism in the chick embryo.
6. Kühn; E.R.; Shimada; K.; Ohkubo; T.; Vleurick; L.M.; Berghman; L.R. and Darras; V.M.
General and Comparative Endocrinology, 1996年, ［査読有り］ - Molecular cloning and characterization of the yellowtail GH gene and its promoter: a consensus sequence for teleost and avian Pit-1/GHF-1 binding sites.
Ohkubo; T.; Araki; M.; Tanaka; M.; Sudo; S. and Nakashima; K., 筆頭著者
Journal of Molecular Endocrinology, 1996年, ［査読有り］ - Induction of brain prolactin receptor long-form mRNA expression and maternal behavior in pup-contacted male rats: promotion by prolactin administration and suppression by female contact.
Sakaguchi; K.; Tanaka; M.; Ohkubo; T.; Doh-ura; K.; Fujikawa; T.; Sudo; S. and Nakashima; K.
Neuroendocrinology, 1996年, ［査読有り］ - Growth hormone-independent expression of insulin-like growth factor I messenger ribonucleic acid in extrahepatic tissues of the chicken.
Tanaka; M.; Hayashida; Y.; Sakaguchi; K.; Ohkubo; T.; Wakita; M.; Hoshino; S. and Nakashima; K.:
Endocrinology, 1996年, ［査読有り］ - Sequence of the flounder (Paralichthys olivaceus) growth hormone encoding gene and its promoter region.
Tanaka; M.; Toma; Y.; Ohkubo; T.; Sudo; S. and Nakashima; K.
Gene, 1995年, ［査読有り］ - ブリ及びヒラメ成長ホルモン遺伝子のクローニング
中島邦夫; 田中実; 大久保武:
月刊海洋, 1995年, ［査読有り］ - Differential regulation of prolactin receptor mRNA expression in rat liver and kidney by testosterone and oestradiol.
Sakaguchi; K.; Ohkubo; T.; Sugiyama; T.; Tanaka; M.; Ushiro; H. and Nakashima; K.
Journal of Endocrinology, 1994年, ［査読有り］ - High-level expression of biologically active chicken prolactin in E. coli.
Ohkubo; T.; Tanaka; M.; Nakashima; K.; Shimada; K.; Saito; N. and Sato; K., 筆頭著者
Comparative Biochemistry and Physiology, 1993年, ［査読有り］ - Effects of removal of chicks from hens on concentrations of prolactin, luteinizing hormone and oestradiol in plasma of brooding Gifujidori hens
Kuwayama; T.; Shimada; K.; Saito; N.; Ohkubo; T.; Sato; K.; Wada; M. and Ichinoe; K
Journal of Reproduction and Fertility, 1992年, ［査読有り］ - Double antenna structure of chicken prolactin receptor deduced from the cDNA sequence.
Tanaka; M.; Maeda; K.; Okubo; T. and Nakashima; K
Biochemical and Biophysical Research Communications, 1992年, ［査読有り］
MISC
- A Bird's-Eye Overview of Leptin and Female Reproduction -with Mammalian Comparisons.
Sadequllah Ahmadi; Takeshi Ohkubo
Journal of Poultry Science, 2025年02月, ［査読有り］, ［招待有り］ - Leptin signaling and action in birds.
Ohkubo; T. and Adachi; H.
Journal of Poultry Science, 2008年, ［査読有り］
筆頭著者 - Cloning and characterization of chicken cholecystokinin receptor.
Ohkubo, T; Shamoto, K
Proceedings of the Fifth Congress of the Asia and Oceania Society for Comparative Endocrinology in Conjunction with the Annual Meeting of the Japan Society for Comparative Endocrinology, 2004年, ［査読有り］
筆頭著者 - Cloning and regulation of chicken cholesterol 7α-hydroxylase.
Yamamoto, Y; Tsukada, A; Ohkubo, T; Umekawa, H; Takahashi, T; Furuichi, Y
Proceedings 6th Asian Pacific Poultry Congress, 1998年, ［査読有り］
書籍等出版物
講演・口頭発表等
- Does leptin have a role in asymmetrical development of chicken ovary?
SHAIKAT AMIR; Namekawa Shoko; Ahmadi Sadequllah; Takeda Misa; Ohkubo Takeshi
日本畜産学会第122回大会, 2017年03月27日 - Action of leptin for pituitary hormone gene expression in the chick
Shoko Namekawa; Takeshi Ohkubo
World's Poultry Congress 2016, 2016年09月10日 - Expression of Pigeon Leptin in vitro with Determination of Biological Activity
Sadequllah Ahmadi; Shoko Namekawa; Takeshi Ohkubo
17th AAAP Animal Science Congress, 2016年08月23日 - Interaction of STAT3 and STAT5 in the leptin signal transduction
Shoko Namekawa; Daisuke Murase; Takeshi Ohkubo
17th AAAP Animal Science Congress, 2016年08月23日 - ニワトリの下垂体ホルモン遺伝子発現に対するレプチンの作用
滑川晶子、大久保武
日本家禽学会２０１６年度春季大会, 2016年03月30日 - 鶏の就巣性の制御について
大久保武
平成27年度関東甲信越地域鶏試験研究推進協議会全体会議, 2015年10月08日, ［招待有り］ - レプチン情報伝達における STAT3 と STAT5 の相互作用
滑川晶子、大久保武
日本家禽学会２０１５年度秋季大会, 2015年09月10日 - Change of appetite-associated genes in the chicken hypothalamus during incubation behavior
Takeshi Ohkubo; Takahiro Kodama; Rumi Ohnuki
10th Asia Pacific Poultry Conference, 2014年10月21日 - 抱卵行動がニワトリ視床下部の摂食関連遺伝子の発現に及ぼす影響
児玉孝弘、大貫瑠美、大久保武
2014年度日本家禽学会春季大会, 2014年03月29日, 日本家禽学会 - コレシストキニン A受容体遺伝子の一塩基多型は比内鶏発育を改善する
力丸宗弘、武田尚人、小松恵、高橋大希、大久保武、高橋秀彰
2013年度日本家禽学会秋季大会, 2013年09月08日, 日本家禽学会 - Role of transactivation domain of Pit-1 is different in the transcriptional regulation of GH gene by leptin in chicken and mouse
Daisuke Murase; Kaori Ogawa; Takeshi Ohkubo
17th International Congress on Comparative Endocrinology, 2013年07月16日 - 鳥類血清中のレプチン様活性の検出
村瀬大輔、廣田佳菜子、安達洋泉、竹田努、杉田昭栄、大久保武
2013年度家禽学会春季大会, 2013年03月29日 - Leptin regulates Pit-1α-dependent chicken GH gene expression in mammalian cells
10th International Symposium on Avian Endocrinology, 2012年06月06日, Daisuke Murase, Susumu Atomura and Takeshi Ohkubo - Effect of chicken STAT5b mutant on prolactin signal transduction
Susumu Atomura; Hiromi Adachi; Daisuke Murase; Takeshi Ohkubo
10th International Symposium on Avian Endocrinology, 2012年06月06日 - ニワトリGH遺伝子のレプチン応答におけるPit-1転写活性領域の機能解析
村瀬大輔、後村進、大久保武
2012年度家禽学会春季大会, 2012年03月30日
共同研究・競争的資金等の研究課題
