08 Sep. 2013, The Journal of Poultry Science優秀論文賞, Detection of LeptinActivity in Living Cells Expressing Chicken Leptin Receptor and STAT3, 日本家禽学会
Hiromi Adachi;Daisuke Murase;Susumu Atomura;Takeshi Ohkubo

Sep. 2013, 日本家禽学会賞, 日本家禽学会

Sep. 2013, The Journal of Poultry Science優秀論文賞, Detection of LeptinActivity in Living Cells Expressing Chicken Leptin Receptor and STAT3, 日本家禽学会
Hiromi Adachi;Daisuke Murase;Susumu Atomura and Takeshi Ohkubo

Genetic Analysis of HSP70 and HSF3 Polymorphisms and Their Associations with the Egg Production Traits of Bangladeshi Hilly Chickens.
Md Yousuf Ali; Shakila Faruque; Sadequllah Ahmadi; Takeshi Ohkubo, In warm environments, thermoregulation in poultry is controlled by heat shock protein 70 (HSP70), whose expression is controlled by heat shock factor 3 (HSF3). Although the association between genetic polymorphisms in these genes and thermotolerance as well as reproductive traits has been extensively studied in mammals, the association has not yet been studied in poultry. This study aimed to explore the relationship between single-nucleotide polymorphisms (SNPs) in these genes and the egg production traits of Bangladeshi hilly chickens. Sequencing and allele-specific PCR (AS-PCR) were used to detect new SNPs and perform genotyping. We identified two novel SNPs (G-399A and A-68G) in the 5'-flanking regions of HSP70 that were significantly associated with egg numbers (ENs) at 161-190 days and increased egg weight (EW) at 40 weeks of age. Furthermore, three SNPs in HSP70 (A258G, C276G and C1431A) and one SNP in HSF3 (A-1388G) were associated with EN at different ages. The haplotype and combined genotypic effects of these two genes were found to be associated with age at sexual maturity (ASM), EN, EW, and body weight at ASM. The identified SNPs and their corresponding haplotypes may be useful in selective breeding to enhance the productivity of chickens in warm environments.
Animals : an open access journal from MDPI, 10 Dec. 2024

Molecular form identification of anterior pituitary gland-secreted prolactin in chicken
Kansaku N and Ohkubo T, Endocrine changes during bird reproduction are well documented. Prolactin (PRL) exhibits a strong relationship between incubation and broody behavior. The molecular forms of PRL in the anterior pituitary gland during the reproductive cycle have already been previously identified but not those in the secreted form. To identify the molecular forms of secreted PRL during the reproductive cycle, we thus monitored the physiological status and incubation behavior of 10 Silkie hens by a video recording system over 1-2 years. Nine out of ten mature hens exhibited incubation behavior multiple times during the experiment. Ten hens demonstrated two interesting features. In a typical clutch, hens spent 10-15 min in the nest to lay an egg. Once they spent over 1 h in the nest, the nest occupancy increased incrementally. This shift in the nest occupancy occurred 7-10 days before the incubation onset and was highly repeatable. Based on the behavior of the hens, we cultured the anterior pituitary gland during four stages (premature non-laying, laying, trans, and incubation) with physiological PRL-releasing factor, vasoactive intestinal peptide (VIP). Based on our two-dimensional protein analysis, glycosylated PRL (G-PRL) displayed several isoforms with varying isoelectric points (pI), whereas we could detect one primary signal for non-glycosylated PRL (NG-PRL). However, 3-4 NG-PRL isoforms were detected in the anterior pituitary gland. These results suggested that secreted PRL, especially from the trans and incubation stages, contains various isoforms and it is post-translationally glycosylated and phosphorylated., Elsevier
General and Comparative Endocrinology, Jan. 2024, [Reviewed]

〔Major achievements〕Impact of in ovo leptin injection and dietary protein levels on ovarian growth markers and early folliculogenesis in post-hatch chicks (Gallus gallus domesticus)
Ahmadi S; Nemoto Y and Ohkubo T, Corresponding, MDPI
Biology, Jan. 2024, [Reviewed]

Regulation of prolactin release at the end stage of chicken embryogenesis
Kansaku N; Wakui S; Sasanami T; Ohkubo T
Journal of Poultry Science, Oct. 2022, [Reviewed]

〔Major achievements〕Leptin promotes primordial follicle activation by regulating ovarian insulin-like growth factor system in chicken
Ahmadi S; Ohkubo T, Corresponding, Endocrine Society
Endocrinology, Sep. 2022, [Reviewed]

〔Major achievements〕Leptin Modulates the mRNA Expression of Follicle Development Markers in Post-hatch Chicks in an Age-Dependent Manner.
Shaikat AH; Ochiai M; Sasaki A; Takeda M; Arima A and Ohkubo T, Corresponding, Frontiers
Frontiers in Physiology, Jul. 2021, [Reviewed]

Orexin system is expressed in avian liver and regulates hepatic lipogenesis via ERK1/2 activation.
Greene ES; Zampiga M; Sirri F; Ohkubo T; Dridi S
Scientific Reports, Nov. 2020, [Reviewed]

Determination of Polymorphisms in Pituitary Genes of the Native Afghani Naked Neck Chicken　　　　　　　　　　　　　　　
Ahmadi S; Takeda M; Ohkubo T, Corresponding
Journal of poultry Science, Oct. 2019, [Reviewed]

Identification of hypothalamic genes in associating with food intake during incubation behavior in domestic chicken.　　　　　　　　　　　　　　　
Takeda M; Ohkubo T, Corresponding
Animal Science Journal, Sep. 2019, [Reviewed]

AMP-activated protein kinase mediates the effect of leptin on avian autophagy in a tissue-specific manner
Alissa Piekarski; Gurueswar Nagarajan; Peter Ishola; Joshua Flees; Elizabeth S. Greene; Wayne J. Kuenzel; Takeshi Ohkubo; Helena Maier; Walter G. Bottje; Mark A. Cline; Sami Dridi, Frontiers Media S.A.
Frontiers in Physiology, 15 May 2018, [Reviewed]

Gene expression profiling in embryonic chicken ovary during asymmetric development
Amir Hossan Shaikat; Shoko Namekawa; Sadequllah Ahmadi; Misa Takeda; Takeshi Ohkubo, Blackwell Publishing
Animal Science Journal, 01 Apr. 2018, [Reviewed]

Leptin activates chicken growth hormone promoter without chicken STAT3 in vitro
Murase D; Namekawa S; Ohkubo T, Corresponding
Comparative Biochemistry and Physiology Part B, Jan. 2016, [Reviewed]

Heat and oxidative stress alter the expression of orexin and its related receptors in avian liver cells
Greene E; Khaldi S; Ishola P; Bottje W; Ohkubo T; Anthony N; Dridi S
Comparative Biochemistry and Physiology Part A, Jan. 2016, [Reviewed]

黒毛和種繁殖雌牛の成長ホルモン受容体遺伝子多型が子牛市場体重の直接および母性遺伝効果に及ぼす影響について
高橋和裕; 木村 信熙; 田中実; 大久保武, Last, 離乳前の子牛の発育は子牛自身の発育性と母牛の哺育能力に依存し，発育初期の子牛には母牛の哺育能力が非常に重要である．哺育能力に関与する遺伝子が判明されれば，子牛が生産された時点で遺伝的な能力を予測することが可能である．そこで本研究では成長ホルモン受容体遺伝子の肝臓特異的転写制御領域に存在するLINE-1In/Del多型と黒毛和種の直接および母性遺伝効果の育種価との関連性を検討した．直接および母性遺伝効果のそれぞれの育種価はLINE-1配列挿入遺伝子をホモに持つLL型の育種値が13.84kg，4.87kg，LINE-1配列挿入遺伝子と欠損遺伝子をそれぞれ持つLS型の育種値が11.18kg，2.10kg，LINE-1配列欠損遺伝子をホモに持つSS型の育種値が−0.29kg，−8.61kgであり，直接および母性遺伝効果の育種価はともにLL型とSS型，LS型とSS型の間には有意な差が認められた（P<0.01）．このことからGHR遺伝子のLINE-1In/Del多型は子牛自身の発育に関する直接遺伝効果ならびに繁殖雌牛の母性遺伝効果の選抜の一指標となる可能性が推察された．, Japanese Society of Animal Science
日本畜産学会報, 2015, [Reviewed]

Avian blood induced intranuclear translocation of STAT3 via the chicken leptin receptor
Takeshi Ohkubo; Kanako Hirota; Daisuke Murase; Hiromi Adachi; Tsutomu Nozawa-Takeda; Shoei Sugita
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY, Aug. 2014, [Reviewed]

Discovery of the elusive leptin in birds: identification of several 'missing links' in the evolution of leptin and its receptor.
Prokop JW; Schmidt C; Gasper D; Duff RJ; Milsted A; Ohkubo T; Ball HC; Shawkey MD; Mays HL Jr; Cogburn LA and Londraville RL
PLoS One, 24 Mar. 2014, [Reviewed]

コレシストキニンA受容体遺伝子g.420 C > A 一塩基多型は比内鶏の発育を改善する
力丸宗弘; 武田尚人; 大久保武; 高橋大希; 小松恵; 高橋秀彰, 我々は，既報において，発育が異なる比内鶏系統個体を交配し，作出したF2家系集団において，コレシストキニンA受容体遺伝子(CCKAR)の5'非翻訳領域の特定部位における一塩基多型(SNP，g. 420 C>A)とF2個体の発育形質との間に，有意な関連性を確認し，AアリルはCアリルよりも発育形質に対する効果が優れていることを報告した。本研究では，発育形質が改良されていない保存会系統の比内鶏を用いて，当該SNPによって比内鶏の発育が改善されるか検証を行った。比内鶏各個体における当該SNPの遺伝子型(A/A，A/C，C/C)を既報に従って，4週齢になる前に判定した後，4週齢から14週齢まで育雛ケージで飼育した。4週齢から14週齢まで，2週間おきに各個体の体重を測定し，2週間間隔の平均日増体重を算出した。また，2週おきに飼料摂取量を測定し，さらに平均日増体重と飼料摂取量から，飼料要求率を算出した。その結果，A/A型個体は他の遺伝子型個体より14週齢体重が有意に重く，平均日増体重も有意に優れていた。飼料摂取量では，遺伝子型間で有意差は認められなかった。飼料要求率では，4-10週齢において，A/A型個体がC/C型個体より有意に優れていたが，4-14週齢間では，各遺伝子型間に有意な差は認められなかった。以上の結果から，CCKAR遺伝子のg. 420 C>A SNPによって，比内鶏の発育が実際に改善されることが明らかになった。, 日本万国家禽学会
日本家禽学会誌, 2014, [Reviewed]

Inhibitory Mechanism of Signal Transduction through Chicken Leptin Receptor by Suppressor of Cytokine Signaling 3 (SOCS3)
Hiromi Adachi; Daisuke Murase; Takeshi Ohkubo
JOURNAL OF POULTRY SCIENCE, Jul. 2013, [Reviewed]

Detection of leptin activity in living cells expressing chicken leptin receptor and STAT3
Hiromi Adachi; Daisuke Murase and Takeshi Ohkubo, Corresponding
Journal of Poultry Science, 20 Jan. 2012, [Reviewed]

Role of chicken Pit-1 isoforms in activating growth hormone gene.
Daisuke Murase; Shusuke Taniuchi; Sakae Takeuchi; Hiromi Adachi; Norio Kansaku; Katsuichiro Okazaki; Takeshi Ohkubo, Corresponding
General and Comparative Endocrinology, 01 Sep. 2011, [Reviewed]

Central administration of metastin increases food intake through opioid neurons in chicks.
Kahn; M.S.I; Ohkubo; T.; Masuda; N.; Tachibana; T and Ueda; H.
Comparative Biochemistry and Physiology, Part A: Molecular & Integrative Physiology, 2009, [Reviewed]

黒毛和種における成長ホルモン受容体多型と枝肉形質の遺伝的な能力の比較
高橋和裕; 木村 信熙; 田中実; 大久保武, Corresponding, In the present study, we have compared LINE-1 polymorphism in the growth hormone receptor gene and carcass traits in 348 heads of Japanese Black cattles fatten in Kagawa Prefecture. Gene frequency of GHR gene with LINE-1 (L) or without LINE-1 (S) was 0.529 and 0.479, respectively. The estimated breeding values for longissimus muscle area and rib thick ness were greater in LL population than in LS and SS populations, whereas beef marbling score was not significantly different among the populations. The data in the present study suggested that the LINE-1 polymorphism might associate with body weight gain and/or muscle growth, and introducing L type of GHR might be advantage to increases carcass weight in Japanese Black cattle., Japanese Society of Animal Science
日本畜産学会報, 2009, [Reviewed]

Chicken leptin receptor is functional in activating JAK-STAT pathway in vitro.
Adachi; H.; Takemoto; Y.; Bungo; T. and Ohkubo; T., Corresponding
Journal of Endocrinology, 2008, [Reviewed]

Molecular cloning of Pit-1 cDNA and genomic DNA of the domestic duck (Anas platyrhynchos).
Kansaku; N.; Ohkubo; T.; Guémené; D.; Kuhnlein; U.; and Zadworny; D.
Animal Science Journal, 2007, [Reviewed]

Existence of leptin receptor protein in chicken tissues: isolation of a monoclonal antibody against chicken leptin receptor.
Ohkubo; T.; Nishio; M.; Tsurudome; M.; Ito; M. and Ito; Y.:, Lead
General and Comparative Endocrinology, 2007, [Reviewed]

Structure and tissue distribution of cholecystokinin-1 receptor in chicken.
Ohkubo; T.; Shamoto; K. and Ogino; T.:, Lead
Journal of Poultry Science, 2007, [Reviewed]

Bos indicus type of growth hormone receptor gene is retained in Japanese Black cattle.
Ohkubo; T.; Yano; H.; Takahashi; S.; Takahashi; K.; Kimura; N. and Tanaka; M:, Lead
Journal of Animal Breeding and Genetics, 2006, [Reviewed]

Cloning of duck PRL cDNA and genomic DNA.
Kansaku; N.; Ohkubo; T.; Okabayashi; H.; Guémené; D.; Kuhnlein; U.; Zadworny; D. and Shimada; K.
General and Comparative Endocrinology, 2005, [Reviewed]

Comparison of mammalian prolactin-releasing peptide and Carassius RFamide for feeding behavior and prolactin secretion in chicks.
Tachibana; T.; Tsukada; A.; Fujimoto; M.; Takahashi; H.; Ohkubo; T.; Boswell; T. and Furuse; M.
General and Comparative Endocrinology, 2005, [Reviewed]

Characterization of structure and expression of the growth hormone receptor gene of the Japanese flounder (Paralichtys olivaceus).
Nakao; N.; Higashimoto; Y.; Ohkubo; T.; Yoshizato; H.; Nakai; N.; Nakashima; K. and Tanaka; M.
Journal of Endocrinology, 2004, [Reviewed]

Effect of central administration of prolactin-releasing peptide on feeding in chicks.
Tachibana; T.; Saito; S.; Tomonaga; S.; Takagi; T.; Saito; E.; Nakanishi; T.; Koutoku; T.; Tsukada; A.; Ohkubo; T.; Boswell; T. and Furuse; M.
Physiology & Behavior, 2004, [Reviewed]

cDNA cloning of chicken orexin receptor and tissue distribution: sexually dimorphic expression in chicken gonads.
Ohkubo; T.; Tsukada; A. and Shamoto; K., Lead
Journal of Molecular Endocrinology, 2003, [Reviewed]

Fasting differentially regulates expression of agouti-related peptide, pro-opiomelanocortin, prepro-orexin, and vasoactive intestinal polypeptide mRNAs in the hypothalamus of Japanese quail.
Phillips-Singh; D.; Li; Q.; Takeuchi; S.; Ohkubo; T.; Sharp; P.J. and Boswell; T.
Cell and Tissue Research, 2003, [Reviewed]

Up-regulated expression of a novel gene in activated human peripheral blood mononuclear cells that is a truncated paralog of the human system L-amino acid transporter 1.
Ito; M.; Takebayashi; S.-I.; Okumura; K.; Ohkubo; T.; Nishio; M.; Kawano; M.; Komada; H.; Ito; Y. and Tsurudome; M.
International Journal of Biochemistry and Cell Biology, 2002, [Reviewed]

Tryptophans 286 and 288 in the C-terminal region of protein B23.1 are important for its nucleolar localization.
Nishimura; Y.; Ohkubo; T.; Furuichi; Y. and Umekawa; H.
Bioscience, Biotechnology and Biochemistry, 2002, [Reviewed]

Molecular cloning of chicken prepro-orexin cDNA and preferential expression in the chicken hypothalamus.
Ohkubo; T.; Boswell; T. and Lumineau; S., Lead
Biochimica et Biophysica Acta, 2002, [Reviewed]

Structure and tissue distribution of prolactin receptor mRNA in Japanese flounder (Paralichtys olivaceus): conserved and preferential expression in osmoregulatory organs.
Higashimoto; Y.; Nakao; N.; Ohkubo; T.; Tanaka; M. and Nakashima; K.:
General and Comparative Endocrinology, 2001, [Reviewed]

Molecular cloning of chicken vasoactive intestinal polypeptide receptor complementary DNA, tissue distribution and chromosomal localization.
Kansaku; N.; Shimada; K.; Ohkubo; T.; Saito; N.; Suzuki; T.; Matsuda; Y. and Zadworny; D.
Biology of Reproduction, 2001, [Reviewed]

Structure and tissue distribution of chicken leptin receptor (cOb-R) mRNA.
Ohkubo; T.; Tanaka; M. and Nakashima; K., Lead
Biochimica et Biophysica Acta, 2000, [Reviewed]

Molecular cloning of the chicken prolactin gene and activation by Pit-1 and cAMP-induced factor in GH3 cells.
Ohkubo; T.; Tanaka; M. and Nakashima; K., Lead
General and Comparative Endocrinology, 2000, [Reviewed]

Two novel first exons in the prolactin receptor gene are transcribed in a tissue-specific and sexual maturation-dependent manner to encode multiple 5’-truncated transcripts in the testis of the chicken.
Tanaka; M.; Yamamoto; I.; Hayashida; Y.; Nakao; N.; Ohkubo; T.; Wakita; M. and Nakashima; K.
Biochimica et Biophysica Acta, 2000, [Reviewed]

Effects of thyroid hormone on serum insulin-like growth factor binding proteins (IGFBPs) and IGFBP-2 mRNA expression in chickens.
Tsukada; A.; Ohkubo; T.; Tanaka; M.; Nakashima; K.; Wakita; M.; and Hoshino; S.
Japanese Poultry Science, 1999, [Reviewed]

cDNA cloning and developmental alterations in gene expression of the two Pit-1/GHF-1 transcription factors in the chicken pituitary.
Tanaka; M.; Yamamoto; I.; Ohkubo; T.; Wakita; M.; Hoshino; S. and Nakashima; K.:
General and Comparative Endocrinology, 1999, [Reviewed]

Genetic mapping of the chicken prolactin receptor gene: a candidate gene for the control of broodiness.
Dunn; I.C.; McEwan; G.; Okhubo; T.; Sharp; P.J.; Paton; I.R. and Burt; D.W.
British Poultry Science, 1998, [Reviewed]

Prolactin receptor gene expression in the brain and peripheral tissues in broody and nonbroody breeds of domestic hen.
Ohkubo; T.; Tanaka; M.; Nakashima; K.; Talbot; R.T. and Sharp; P.J., Lead
General and Comparative Endocrinology, 1998, [Reviewed]

Relationship between prolactin receptor mRNA in the anterior pituitary gland and hypothalamus and reproductive state in male and female bantams (Gallus domesticus).
Ohkubo; T.; Tanaka; M.; Nakashima; K. and Sharp; P.J.:, Lead
General and Comparative Endocrinology, 1998, [Reviewed]

Cloning and expression of pigeon growth hormone receptor cDNA in COS-7 monkey kidney cells.
Ohkubo T.; Tsukada A.; Tanaka M. and Nakashima K.:, Lead
Comparative Biochemistry and Physiology, 1998, [Reviewed]

Tissue-specific regulation of growth hormone receptor and growth hormone binding protein gene expression during pregnancy and lactation in the rat.
Sakaguchi; K.; Tanaka; M.; Ohkubo; T.; Yoshizato; H.; Hanai; Y.; Fujikawa; T.; Kaneko; H. and Nakashima; K.:
Endocrine Journal, 1998, [Reviewed]

cDNA cloning and characterization of neuron-specific enolase from chicken.
Tanaka; M.; Taniguchi; T; Ohkubo; T. and Nakashima; K.
Biochimica et Biophysica Acta, 1998, [Reviewed]

Gene and cDNA structures of flounder insulin-like growth factor-I (IGF-I): Multiple mRNA species encode a single short mature IGF-I.
Tanaka; M.; Taniguchi; T.; Yamamoto; I.; Sakaguchi; K; Yoshizato; H.; Ohkubo; T. and Nakashima; K.
DNA and Cell Biology, 1998, [Reviewed]

Thyroid hormones are involved in insulin-like growth factor-I (IGF-I) production by stimulating hepatic growth hormone receptor (GHR) gene expression in the chicken.
Tsukada; A.; Ohkubo; T.; Sakaguchi; K.; Tanaka; M.; Nakashima; K.; Hayashida; Y.; Wakita; M. and Hoshino; S.
Growth Hormone and IGF Research, 1998, [Reviewed]

Structures of mollusc shell framework proteins.
Sudo; S.; Fujikawa; T.; Nagakura; T.; Ohkubo; T.; Sakaguchi; K.; Tanaka; M.; Nakashima; K. and Takahashi; T.:, Nature Publishing Group
Nature, 1997, [Reviewed]

Influence of recombinant chicken prolactin on thyroid hormone metabolism in the chick embryo.
6. Kühn; E.R.; Shimada; K.; Ohkubo; T.; Vleurick; L.M.; Berghman; L.R. and Darras; V.M.
General and Comparative Endocrinology, 1996, [Reviewed]

Molecular cloning and characterization of the yellowtail GH gene and its promoter: a consensus sequence for teleost and avian Pit-1/GHF-1 binding sites.
Ohkubo; T.; Araki; M.; Tanaka; M.; Sudo; S. and Nakashima; K., Lead
Journal of Molecular Endocrinology, 1996, [Reviewed]

Induction of brain prolactin receptor long-form mRNA expression and maternal behavior in pup-contacted male rats: promotion by prolactin administration and suppression by female contact.
Sakaguchi; K.; Tanaka; M.; Ohkubo; T.; Doh-ura; K.; Fujikawa; T.; Sudo; S. and Nakashima; K.
Neuroendocrinology, 1996, [Reviewed]

Growth hormone-independent expression of insulin-like growth factor I messenger ribonucleic acid in extrahepatic tissues of the chicken.
Tanaka; M.; Hayashida; Y.; Sakaguchi; K.; Ohkubo; T.; Wakita; M.; Hoshino; S. and Nakashima; K.:
Endocrinology, 1996, [Reviewed]

Sequence of the flounder (Paralichthys olivaceus) growth hormone encoding gene and its promoter region.
Tanaka; M.; Toma; Y.; Ohkubo; T.; Sudo; S. and Nakashima; K.
Gene, 1995, [Reviewed]

ブリ及びヒラメ成長ホルモン遺伝子のクローニング　　　　　　　　　　　　　　　
中島邦夫; 田中実; 大久保武
月刊海洋, 1995, [Reviewed]

Differential regulation of prolactin receptor mRNA expression in rat liver and kidney by testosterone and oestradiol.
Sakaguchi; K.; Ohkubo; T.; Sugiyama; T.; Tanaka; M.; Ushiro; H. and Nakashima; K.
Journal of Endocrinology, 1994, [Reviewed]

High-level expression of biologically active chicken prolactin in E. coli.
Ohkubo; T.; Tanaka; M.; Nakashima; K.; Shimada; K.; Saito; N. and Sato; K., Lead
Comparative Biochemistry and Physiology, 1993, [Reviewed]

Effects of removal of chicks from hens on concentrations of prolactin, luteinizing hormone and oestradiol in plasma of brooding Gifujidori hens
Kuwayama; T.; Shimada; K.; Saito; N.; Ohkubo; T.; Sato; K.; Wada; M. and Ichinoe; K
Journal of Reproduction and Fertility, 1992, [Reviewed]

Double antenna structure of chicken prolactin receptor deduced from the cDNA sequence.
M TANAKA; K MAEDA; T OKUBO; K NAKASHIMA
Biochemical and Biophysical Research Communications, 1992, [Reviewed]

A Bird's-Eye Overview of Leptin and Female Reproduction -with Mammalian Comparisons.
Sadequllah Ahmadi; Takeshi Ohkubo
Journal of Poultry Science, Feb. 2025, [Reviewed], [Invited]

Recent progress in avian leptin research
Takeshi Ohkubo
Journal pf Poultry Science, 2014, [Reviewed]

Leptin signaling and action in birds.
Ohkubo; T. and Adachi; H.
Journal of Poultry Science, 2008, [Reviewed]
Lead

Cloning and characterization of chicken cholecystokinin receptor.　　　　　　　　　　　　　　　
Ohkubo; T. and Shamoto; K.
Proceedings of the Fifth Congress of the Asia and Oceania Society for Comparative Endocrinology in Conjunction with the Annual Meeting of the Japan Society for Comparative Endocrinology, 2004, [Reviewed]
Lead

Cloning and regulation of chicken cholesterol 7α-hydroxylase.　　　　　　　　　　　　　　　
Yamamoto; Y.; Tsukada; A.; Ohkubo; T.; Umekawa; H.; Takahashi; T and Furuichi; Y.:
Proceedings 6th Asian Pacific Poultry Congress, 1998, [Reviewed]

Neuroendocrine Control of Broodiness　　　　　　　　　　　　　　　
Ohkubo; T, Contributor
Springer, 29 Jun. 2017

ニワトリの科学　　　　　　　　　　　　　　　
Joint work
朝倉書店, 10 Jul. 2014

The molecular biology of prolactin　　　　　　　　　　　　　　　
Shimada; K.; Ohkubo; T.; Saito; N.; Talbot; R.T.; Sharp; P.J, Joint work
1993

Does leptin have a role in asymmetrical development of chicken ovary?　　　　　　　　　　　　　　　
SHAIKAT AMIR; Namekawa Shoko; Ahmadi Sadequllah; Takeda Misa; Ohkubo Takeshi
日本畜産学会第122回大会, 27 Mar. 2017

Action of leptin for pituitary hormone gene expression in the chick　　　　　　　　　　　　　　　
Shoko Namekawa and Takeshi Ohkubo
World's Poultry Congress 2016, 10 Sep. 2016

Expression of Pigeon Leptin in vitro with Determination of Biological Activity　　　　　　　　　　　　　　　
Sadequllah Ahmadi; Shoko Namekawa and Takeshi Ohkubo
17th AAAP Animal Science Congress, 23 Aug. 2016

Interaction of STAT3 and STAT5 in the leptin signal transduction　　　　　　　　　　　　　　　
Shoko Namekawa; Daisuke Murase and Takeshi Ohkubo
17th AAAP Animal Science Congress, 23 Aug. 2016

ニワトリの下垂体ホルモン遺伝子発現に対するレプチンの作用　　　　　　　　　　　　　　　
滑川晶子; 大久保武
日本家禽学会２０１６年度春季大会, 30 Mar. 2016

鶏の就巣性の制御について　　　　　　　　　　　　　　　
大久保武
平成27年度関東甲信越地域鶏試験研究推進協議会全体会議, 08 Oct. 2015, [Invited]

レプチン情報伝達における STAT3 と STAT5 の相互作用　　　　　　　　　　　　　　　
滑川晶子; 大久保武
日本家禽学会２０１５年度秋季大会, 10 Sep. 2015

Change of appetite-associated genes in the chicken hypothalamus during incubation behavior　　　　　　　　　　　　　　　
Takeshi Ohkubo; Takahiro Kodama; Rumi Ohnuki
10th Asia Pacific Poultry Conference, 21 Oct. 2014

抱卵行動がニワトリ視床下部の摂食関連遺伝子の発現に及ぼす影響　　　　　　　　　　　　　　　
児玉孝弘; 大貫瑠美; 大久保武
2014年度日本家禽学会春季大会, 29 Mar. 2014, 日本家禽学会

コレシストキニン A受容体遺伝子の一塩基多型は比内鶏発育を改善する　　　　　　　　　　　　　　　
力丸宗弘; 武田尚人; 小松恵; 高橋大希; 大久保武; 高橋秀彰
2013年度日本家禽学会秋季大会, 08 Sep. 2013, 日本家禽学会

Role of transactivation domain of Pit-1 is different in the transcriptional regulation of GH gene by leptin in chicken and mouse　　　　　　　　　　　　　　　
Daisuke Murase; Kaori Ogawa and Takeshi Ohkubo
17th International Congress on Comparative Endocrinology, 16 Jul. 2013

鳥類血清中のレプチン様活性の検出　　　　　　　　　　　　　　　
村瀬大輔; 廣田佳菜子; 安達洋泉; 竹田努; 杉田昭栄; 大久保武
2013年度家禽学会春季大会, 29 Mar. 2013

Leptin regulates Pit-1α-dependent chicken GH gene expression in mammalian cells　　　　　　　　　　　　　　　
10th International Symposium on Avian Endocrinology, 06 Jun. 2012, Daisuke Murase, Susumu Atomura and Takeshi Ohkubo

Effect of chicken STAT5b mutant on prolactin signal transduction　　　　　　　　　　　　　　　
Susumu Atomura; Hiromi Adachi; Daisuke Murase; Takeshi Ohkubo
10th International Symposium on Avian Endocrinology, 06 Jun. 2012

ニワトリGH遺伝子のレプチン応答におけるPit-1転写活性領域の機能解析　　　　　　　　　　　　　　　
村瀬大輔; 後村進; 大久保武
2012年度家禽学会春季大会, 30 Mar. 2012

日本分子生物学会

日本畜産学会

日本家禽学会

日本比較内分泌学会