家庭における主食としての米粉パン普及の可能性について
西川陽子、秋葉さくら, 筆頭著者, 茨城大学教育学部
茨城大学教育学部紀要（自然科学）, 2024年01月31日
家庭における野菜再生栽培による環境負荷低減の可能性
西川陽子, 宮田恵里花, 筆頭著者, 茨城大学教育学部
茨城大学教育学部紀要(自然科学), 2023年02月
大学教育に求められる変化,－「何を教えたか」から「何を身につけられたか」へ －
西川 陽子, 茨城大学 全学教育機構
茨城大学全学教育機構論集 大学教育研究, 2022年03月, ［査読有り］, ［招待有り］
食品廃棄部位の栄養学的有用性の検討
西川陽子、原田萌, 筆頭著者, 茨城大学 教育学部
茨城大学教育学部紀要（教育科学）, 2022年01月
いきいき茨城ゆめ大会選手団サポートボランティア,の育成と代替ボランティア活動に関する実践報告
矢嶋 敬紘、沼田 世里、上地 勝、西川 陽子, ラスト(シニア)オーサー, 茨城大学 全学教育機構
茨城大学全学教育機構論集（大学教育研究）, 2021年04月, ［査読有り］
米粉パンの需要における今後の展望について
西川 陽子、軍司 美南, 筆頭著者, 茨城大学 教育学部
茨城大学教育学部紀要（教育科学）, 2021年01月
食品の乾燥加工保存における栄養学的評価
西川陽子・石崎祐香・野部瞳, 筆頭著者, 茨城大学 教育学部
茨城大学教育学部紀要（自然科学）, 2020年01月
伝統的食品保蔵手段の栄養学的評価
西川陽子・上杉望・森三千歌, 筆頭著者, 茨城大学 教育学部
茨城大学教育学部紀要（自然科学）, 2019年01月29日
茨大なんでも相談室及びバリアフリー推進室の利用状況と今後の課題
矢嶋敬紘; 額賀沙弥香; 門馬綾; 曽田陽子; 沼田世里; 深谷佳子、中井川香梨; 西川陽子, 責任著者, 茨城大学全学教育機構
茨城大学全学教育機構論集 大学教育研究, 2018年03月01日
家庭科食分野における米粉を用いたサステナビリティ教 育
西川陽子・向井彩, 高校生を対象としたサステナビリティ教育を家庭科教育食物分野の教育として行う場合の小麦粉代替用米粉の教材価値について、考案したモデル授業の実地試行結果を踏まえ評価検討し、その有効性を証明した。, 茨城大学教育学部
茨城大学教育学部紀要 教育科学, 2018年01月30日
イチゴの有効利用を目的とする加工品の検討
西川陽子,藤枝里衣
茨城大学教育学部紀要(教育科学), 2013年03月
加工法の異なるリンゴジュースにおける保蔵中のアスコルビン酸動態について
西川 陽子,栗林 愛美
茨城大学教育学部紀要（教育科学）, 2011年03月
Chemical Characteristics of the Proteinaceous Material in the Nests of Six Polistine Species (Hymenoptera; Vespidae)Takaaki Kuwahara; Sôichi Yamane; I-Hsin Sung Sirinee Poonchaisri; Yoko Nishikawa, Some chemical characteristics of oral secretions and larval silk, which contain proteinaceous substances, were analyzed in the nests of four Ropalidia species, R. fasciata, R. taiwana, R. rufocollaris and R. flavopicta, and two Polistes species, P. gigas and P. tenebricosus. Nitrogen contents in pure oral secretions ranged between 13-14%, and crude protein contents, calculated from the N contents, were 84-89%. The protein content in the larval silk was approximately 90%. The three major amino acids in the nest parts were Gly (23-48%), Ala (16-22%) and Ser (6-19%) in Ropalidia species, and Gly (20-32%), Ser (11-14%) and Pro (10-13%) in Polistes species. These items occupied about 60% of the residues. The three major amino acids in the larval silk were Ala (33-34%), Ser (19-21%) and Glx or Asx (9%). Ala and Ser comprised about half of the residues. In some species, the relative abundance of amino acids in the oral secretions varied depending on the parts of nest, especially in the proportion of Gly. Cluster analyses carried out on the amino acid compositions in the oral secretions generated two distinct groups: One consisted of the nest paper, which contained a small amount of secretion coating and the other consisted of secretion layers of the petiole and secretion membranes made at the bottom of Ropalidia cells. These results suggest a possibility that these wasps can produce oral secretions with different kinds and/or ratios of protein(s) according to their purposes, i.e., construction or maintenance., CALIFORNIA STATE UNIV
Sociobiology, 2011年,
［査読有り］ 小学生の着実な調理技能習得に向けての教育方法の検討, ― 包丁技能を中心に ―
星さやか,西川陽子, 家庭科では，近年の著しい授業時数の削減により，技能習得のための十分な実技教育ができない状況が生じている。調理における基礎技能習得は，主に小学校のうちに行われるのが望ましいが，この技能教育における教育時間と必要性のギャップを現行の小学校教育の中で埋めていくには，家庭科だけではなく他の授業時間の利用が有効と考えられる。その可能性を探るため，本研究では包丁技能習得教育を中心に，文献調査及び小学生を対象とした包丁技能テストを行い検討した。その結果，高学年の家庭科の授業を待たずとも，低学年のうちから教育は可能であり，成長段階に応じて内容を吟味すれば高い教育効果が得られると推察された。また，現在の家庭科教科書に掲載されている調理実習内容は，そのほとんどが調理科学的視点から編集されたものであり，技能習得に視点を置いた教科書の見直しが必要であると考えられた。
茨城大学教育実践研究, 2010年12月01日
家庭科調理実習における今後のあり方について西川陽子,大内華子,鈴木美穂,大村奈実, 今後の学校家庭科調理実習における改革案として，調理実験的要素を盛り込み科学の知識の応用の場として活用することを提案するために，特に調理初歩段階にある男子学生へのメリットについて実験的検証を試みたもの。, 茨城大学教育学部
茨城大学教育学部紀要（教育科学）, 2008年03月
消化器炎症性疾患と栄養・機能性食品
宮川八平,西川陽子, 消化器の疾病予防に特に有効な機能性食品について，現在その効果が既に学術的に証明されているものを整理し，それぞれの機能性とその機能が証明されたエヴィデンスについて概説したもの。, (株)インフォノーツパブリッシング
機能性食品と薬理栄養, 2008年02月29日
流通及び保蔵中における食品中ビタミンCの動態に関する研究
西川 陽子
研究成果集446集｢食品の安全性及び機能性に関する総合研究 －機能性－｣, 2008年01月18日
流通及び保蔵中における食品中ビタミンCの動態に関する研究
｢食品の安全性及び機能性に関する総合研究（第二分冊）｣ （独立行政法人食品総合研究所）, 2006年02月
高齢者の食教育および指導の有効性について
頼久美,植田勇治,細貝光恵,西川陽子
栄養日本(社団法人 日本栄養士会), 2006年02月01日
高齢者の食教育及び指導の有効性について
西川 陽子・頼 久美・植田 勇治・細貝 光恵
｢栄養指導等に関する研究助成事業報告書 第4号（平成16年度）,｣ 社団法人日本栄養士会, 2005年03月, ［査読有り］
食育の必要性と食育が求める生活者像
西川陽子
チクサン出版社（(株)緑書房）『月刊 養豚界』, 2004年08月
酸化型L－アスコルビン酸の化学的特性
倉田忠男,西川陽子
日本農芸化学会誌, 2003年
Vitamin C metabolomic mapping in the lens with 6-deoxy-6-fluoro-ascorbic acid and high-resolution 19F-NMR spectroscopy.Satake M; Dmochowska B; Nishikawa Y; Madaj J; Xue J; Guo Z; Reddy DV; Rinaldi PL; Monnier VM., PURPOSE. Metabolomics, or metabolic profiling, is an emerging discipline geared to providing information on a large number of metabolites, as a complement to genomics and proteomics. In the current study, a fluorine-labeled derivative of ascorbic acid (F-ASA), a major antioxidant- and UV-trapping molecule in the aqueous humor and the tens, was used to investigate the extent to which the lens accumulates potentially toxic degradation products of vitamin C.
METHODS. Human lens epithelial cells (HLE-B3) and rat lenses were exposed to hyperglycemic or oxidative stress in vitro or in vivo and probed for accumulation of F-ASA, fluoro-dehydroascorbate (F-DHA), fluoro-2,3-diketogulonate (F-DKG), and their degradation products in protein-free extracts, by proton-decoupled 750-MHz F-19-nuclear magnetic resonance (NMR) spectroscopy.
RESULTS. F-ASA and F-DHA were taken up into HLE B-3 cells by an Na+-dependent transporter. Their uptake was unexpectedly only slightly affected by hyperglycemia in vitro, unless glutathione was severely depleted. Glycemic stress catalyzed oxidation of F-ASA into a single novel F-compound at -212.4 ppm, whereas F-DHA and F-DKG were the major degradation products observed after GSH depletion. In contrast, F-ASA uptake was markedly suppressed in diabetic cataractous rat lenses, which accumulated both the F-DHA and the - 212.4-ppm compound. In an unexpected finding, the latter formed only from F-ASA and not F-DHA or F-DKG, suggesting a novel pathway of in vivo F-ASA degradation. Both the cells and the intact rat and human lenses were permeable to several advanced F-ASA and F-DHA degradation products, except F-DKG. The unknown compound at -212.4 ppm was the only F-ASA degradation product that spontaneously formed in rabbit aqueous humor upon incubation with F-ASA.
CONCLUSIONS. These studies suggest the existence of a novel ascorbic-acid-degradation pathway in the lens and aqueous humor that is influenced by the nature of the oxidant stress. Under similar culture conditions, intact lenses are more prone to hyperglycemia-mediated oxidant stress than are lens epithelial cells, but both are permeable to various F-ASA degradation products, the structure and biological roles of which remain to be established., ASSOC RESEARCH VISION OPHTHALMOLOGY INC
Invest. Ophthalmol. Vis. Sci., 2003年
Vitamin C metabolomic mapping in experimental diabetes with 6-deoxy-6-fluoro-ascorbic acid and high resolution 19F-nuclear magnetic resonance spectroscopy.Nishikawa Y; Dmochowska B; Madaj J; Xue J; Guo Z; Satake M; Reddy DV; Rinaldi PL; Monnier VM., Metabolomic mapping is an emerging discipline geared at providing information on a large number of metabolites as a complement to genomics and proteomics. Here we have probed ascorbic acid homeostasis and degradation in diabetes using 6-deoxy-6-fluoro ascorbic acid (F-ASA) and 750 MHz F-19-nuclear magnetic resonance (NMR) spectroscopy with proton decoupling In vitro, Cu2+-mediated degradation of F-ASA revealed the formation of 4 major stable degradation products at 24 hours. However, when normal or diabetics rats were injected with F-ASA intraperitoneally (IP) for 4 days, up to 20 fluorine-labeled compounds were observed in the urine. Their composition resembled, in part, metal catalyzed degradation of F-ASA and was not explained by spontaneous degradation in the urine. Diabetes led to a dramatic increase in urinary F-ASA loss and a relative decrease in most other urinary F-compounds. Diabetes tilted F-ASA homeostasis toward oxidation in liver [P < .01), kidney (P < .01), spleen (P < .01), and plasma (P < .01), but tended to decrease oxidation in brain, adrenal glands, and heart. Surprisingly, however, besides the major oxidation product fluoro-dehydroascorbic acid (F-DHA), no F-ASA advanced catabolites were detected in tissues at 5 mu mol/L sensitivity. These findings not only confirm the key role of the kidney in diabetes-mediated loss of ascorbic acid, but demonstrate that only selected tissues are prone to increased oxidation in diabetes. While the structure of most degradation products needs to be established, the method illustrates the power of high resolution F-19-NMR spectroscopy for the mapping of complex metabolomic pathways in disease states. (C) 2003 Elsevier Inc. All rights reserved., W B SAUNDERS CO
Metabolism., 2003年
Identification of 3,4-dihydroxy-2-oxo-butanal (L-threosone) as an intermediate compound in oxidative degradation of dehydro-L-ascorbic acid and 2,3-diketo-L-gulonic acid in a deuterium oxide phosphate buffer.Nishikawa Y; Toyoshima Y; Kurata T., Dehydro-L-ascorbic acid (DAA), an oxidation product of L-ascorbic acid (vitamin C), is unstable in the neutral and basic pH regions. When DAA was incubated in a phosphate buffer with deuterium oxide (pH 7.4), it was degraded to form the main degradation compound, which was identified as 3,4-dihydroxy-2-oxobutanal (L-threosone). This compound was also formed from diketo-L-gulonic acid (DKG) in a phosphate buffer with deuterium oxide. L-threosone had reducing activity, probably due to its enolization, and is likely to have been involved in the formation of the reducing activity that was observed in aqueous DAA and DKG solutions. As a reactive dicarbonyl compound, L-threosone might also take some role in the cross-linking of tissue proteins that are formed in vivo in the Maillard reaction., TAYLOR & FRANCIS LTD
Biosci.Biotechnol.Biochem., 2001年
Time-dependent changes of tissue erythorbic acid concentrations in guinea pigs.Suzuki E; Kurata T; Miyake N; Nishikawa Y; Arakawa N., The concentrations of erythorbic acid(ErA) and L-ascorbic acid(AsA) in the tissues of guinea pigs orally administered AsA or ErA were measured over the passage of time using high-performance liquid chromatography Guinea pigs were each administered 5 mg AsA or 100 mg ErA, and killed at a specified time thereafter. The AsA concentrations in the tissues of AsA-administered guinea pigs and the ErA concentrations in the tissues of ErA-administered guinea pigs increased for 3 h after the respective administrations and decreased thereafter in both groups. The AsA concentration in the tissues of AsA-administered guinea pigs tended to be similar to the sum of AsA and ErA concentrations in the ErA-administered guinea pigs within 3 h after administration., CENTER ACADEMIC PUBL JAPAN
J. Nutr. Sci. Vitaminal., 2000年
6-Deoxy-6-fluoro-L-ascorbic acid: crystal structure and oxidative degradation.Madaj J; Nishikawa Y; Reddy VP; Rinaldi P; Kurata T; Monnier VM., Ascorbic acid and its oxidation products have been implicated in non-enzymatic modification of proteins in aging and diseases of oxidative stress. We have studied the feasibility of using 6-deoxy-6-fluoroascorbic acid (6) for identification of ascorbic acid degradation products by F-19 NMR spectroscopy. Crystals of compound 6 from nitromethane belonged to the space group P2(1) with a = 5.547(2), b = 6.769(3), c = 9.302(2) Angstrom, beta = 91.80(3)degrees and Z = 2. Atomic coordinates, bond lengths and angles, hydrogen coordinates, anisotropic and isotropic displacement parameters were similar if not identical with those of native ascorbic acid. Similarly, UV properties and oxidation kinetics by CuCl2 at different pH values were essentially identical with ascorbic acid. Using 750 MHz F-19 NMR spectroscopy, five to six new fluorinated products were detected after overnight oxidation of 6 with Cu2+, suggesting that 6 may be a powerful and sensitive tool for assessment of its catabolism in vivo. (C) 2000 Elsevier Science Ltd. All rights reserved., ELSEVIER SCI LTD
Carbohydr. Res., 2000年
Chemical characteristics of dehydro-L-ascorbic acid.Kurata T; Nishikawa Y, Dehydro-L-ascorbic acid (DAA) exists mainly in its C2 hydrated bicyclic form (5) in an aqueous solution, and monocyclic DAA (3), which is the expected reaction product immediately after the oxidation of AA, has not been observed by NMR spectroscopy, The formation mechanism for 5 from 3 and the stability of 5 were examined by the semi-empirical molecular orbital method (MOPAC). It was indicated that the protonation reaction was the key step in the formation of 5, therefore, the formation of 5 Is thought to be more difficult under physiological conditions which mostly involve in the neutral or slightly alkaline state. However, by NMR, it was confirmed that, even In a neutral or slightly alkaline state very close to physiological conditions, the predominant form of DAA existing in an aqueous solution immediately after the enzymatic oxidation of AA was confirmed to be 5, although the possible existence of other farms of DAA at very low concentrations could not be completely excluded., TAYLOR & FRANCIS LTD
Biosci. Biotechnol. Biochem., 2000年
Interconversion between dehydro-L-ascorbic acid and L-ascorbic acid.Nishikawa Y; Kurata T., L-Ascorbic acid (AA) plays an important role in biological systems as an electron donor. Erythorbic acid (EA) is the epimer of AA and has chemical characteristics very similar to those of AA, It is demonstrated in the present study by H-1-NMR that dehydro-L-ascorbic acid (DAA) was reduced by EA under neutral conditions but not acidic, and that dehydroerythrobic acid (DEA) was also reduced by AA under the same conditions.. These reactions also occurred at a low concentration dose to the concentration of AA in such biological tissue as the liver. Furthermore, the interconversion of DAA and AA at neutral pH and low concentration was also confirmed by radioluminography. These results Suggest the interconversion between DAA and AA in vivo., TAYLOR & FRANCIS LTD
Biosci. Biotech. Biochem., 2000年
The behavior of erythorbic acid in water-dehydroerythorbic acid as a main compound.
Nishikawa Y; Kurata T
Research of Erythorbate, 1999年
