Hodaka SuzukiProfessor
■Researcher basic information
Organization
Research Areas
■Research activity information
Paper
- Necessity of redefinition and revision of mouse unit for tetrodotoxin: Relationship between lethal time and mouse unit of tetrodotoxin in mouse bioassay.
Hodaka Suzuki, Lead, BACKGROUND: An assay that utilizes the relationship between the amount of toxin administered and the lethal time of mice is called a mouse bioassay (MBA) and has been used as an assay for marine neurotoxins such as paralytic shellfish poison toxins and pufferfish toxins. The MBA for tetrodotoxin (TTX), which is possessed by pufferfish, has been used for many years in Japan. In the Japanese reference method, equivalent to the official method, the toxicity of TTX is expressed in mouse units (M.U.), and 1 M.U. is defined as the amount of the toxins required to kill a 20 g mouse in 30 min and is stated as 0.22 μg of TTX. The regulation limit in food is also expressed in M.U. in Japan. OBJECTIVES: In the previous studies, we have questioned the definition of 1 M.U. of TTX in the currently used Japanese reference method. In this study, we investigated the dose-lethal time relationship of TTX in mice. METHODS: Followed by the Japanese reference method, various doses of TTX were inoculated intraperitoneally into mice (n = 3/each dose) and the time from the end of the injection to the last gasp of breath was measured. RESULTS: The dose-lethal time relationship curve obtained in this study showed quite similar curves described in the reference method, but lethal time was always shorter than the time in the reference method. Also, the amount of 1 M.U. of TTX could not be determined based on the definition because most of the mice died earlier than 30 min after injection or survived. DISCUSSION: Based on the dose-lethal time relationship curve obtained in this study, 1 M.U. might be 0.1727 μg of TTX, which was about 22 % smaller than 0.22 μg. Furthermore, based on the definition, it was impossible to determine the amount of TTX for 1 M.U. The author asserts that the definition of M.U. and the amount of TTX for 1 M.U. should be reviewed.
Toxicon : official journal of the International Society on Toxinology, Oct. 2025, [Reviewed] - Hygienic indicator bacteria in the 2 species of wild-caught Japanese cicadas, large brown cicadas and robust cicadas
Takuro Ueda; Bontetsu Haga; Hodaka Suzuki, Last
JOURNAL OF INSECTS AS FOOD AND FEED, May 2024, [Reviewed] - 加熱不十分な鶏肉製品に対する調理前の高圧処理による食中毒菌低減効果の検討
岡田由美子; 鈴木穂高; 筒浦さとみ; 西海理之; 百瀬愛佳; 野田衛
日本食品微生物学会雑誌, Mar. 2024, [Reviewed] - Microbiological Assessment of Pasteurized Milk in Japan by Different Testing Methods
Hodaka Suzuki; Amalia Widya Rizky Sahoed; Rikako Midoh; Yumiko Okada, Lead, Science and Education Publishing Co., Ltd.
Journal of Food and Nutrition Research, Mar. 2023, [Reviewed] - Impacts of Subchronic and Mild Social Defeat Stress on Plasma Putrefactive Metabolites and Cardiovascular Structure in Male Mice
Atsushi Toyoda; Kina Kawakami; Yuto Amano; Hideaki Nishizawa; Shin-ichi Nakamura; Takahiro Kawase; Yuta Yoshida; Hodaka Suzuki; Takamitsu Tsukahara, Psychosocial stress precipitates mental illnesses, such as depression, and increases the risk of other health problems, including cardiovascular diseases. In this study, we observed the effects of psychosocial stress on the histopathological features of systemic organs and tissues in a mouse psychosocial stress model, namely the subchronic and mild social defeat stress (sCSDS) model. There were several pathological findings in the tissues of both sCSDS and control mice. Mild fibrosis of the heart was observed in sCSDS mice but not in control mice. Extramedullary hematopoiesis in the spleen and hemorrhage in the lungs were observed in both the control and sCSDS mice. Focal necrosis of the liver was seen only in control mice. Furthermore, putrefactive substances in the blood plasma were analyzed because these metabolites originating from intestinal fermentation might be linked to heart fibrosis. Among them, plasma p-cresyl glucuronide and p-cresyl sulfate concentrations significantly increased owing to subchronic social defeat stress, which might influence cardiac fibrosis in sCSDS mice. In conclusion, several pathological features such as increased cardiac fibrosis and elevated plasma putrefactive substances were found in sCSDS mice. Thus, sCSDS mice are a potential model for elucidating the pathophysiology of psychosocial stress and heart failure., MDPI AG
International Journal of Molecular Sciences, Jan. 2023, [Reviewed] - Drastic Hypothermia after Intraperitoneal Injection of Okadaic Acid, a Diarrhetic Shellfish Poisoning Toxin, in Mice.
Suzuki; H., Lead
Exp. Anim., Aug. 2021, [Reviewed] - Anterior Segment Dysmorphogenesis of the Eye and Glaucoma in MG-W Gerbils.
Fukunaga; Y.; Ogawa; T.; Suzuki; H.; Okada; Y.; Nakazawa; T.; Yamaguchi; Y.
J. Toxicol. Pathol., Jul. 2021, [Reviewed] - Comparison of the Susceptibility to Tetrodotoxin in ddY Strain Mice from Different Breeder Companies.
Suzuki; H., Lead
Food Hyg. Saf. Sci., Feb. 2020, [Reviewed] - Prevalence of Cronobacter spp. in Retail Foods and Farm-Associated Environments in Japan.
H. Ogihara; N. Fukuda; A. Fujiwara; H. Suzuki; H. Yamamoto; D. Kyoui; Y. Okada; S. Igimi
Food Sci. Tech. Res., Apr. 2019, [Reviewed] - Comparative Toxicity of Dinophysistoxin-1 and Okadaic Acid in Mice.
H. Suzuki; Y. Okada, Lead, Japanese Society of Veterinary Science
J. Vet. Med. Sci., Apr. 2018, [Reviewed] - Effects of High Hydrostatic Pressure Processing on the Number of Bacteria and Texture of Beef Liver.
H. Ogihara; H. Suzuki; M. Michishita; H. Hatakeyama; Y. Okada, Corresponding
J. Food Qual., May 2017, [Reviewed] - Differences in susceptibility of mouse strains to tetrodotoxin
Hodaka Suzuki, Lead
TOXICON, Sep. 2016, [Reviewed] - 水晶体脱臼を伴う眼球腫大のスナネズミ4症例
小川竜也; 岡田由美子; 久世博; 花見正幸; 鈴木穂高, Last
比較眼科研究, Oct. 2015, [Reviewed] - Antimicrobial Susceptibilities of Listeria monocytogenes Isolated from the Imported and the Domestic Foods in Japan.
Y. Okada; S. Monden; H. Suzuki; A. Nakama; M. Ida; S. Igimi
J. Food Nutr. Sci., Jan. 2015, [Reviewed] - Comparison of Toxicity between Saxitoxin and Decarbamoyl Saxitoxin in the Mouse Bioassay for Paralytic Shellfish Poisoning Toxins
Hodaka Suzuki; Kenji Machii, Lead
JOURNAL OF VETERINARY MEDICAL SCIENCE, Nov. 2014, [Reviewed] - Influence of body weight of mice on the susceptibility to okadaic acid, a diarrhetic shellfish poisoning toxin
Hodaka Suzuki, Lead
FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT, Apr. 2014, [Reviewed] - Bacterial Translocation in Alymphoplasia (aly/aly) Mice
Hodaka Suzuki; Yumiko Okada, Lead
FOLIA BIOLOGICA-KRAKOW, 2014, [Reviewed] - Growth of Listeria monocytogenes in refrigerated ready-to-eat foods in Japan
Yumiko Okada; Izumi Ohnuki; Hodaka Suzuki; Shizunobu Igimi
Food Additives and Contaminants - Part A Chemistry, Analysis, Control, Exposure and Risk Assessment, Aug. 2013, [Reviewed] - Sequence of busulfan-induced neural progenitor cell damage in the fetal rat brain
Toko Ohira; Ryo Ando; Yumiko Okada; Hodaka Suzuki; Tsubasa Saito; Tomomi Nakazawa; Kaori Nishihara; Satoshi Yamamoto; Norihiko Nakamura; Kazutoshi Tamura
Experimental and Toxicologic Pathology, Jul. 2013, [Reviewed] - Differences in Susceptibility to Okadaic Acid, a Diarrhetic Shellfish Poisoning Toxin, between Male and Female Mice
Hodaka Suzuki, Lead
TOXINS, Jan. 2013, [Reviewed] - Effects of injection speed of test samples on the mouse bioassay for paralytic shellfish poisoning toxins
Hodaka Suzuki; Kenji Machii, Lead
Italian Journal of Food Safety, 2013, [Reviewed] - Age-dependent changes in intraepithelial lymphocytes (IELs) of the small intestine, cecum, and colon from young adult to aged mice
Hodaka Suzuki, Lead
ARCHIVES OF GERONTOLOGY AND GERIATRICS, Sep. 2012, [Reviewed] - Rapid and Drastic Decreases of Body Temperature in Mice Intraperitoneally Injected with Lethal Dose of Okadaic Acid.
H. Suzuki, Lead
Proceedings of the 14th ICHA, Jul. 2012 - Susceptibility of different mice strains to okadaic acid, a diarrhetic shellfish poisoning toxin
Hodaka Suzuki, Lead
FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT, 2012, [Reviewed] - Antimicrobial Susceptibilities of Listeria monocytogenes Isolated in Japan
Yumiko Okada; Akiko Okutani; Hodaka Suzuki; Hiroshi Asakura; Shuko Monden; Akiko Nakama; Tsutomu Maruyama; Shizunobu Igimi
JOURNAL OF VETERINARY MEDICAL SCIENCE, Dec. 2011, [Reviewed] - Differences in gene expression profiles among the proximal, middle and distal Peyer's patches in the mouse small intestine
Hodaka Suzuki; R. Ohtsuka; M. Takeda, Lead
Research Journal of Immunology, 2011, [Reviewed] - Quantitative Risk Assessment of Vibrio parahaemolyticus in Finfish: A Model of Raw Horse Mackerel Consumption in Japan
Jun'ichiro Iwahori; Akio Yamamoto; Hodaka Suzuki; Takehisa Yamamoto; Toshiyuki Tsutsui; Keiko Motoyama; Mikiko Sawada; Tomoki Matsushita; Atsushi Hasegawa; Ken Osaka; Hajime Toyofuku; Fumiko Kasuga
RISK ANALYSIS, Dec. 2010, [Reviewed] - Differences in Intraepithelial Lymphocytes in the Proximal, Middle, Distal Parts of Small Intestine, Cecum, and Colon of Mice
Hodaka Suzuki, Lead
IMMUNOLOGICAL INVESTIGATIONS, 2009, [Reviewed] - 米国産輸入牛肉と我が国の腸管出血性大腸菌による食中毒，および感染症発生に関する研究
鈴木穂高; 山本茂貴, Lead, 国立医薬品食品衛生研究所安全情報部
国立医薬品食品衛生研究所報告, Dec. 2008, [Reviewed] - Regional variations in the distributions of small intestinal intraepithelial lymphocytes (IELs) in outbred laboratory mice (Mus musculus domesticus) and the inbred strain of mice established from Japanese fancy mice (Mus musculus molossinus)
H Suzuki; S Yamamoto, Lead
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 2006, [Reviewed] - Development of early apoptosis and changes in T-cell subsets in mouse thymocyte primary cultures treated with nivalenol
A Poapolathep; S Kumagai; H Suzuki; K Doi
EXPERIMENTAL AND MOLECULAR PATHOLOGY, Oct. 2004, [Reviewed] - Development of early apopotosis and changes in lymphocyte subsets in lymphoid organs of mice orally inoculated with nivalenol
A Poapolathep; T Nagata; H Suzuki; S Kumagai; K Doi
EXPERIMENTAL AND MOLECULAR PATHOLOGY, Aug. 2003, [Reviewed] - Age-related changes in the regional variations in the number and subsets of intraepithelial lymphocytes in mouse small intestine
H Suzuki; KI Jeong; K Doi, Lead
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, Jul. 2002, [Reviewed] - Regional variations in the distributions of small intestinal Intraepithelial lymphocytes in germ-free and specific pathogen-free mice
H Suzuki; KI Jeong; K Itoh; K Doi, Lead
EXPERIMENTAL AND MOLECULAR PATHOLOGY, Jun. 2002, [Reviewed] - CD8(+)-T-cell depletion ameliorates circulatory shock in Plasmodium berghei-infected mice
WL Chang; SP Jones; DJ Lefer; T Welbourne; G Sun; LJ Yin; H Suzuki; J Huang; DN Granger; HC van der Heyde
INFECTION AND IMMUNITY, Dec. 2001, [Reviewed] - Regional Variations in the Distribution of Small Intestinal Intraepithelial Lymphocytes in Alymphoplasia (aly/aly) Mice and Heterozygous (aly/+) Mice.
H. Suzuki; K. I. Jeong; K. Doi, Lead
Immunol. Invest., Nov. 2001, [Reviewed] - Development of apoptosis and changes in lymphocyte subsets in thymus, mesenteric lymph nodes and PEYER'S patches of mice orally inoculated with T-2 toxin
T Nagata; H Suzuki; N Ishigami; J Shinozuka; K Uetsuka; H Nakayama; KN Doi
EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY, Sep. 2001, [Reviewed] - Regional variations in the distributions of small intestinal intraepithelial lymphocytes (IELs) in BALB/c+/+, nu/+, and nu/nu mice
H Suzuki; KI Jeong; K Doi, Lead
COMPARATIVE MEDICINE, Apr. 2001, [Reviewed] - Respiratory Reflexes in Spontaneously Breathing Anesthetized Dogs in Response to Nasal Administration of Sevoflurane, Isoflurane, or Halothane.
T. Mutoh; A. Kanamaru; H. Suzuki; H. Tsubone; R. Nishimura; N. Sasaki
Am. J. Vet. Res., Mar. 2001, [Reviewed] - T-2 toxin-induced apoptosis and c-fos mRNA expression in Con A-stimulated mouse thymocyte primary cultures
Junko Shinozuka; Hodaka Suzuki; Shigeki Tsutsui; Hiroyuki Nakayama; Kunio Doi, Japanese Society of Toxicologic Pathology
Journal of Toxicologic Pathology, 2001, [Reviewed] - Regional Variations in the Distributions of Small Intestinal Intraepithelial Lymphocytes (IELs) in Three Inbred Strains of Mice.
H. Suzuki; K. I. Jeong; T. Okutani; K. Doi, Lead
J. Vet. Med. Sci., Aug. 2000, [Reviewed] - Picryl chloride-induced allergic dermatitis in IQI/Jic female mice
M Ikeda; K Kuroki; H Suzuki; H Nakayama; J Saegusa; K Doi
EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY, Jun. 2000, [Reviewed] - Ultrastructural study on the follicle-associated epithelium of nasal-associated lymphoid tissue in specific pathogen-free (SPF) and conventional environment-adapted (SPF-CV) rats
KI Jeong; H Suzuki; H Nakayama; K Doi
JOURNAL OF ANATOMY, Apr. 2000, [Reviewed] - Regional variations in the number and subsets of intraepithelial lymphocytes in the mouse small intestine
H Suzuki; KI Jeong; T Okutani; K Doi, Lead
COMPARATIVE MEDICINE, Feb. 2000, [Reviewed] - Regional variations in the number and subsets of intraepithelial lymphocytes in the mouse small intestine
Hodaka Suzuki; Kwang H Jeong; Taichi Okutani; Kunio Doi, Lead
Comparative Medicine, 2000, [Reviewed] - Effects of Permanent Tracheostomy on Respiratory Reflexes to Lung Inflation and Capsaicin in Sevoflurane-Anaesthetized Dogs.
T. Mutoh; A. Kanamaru; H. Suzuki; R. Nishimura; N. Sasaki; H. Tsubone
J. Vet. Med. A, Aug. 1999, [Reviewed] - Diurnal changes in intraepithelial lymphocytes (IELs) in the small intestine of mice
H Suzuki; S Shibata; T Okutani; M Suzuki; M Nakayama; T Nishimura; K Doi, Lead
EXPERIMENTAL ANIMALS, Apr. 1999, [Reviewed] - Involvement of Macrophage Scavenger Receptors in Protection against Murine Malaria.
S. Nogami; J. Watanabe; K. Nakagami; K. Nakata; H. Suzuki; H. Suzuki; M. Fujisawa; T. Kodama; S. Kojima
Am. J. Trop. Med. Hyg., Nov. 1998, [Reviewed] - Age-related changes in susceptibility of mice to low-virulent mouse hepatitis virus (MHV-2-CC) infection
H Suzuki; W Kiatipattanasakul; S Kajikawa; S Tsutsui; H Nakayama; N Goto; K Doi, Lead
EXPERIMENTAL ANIMALS, Jul. 1997, [Reviewed] - Adrenocortical Carcinoma Treated with Adrenalectomy in a Dog.
T. Itoh; T. Kadosawa; M. Mochizuki; R. Nishimura; S. Matsunaga; H. Suzuki; H. Nakayama; N. Sasaki, A 13-year-old female English Setter with adrenocortical carcinoma was treated with adrenalectomy before onset of hyperadrenocorticism. The grossly visible neoplastic mass including the ipsilateral adrenal gland was completely removed. The contralateral adrenal gland seemed to be normal, however postsurgical hyperkalemia caused from mineral corticoid deficiency appeared and was corrected by predonisolone administration. Ten months after surgery, lung metastasis was radiographically observed and several abnormalities associated with hyperadrenocorticism were detected on both physical and blood examinations. By administration of cisplatin, a transient improvement of the clinical signs and a decrease in plasma cortisol concentration were obtained, however 2 weeks later, the patient died. Necropsy revealed severe metastatic lesions in the lung, spleen, liver, kidney, small intestine, and brain., Japanese Society of Veterinary Anesthesia & Surgery
Jpn. J. Vet. Anesth. Surg., Jul. 1997, [Reviewed]
MISC
- 【質疑応答】 臨床一般／法律・雑件：飛沫の飛ぶ距離は？ 対面調理時の衛生面への影響は？
鈴木穂高
週刊日本医事新報, Jul. 2016, [Invited]
Lead - Campylobacter contamination in retail poultry meats and by-products in Japan: A literature survey
Hodaka Suzuki; Shigeki Yamamoto
FOOD CONTROL, Jun. 2009, [Reviewed]
Lead - Campylobacter Contamination in Retail Poultry Meats and By-Products in the World: A Literature Survey
Hodaka Suzuki; Shigeki Yamamoto
JOURNAL OF VETERINARY MEDICAL SCIENCE, Mar. 2009, [Reviewed]
Lead - 入門講座 国内の冷凍パン生地，ならびに原材料の汚染実態調査
鈴木穂高; 土屋禎; 田中廣行; 今溝洋子; 佐々木直; 森曜子; 五十君靜信; 豊福肇; 春日文子; 山本茂貴
食品衛生学雑誌, Aug. 2007, [Reviewed], [Invited]
Lead - 入門講座 小麦玄麦，小麦粉，および小麦粉を原料とする生地，生麺の微生物汚染に関する文献調査
鈴木穂高; 吉池由美子; 杉山恵; 長谷川専; 五十君静信; 豊福肇; 山本茂貴; 春日文子
食品衛生学雑誌, Apr. 2007, [Reviewed], [Invited]
Lead
Books and other publications
- フレックネル実験動物の麻酔と鎮痛 第５版
Paul Flecknel(著者)、笠井憲雪(訳者); 鈴木穂高(翻訳協力者), Others
株式会社アドスリー, Dec. 2023
9784910513164 - 米国獣医学会 動物の安楽死指針（安楽死ガイドライン）：２０２０年版
黒澤努、鈴木真 (鈴木穂高:翻訳協力), Others
株式会社アドスリー, May 2022
9784910513072 - 食品衛生検査指針 微生物編 改訂第2版 2018
鈴木穂高, Joint work
公益社団法人日本食品衛生協会, Mar. 2018
9784889250985 - 食品衛生検査指針 微生物編 2015
鈴木穂高, Joint work
公益社団法人日本食品衛生協会, Mar. 2015
9784889250725 - Shellfish: Human Consumption, Health Implications and Conservation Concerns
H. Suzuki, Joint work
Nova Science Publishers, Inc., Aug. 2014
9781633211957 - リスク学用語小辞典
鈴木穂高, Contributor
丸善, Jan. 2008
9784621078495 - Old Herborn University Seminar Monograph 19. Defense Mechanisms of the Innate System: Influence of Microbes
J. J. Cebra; N. A. Bos; N. V. Boyko; N. Kushnir; M. Stoel; C. Surh; H. Suzuki; M. C. Thurnheer; G. D. Wu; K. Uchida; A. W. Zuercher, Contributor
Herborn Litterae, Jan. 2006
3923022301
Research Themes
- Studies on the mechanism of mouse bioassay for diarrhetic shellfish poisoning toxins and its improvement in consideration of animal welfare
Grant-in-Aid for Scientific Research (C)
National Institute of Health Sciences
Apr. 2013 - Mar. 2016 - Intestinal immune system : its development and interaction with intestinal bacteria
Grant-in-Aid for Young Scientists (B)
National Institute of Health Sciences
2007 - 2009
