May 2021, Excellent Paper Award Animal Science Journal, Social defeat models in animal science: What we have learned from rodent models, Animal Science Journal 88 944-952, 2017, 日本畜産学会
豊田 淳

Jun. 2019, 令和元年度国立大学法人茨城大学学長学術表彰優秀賞, 心理社会的ストレスモデル動物の栄養・代謝に関する研究, 国立大学法人茨城大学
豊田 淳

Mar. 2019, 日本畜産学会賞, 心理社会的ストレスモデル動物の栄養・代謝に関する研究, 日本畜産学会
豊田 淳
Japan society

Mar. 2017, Animal Science Journal Reviewers Award, 日本畜産学会
豊田 淳

Potential non-invasive biomarkers of chronic sleep disorders identified by salivary metabolomic profiling among middle-aged Japanese men.
Katsutaka Oishi; Yuta Yoshida; Kosuke Kaida; Kozue Terai; Hiroyuki Yamamoto; Atsushi Toyoda, Last, Sleep disorders have become a global social problem that increases the risk of developing mental illnesses and metabolic diseases. We aimed to identify biomarkers with which to non-invasively and objectively evaluate chronic sleep disorders. We used capillary electrophoresis-Fourier transform mass spectrometry (CE-FTMS) to analyze metabolomes in saliva collected from 50 persons each with good (≤ 2) and poor (≥ 6) sleep quality scored according to the Japanese version of the Pittsburgh Sleep Quality Index (PSQI-J) self-report questionnaire. The levels of five metabolites including glycerol and hippuric acid and eight including 2-hydroxybutyric acid (2HB), were respectively decreased and increased in participants with poor sleep quality. We established a random forest model consisting of six metabolites, including glycerol and hippuric acid, with a prediction accuracy of 0.866. Correlations between metabolites and sleep satisfaction were assessed using the Oguri-Shirakawa-Azumi sleep inventory, middle-age and aged version (OSA-MA) questionnaire. The results showed that 2'-deoxyguanosine, N1-acetylspermine, and 2,4-dihydroxybenzoic acid correlated positively, whereas glucosamine 6-phosphate and trimethylamine N-oxide correlated negatively with sleep quality. These findings suggested that changes in salivary metabolites reflect pathophysiological mechanisms of chronic sleep disorders, and that saliva samples could serve as non-invasive and objective diagnostic targets for predicting habitual sleep quality.
Scientific reports, 21 Apr. 2025, [Reviewed]

Large-scale animal model study uncovers altered brain pH and lactate levels as a transdiagnostic endophenotype of neuropsychiatric disorders involving cognitive impairment.
Hideo Hagihara; Hirotaka Shoji; Satoko Hattori; Giovanni Sala; Yoshihiro Takamiya; Mika Tanaka; Masafumi Ihara; Mihiro Shibutani; Izuho Hatada; Kei Hori; Mikio Hoshino; Akito Nakao; Yasuo Mori; Shigeo Okabe; Masayuki Matsushita; Anja Urbach; Yuta Katayama; Akinobu Matsumoto; Keiichi I Nakayama; Shota Katori; Takuya Sato; Takuji Iwasato; Haruko Nakamura; Yoshio Goshima; Matthieu Raveau; Tetsuya Tatsukawa; Kazuhiro Yamakawa; Noriko Takahashi; Haruo Kasai; Johji Inazawa; Ikuo Nobuhisa; Tetsushi Kagawa; Tetsuya Taga; Mohamed Darwish; Hirofumi Nishizono; Keizo Takao; Kiran Sapkota; Kazutoshi Nakazawa; Tsuyoshi Takagi; Haruki Fujisawa; Yoshihisa Sugimura; Kyosuke Yamanishi; Lakshmi Rajagopal; Nanette Deneen Hannah; Herbert Y Meltzer; Tohru Yamamoto; Shuji Wakatsuki; Toshiyuki Araki; Katsuhiko Tabuchi; Tadahiro Numakawa; Hiroshi Kunugi; Freesia L Huang; Atsuko Hayata-Takano; Hitoshi Hashimoto; Kota Tamada; Toru Takumi; Takaoki Kasahara; Tadafumi Kato; Isabella A Graef; Gerald R Crabtree; Nozomi Asaoka; Hikari Hatakama; Shuji Kaneko; Takao Kohno; Mitsuharu Hattori; Yoshio Hoshiba; Ryuhei Miyake; Kisho Obi-Nagata; Akiko Hayashi-Takagi; Léa J Becker; Ipek Yalcin; Yoko Hagino; Hiroko Kotajima-Murakami; Yuki Moriya; Kazutaka Ikeda; Hyopil Kim; Bong-Kiun Kaang; Hikari Otabi; Yuta Yoshida; Atsushi Toyoda; Noboru H Komiyama; Seth G N Grant; Michiru Ida-Eto; Masaaki Narita; Ken-Ichi Matsumoto; Emiko Okuda-Ashitaka; Iori Ohmori; Tadayuki Shimada; Kanato Yamagata; Hiroshi Ageta; Kunihiro Tsuchida; Kaoru Inokuchi; Takayuki Sassa; Akio Kihara; Motoaki Fukasawa; Nobuteru Usuda; Tayo Katano; Teruyuki Tanaka; Yoshihiro Yoshihara; Michihiro Igarashi; Takashi Hayashi; Kaori Ishikawa; Satoshi Yamamoto; Naoya Nishimura; Kazuto Nakada; Shinji Hirotsune; Kiyoshi Egawa; Kazuma Higashisaka; Yasuo Tsutsumi; Shoko Nishihara; Noriyuki Sugo; Takeshi Yagi; Naoto Ueno; Tomomi Yamamoto; Yoshihiro Kubo; Rie Ohashi; Nobuyuki Shiina; Kimiko Shimizu; Sayaka Higo-Yamamoto; Katsutaka Oishi; Hisashi Mori; Tamio Furuse; Masaru Tamura; Hisashi Shirakawa; Daiki X Sato; Yukiko U Inoue; Takayoshi Inoue; Yuriko Komine; Tetsuo Yamamori; Kenji Sakimura; Tsuyoshi Miyakawa, Increased levels of lactate, an end-product of glycolysis, have been proposed as a potential surrogate marker for metabolic changes during neuronal excitation. These changes in lactate levels can result in decreased brain pH, which has been implicated in patients with various neuropsychiatric disorders. We previously demonstrated that such alterations are commonly observed in five mouse models of schizophrenia, bipolar disorder, and autism, suggesting a shared endophenotype among these disorders rather than mere artifacts due to medications or agonal state. However, there is still limited research on this phenomenon in animal models, leaving its generality across other disease animal models uncertain. Moreover, the association between changes in brain lactate levels and specific behavioral abnormalities remains unclear. To address these gaps, the International Brain pH Project Consortium investigated brain pH and lactate levels in 109 strains/conditions of 2294 animals with genetic and other experimental manipulations relevant to neuropsychiatric disorders. Systematic analysis revealed that decreased brain pH and increased lactate levels were common features observed in multiple models of depression, epilepsy, Alzheimer's disease, and some additional schizophrenia models. While certain autism models also exhibited decreased pH and increased lactate levels, others showed the opposite pattern, potentially reflecting subpopulations within the autism spectrum. Furthermore, utilizing large-scale behavioral test battery, a multivariate cross-validated prediction analysis demonstrated that poor working memory performance was predominantly associated with increased brain lactate levels. Importantly, this association was confirmed in an independent cohort of animal models. Collectively, these findings suggest that altered brain pH and lactate levels, which could be attributed to dysregulated excitation/inhibition balance, may serve as transdiagnostic endophenotypes of debilitating neuropsychiatric disorders characterized by cognitive impairment, irrespective of their beneficial or detrimental nature.
eLife, 26 Mar. 2024, [Reviewed]

Alpha-glycosyl isoquercitrin alleviates subchronic social defeat stress-induced depression symptoms by modulating the microbiota-gut-brain axis in mice.
Hong Liu; Junjie Li; Shogo Takahashi; Atsushi Toyoda; Ryo Inoue; Mihoko Koyanagi; Shim-Mo Hayashi; Meiyu Xu; Yuki Yamamoto; Kentaro Nagaoka, AIMS: Increasing evidence suggests a link between gut microbial dysbiosis and the pathogenesis of depression. Alpha-glycosyl isoquercitrin (AGIQ), consisting of isoquercitrin and its glycosylated quercetin, has beneficial effects on the gut microbiome and brain function. Here, we detected the potential antidepressant impact of a four-week administration of AGIQ and its underlying mechanisms using a mouse model of depression. MAIN METHODS: Male C57BL/6 mice were orally administered AGIQ (0.05 % or 0.5 % in drinking water) for 28 days; subchronic social defeat stress was performed in the last 10 days. Behavior tests were conducted to assess anxiety and depressive-like behaviors. Additionally, evaluations encompassed 5-hydroxytryptamine (5-HT) levels, the gut microbiota composition, lipopolysaccharide (LPS) concentrations, short-chain fatty acids levels, and intestinal barrier integrity changes. KEY FINDINGS: AGIQ significantly alleviated depression-like behaviors and increased hippocampal 5-HT levels. Further, AGIQ mitigated stress-induced gut microbial abnormalities and reduced the levels of LPS in the serum, which affected the relative gene expression levels of 5-HT biosynthesis enzymes in vitro. Furthermore, AGIQ reversed the reduced butyrate levels in cecal contents and improved the impaired intestinal barrier by increasing the expression of colonic zonula occluden-1 (ZO-1) and occludin, thereby decreasing LPS leakage. SIGNIFICANCE: Our results suggest that AGIQ could improve stress-induced depression by regulating the gut microbiome, which inhibits LPS production and maintains the gut barrier. This is the first report on the potential effect of AGIQ on depression via the gut microbiota-brain axis, shedding new light on treatment options.
Life sciences, 13 Mar. 2024, [Reviewed]

Effects of subchronic and mild social defeat stress on the intestinal microbiota and fecal bile acid composition in mice
Naoko YAMAGISHI; Daisuke KYOUI; Naoko MORIYA; Ayako AOKI-YOSHIDA; Tatsuhiko GOTO; Atsushi TOYODA; Katsunari IPPOUSHI; Mari MAEDA-YAMAMOTO; Yoshiharu TAKAYAMA; Chise SUZUKI, BMFH Press
Bioscience of Microbiota, Food and Health, Mar. 2024, [Reviewed]

Metabolic profiles of saliva in male mouse models of chronic sleep disorders induced by psychophysiological stress.
Katsutaka Oishi; Yuhei Yajima; Yuta Yoshida; Hideo Hagihara; Tsuyoshi Miyakawa; Sayaka Higo-Yamamoto; Atsushi Toyoda, Last, Disordered sleep is a global social problem and an established significant risk factor for psychological and metabolic diseases. We profiled non-targeted metabolites in saliva from mouse models of chronic sleep disorder (CSD). We identified 288 and 55 metabolites using CE-FTMS and LC-TOFMS, respectively, among which concentrations of 58 (CE-FTMS) and three (LC-TOFMS) were significantly changed by CSD. Pathway analysis revealed that CSD significantly suppressed glycine, serine and threonine metabolism. Arginine and proline metabolic pathways were among those that were both upregulated and downregulated. Pathways of alanine, aspartate and glutamate metabolism, genetic information processing, and the TCA cycle tended to be downregulated, whereas histidine metabolism tended to be upregulated in mice with CSD. Pyruvate, lactate, malate, succinate and the glycemic amino acids alanine, glycine, methionine, proline, and threonine were significantly decreased, whereas 3-hydroxybutyric and 2-hydroxybutyric acids associated with ketosis were significantly increased, suggesting abnormal glucose metabolism in mice with CSD. Increases in the metabolites histamine and kynurenic acid that are associated with the central nervous system- and decreased glycine, might be associated with sleep dysregulation and impaired cognitive dysfunction in mice with CSD. Our findings suggested that profiling salivary metabolites could be a useful strategy for diagnosing CSD.
Scientific reports, 10 Jul. 2023, [Reviewed]

Impacts of Subchronic and Mild Social Defeat Stress on Plasma Putrefactive Metabolites and Cardiovascular Structure in Male Mice.
Atsushi Toyoda; Kina Kawakami; Yuto Amano; Hideaki Nishizawa; Shin-Ichi Nakamura; Takahiro Kawase; Yuta Yoshida; Hodaka Suzuki; Takamitsu Tsukahara, Lead, Psychosocial stress precipitates mental illnesses, such as depression, and increases the risk of other health problems, including cardiovascular diseases. In this study, we observed the effects of psychosocial stress on the histopathological features of systemic organs and tissues in a mouse psychosocial stress model, namely the subchronic and mild social defeat stress (sCSDS) model. There were several pathological findings in the tissues of both sCSDS and control mice. Mild fibrosis of the heart was observed in sCSDS mice but not in control mice. Extramedullary hematopoiesis in the spleen and hemorrhage in the lungs were observed in both the control and sCSDS mice. Focal necrosis of the liver was seen only in control mice. Furthermore, putrefactive substances in the blood plasma were analyzed because these metabolites originating from intestinal fermentation might be linked to heart fibrosis. Among them, plasma p-cresyl glucuronide and p-cresyl sulfate concentrations significantly increased owing to subchronic social defeat stress, which might influence cardiac fibrosis in sCSDS mice. In conclusion, several pathological features such as increased cardiac fibrosis and elevated plasma putrefactive substances were found in sCSDS mice. Thus, sCSDS mice are a potential model for elucidating the pathophysiology of psychosocial stress and heart failure.
International journal of molecular sciences, 08 Jan. 2023, [Reviewed]

Effects of Farming Activity, Including Horticulture and Interaction With Farm Animals, on the Psychological and Physiological Status of Adults With Mental Disorders　　　　　　　　　　　　　　　
Takeshi YASUE; Nozomi SAKAMOTO; Nozomi HIRAYAMA; Masakazu KOMATSUZAKI; Yuriko YAMAKAWA; Hiromi TAKAHASHI; Saori SHIBANUMA; Daisuke KOHARI; Tsuyoshi OKAYAMA; Atsushi TOYODA, Last
Japan. J. Hum. Anim. Relat, Jan. 2023, [Reviewed]

Identification of salivary microRNA profiles in male mouse model of chronic sleep disorder.
Yuta Yoshida; Yuhei Yajima; Yuri Fujikura; Haotong Zhuang; Sayaka Higo-Yamamoto; Atsushi Toyoda; Katsutaka Oishi, Chronic sleep disorders (CSD) comprise a potential risk factor for metabolic and cardiovascular diseases, obesity and stroke. Thus, the identification of biomarkers for CSD is an important step in the early prevention of metabolic dysfunctions induced by sleep dysfunction. Diagnostic saliva samples can be easily and noninvasively collected. Thus, we aimed to identify whole microRNA (miRNA) profiles of saliva in control and psychophysiologically stressed CSD mouse models and compare them at Zeitgeber time (ZT) 0 (lights on) and ZT12 (lights off). The findings of two-way ANOVA revealed that the expression of 342 and 109 salivary miRNAs was affected by CSD and the time of day, respectively. Interactions were found in 122 miRNAs among which, we identified 197 (ZT0) and 62 (ZT12) upregulated, and 40 (ZT0) and seven (ZT12) downregulated miRNAs in CSD mice. We showed that miR-30c-5p, which is elevated in the plasma of patients with hypersomnia, was upregulated in the saliva of CSD mice collected at ZT0. The miRNAs, miR-10a-5p, miR-146b-5p, miR-150-5p, and miR-25-3p are upregulated in the serum of humans with poor sleep quality, and these were also upregulated in the saliva of CSD mice collected at ZT0. The miRNAs miR-30c, miR146b-5p, miR150, and miR-25-5p are associated with cardiovascular diseases, and we found that plasma concentrations of brain natriuretic peptides were significantly increased in CSD mice. The present findings showed that salivary miRNA profiles could serve as useful biomarkers for predicting CSD.
Stress (Amsterdam, Netherlands), Jan. 2023, [Reviewed]

Salivary microRNA and Metabolic Profiles in a Mouse Model of Subchronic and Mild Social Defeat Stress.
Yuta Yoshida; Yuhei Yajima; Kina Kawakami; Shin-Ichi Nakamura; Takamitsu Tsukahara; Katsutaka Oishi; Atsushi Toyoda, Last, Identification of early biomarkers of stress is important for preventing mood and anxiety disorders. Saliva is an easy-to-collect and non-invasive diagnostic target. The aim of this study was to characterize the changes in salivary whole microRNAs (miRNAs) and metabolites in mice subjected to subchronic and mild social defeat stress (sCSDS). In this study, we identified seven upregulated and one downregulated miRNAs/PIWI-interacting RNA (piRNA) in the saliva of sCSDS mice. One of them, miR-208b-3p, which is reported as a reliable marker for myocardial infarction, was upregulated in the saliva of sCSDS mice. Histological analysis showed frequent myocardial interstitial fibrosis in the heart of such mice. In addition, gene ontology and pathway analyses suggested that the pathways related to energy metabolism, such as the oxidative phosphorylation and the pentose phosphate pathway, were significantly related to the miRNAs affected by sCSDS in saliva. In contrast, salivary metabolites were not significantly changed in the sCSDS mice, which is consistent with our previous metabolomic study on the plasma of sCSDS mice. Taken in the light of previous studies, the present study provides novel potential stress biomarkers for future diagnosis using saliva.
International journal of molecular sciences, 21 Nov. 2022, [Reviewed]

Dietary Hesperidin Suppresses Lipopolysaccharide-Induced Inflammation in Male Mice.
Mizuho Sato; Alato Okuno; Keita Ishisono; Yuhei Yajima; Atsushi Toyoda, Last, Depressive disorders are partially attributed to chronic inflammation associated with the tryptophan (Trp)-kynurenine (Kyn) pathway. Recent evidence suggests that anti-inflammatory agents may reduce the risk of depression. The present study aimed to elucidate the potential of the citrus flavonoid hesperidin, which exhibits anti-inflammatory activity, in suppressing the Trp-Kyn pathway in the brain, using a lipopolysaccharide (LPS)-induced inflammation mouse model. Dietary hesperidin was found to suppress activation of the Trp-Kyn pathway in the prefrontal cortex. In addition, it reduced systemic LPS-induced signs of illness, such as low skin temperature and enhanced leukocyte count in the blood. However, dietary supplementation with hesperidin did not improve body weight loss, food intake, water intake, or splenic increases in leukocyte numbers in the LPS model. Collectively, the results suggest that dietary hesperidin can partially regulate central and peripheral events linked to inflammation in LPS mouse models.
International journal of tryptophan research : IJTR, Oct. 2022, [Reviewed]

Effect of Probiotic Bifidobacterium bifidum TMC3115 Supplementation on Psychosocial Stress Using a Sub-Chronic and Mild Social Defeat Stress in Mice.
Kazutoyo Yoda; Gaku Harata; Mizuho Sato; Kenji Miyazawa; Natsuki Ohsawa; Fang He; Atsushi Toyoda, Last, With the accumulation of knowledge on the relation between psychological stress and gut microbiota, there is growing interest in controlling stress and/or mood disorders via probiotic supplementation. We aimed to examine the effect of probiotic Bifidobacterium bifidum TMC3115 (TMC3115) supplementation using a sub-chronic and mild social defeat stress murine model in this study. TM3115 supplementation maintained body weight gain and alleviated a polydipsia-like symptom induced by the stress. In the analyses of fecal and cecal bacterial profiles, expansions of Proteobacteria in stressed mice and increases in Actinobacteria and Bifidobacterium in mice supplemented with TMC3115 were observed. There was no marked difference in the diversity of cecal bacteria between the tested mice. Elevated serum levels of inflammatory markers such as tumor necrosis factor (TNF)-α and interleukin (IL)-6 were observed in the stressed mice, while TMC3115 only reduced the IL-6 level. These findings suggest that TMC3115 supplementation confers tolerance to psychosocial stress in the host through modulation of the gut microbiota and alleviation of stress-induced inflammatory responses. Furthermore, it may be expected to exert prevention and treatment of disorders related to peripheral IL-6, including depression.
Nutrients, 24 Feb. 2022, [Reviewed]

Differential Effect of Non-Purified and Semi-Purified Standard Diets on Kynurenine and Peripheral Metabolites in Male C57BL/6J Mice.
Yuhei Yajima; Alato Okuno; Isamu Nakamura; Teruo Miyazaki; Akira Honda; Atsushi Toyoda, Last, The kynurenine (Kyn) pathway plays crucial roles in several inflammation-induced disorders such as depression. In this study, we measured Kyn and other related molecules in the blood plasma, brain, and urine of male C57BL/6J mice (B6) fed non-purified (MF) and semi-purified (AIN-93G and AIN-93M) standard rodent diets. Mice fed MF had increased plasma Kyn levels compared with those on AIN93-based diets, as well as decreased hippocampal Kyn levels compared with those fed AIN-93G. Previous studies showed that branched chain amino acids (BCAAs) suppress peripheral blood Kyn transportation to the brain, but plasma BCAA levels were not significantly different between the diet groups in our study. Urine metabolome analysis revealed that feed ingredients affected the excretion of many metabolites, and MF-fed mice had elevated excretion of kynurenic and quinolinic acids, pivotal metabolites in the Kyn pathway. Collectively, the level of critical metabolites in the Kyn pathway in the central and peripheral tissues was strongly affected by feed ingredients. Therefore, feed selection is a critical factor to ensure the reproducibility of experimental data in studies involving rodent models.
International journal of tryptophan research : IJTR, 2022, [Reviewed]

Estimating body weight of pigs from posture analysis using a depth camera.
Tsuyoshi Okayama; Yoshifumi Kubota; Atsushi Toyoda; Daisuke Kohari; Go Noguchi, A noninvasive method for estimating the body weight (BW) of a pig considering its posture using a low-cost depth camera (Kinect v2) was proposed. A total of 150 pigs were used, and 738 depth images (point clouds) were obtained for them. The pig "volume" was calculated from the pig point cloud, and it was found to have a very high correlation to BW. To evaluate the posture of a pig quantitatively, seven posture angles were calculated based on the "spine" extracted from a pig point cloud. We found the posture angles representing the height of the head position correlated with the accuracy of BW estimation using the "volume." Based on this finding, we proposed an "adjusted volume," which was adjusted based on the relationship between the posture angles and the estimation error. The BW of pigs was estimated using the simple regression model with the "adjusted volume," and the MAPE and RMSPE were 4.87% and 6.13%, respectively. The accuracy of the suggested model was similar to that of the volume-based estimation models of other studies that used only data with an appropriate pig posture for BW estimation.
Animal science journal = Nihon chikusan Gakkaiho, Dec. 2021, [Reviewed]

Protein lactylation induced by neural excitation.
Hideo Hagihara; Hirotaka Shoji; Hikari Otabi; Atsushi Toyoda; Kaoru Katoh; Masakazu Namihira; Tsuyoshi Miyakawa, Lactate has diverse roles in the brain at the molecular and behavioral levels under physiological and pathophysiological conditions. This study investigates whether lysine lactylation (Kla), a lactate-derived post-translational modification in macrophages, occurs in brain cells and if it does, whether Kla is induced by the stimuli that accompany changes in lactate levels. Here, we show that Kla in brain cells is regulated by neural excitation and social stress, with parallel changes in lactate levels. These stimuli increase Kla, which is associated with the expression of the neuronal activity marker c-Fos, as well as with decreased social behavior and increased anxiety-like behavior in the stress model. In addition, we identify 63 candidate lysine-lactylated proteins and find that stress preferentially increases histone H1 Kla. This study may open an avenue for the exploration of a role of neuronal activity-induced lactate mediated by protein lactylation in the brain.
Cell reports, 12 Oct. 2021, [Reviewed]

Subchronic and mild social defeat stress downregulates peripheral expression of sweet and umami taste receptors in male mice.
Yuta Yoshida; Misa Miyazaki; Yuhei Yajima; Atsushi Toyoda, Last, Depression is associated with taste disorders; however, the mechanisms by which mental stress affects taste perception are not well understood. This study aimed to elucidate the effects of psychosocial stress on peripheral taste-sensing systems using a mouse depression model. Male mice were subjected to subchronic and mild social defeat stress (sCSDS). Results showed that sCSDS significantly increased body weight, food and water intake, and social avoidance behavior and that sCSDS did not change reward-seeking behavior on sucrose preference but tended to decrease pheromonal preference for female urine. Furthermore, sCSDS downregulated the mRNA levels of sweet and umami taste receptor subunits, i.e., sweet taste receptor type 1 members 2 and 3 (T1R2 and T1R3), but not the umami taste receptor subunit, i.e., taste receptor type 1 member 1 (T1R1), in the circumvallate papillae of mice. It is known that sucrose preference is mediated by the gut-brain axis without taste perception; thus, it was considered that sCSDS affected the peripheral taste-sensing systems, rather than the central reward systems, which mediate sucrose preference. This is the first study to report that psychosocial stress affects peripheral sweet and umami taste-sensing systems.
Biochemical and biophysical research communications, 24 Sep. 2021, [Reviewed]

Metabolic and Microbial Characterizations for the Gastrointestinal Digesta of the Zoo Colobus guereza
Toyoda A; Shionome N; Kohari D; Iida S; Masato H; Namae N; Nakamura S; Tsukahara T, Lead, Austin publishing
Journal of Bacteriology and Mycology, 12 Feb. 2021, [Reviewed]

The effects of chronic social defeat stress on solid gastric epmtying and defecation in C57BL/6J mice
Naoko Moriya; Naoko Yamagishi; Tatsuhiko Goto; Hikari Otabi; Hiromi Nira-Kimoto; Atsushi Toyoda; Chise Suzuki, Japan International Research Center for Agricultural Sciences
Japan Agriculture Research Quarterly, Jan. 2021, [Reviewed]

Consecutive intra-gingival injections of lipopolysaccharide and butyric acid to mice induce abnormal behavior and changes in cytokine concentrations.
Takamitsu Tsukahara; Atsushi Toyoda; Takahiro Kawase; Shin-Ichi Nakamura; Kuniyasu Ochiai, BACKGROUND: Periodontopathic bacteria such as Porphyromonas gingivalis produce several metabolites, including lipopolysaccharide (LPS) and n-butyric acid (BA). Past work suggested that periodontal infection may cause cognitive impairment in mice. AIMS: To elucidate the mechanisms by which metabolites such as LPS and BA, resulting from Porphyromonas gingivalis activity, induce immunological and physiological abnormalities in mice. METHODS: In the present work, 28 male ICR mice were placed in an open-field arena and the total distance (cm/600 s) they covered was recorded. Based on their moving distances, mice were divided into 4 groups (n = 7) and injected the following substances into their gingival tissues for 32 consecutive days: saline (C), 5 mmol/L of BA (B), 1 μg/mouse of LPS (L), and BA-LPS (BL) solutions. Distances covered by mice were also measured on days 14 and 21, with their habituation scores considered as "(moving distance on day 14 or 21)/(moving distance on day 0)". Afterwards, mice were dissected, and hippocampal gene expression and the concentrations of short-chain fatty acids, neurotransmitters and cytokines in their blood plasma and brains were analyzed. In addition, mouse brain and liver tissues were fixed and visually assessed for histopathological abnormalities. RESULTS: Group BL had significantly higher habituation scores than C and B on day 14. LPS induced higher habituation scores on day 21. LPS induced significant decreases in the mRNA levels of interleukin (IL)-6 and brain-derived neurotrophic factors, and an increase in neurotrophic tyrosine kinase receptor type 2. In both plasma and brain, LPS induced a significant acetate increase. Moreover, LPS significantly increased acetylcholine in brain. In plasma alone, LPS and BA significantly decreased monocyte chemoattractant protein 1 (MCP-1). However, while LPS significantly decreased tyrosine, BA significantly increased it. Lastly, LPS significantly decreased IL-6 and tumor necrosis factor in plasma. No histopathological abnormalities were detected in liver or brain tissues of mice. CONCLUSION: We showed that injections of LPS and/or BA induced mice to move seemingly tireless and that both LPS and BA injections strongly induced a reduction of MCP-1 in blood plasma. We concluded that LPS and BA may have been crucial to induce and/or aggravate abnormal behavior in mice.
Journal of neuroinflammation, 05 Nov. 2020, [Reviewed]

Reduction in BDNF from Inefficient Precursor Conversion Influences Nest Building and Promotes Depressive-Like Behavior in Mice.
Masami Kojima; Hikari Otabi; Haruko Kumanogoh; Atsushi Toyoda; Masahito Ikawa; Masaru Okabe; Toshiyuki Mizui, We generated a knock-in mouse line in which the gene encoding brain-derived neurotrophic factor (Bdnf) was replaced with a sequence for proBDNF containing human single nucleotide polymorphisms encoding arginines proximal to the cleavage site (R125M and R127L). The ratio of the mature form of BDNF (mBDNF) to precursor BDNF (proBDNF) in hippocampal tissue lysates was decreased in a manner dependent on the number of copies of the mutant gene, indicating that the mutations inhibited proteolytic conversion of proBDNF into mBDNF. Although homozygous mice had a proBDNF/mBDNF ratio of ~9:1, they survived until adulthood. The levels of mBDNF were reduced by 57% in heterozygous mutant mice, which exhibited a depressive-like behavior in the tail suspension test and weight gain when housed in social isolation, showing that impaired proBDNF cleavage contributes to stress-induced depressive-like phenotypes. Furthermore, socially isolated heterozygous mice displayed a pronounced deficit in daily nest-building behaviors. These findings suggest that the decreased production of mBDNF by impaired proBDNF cleavage disturbs daily activities in mice.
International journal of molecular sciences, 01 Jun. 2020, [Reviewed]

Impaired bile acid metabolism with defectives of mitochondrial-tRNA taurine modification and bile acid taurine conjugation in the taurine depleted cats.
Teruo Miyazaki; Sei-Ich Sasaki; Atsushi Toyoda; Fan-Yan Wei; Mutsumi Shirai; Yukio Morishita; Tadashi Ikegami; Kazuhito Tomizawa; Akira Honda, Taurine that conjugates with bile acid (BA) and mitochondrial-tRNA (mt-tRNA) is a conditional essential amino acid in humans, similarly to cats. To better understand the influence of acquired depletion of taurine on BA metabolism, the profiling of BAs and its intermediates, BA metabolism-enzyme expression, and taurine modified mt-tRNAs were evaluated in the taurine deficient diet-supplemented cats. In the taurine depleted cats, taurine-conjugated bile acids in bile and taurine-modified mt-tRNA in liver were significantly decreased, whereas unconjugated BA in serum was markedly increased. Impaired bile acid metabolism in the liver was induced accompanied with the decreases of mitochondrial cholesterol 27-hydroxylase expression and mitochondrial activity. Consequently, total bile acid concentration in bile was significantly decreased by the low activity of mitochondrial bile acid synthesis. These results implied that the insufficient dietary taurine intake causes impaired bile acid metabolism, and in turn, a risk for the various diseases similar to the mitochondrial diseases would be enhanced.
Scientific reports, 18 Mar. 2020, [Reviewed]

Coenzyme A and Its Thioester Pools in Obese Zucker and Zucker Diabetic Fatty Rats.
Shigeru Chohnan; Shiori Matsuno; Kei Shimizu; Yuka Tokutake; Daisuke Kohari; Atsushi Toyoda, Last, Feeding behavior is closely related to hypothalamic malonyl-CoA level in the brain and diet-induced obesity affects total CoA pools in liver. Herein, we performed a comprehensive analysis of the CoA pools formed in thirteen tissues of Zucker and Zucker diabetic fatty (ZDF) rats. Hypothalamic malonyl-CoA levels in obese rats remained low and were almost the same as those of lean rats, despite obese rats having much higher content of leptin, insulin, and glucose in their sera. Regardless of the fa-genotypes, larger total CoA pools were formed in the livers of ZDF rats and the size of hepatic total CoA pools in Zucker rats showed almost one tenth of the size of ZDF rats. The decreased total CoA pool sizes in Zucker rats was observed in the brown adipose tissues, while ZDF-fatty rats possessed 6% of total CoA pool in the lean rats in response to fa deficiency. This substantially lower CoA content in the obese rats would be disadvantageous to non-shivering thermogenesis. Thus, comparing the intracellular CoA behaviors between Zucker and ZDF rats, as well as the lean and fatty rats of each strain would help to elucidate features of obesity and type 2 diabetes in combination with result (s) of differential gene expression analysis and/or comparative genomics.
Nutrients, 06 Feb. 2020, [Reviewed]

Metabolomic analyses of plasma and liver of mice fed with immature Citrus tumida peel.
Atsushi Toyoda; Mizuho Sato; Masaki Muto; Tatsuhiko Goto; Yuji Miyaguchi; Eiichi Inoue, Lead, In this study, we investigated the effects of dietary supplementation of Citrus tumida hort. ex Tanaka on food intake, body and fat tissue weights, and metabolic profiles of plasma and liver in mice. Supplementation with 5% (w/w) of peels of immature C. tumida (PIC) for 4 weeks significantly suppressed body weight gain and decreased adipose tissue weight in epididymal, perirenal, and subcutaneous fats. Metabolome analyses showed that 2-hydroxyvaleric acid levels were reduced in the blood plasma of mice fed with PIC. PIC supplementation significantly elevated dipeptide (Thr-Asp, Ser-Glu, and Ala-Ala), glucuronic acid, and S-methylglutathione levels, and significantly reduced betaine aldehyde levels in the liver. In conclusion, PIC supplementation affects the metabolism of fatty acids, pectin, glutathione, and choline, showing potential beneficial effects for metabolic syndrome and obesity. PIC may be developed as a functional food and used in the treatment of these diseases.
Bioscience, biotechnology, and biochemistry, 04 Feb. 2020, [Reviewed]

Assessment of nest building and social interaction behavior in mice exposed to acute social defeat stress using a three-dimensional depth camera.
Hikari Otabi; Tsuyoshi Okayama; Atsushi Toyoda, Last, Nest building is an instinctive behavior toward protection from predators, body temperature regulation, and courtship. Previously, we discovered that acute and chronic social defeat stress suppresses the onset of nest-building behavior in male mice (C57BL/6J). Here, we analyzed nest building and other behavioral deficits induced by acute social defeat stress (ASDS). We utilized a customized cage and specifically developed observational programs for nest building, social avoidance, and other behaviors using an infrared depth camera to acquire three-dimensional (3D) data of animal behavior (Negura system). We determined the volume of nesting materials from these 3D depth images. Mice exposed to ASDS showed increased spontaneous activities, decreased rearing, and delayed nest building; however, nest-building activity was gradually recovered during the dark period of the 24 hr observation interval. At the endpoint following 24 hr, the ASDS and control groups showed no differences in nest volumes. Furthermore, we observed the time courses of both nest building and social avoidance behaviors and their relationship using the Negura system. Our data demonstrated a weak positive correlation between nest-building delay and social avoidance in ASDS mice. The Negura system can observe various behaviors that reflect the effects of social defeat stress.
Animal science journal = Nihon chikusan Gakkaiho, Jan. 2020, [Reviewed]

Effects of dietary intake of heat-inactivated Lactobacillus gasseri CP2305 on stress-induced behavioral and molecular changes in a subchronic and mild social defeat stress mouse model.
Atsushi Toyoda; Takahiro Kawase; Takamitsu Tsukahara, Lead, The intestinal ecosystem is involved in the pathogenesis of mood disorders such as depression. Intestinal microbes can affect the central nervous system through the gut-brain axis, which raises the possibility of using probiotics for preventing depression. In this study, we examined the effect of heat-inactivated Lactobacillus gasseri CP2305 (CP2305) in a subchronic and mild social defeat stress (sCSDS) mouse model. sCSDS suppressed food intake. However, dietary CP2305 intake rescued it, suggesting that CP2305 improved the decreased appetite in sCSDS mice. sCSDS did not alter the gene expression of brain-derived neurotrophic factor, nerve growth factor, and neurotrophin-3 in the hippocampus. However, dietary CP2305 provided following sCSDS increased the gene expression of these neurotrophins in the hippocampus. These findings suggest that CP2305 supplementation would aid in preventing psychosocial stress-induced disorders.
Biomedical research (Tokyo, Japan), 2020, [Reviewed]

Preliminary investigation of the effect of oral supplementation of Lactobacillus plantarum strain SNK12 on mRNA levels of neurotrophic factors and GABA receptors in the hippocampus of mice under stress-free and sub-chronic mild social defeat-stressing con
Tsukahara T; Kawase T; Yoshida H; Bukawa W; Kan T; Toyoda A, Last
Bioscience, biotechnology, and biochemistry, Sep. 2019, [Reviewed]

Dietary intake of the citrus flavonoid hesperidin affects stress-resilience and brain kynurenine levels in a subchronic and mild social defeat stress model in mice.
Sato M; Okuno A; Suzuki K; Ohsawa N; Inoue E; Miyaguchi Y; Toyoda A, Last, Depressive disorders are partly caused by chronic inflammation through the kynurenine (KYN) pathway. Preventive intervention using anti-inflammatory reagents may be beneficial for alleviating the risk of depression. In this study, we focused on the Japanese local citrus plant, Citrus tumida hort. ex Tanaka (C. tumida; CT), which contains flavonoids such as hesperidin that have anti-inflammatory actions. The dietary intake of 5% immature peels of CT fruits slightly increased stress resilience in a subchronic and mild social defeat (sCSDS) model in mice. Moreover, the dietary intake of 0.1% hesperidin significantly increased stress resilience and suppressed KYN levels in the hippocampus and prefrontal cortex in these mice. In addition, KYN levels in the hippocampus and prefrontal cortex were significantly correlated with the susceptibility to stress. In conclusion, these results suggest that dietary hesperidin increases stress resilience by suppressing the augmentation of KYN signaling under sCSDS.
Bioscience, biotechnology, and biochemistry, May 2019, [Reviewed]

Heat-killed Lactobacillus helveticus strain MCC1848 confers resilience to anxiety or depression-like symptoms caused by subchronic social defeat stress in mice.
Maehata H; Kobayashi Y; Mitsuyama E; Kawase T; Kuhara T; Xiao JZ; Tsukahara T; Toyoda A, Last
Bioscience, biotechnology, and biochemistry, Mar. 2019, [Reviewed]

Comparison of gut tight junction gene expression in C57BL/6J and BALB/c mice after chronic social defeat stress.
Yamagishi N; Omata Y; Aoki-Yoshida A; Moriya N; Goto T; Toyoda A; Aoki R; Suzuki C; Takayama Y
Japan Agricultural Research Quartely, Jan. 2019, [Reviewed]

Dietary Intake of Immature Citrus tumida Hort. ex Tanaka Peels Suppressed Body Weight Gain and Fat Accumulation in a Mouse Model of Acute Obesity.
Sato M; Goto T; Inoue E; Miyaguchi Y; Toyoda A, Last
Journal of nutritional science and vitaminology, 2019, [Reviewed]

Trunk Movement Quantification of Adult with and without Mental Disability during Gardening Task Using Wireless Tri-Axial Accelerometer　　　　　　　　　　　　　　　
Nugrahaning Sani DEWI; Masakazu KOMATSUZAKI; Yuriko YAMAKAWA; Hiromi TAKAHASHI; Saori SHIBANUMA; Takeshi YASUE; Tsuyoshi OKAYAMA; Atsushi TOYODA, Last
Japanese Journal of Farm Work Research, Dec. 2018, [Reviewed]

Effects of housing conditions on behaviors and biochemical parameters in juvenile cynomolgus monkeys (Macaca fascicularis).
Koyama H; Tachibana Y; Takaura K; Takemoto S; Morii K; Wada S; Kaneko H; Kimura M; Toyoda A, Last
Experimental animals, Dec. 2018, [Reviewed]

Reduced fucosylation in the distal intestinal epithelium of mice subjected to chronic social defeat stress.
Yasuhiro Omata; Reiji Aoki; Ayako Aoki-Yoshida; Keiko Hiemori; Atsushi Toyoda; Hiroaki Tateno; Chise Suzuki; Yoshiharu Takayama, Psychological stress can cause dysfunction of the gastrointestinal tract by regulating its interaction with central nervous system (brain-gut axis). Chronic social defeat stress (CSDS) is widely used to produce a rodent model of stress-induced human mood disorders and depression. We previously showed that CSDS significantly affects the intestinal ecosystem including cecal and fecal microbiota, intestinal gene expression profiles and cecal metabolite profiles. Here, we investigated whether the glycosylation pattern in the intestinal epithelium was affected in C57BL/6 mice exposed to CSDS (hereinafter referred to as CSDS mice). A lectin microarray analysis revealed that CSDS significantly reduced the reactivity of fucose-specific lectins (rAOL, TJA-II, rAAL, rGC2, AOL, AAL, rPAIIL and rRSIIL) with distal intestinal mucosa, but not with mucosa from proximal intestine and colon. Flow cytometric analysis confirmed the reduced TJA-II reactivity with intestinal epithelial cells in CSDS mice. In addition, distal intestine expression levels of the genes encoding fucosyltransferase 1 and 2 (Fut1 and Fut2) were downregulated in CSDS mice. These findings suggest that CSDS alters the fucosylation pattern in the distal intestinal epithelium, which could be used as a sensitive marker for CSDS exposure.
Scientific reports, 04 Sep. 2018, [Reviewed]

Development of Implantable Wireless Sensor Nodes for Animal Husbandry and MedTech Innovation.
Jian Lu; Lan Zhang; Dapeng Zhang; Sohei Matsumoto; Hiroshi Hiroshima; Ryutaro Maeda; Mizuho Sato; Atsushi Toyoda; Takafumi Gotoh; Nobuhiro Ohkohchi, In this paper, we report the development, evaluation, and application of ultra-small low-power wireless sensor nodes for advancing animal husbandry, as well as for innovation of medical technologies. A radio frequency identification (RFID) chip with hybrid interface and neglectable power consumption was introduced to enable switching of ON/OFF and measurement mode after implantation. A wireless power transmission system with a maximum efficiency of 70% and an access distance of up to 5 cm was developed to allow the sensor node to survive for a duration of several weeks from a few minutes' remote charge. The results of field tests using laboratory mice and a cow indicated the high accuracy of the collected biological data and bio-compatibility of the package. As a result of extensive application of the above technologies, a fully solid wireless pH sensor and a surgical navigation system using artificial magnetic field and a 3D MEMS magnetic sensor are introduced in this paper, and the preliminary experimental results are presented and discussed.
Sensors (Basel, Switzerland), 26 Mar. 2018, [Reviewed]

Effects of non-purified and semi-purified commercial diets on behaviors, plasma corticosterone levels, and cecum microbiome in C57BL/6J mice
Atsushi Toyoda; Hikari Shimonishi; Mizuho Sato; Kento Usuda; Natsuki Ohsawa; Kentaro Nagaoka, Lead, Elsevier Ireland Ltd
Neuroscience Letters, 23 Mar. 2018, [Reviewed]

Effects of Diet Quality and Psychosocial Stress on the Metabolic Profiles of Mice
Tatsuhiko Goto; Shozo Tomonaga; Atsushi Toyoda, Last
JOURNAL OF PROTEOME RESEARCH, May 2017, [Reviewed]

The acute social defeat stress and nest-building test paradigm: A potential new method to screen drugs for depressive-like symptoms
Hikari Otabi; Tatsuhiko Goto; Tsuyoshi Okayama; Daisuke Kohari; Atsushi Toyoda
BEHAVIOURAL PROCESSES, Feb. 2017, [Reviewed]

Effects of combined treatment with fermented soybean (natto) intake and exercise on bone metabolism in ovariectomized rats.
Kawano M; Itomine I; Monma M; Asakawa K; Toyoda A; Miyaguchi Y, OBJECTIVES: Using ovariectomized rats, we examined the influence of combined exercise tolerance and natto intake on the bone loss inhibitory effect. METHODS: We divided female Wistar rats into the following groups: Ovariectomy, Ovariectomy + Exercise, Ovariectomy + Natto Intake, Ovariectomy + Exercise + Natto Intake, and Pseudo-operative (Sham group). After conducting experiments on each group, we collected the tissues and performed morphological and molecular biological analyses. RESULTS: In comparison with the Ovariectomy group, only in the Ovariectomy + Exercise group was there a significant bone loss inhibitory effect in the femoral cancellous bone. Although there was a tendency toward this trend seen in the Natto Intake and Exercise + Natto Intake groups, these differences were not significant. The increase in messenger RNA expression levels of alkaline phosphatase (osteoblast marker) in the bone marrow caused by ovariectomy was suppressed by individual factors, and by those in combination. However, messenger RNA expression levels of estrogen receptor alpha in the bone marrow showed a decreasing tendency with each factor, and decreased significantly with the combination, similar to the Sham group. CONCLUSION: This suggests that natto intake and exercise maintain bone mass by different molecular mechanisms and that these two factors do not simply act synergistically in combination to maintain bone mass.
SAGE open medicine, 2017, [Reviewed]

Community Gardens as Health Promoters: Effects on Mental and Physical Stress Levels in Adults with and without Mental Disabilities
Nugrahaning Sani Dewi; Masakazu Komatsuzaki; Yuriko Yamakawa; Hiromi Takahashi; Saori Shibanuma; Takeshi Yasue; Tsuyoshi Okayama; Atsushi Toyoda; Hikari Shimonishi; Seiichi Sasaki
SUSTAINABILITY, Jan. 2017, [Reviewed]

Omics Studies of the Murine Intestinal Ecosystem Exposed to Subchronic and Mild Social Defeat Stress
Ayako Aoki-Yoshida; Reiji Aoki; Naoko Moriya; Tatsuhiko Goto; Yoshifumi Kubota; Atsushi Toyoda; Yoshiharu Takayama; Chise Suzuki
JOURNAL OF PROTEOME RESEARCH, Sep. 2016, [Reviewed]

未熟フクレミカン果皮の給与がマウスの増体に及ぼす影響　　　　　　　　　　　　　　　
佐藤 瑞穂; 白取 知大; 後藤 達彦; 井上 栄一; 豊田 淳, (公社)日本栄養・食糧学会
日本栄養・食糧学会大会講演要旨集, Apr. 2016

Decreased hepatic contents of coenzyme A molecular species in mice after subchronic mild social defeat stress
Yoshifumi Kubota; Tatsuhiko Goto; Yuki Hagiya; Shigeru Chohnan; Atsushi Toyoda
STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS, Mar. 2016, [Reviewed]

Effects of diet quality on vulnerability to mild subchronic social defeat stress in mice
Tatsuhiko Goto; Yoshifumi Kubota; Atsushi Toyoda
NUTRITIONAL NEUROSCIENCE, 2016, [Reviewed]

Subchronic and mild social defeat stress alter mouse nest building behavior
Hikari Otabi; Tatsuhiko Goto; Tsuyoshi Okayama; Daisuke Kohari; Atsushi Toyoda
BEHAVIOURAL PROCESSES, Jan. 2016, [Reviewed]

A Mouse Model of Subchronic and Mild Social Defeat Stress for Understanding Stress-induced Behavioral and Physiological Deficits
Tatsuhiko Goto; Atsushi Toyoda
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, Nov. 2015, [Reviewed]

Strain differences in temporal changes of nesting behaviors in C57BL/6N, DBA/2N, and their F-1 hybrid mice assessed by a three-dimensional monitoring system
Tatsuhiko Goto; Tsuyoshi Okayama; Atsushi Toyoda
BEHAVIOURAL PROCESSES, Oct. 2015, [Reviewed]

Assessing nest-building behavior of mice using a 3D depth camera
Tsuyoshi Okayama; Tatsuhiko Goto; Atsushi Toyoda
JOURNAL OF NEUROSCIENCE METHODS, Aug. 2015, [Reviewed]

Influence of Chronic Social Defeat Stress on Digestive System Functioning in Rats
Atsushi Toyoda; Wataru Iio; Noriko Matsukawa; Takamitsu Tsukahara
JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY, Jun. 2015, [Reviewed]

Effect of Yacon Tuber (Smallanthus sonchifolius)-derived Fructooligosaccharides on the Intestinal Flora and Immune System of OVA-sensitized BALB/c Mice
Yuji Miyaguchi; Takuya Tomatsuri; Atsushi Toyoda; Eiichi Inoue; Yasuki Ogawa
FOOD SCIENCE AND TECHNOLOGY RESEARCH, Mar. 2015, [Reviewed]

Plasma and Liver Metabolic Profiles in Mice Subjected to Subchronic and Mild Social Defeat Stress
Tatsuhiko Goto; Yoshifumi Kubota; Atsushi Toyoda
JOURNAL OF PROTEOME RESEARCH, Feb. 2015, [Reviewed]

Effects of chronic mild food restriction on behavior and the hypothalamic malonyl-CoA signaling pathway
Wataru Iio; Yuka Tokutake; Hiroaki Koike; Noriko Matsukawa; Takamitsu Tsukahara; Shigeru Chohnan; Atsushi Toyoda
ANIMAL SCIENCE JOURNAL, Feb. 2015, [Reviewed]

Differential expression of genes encoding neurotrophic factors and their receptors along the septal-temporal axis of the rat hippocampus
Atsushi Toyoda; Wataru Iio; Tatsuhiko Goto; Hiroaki Koike; Takamitsu Tsukahara
ANIMAL SCIENCE JOURNAL, Dec. 2014, [Reviewed]

Subchronic and mild social defeat stress accelerates food intake and body weight gain with polydipsia-like features in mice
Tatsuhiko Goto; Yoshifumi Kubota; Yuki Tanaka; Wataru Iio; Naoko Moriya; Atsushi Toyoda
BEHAVIOURAL BRAIN RESEARCH, Aug. 2014, [Reviewed]

Effects of chronic social defeat stress on peripheral leptin and its hypothalamic actions
Wataru Iio; Haruyoshi Takagi; Yasuki Ogawa; Takamitsu Tsukahara; Shigeru Chohnan; Atsushi Toyoda
BMC NEUROSCIENCE, Jun. 2014, [Reviewed]

The effects of oral taurine administration on behavior and hippocampal signal transduction in rats
Wataru Iio; Noriko Matsukawa; Takamitsu Tsukahara; Atsushi Toyoda
AMINO ACIDS, Nov. 2012, [Reviewed]

Effect of diet composition on coenzyme A and its thioester pools in various rat tissues
Yuka Tokutake; Wataru Iio; Naoki Onizawa; Yuta Ogata; Daisuke Kohari; Atsushi Toyoda; Shigeru Chohnan
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Jul. 2012, [Reviewed]

Anorexic behavior and elevation of hypothalamic malonyl-CoA in socially defeated rats
Wataru Iio; Yuka Tokutake; Noriko Matsukawa; Takamitsu Tsukahara; Shigeru Chohnan; Atsushi Toyoda
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, May 2012, [Reviewed]

Effects of chronic social defeat stress on MAP kinase cascade
Wataru Iio; Noriko Matsukawa; Takamitsu Tsukahara; Daisuke Kohari; Atsushi Toyoda
NEUROSCIENCE LETTERS, Oct. 2011, [Reviewed]

The effects of concentrations of lysine in media on differentiation of 3T3-L1 preadipocytes
Takahito Kyoya; Aiko Ishida; Kazuki Nakashima; Ikuyo Nakajima; Atsushi Toyoda; Yutaka Nakamura; Masaya Katsumata
ANIMAL SCIENCE JOURNAL, 2011, [Reviewed]

Coenzyme A and its thioester pools in fasted and fed rat tissues
Yuka Tokutake; Naoki Onizawa; Hiroki Katoh; Atsushi Toyoda; Shigeru Chohnan
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Nov. 2010, [Reviewed]

Effect of Bacillus subtilis var. natto Fermented Soybean on Growth Performance, Microbial Activity in the Caeca and Cytokine Gene Expression of Domestic Meat Type Chickens
Ken-ichiro Fujiwara; Makoto Yamazaki; Hiroyuki Abe; Kazuki Nakashima; Yoko Yakabe; Makoto Otsuka; Yasunobu Ohbayashi; Yukino Kato; Kazuo Namai; Atsushi Toyoda; Yuji Miyaguchi; Yutaka Nakamura
JOURNAL OF POULTRY SCIENCE, Apr. 2009, [Reviewed]

Isolation and Identification of Cellulose-Binding Proteins from Sheep Rumen Contents
Atsushi Toyoda; Wataru Iio; Makoto Mitsumori; Hajime Minato
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, Mar. 2009, [Reviewed]

Effect of Fermented Soybean, "Natto" on the Production and Qualities of Chicken Meat
K. Fujiwara; Y. Miyaguchi; X. H. Feng; A. Toyoda; Y. Nakamura; M. Yamazaki; K. Nakashima; H. Abe
ASIAN-AUSTRALASIAN JOURNAL OF ANIMAL SCIENCES, Dec. 2008, [Reviewed]

Effect of fermented soybean "natto" supplement on egg production and qualities
K. Fujiwara; Y. Miyaguchi; A. Toyoda; Y. Nakamura; M. Yamazaki; K. Nakashima; H. Abe, Asian-Australasian Association of Animal Production Societies
Asian-Australasian Journal of Animal Sciences, 2008, [Reviewed]

Biochemical characterization of cellulose-binding proteins (CBPA and CBPB) from the rumen cellulolytic bacterium Eubacterium cellulosolvens 5
Miho Yoshimatsu; Atsushi Toyoda; Naoki Onizawa; Yutaka Nakamura; Hajime Minato
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, Oct. 2007, [Reviewed]

Purification, characterization, and gene analysis of cellulase (Cel8A) from Lysobacter sp IB-9374
Jiro Ogura; Atsushi Toyoda; Taisuke Kurosawa; Ai Leng Chong; Shigeru Chohnan; Takeharu Masaki
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, Oct. 2006, [Reviewed]

Cloning, sequencing, and expression of a Eubacterium cellulosolvens 5 gene encoding an endoglucanase (Cel5A) with novel carbohydrate-binding modules, and properties of Cel5A
K Yoda; A Toyoda; Y Mukoyama; Y Nakamura; H Minato
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, Oct. 2005, [Reviewed]

Cloning, nucleotide sequence and module structure of the gene encoding the cellulose-binding protein B (CBPB) of Eubacterium cellulosolvens 5
A Toyoda; M Yoshimatsu; K Takano; H Minato
JOURNAL OF GENERAL AND APPLIED MICROBIOLOGY, Aug. 2005, [Reviewed]

PCR detection of bovine mitochondrial DNA derived from meat and bone meal in feed
A Toyoda; M Nakajo; H Kawachi; T Matsui; H Yano
JOURNAL OF FOOD PROTECTION, Dec. 2004, [Reviewed]

A possible role of cellulose-binding protein A (CBPA) in the adhesion of Eubacterium cellulosolvens 5 to cellulose
A Toyoda; K Takano; H Minato
JOURNAL OF GENERAL AND APPLIED MICROBIOLOGY, Aug. 2003, [Reviewed]

Identification of the cellulose-binding and the cell wall-binding domains of Eubacterium cellulosolvens 5 celluloseb-binding protein A (CBPA)
A Toyoda; H Minato
FEMS MICROBIOLOGY LETTERS, Aug. 2002, [Reviewed]

Cloning, nucleotide sequence and expression of the gene encoding the cellulose-binding protein A (CBPA) of Eubacterium cellulosolvens 5
A Toyoda; H Minato
FEMS MICROBIOLOGY LETTERS, Feb. 2002, [Reviewed]

Presence of several cellulose-binding proteins in culture supernatant and cell lysate of Eubacterium cellulosolvens 5
A Toyoda; K Yoda; Y Nakamura; H Minato
JOURNAL OF GENERAL AND APPLIED MICROBIOLOGY, Dec. 2001, [Reviewed]

Effects of the Administration of Yucca shidigera Saponins on Pigs Intestinal Microbial Population
KATSUNUMA Yu; OTSUKA Makoto; NAKAMURA Yutaka; TOYODA Atsushi; TAKADA Ryozo; MINATO Hajime, Three pigs were fed a diet supplemented with 50ppm Yucca shidigera saponins, and the remaining three pigs were given a nonsupplemented diet. The feces of the pigs were collected at 103 days of age after birth. The concentration of ammonia-N in the feces of pigs given a diet supplemented with saponins was significantly lower than the pigs given the nonsupplemented diet. The total volatile fatty acids concentration in the feces was not significantly different between the pigs given a diet supplemented with or without saponins. However, the molar proportion of the acetic acid in the feces of pigs given a diet supplemented with saponins was lower, and inversely the concentration of the propionic, butyric and n-valeric acids was higher in comparison with the pigs given the nonsupplemented diet. The total viable counts in the feces were not different between the pigs given a diet supplemented with or without saponins. Bifidobacteria, eubacteria, and staphylococci were more abundant in the feces of pigs given a diet supplemented with saponins, as compared with the pigs given the non-supplemented diet. Veillonella was less abundant in the feces of pigs given a diet supplemented with saponins than the pigs given the non-supplemented diet., Japanese Society of Animal Science
Nihon Chikusan Gakkaiho, Nov. 2000, [Reviewed]

Effects of the Administration of Yucca shidigera Saponins on Pigs Intestinal Microbial Population
KATSUNUMA Yu; OTSUKA Makoto; NAKAMURA Yutaka; TOYODA Atsushi; TAKADA Ryozo; MINATO Hajime, Three pigs were fed a diet supplemented with 50ppm Yucca shidigera saponins, and the remaining three pigs were given a nonsupplemented diet. The feces of the pigs were collected at 103 days of age after birth. The concentration of ammonia-N in the feces of pigs given a diet supplemented with saponins was significantly lower than the pigs given the nonsupplemented diet. The total volatile fatty acids concentration in the feces was not significantly different between the pigs given a diet supplemented with or without saponins. However, the molar proportion of the acetic acid in the feces of pigs given a diet supplemented with saponins was lower, and inversely the concentration of the propionic, butyric and n-valeric acids was higher in comparison with the pigs given the nonsupplemented diet. The total viable counts in the feces were not different between the pigs given a diet supplemented with or without saponins. Bifidobacteria, eubacteria, and staphylococci were more abundant in the feces of pigs given a diet supplemented with saponins, as compared with the pigs given the non-supplemented diet. Veillonella was less abundant in the feces of pigs given a diet supplemented with saponins than the pigs given the non-supplemented diet., Japanese Society of Animal Science
Nihon Chikusan Gakkaiho, 2000, [Reviewed]

Effect of Yucca shidigera Extract and Saponins on Growth of Bacteria Isolated from Animal Intestinal Tract
KATSUNUMA Yu; NAKAMURA Yutaka; TOYODA Atsushi; MINATO Hajime, Influence of Yucca shidigera extract and saponins on the growth of bacteria isolated from the animal intestinal tract was investigated in in vitro. Among a total of 20 strains examined, seven strains classified into 7 species of Lactobacillus plantarum, Lactobacillus rhamnosus, Enterococcus hirae, Escherichia coli, Biftdobacterium thermophilum, Bifidobacterium longum and Streptococcus bovis grew well on the media containing 10% Yucca shidigera extract. In addition, the minimum inhibitory concentration (MIC) of Y, shidigera saponins prepared from Y. shidigera extract against these 7 strains exceeded 28mg/ml. Meanwhile, the other 13 strains which include Bacteroides fragilis, Fusobacterium varium, Fusobacterium necrophorum, Clostridium perfringens, Clostridium innocuum, Clostridium sporogenes, Veillonella parvula, Propionibacterium acnes, Eubacterium aerofaciens, Selenomonas ruminantium, Peptococcus asaccharolyticus, Ruminococcus productus and Megasphaera elsdenii did not grow on the media containing 10% Y. shidigera extract. And, the MICs of the Y. shidigera saponins against these 13 strains was in the range of 14 to 0.7mg/ml. The results obtained in this investigation provide useful and basic information for analyzing the effects of Y shidigera extract and saponins on the constitution of microflora in the animal intestinal tract., Japanese Society of Animal Science
Nihon Chikusan Gakkaiho, 2000, [Reviewed]

A comparison of features and the microbial constitution of the fresh feces of pigs fed diets supplemented with or without dietary microbes
Nagamine, I; J Shimada; Y Nakamura; A Toyoda; H Minato
JOURNAL OF GENERAL AND APPLIED MICROBIOLOGY, Dec. 1998, [Reviewed]

BEGAIN (brain-enriched guanylate kinase-associated protein), a novel neuronal PSD-95/SAP90-binding protein
M Deguchi; Y Hata; M Takeuchi; N Ide; K Hirao; IK Yao; M Irie; A Toyoda; Y Takai
JOURNAL OF BIOLOGICAL CHEMISTRY, Oct. 1998, [Reviewed]

A novel multiple PDZ domain-containing molecule interacting with N-methyl-D-aspartate receptors and neuronal cell adhesion proteins
K Hirao; Y Hata; N Ide; M Takeuchi; M Irie; Yao, I; M Deguchi; A Toyoda; TC Sudhof; Y Takai
JOURNAL OF BIOLOGICAL CHEMISTRY, Aug. 1998, [Reviewed]

Molecular cloning and characterization of rat Lin-10
N Ide; K Hirao; Y Hata; M Takeuchi; M Irie; Yao, I; M Deguchi; A Toyoda; H Nishioka; A Mizoguchi; Y Takai
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Feb. 1998, [Reviewed]

Binding of neuroligins to PSD-95
M Irie; Y Hata; M Takeuchi; K Ichtchenko; A Toyoda; K Hirao; Y Takai; TW Rosahl; TC Sudhof
SCIENCE, Sep. 1997, [Reviewed]

SAPAPs - A family of PSD-95/SAP90-associated proteins localized at postsynaptic density
M Takeuchi; Y Hata; K Hirao; A Toyoda; M Irie; Y Takai
JOURNAL OF BIOLOGICAL CHEMISTRY, May 1997, [Reviewed]

Possible nicotinic receptor-mediated modulation of synaptic transmission in nucleus of the solitary tract
Takuma Shiraki; Atsushi Toyoda; Haruhiko Sugino; Aiko Hori; Shigeo Kobayashi
American Journal of Physiology - Regulatory Integrative and Comparative Physiology, Mar. 1997, [Reviewed]

亜鉛欠乏がラットの脳内亜鉛濃度に与える影響
豊田 淳; 白木琢磨; 矢野史子; 松井 徹; 矢野秀雄
微量栄養素研究, 1993, [Reviewed]

Acquisiton of 3D facial shape data of Japanese Macaque (Macaca fuscata) using video　　　　　　　　　　　　　　　
岡山毅; 小針大助; 豊田淳; 西川夏美; 染谷祐也; 正藤陽久; 飯田伸弥; 川瀬啓祐
Zoo Science Journal, 21 Mar. 2025

Discovery of Depression-Related Biomarkers using Psychosocial Stress Model Mice　　　　　　　　　　　　　　　
Atsushi Toyoda
BIO INDUSTRY, 12 Jul. 2024, [Invited]
Lead

心理社会的ストレスモデルマウスにおける肝臓代謝物の網羅解析　　　　　　　　　　　　　　　
谷島 優平; 中村 勇; 川瀬 貴博; 塚原 隆充; 高橋 阿貴; 豊田 淳
日本畜産学会大会講演要旨集, Sep. 2023
Corresponding

ヘスペリジンの給与がBALB/cオスマウスの社会行動及び脳内キヌレニン経路に及ぼす影響　　　　　　　　　　　　　　　
田中 彩加里; 佐藤 瑞穂; 川瀬 貴博; 塚原 隆充; 豊田 淳
日本栄養・食糧学会大会講演要旨集, Mar. 2023

Impaired Bile Acid Synthesis in a Taurine-Deficient Cat Model.
Teruo Miyazaki; Sei-Ich Sasaki; Atsushi Toyoda; Mutsumi Shirai; Tadashi Ikegami; Akira Honda
Advances in experimental medicine and biology, 2022

うつ病モデルのストレス感受性と給与飼料の関係性
豊田 淳
LABIO21, 01 Jan. 2022, [Invited]
Lead

実験動物用飼料がマウス脳のキヌレニン濃度におよぼす影響　　　　　　　　　　　　　　　
谷島 優平; 奥野 海良人; 中村 勇; 宮崎 照雄; 本多 彰; 豊田 淳
日本畜産学会大会講演要旨集, Sep. 2021

実験動物用飼料がマウス脳のキヌレニン濃度におよぼす影響　　　　　　　　　　　　　　　
谷島 優平; 奥野 海良人; 中村 勇; 宮崎 照雄; 本多 彰; 豊田 淳
日本畜産学会大会講演要旨集, Sep. 2021

後天的タウリン欠乏による結合組織の増加
宮崎照男; 佐々木誠一; 豊田淳; 白井睦; 森下由紀雄; 池上正; 本多彰
タウリンリサーチ, Sep. 2021, [Reviewed]

ウシの飼育管理作業が大学生の心理・生理的状態に及ぼす影響
安江健; 平山望; 武田愛生; 小針大助; 岡山毅; 小松崎将一; 山川百合子; 佐々木誠一; 豊田淳
日本畜産学会報, May 2021, [Reviewed]
Last

Effects of differences in standard diets on the behaviors in social defeated BALB/c mice
石其慧太; 佐藤瑞穂; 佐藤瑞穂; 谷島優平; 豊田淳; 豊田淳
日本農芸化学会大会講演要旨集(Web), 2020

ヘスペリジンはLPS投与モデルマウスの血中白血球および脳内キヌレニンの増加を抑制する
佐藤瑞穂; 佐藤瑞穂; 奥野海良人; 鈴木一徳; 石其慧太; 谷島優平; 豊田淳; 豊田淳
日本栄養・食糧学会大会講演要旨集, 2020

〔Major achievements〕Nutritional interventions for promoting stress resilience: Recent progress using psychosocial stress models of rodents.
Atsushi Toyoda
Animal science journal = Nihon chikusan Gakkaiho, Jan. 2020, [Reviewed], [Invited]
Lead

タウリン欠乏による胆汁酸代謝の変化　　　　　　　　　　　　　　　
宮﨑照雄; 佐々木誠一; 豊田淳; 白井睦; 池上正; 本多彰
タウリンリサーチ, Sep. 2019, [Reviewed]

ガラクトオリゴ糖の長期給が食事誘発性肥満モデルマウスにおよぼす影響　　　　　　　　　　　　　　　
鈴木 一徳; 佐藤 瑞穂; 中島 聡美; 堀端 大路; 塚原 隆充; 豊田 淳
日本栄養・食糧学会大会講演要旨集, Apr. 2019

The effects of taurine depletion on bile acid composition and its amino acid-conjugation in the bile of cats
Teruo Miyazaki; Sei-ich Sasaki; Atsushi Toyoda; Mutsumi Shirai; Tadashi Ikegami; Yasushi Matsuzaki; Akira Honda
FASEB JOURNAL, Apr. 2019

ヘスペリジンの給与は慢性社会的敗北ストレスによる脳内キヌレニンの増加を抑制し,社会的ストレスに対する抵抗性を付与する
佐藤瑞穂; 佐藤瑞穂; 奥野海良人; 鈴木一徳; 大澤夏樹; 井上栄一; 井上栄一; 宮口右二; 宮口右二; 豊田淳; 豊田淳
日本栄養・食糧学会大会講演要旨集, 2019

Influences of Taurine Deficiency on Bile Acids of the Bile in the Cat Model.
Miyazaki T; Sasaki SI; Toyoda A; Shirai M; Ikegami T; Matsuzaki Y; Honda A
Advances in experimental medicine and biology, 2019, [Reviewed]

ガラクトオリゴ糖の給与が慢性社会的敗北ストレスモデルマウスのストレス抵抗性におよぼす影響　　　　　　　　　　　　　　　
鈴木 一徳; 市川 美沙紀; 佐藤 瑞穂; 中島 聡美; 小田原 達郎; 堀端 大路; 鏡 朋和; 豊田 淳
日本栄養・食糧学会大会講演要旨集, Apr. 2018

幼若期のマウスを用いた社会的敗北モデルの作成と評価
大澤夏樹; 奥野海良人; 豊田淳
日本分子生物学会年会プログラム・要旨集(Web), 2018

タウリンの胆汁酸代謝に及ぼす作用に評価におけるネコモデルの有用性　　　　　　　　　　　　　　　
宮崎照雄; 佐々木誠一; 豊田 淳; 白井 睦; 池上 正; 松崎靖司; 本多 彰
タウリンリサーチ, 2018, [Reviewed]

Development of wireless sensor nodes for animals husbandry and medical applications
J. Lu; L. Zhang; S. Matsumoto; H. Hiroshima; R. Maeda; T. Gotoh; M. Sato; A. Toyoda; N. Ohkohchi
Proceedings of IEEE Sensors, 21 Dec. 2017, [Reviewed]

Effects of dietary intake of Lactobacillus gasseri CP2305 (CP2305) on the depressive-like behaviours in subchronic mild social defeat stress (sCSDS) model of mice
A. Toyoda; T. Goto; T. Kawase; T. Tsukahara; S. Fujiwara
NEUROGASTROENTEROLOGY AND MOTILITY, Aug. 2017, [Reviewed]
Lead

未熟フクレミカンの果皮給与がC57BL/6Jオスマウスの体重と代謝産物に与える影響　　　　　　　　　　　　　　　
豊田 淳; 佐藤 瑞穂; 井上 栄一
日本栄養・食糧学会大会講演要旨集, Apr. 2017

〔Major achievements〕Social defeat models in animal science: What we have learned from rodent models
Toyoda, A.
Animal Science Journal, Apr. 2017, [Reviewed], [Invited]
Lead

家畜とのふれあいを含む農作業活動が精神疾患者の心理・生理的状態に及ぼす効果　　　　　　　　　　　　　　　
安江 健; 竹村 紀穂; 高橋 弘美; 柴沼 沙織; 下西 ひかり; 水野 高昌; 小松崎 将一; 山川 百合子; 小針 大助; 岡山 毅; 佐々木 誠一; 豊田 淳
日本畜産学会大会講演要旨集, Mar. 2017

社会的敗北ストレスモデルを用いた増体および摂食行動に関する研究　　　　　　　　　　　　　　　
飯尾 恒; 塚原隆充; 小川恭喜; 長南 茂; 豊田 淳
栄養生理研究会報, Mar. 2017, [Reviewed], [Invited]

社会的敗北モデルマウスのメタボローム解析　　　　　　　　　　　　　　　
豊田 淳; 後藤達彦; 友永省三
タウリンリサーチ, 2017, [Reviewed]

タウリン欠乏モデルネコの作製　　　　　　　　　　　　　　　
宮崎照雄; 佐々木誠一; 豊田淳; 白井睦; 池上正; 松﨑靖司; 本多彰
タウリンリサーチ, 2017, [Reviewed]

Murine Depression Model and its Potential Applications for Discovering Foods and Farm Products with Antidepressant-Like Effects
Tatsuhiko Goto; Shozo Tomonaga; Tsuyoshi Okayama; Atsushi Toyoda
FRONTIERS IN NEUROSCIENCE, Mar. 2016, [Reviewed], [Invited]

和牛の分娩前の尾挙げ時間に関わる要因
佐藤晴香; 小針大助; 岡山毅; 豊田淳; 小迫孝実
Animal Behaviour and Management, 2016

食肉の給与が海馬のタンパク質リン酸化および遺伝子発現に及ぼす影響　　　　　　　　　　　　　　　
豊田 淳; 下西ひかり; 後藤達彦
平成26年度食肉に関する助成研究調査成果報告書, Nov. 2015

慢性的な社会敗北ストレスはC57BL/6Jマウスの消化管機能に影響をおよぼす
守谷直子; 山岸直子; 木元広実; 大森英之; 青木綾子; 後藤達彦; 豊田淳; 鈴木チセ
日本畜産学会大会講演要旨, 28 Mar. 2015

社会的敗北ストレス負荷がマウスの胆汁酸産生に及ぼす影響
麻生愛花; 一法師克成; 山岸直子; 守谷直子; 青木(吉田)綾子; 後藤達彦; 豊田淳; 山本(前田)万里; 鈴木チセ
日本農芸化学会大会講演要旨集(Web), 05 Mar. 2015

深度センサを用いたインゲンマメの水ストレス反応の三次元計測
岡山毅; 鈴木丈詞; 豊田淳
農業環境工学関連学会合同大会講演要旨集(CD-ROM), 2015

社会心理的ストレスモデルマウスの腸内細菌叢プロファイル
山岸直子; 青木綾子; 青木綾子; 守谷直子; 後藤達彦; 豊田淳; 豊田淳; 青木玲二; 鈴木チセ; 鈴木チセ; 高山喜晴
臨床ストレス応答学会大会抄録集, 2015

慢性社会的敗北ストレスがマウス大腸のタイト結合構成蛋白質の遺伝子発現に与える効果
山岸直子; 青木(吉田)綾子; 守谷直子; 後藤達彦; 後藤達彦; 豊田淳; 豊田淳; 豊田淳; 青木玲二; 鈴木チセ; 高山喜晴
日本生化学会大会(Web), 2015

Effects of Chronic Taurine Administration on Gene Expression, Protein Translation and Phosphorylation in the Rat Hippocampus
Atsushi Toyoda; Hiroaki Koike; Kouichiro Nishihata; Wataru Iio; Tatsuhiko Goto
TAURINE 9, 2015, [Reviewed]

Monitoring Nest Building in Mice and Leaf Movement of Kidney Beans using an Infrared Range Camera
Tsuyoshi Okayama; Tatsuhiko Goto; Takeshi Suzuki; Atsushi Toyoda
International Conference on Agro-Industry (IcoA): Sustainable and Competitive Agro-Industry for Human Welfare Yogyakarta-INDONESIA 2014, 2015, [Reviewed]

食肉の給与が海馬のタンパク質リン酸化および遺伝子発現におよぼす影響　　　　　　　　　　　　　　　
豊田 淳
平成25年度食肉に関する助成研究成果報告書, Dec. 2014

慢性社会的敗北ストレスがマウスの行動および血液生化学性状におよぼす影響
後藤達彦; 久保田祥史; 吉田綾子; 青木玲二; 高山喜晴; 守谷直子; 鈴木チセ; 豊田淳
日本畜産学会大会講演要旨, 2014

C57BL/6Jマウスの慢性社会的敗北ストレス負荷による腸内細菌叢の変動
吉田綾子; 後藤達彦; 青木玲二; 高山喜晴; 守谷直子; 豊田淳; 鈴木チセ
日本畜産学会大会講演要旨, 2014

腸管オルガノイド及び社会的ストレス負荷マウスを用いた精神的ストレス評価系の構築
青木(吉田)綾子; 濱田晃弘; 後藤達彦; 青木玲二; 高山喜晴; 守谷直子; 豊田淳; 鈴木チセ; 園山慶
日本栄養・食糧学会大会講演要旨集, 2014

赤外線深度センサを利用した動物,植物の動きの解析
豊田淳; 豊田淳; 豊田淳; 後藤達彦; 後藤達彦; 荒川俊也; 小針大助; 小針大助; 小針大助; 鈴木丈詞; 岡山毅; 岡山毅; 岡山毅
日本生化学会大会(Web), 2014

Antidepressant-like effect of chronic taurine administration and its hippocampal signal transduction in rats
Atsushi Toyoda; Wataru Iio
Advances in Experimental Medicine and Biology, 2013, [Reviewed]

飼料中リジン濃度の低減によるブタ筋肉内脂肪の畜積促進機構の解明
京谷隆侍; 石田藍子; 中島一喜; 中島郁世; 豊田淳; 中村豊; 勝俣昌也
栄養生理研究会報, Jun. 2011, [Reviewed]

Effects of chronic taurine administration on behavioral and biochemical parameters in Wistar rats
Wataru Iio; Atsushi Toyoda
NEUROSCIENCE RESEARCH, 2011

食肉由来機能性成分クレアチンによる脳機能の維持・改善に関する研究　　　　　　　　　　　　　　　
鬼澤直樹; 豊田裕子; 豊田淳
食肉に関する助成研究調査成果報告書, 2011

The magnitudes of promoted accumulation of intramuscular fat in responding to dietary low lysine in five distinct skeletal muscles of fattening pigs
Kyoya, T.; Ishida, A.; Nakashima, K.; Toyoda, A.; Nakamura, Y.; Katsumata, M.
EAAP Scientific Series, 2010, [Reviewed]

成長および低リジン飼料給与に伴う豚筋肉内脂肪細胞の数と大きさの変化
京谷隆侍; 京谷隆侍; 石田藍子; 中島一喜; 豊田淳; 豊田淳; 中村豊; 中村豊; 勝俣昌也
日本畜産学会大会講演要旨, 2010

うつ病モデルラットの作製　　　　　　　　　　　　　　　
豊田淳
財団法人 タカノ農芸化学研究助成財団平成21年度助成研究報告書, 2010

食肉由来機能性成分クレアチンによる脳機能の維持・改善に関する研究　　　　　　　　　　　　　　　
鬼澤直樹; 豊田淳
食肉に関する助成研究調査成果報告書, 2010

Annual Differences of Sugar Production in Sweet Sorghum (Sorghum bicolor (L.) Moench) Stem
KAMIYAMA Akinori; NARISAWA Kazuhiko; KURUSU Yasurou; OHTA Hiroyuki; CHOHNAN Shigeru; MIYAGUCHI Yuji; TOYODA Atsushi; KATO Tasuku; KOBAYASHI Hisashi; KOMATSUZAKI Masakazu; SATO Tatsuo; NITTA Youji; YOSHIDA Koushi; HOMMA Takashi; UMEHARA Ryouhei; KOBAYASI Ryo; MATSUDA Toshiaki; NAKAMURA Satoshi; GOTO Yusuke; INOUE Eiichi
Tohoku Journal of Crop Science, 2009

Effect of Weather Condition on Sugar Yield in Sweet Sorghum (Sorghum bicolor (L.) Moench) Stem
KAMIYAMA Akinori; NARISAWA Kazuhiko; KURUSU Yasurou; OHTA Hiroyuki; CHOHNAN Shigeru; MIYAGUCHI Yuji; TOYODA Atsushi; KATO Tasuku; KOBAYASHI Hisashi; KOMATSUZAKI Masakazu; SATO Tatsuo; NITTA Youji; YOSHIDA Koushi; HOMMA Takashi; UMEHARA Ryouhei; KOBAYASI Ryo; MATSUDA Toshiaki; NAKAMURA Satoshi; GOTO Yusuke; INOUE Eiichi
Tohoku Journal of Crop Science, 2009

低リジン飼料を豚に給与したときの筋肉内脂肪の蓄積は筋肉の種類によって異なる
京谷隆侍; 京谷隆侍; 石田藍子; 中島一喜; 豊田淳; 中村豊; 勝俣昌也
日本畜産学会大会講演要旨, 2009

食肉由来機能性成分クレアチンによる脳機能の維持・改善に関する研究　　　　　　　　　　　　　　　
鬼澤直樹; 豊田 淳
食肉に関する助成研究調査成果報告書, 2009

Sweet Sorghum Cultivation as a Bio-fuel Crop in Ibaraki Prefecture
NITTA Youji; KAMIYAMA Akinori; MATSUDA Toshiaki; NAKAMURA Satoshi; GOTO Yusuke; INOUE Eiichi; NARISAWA Kazuhiko; KURUSU Yasurou; OHTA Hiroyuki; CHONAN Shigeru; TOYODA Atsushi; KATO Tasuku; KOBAYASHI Hisashi; KOMATSUZAKI Masakazu; SATO Tatsuo
Jpn. J. Crop Sci., 27 Mar. 2008

納豆残さの給与が採卵鶏および筑波地鶏の飼養成績および盲腸内環境に及ぼす影響
藤原謙一郎; 加藤由紀乃; 大林康信; 生井和夫; 磯政男; 山崎信; 阿部啓之; 中島一喜; 石田藍子; 大塚誠; 豊田淳; 宮口右二; 中村豊; 金子謙一郎
日本畜産学会大会講演要旨, 2005

ルミノロジー研究における最近の進歩（4）　　　　　　　　　　　　　　　
湊 一; 三森真琴; 豊田 淳
畜産の研究, 2005

ルミノロジー研究における最近の進歩（3）　　　　　　　　　　　　　　　
湊 一; 三森真琴; 豊田 淳
畜産の研究, 2005

ルミノロジー研究における最近の進歩（2）　　　　　　　　　　　　　　　
湊 一; 三森真琴; 豊田 淳
畜産の研究, 2005

ルミノロジー研究における最近の進歩（１）　　　　　　　　　　　　　　　
湊 一; 三森真琴; 豊田 淳
畜産の研究, 2005

ルーメン内主要セルロース分解菌、Eubacterium cellulosolvens 5、のセルロースへの付着機構　　　　　　　　　　　　　　　
豊田淳
栄養生理研究会報, May 2004, [Reviewed]

繊維質分解性ルーメン細菌のセルロースへの付着機構に関する研究の現状
湊一, 豊田淳
日本微生物生態学会誌, Mar. 2004

The cell wall-anchoring module of cellulose-binding protein A from rumen cellulolytic bacterium Eubacterium cellulosolvens 5　　　　　　　　　　　　　　　
Akio Ichihara; Atsushi Toyoda; Miho Yoshimatsu; Yutaka Nakamura; Hajime Minato
Biotechnology of lignocellulose degradation and biomass utilization., 2004, [Reviewed]

Gene cluster for the cellulose degradation in rumen cellulolytic bacterium Eubacterium cellulosolvens 5　　　　　　　　　　　　　　　
Miho Yoshimatsu; Atsushi Toyoda; Akio Ichihara; Yutaka Nakamura; Hajime Minato
Biotechnology of lignocellulose degradation and biomass utilization., 2004, [Reviewed]

A possible role of cellulose-binding protein A (CBPA) in adhesion of Eubacterium cellulosolvens 5 to cellulose　　　　　　　　　　　　　　　
Atsushi Toyoda; Kazunori Takano; Akio Ichihara; Miho Yoshimatsu; Hajime Minato
Biotechnology of lignocellulose degradation and biomass utilization., 2004, [Reviewed]

反芻胃内セルロース分解菌の有用代謝産物に関する研究　　　　　　　　　　　　　　　
豊田 淳; 中村 豊; 湊 一
食肉に関する助成研究調査成果報告書, 2004

反芻胃内由来繊維分解細菌の繊維結合性因子の分子的機能解析　　　　　　　　　　　　　　　
豊田 淳; 中村 豊; 湊 一
食肉に関する助成研究調査成果報告書, 2003

Eubacterium cellulosolvens 5のセルロース結合性蛋白質CBPAは菌体のセルロースへの付着に必要である
豊田淳; 市原朗雄; 高野和儀; 依田一豊; 湊一
日本畜産学会大会講演要旨, 2002

Eubacterium cellulosolvens 5のセルロース分解系遺伝子の解析　　　　　　　　　　　　　　　
吉松美帆; 豊田 淳; 市原朗雄; 中村 豊; 湊 一
ルーメン研究会報, 2002

ルーメン内セルロース分解菌Eubacterium cellulosolvens 5のセルロース結合性タンパク質(CBPA)のC末端側の機能解析　　　　　　　　　　　　　　　
市原朗雄; 豊田 淳; 高野和儀; 吉松美帆; 中村 豊; 湊 一
ルーメン研究会報, 2002

反芻胃内由来繊維分解性細菌の繊維結合因子に関する研究　　　　　　　　　　　　　　　
豊田 淳; 中村 豊; 湊 一
食肉に関する助成研究調査成果報告書, 2002

Eubacterium cellulosolvensの繊維分解機構　　　　　　　　　　　　　　　
豊田淳
Proceedings of Japanese Society for Rumen Metabolism and Physiology, 2001, [Reviewed]

豚の腸内微生物叢に及ぼすユッカ抽出物サポニン給与の影響　　　　　　　　　　　　　　　
湊 一; 中村 豊; 豊田 淳
食肉に関する助成研究調査成果報告書, 2000

豚の腸内微生物叢に及ぼす微生物資材投与の影響　　　　　　　　　　　　　　　
湊 一; 中村 豊; 豊田 淳
食肉に関する助成研究調査成果報告書, 1999

PSD-95/SAP90に結合する新しい蛋白質のクローニングとその性状解析
竹内 勝一; 畑 裕; 入江 美奈; 平尾 和世; 豊田 淳; 高井 義美
日本分子生物学会年会プログラム・講演要旨集, 01 Aug. 1996

麹菌による発酵がカンキツ果皮粉末のポリメトシキフラボノイド含有量に及ぼす影響　　　　　　　　　　　　　　　
阿武佑弥; 藤井智教; 大西賢一; 柳橋 諒; 長谷川守文; 豊田 淳; 望月佑哉; 井上栄一
園芸学会 令和7年度春季大会, 21 Mar. 2025
20250320, 20250321

麹菌の資化によるカンキツ果皮中の ポリメトシキフラボノイド含有量の増加　　　　　　　　　　　　　　　
阿武佑弥; 藤井智教; 大西賢一; 柳橋諒; 長谷川守文; 豊田淳; 望月佑哉; 井上栄一
第22回日本機能性食品医用学会総会, 07 Dec. 2024
20241207, 20241208

Evaluation of the effects of psychosocial stress on the level of DNA damage in mouse tissues　　　　　　　　　　　　　　　
Shinya Masugata; Aiko Tsujita; Misa Iwasaki; Atsushi Toyoda; Asako J. Nakamur
第67回日本放射線影響学会, 25 Sep. 2024
20240928

マウスの行動実験を通して痛感した飼料の大切さ
豊田 淳
日本畜産学会第132回大会 企業協賛シンポジウム２, 18 Sep. 2024

D-Ala intervention from middle age prevents age-related behavioural deficits in mice.　　　　　　　　　　　　　　　
Sumika Nishi; Atsushi Toyoda
Taiwan Society for Neuroscience, 25 Aug. 2024
20240823, 20240825

Effects of cold environment exposure on nesting deficits in the acute social defeat stress model of mice　　　　　　　　　　　　　　　
Chiho Kozaw; Hikari Otabi; Atsushi Toyoda
NEURO2024, 25 Jul. 2024

Environmental enrichment (EE) increases behavioral diversity in male mice.　　　　　　　　　　　　　　　
Misa Iwasaki; Hodaka Suzuki; Asako Nakamura; Atsushi Toyoda
NEURO2024, 25 Jul. 2024

半精製飼料に配合されるカゼインの種類が 亜慢性社会的敗北ストレス負荷マウスの行動に及ぼす影響　　　　　　　　　　　　　　　
川瀬貴博; 池田裕美; 西澤秀朗; 小澤智穂; 小林洋大; 豊田淳; 塚原隆充
第78回日本栄養・食糧学会大会, 26 May 2024

実験動物を用いた栄養とレジリエンスの関係性の解明　　　　　　　　　　　　　　　
豊田 淳
第78回日本栄養・食糧学会大会, 25 May 2024, [Invited]

D-アラニンの経口摂取が中年マウスの行動に及ぼす影響　　　　　　　　　　　　　　　
西純可; 豊田淳
日本農芸化学会2024年度大会, 25 Mar. 2024

The effects of subchronic and mild social defeat stress on taste buds in male mice.　　　　　　　　　　　　　　　
宮崎 美沙; 豊田 淳; 吉田 悠太
第46回日本分子生物学会年会, 07 Dec. 2023

The effect of subchronic and mild social defeat stress on salt preference in male mice　　　　　　　　　　　　　　　
門脇 崇; 湯澤 亜利沙; 豊田 淳; 吉田 悠太
第46回日本分子生物学会年会, 07 Dec. 2023

A study on the relationship between salivary miR-208b-3p and stress-induced cardiac fibrosis in male mice subjected to sub-chronic and mild social defeat stress (sCSDS)　　　　　　　　　　　　　　　
Finandya Fatihasari; Yuta Yoshida; Yuhei Yajima; Kina Kawakami; Shin-ichi Nakamura; Takamitsu Tsukahara; Katsutaka Oishi; Atsushi Toyoda
第46回日本分子生物学会年会, 06 Dec. 2023

Assessment of nest-building behaviors in juvenile male mice exposed to social isolation stress　　　　　　　　　　　　　　　
礒嵜 友輔; 竹ケ原 菜月; 岩崎 実紗; 川瀬 貴博; 塚原 隆充; 遠野 雅徳; 岡山 毅; 豊田 淳
第46回日本分子生物学会年会, 06 Dec. 2023

心理社会的ストレスモデルにおけるストレス感受性と関連する腸内細菌叢の探索　　　　　　　　　　　　　　　
谷島優平; 中村勇; 川瀬貴博; 塚原隆充; 高橋阿貴; 豊田淳
Hindgut Club Japan2023, 02 Dec. 2023

心理社会的ストレスモデルマウスにおける肝臓代謝物の網羅解析
谷島優平; 中村 勇; 川瀬貴博; 塚原隆充; 高橋阿貴; 豊田 淳
日本畜産学会第131回大会, 20 Sep. 2023, 日本畜産学会
20230918, 20230921

D-アラニンの慢性経口摂取は中年マウスの短期および長期記憶、動機付け行動に影響する　　　　　　　　　　　　　　　
西 純可; 豊田 淳
第46回日本神経科学大会, 03 Aug. 2023
20230801, 20230804

マウス脳のメタボローム解析用前処理法の検討　　　　　　　　　　　　　　　
廣瀬 恵太郎; 谷島 優平; 中村 勇; 豊田 淳
第46回日本神経科学大会, 02 Aug. 2023
20230801, 20230804

環境エンリッチメント処置がC57BL/6J系統オスマウスの各種行動に及ぼす影響　　　　　　　　　　　　　　　
岩崎 実紗; 鈴木 穂高; 中村 麻子; 豊田 淳
第46回日本神経科学大会, 01 Aug. 2023
20230801, 20230804

Effects of dietary hesperidin on the social behavior and the brain kynurenine pathway in BALB/c male mice.　　　　　　　　　　　　　　　
田中彩加里; 佐藤瑞穂; 川瀬貴博; 塚原 隆充; 豊田 淳
第77回日本栄養・食糧学会大会, 14 May 2023
20230511, 20230514

Effects of the type of casein in semi-purified diets on the behaviors in male mice　　　　　　　　　　　　　　　
西澤秀朗; 小澤智穂; 川瀬貴博; 塚原隆充; 豊田 淳
第77回日本栄養・食糧学会大会, 13 May 2023
20230511, 20230514

大腸水素はうつ病モデルマウスの非レリジエント個体に対して抗うつ作用を示す　　　　　　　　　　　　　　　
山本達朗; 奥谷紗羽; 山本恵美里; 杉山夏菜; 糸澤久美; 田邊宏基; 豊田淳; 西村直道
第127回日本解剖学会総会・全国学術集会, Mar. 2023

レンコン粉末の麹化による ヌシフェリン産生機構の解明　　　　　　　　　　　　　　　
柳橋 諒; 藤井智教; 大西賢一; 長谷川守文; 豊田 淳; 望月佑哉; 井上栄一
一般社団法人園芸学会令和5年度春季大会, 20 Mar. 2023
2023, 2023

慢性的な睡眠障害モデルマウスの唾液におけるmiRNA-seq解析　　　　　　　　　　　　　　　
吉田悠太; 谷島優平; 藤倉祐里; 庄皓桐; 山本明花; 豊田淳; 大石勝隆
第29回 日本時間生物学会学術大会, 03 Dec. 2022

半精製飼料に配合するカゼインの種類がオスマウスの行動におよぼす影響
西澤秀朗; 小澤智穂; 川瀬貴博; 塚原隆充; 豊田 淳
日本畜産学会第130回大会, 16 Sep. 2022
20220914, 20220917

慢性的な睡眠障害モデルマウスにおける唾液microRNAプロファイルの解析　　　　　　　　　　　　　　　
吉田悠太; 谷島優平; 藤倉祐里; 庄皓桐; 山本明花; 豊田淳; 大石勝隆
第9回 日本時間栄養学会学術大会, 26 Aug. 2022

身体的ストレスを軽減させたプロトコルによる社会的敗北ストレスモデルマウスの確立とその行動解析
西澤秀朗; 谷島優平; 豊田 淳
Neuro2022, 30 Jun. 2022
20220630, 20220703

社会的敗北ストレスモデルマウスの糞便、血漿からストレスバイオマーカー探索の試み
谷島優平; 中村 勇; 川瀬貴弘; 塚原隆充; 豊田 淳
Neuro2022, 30 Jun. 2022
20220630, 20220703

新しいタンパク質修飾・乳酸修飾とストレス　　　　　　　　　　　　　　　
萩原 英雄; 昌子 浩孝; 大給 日香里; 豊田 淳; 加藤 薫; 波平 昌一; 宮川 剛
第1回日本科学振興協会（JAAS）総会・キックオフミーティング, 18 Jun. 2022
20220618, 20220624

うつ病モデルマウスを用いた大腸水素の抗うつ作用に関する行動学的分析
山本達朗; 杉山夏菜; 糸澤久美; 田邊宏基; 豊田 淳 西村直道
第76回日本栄養・食糧学会, 12 Jun. 2022
20220610, 20220612

タウリン⽋乏によるアミロイドーシスの発症　　　　　　　　　　　　　　　
宮﨑照雄; 佐々木誠一; 豊田淳; 白井睦; 森下由紀雄; 池上正; 本多彰
第8回国際タウリン研究会日本部会学術会議, 08 Mar. 2022
20220307, 20220308

Effects of aging on the behaviors in C57BL/6J male mice
西 純可; 礒嵜友輔; 豊田 淳
第44回日本分子生物学会年会, 03 Dec. 2021
20211201, 20211203

実験動物用飼料がマウス脳のキヌレニン濃度におよぼす影響　　　　　　　　　　　　　　　
谷島 優平; 奥野海良人; 中村 勇; 宮崎照雄; 本多 彰; 豊田 淳
日本畜産学会第129回大会, 15 Sep. 2021

麹化によるレンコン粉末の機能性成分の改変
柳橋諒; 藤井智教; 大西賢一; 長谷川守文; 豊田淳; 井上栄一
園芸学会令和3年度秋季大会, 園芸学会
20210908, 20210914

未病モデルマウスに対する福来 (フクレ) ミカン果皮摂取の有効性の解析　　　　　　　　　　　　　　　
定光祐佳; 伊藤直樹; 豊田淳; 井上栄一; 小田口浩; 清原寛章
第38回和漢医薬学会, 04 Sep. 2021
20210904, 20210904

〔Major achievements〕うつ病モデルマウスを用いた微生物資材の評価研究
豊田 淳
第一回ヘルスケア・フーズ研究会, 06 Aug. 2021, 茨城県, [Invited]

マウス海馬のキヌレニンレベルは飼料内容の影響を受ける
谷島 優平; 奥野海良人; 中村 勇; 宮崎照雄; 本多彰; 豊田 淳
第44回日本神経科学大会, 30 Jul. 2021, 日本神経科学会
20210728, 20210731

深度センサによる牛分娩前体型変化の検出
岡山毅; 小針大助; 豊田淳
日本畜産学会第128回大会, 29 Mar. 2021, 日本畜産学会
20210327, 20210330

情動と巣作りに対する飼育ストレスの影響：BDNF一塩基多型モデルマウスの研究　　　　　　　　　　　　　　　
小島 正己; 小西 行雄; 水井 利幸; 熊ノ郷 晴子; 大給 日香里; 豊田 淳
第43回日本神経科学大会, 30 Jul. 2020

３次元深度カメラによる急性社会的敗北ストレスモデルマウスにおける巣作りと社会行動の解析　　　　　　　　　　　　　　　
大給 日香里; 岡山 毅; 豊田 淳
第43回日本神経科学大会, 30 Jul. 2020

ヘスペリジンの給与はリポ多糖投与モデルマウスの血中白血球数と脳内キヌレニンレベルの増加を抑制する　　　　　　　　　　　　　　　
佐藤 瑞穂; 佐藤 瑞穂; 奥野 海良人; 鈴木 一徳; 石其 慧太; 谷島 優平; 豊田 淳
第43回日本神経科学大会, 29 Jul. 2020

飼料の違いが慢性社会的敗北ストレスモデルマウスのレジリエンスと脳のキヌレニン経路におよぼす影響　　　　　　　　　　　　　　　
谷島 優平; 佐藤 瑞穂; 石其 慧太; 奥野 海良人; 豊田 淳
第43回日本神経科学大会, 29 Jul. 2020

慢性社会的敗北ストレスモデルマウスを用いたビフィズス菌Bifidobacterium bifidum TMC3115株給与の評価　　　　　　　　　　　　　　　
依田一豊; 佐藤瑞穂; 原田岳; 大澤夏樹; 何方; 豊田淳
日本農芸化学会2020年度大会, 27 Mar. 2020
20200326, 20200328

飼料の違いが社会的敗北BALB/cマウスの行動に与える影響　　　　　　　　　　　　　　　
石其 慧太; 佐藤 瑞穂; 谷島 優平; 豊田 淳
日本農芸化学会2020年度大会, 27 Mar. 2020
20200325, 20200328

飼料の違いが社会的敗北BALB/cマウスの行動に与える影響（優秀発表）　　　　　　　　　　　　　　　
石其慧太; 佐藤瑞穂; 谷島優平; 豊田淳
日本農芸化学会2020年度大会, 26 Mar. 2020, [Invited]
20200325, 20200328

〔Major achievements〕ヘスペリジンは心理社会的ストレスに対するレジリエンスを向上させる
豊田 淳
ヘスペリジン研究会第11回研究発表会, 16 Dec. 2019, [Invited]

脳由来神経成長因子BDNF産生不全マウスの腸内細菌と腸管機能の解析　　　　　　　　　　　　　　　
小島正己; 大給日香里; 豊田 淳; 塚原隆充; 松井このみ
第25回Hindgut Club JAPANシンポジウム, 07 Dec. 2019

ガラクトオリゴ糖の長期給与が食事誘発性肥満モデルマウスの増体、盲腸内細菌叢、肝臓の代謝におよぼす影響　　　　　　　　　　　　　　　
鈴木一徳; 佐藤瑞穂; 中島聡美; 堀端大路; 塚原隆充; 豊田 淳
第25回Hindgut Club JAPANシンポジウム, 07 Dec. 2019

慢性および亜慢性社会的敗北ストレスモデルマウスの作製と比較
寺本朱里; 鍵和田 晴美; 堀本 勝久; 豊田 淳
第42回日本分子生物学会年会, 03 Dec. 2019

Subchronic and mild social defeat stress impacts on brain kynurenine and cecum microbiota in juvenile mice
Atsushi Toyoda; Natsuki Ohsawa; Alato Okuno; Takamitsu Tsukahara
The 42nd Annual Meeting of the Japan Neuroscience Society, 25 Jul. 2019

Effects of chronic dietary galacto-oligosaccharides on the diet-induced obesity model of mouse　　　　　　　　　　　　　　　
Suzuki Kazunori; Sato Mizuho; Nakajima Satomi; Horibata Oji; Tsukahara Takamitsu; Toyoda Atsushi
第73回日本栄養・食糧学会, 18 May 2019

Dietary intake of hesperidin suppresses brain kynurenine increments and social avoidance behaviors in mice subjected to subchronic and mild social defeat stress　　　　　　　　　　　　　　　
ato Mizuho; Okuno Alato; Suzuki Kazunori; Ohsawa Natsuki; Inoue Eiichi; Miyaguchi Yuji; Toyoda Atsushi
第73回日本栄養・食糧学会, 18 May 2019

Flavonoid content of fukure mikan (Citrus tumida hort. ex Tanaka) produced in Ibaraki　　　　　　　　　　　　　　　
Fujii Tomonori; Hasegawa Morifumi; Toyoda Atsushi; Inoue Eiichi
第73回日本栄養・食糧学会, 18 May 2019

〔Major achievements〕心理社会的ストレスモデル動物の栄養・代謝に関する研究
豊田 淳
日本畜産学会第125回大会（日本畜産学会賞受賞者講演）, 28 Mar. 2019, [Invited]

P. gingivalis由来LPS及び酪酸の継続的な歯周組織内接種は，マウスの行動異常を惹起する　　　　　　　　　　　　　　　
川瀬貴博; 中村進一; 豊田 淳; 落合邦康; 塚原隆充
第24回 Hindgut Club Japanシンポジウム, 08 Dec. 2018

ヘスペリジンの給与は慢性社会的敗北ストレスによる脳内キヌレニンの増加を抑制し、社会的ストレスに対する抵抗性（レジリエンス）を付与する　　　　　　　　　　　　　　　
佐藤瑞穂; 奥野海良人; 鈴木一徳; 大澤夏樹; 井上栄一; 宮口右二; 豊田 淳
第24回 Hindgut Club Japanシンポジウム, 08 Dec. 2018

幼若期慢性社会的敗北モデルマウスの作成と評価ーブリーダーの影響ー　　　　　　　　　　　　　　　
大澤夏樹; 奥野海良人; 塚原隆充; 豊田 淳
第24回 Hindgut Club Japanシンポジウム, 08 Dec. 2018

アビシニアコロブス（Colobus guereza）の消化管各部位における腸内細菌叢および代謝産物の網羅的解析　　　　　　　　　　　　　　　
中村進一; 川瀬貴博; 豊田 淳; 飯田伸弥; 正藤晴久; 塚原隆充
第24回 Hindgut Club Japanシンポジウム, 08 Dec. 2018

赤外線深度センサを用いた動物の３次元行動解析
豊田 淳; 大給 日香里; 新納 浩幸; 小針 大助; 岡山 毅
第41回日本分子生物学会年会, 30 Nov. 2018, [Invited]

幼若期のマウスを用いた社会的敗北モデルの作成と評価
大澤 夏樹; 奥野 海良人; 豊田 淳
第41回日本分子生物学会年会, 29 Nov. 2018

A potential screening paradigm for antidepressants using the nest building evaluation after acute social defeat stress (ASDS)
H. OTABI; T. OKAYAMA; D. KOHARI; A. TOYODA
Neuroscience2018, 05 Nov. 2018

Abnormal behavior is induced by consecutive injection of lipopolysaccharide and butyric acid to murine gingival tissue
Takahiro Kawase; Shin-ichi Nakamura; Atsushi Toyoda; Kuniyasu Ochiai; Takamitsu Tsukahara
第61回秋季日本歯周病学会学術大会, 26 Oct. 2018

Dietary intake of hesperidin suppresses brain kynurenine levels and social avoidance behavior in the depression model of mouse
Mizuho Sato; Arato Okuno; Kazunori Suzuki; Natsuki Ohsawa; Eiichi Inoue; Yuji Miyaguchi; Atsushi Toyoda
The 15th International Society for Tryptophan Research (ISTRY) Conference – Tryptophan Research from Bench Research to Clinical Outcome –, 20 Sep. 2018

アビシニアコロブスの消化管各部位における腸内細菌叢および代謝産物の網羅的解析
中村 進一; 川瀬 貴博; 豊田 淳; 飯田 伸弥; 正藤 晴久; 塚原 隆充
第24回日本野生動物医学会大会, 01 Sep. 2018

Effects of dietary galacto-oligosaccharide on stress-related behaviors in a subchronic mild social defeat stress model of mice
Atsushi Toyoda; Kazunori Suzuki; Misaki Ichikawa; Mizuho Sato; Satomi Nakashima; Tatsuro Odawara; Oji Horibata; Tomokazu Kagami
FNM 2018 – 3rd Meeting of the Federation of Neurogastroenterology and Motility, 30 Aug. 2018

Dietary Ingestion of Lactobacillus Helveticus Strain MCC1848 Increases Resilience in a Subchronic Social Defeat Stress Model of Mice
Hazuki Maehata; Takahiro Kawase; Yodai Kobayashi; Tetsuya Kuhara; Jin-Zhong Xiao; Atsushi Toyoda
The 41st Annual Meeting of the Japan Neuroscience Society, 27 Jul. 2018

Dietary supplementation of hesperidin increased stress resilience in a subchronic and mild social defeat model of mice
Mizuho Sato; Kazunori Suzuki; Natsuki Ohsawa; Arato Okuno; Eiich Inoue; Yuji Miyaguchi; Atsushi Toyoda
The 41st Annual Meeting of the Japan Neuroscience Society, 27 Jul. 2018

Decreased brain pH in patients with depression and in a social defeat mouse model
Hideo Hagihara; Hirotaka Shoji; Hikari Otabi; Atsushi Toyoda; Tsuyoshi Miyakawa
The 41st Annual Meeting of the Japan Neuroscience Society, 27 Jul. 2018

Decreased brain pH in patients with depression and in a social defeat mouse model
Hideo Hagihara; Hirotaka Shoji; Hikari Otabi; Atsushi Toyoda; Tsuyoshi Miyakawa
CINP2018, 16 Jun. 2018

うつ病モデル動物の栄養代謝研究 −レジリエンスに関わる分子の探索−
豊田 淳
第72回日本栄養・食糧学会大会 特別講演「アミノ酸栄養に対するアニマルサイエンスからのアプローチ」, 13 May 2018, [Invited]

未熟フクレミカンの果皮粉末の給与が慢性社会 的敗北モデルマウスのレジリエンスにおよぼす 影響
佐藤 瑞穂; 鈴木 一徳; 大澤 夏樹; 井上 栄一; 宮口 右二; 豊田 淳
第72回日本栄養・食糧学会大会, 12 May 2018

ガラクトオリゴ糖の給与が慢性社会的敗北スト レスモデルマウスのストレス抵抗性におよぼす 影響
鈴木 一徳; 市川 美沙紀; 佐藤 瑞穂; 中島 聡美; 小田原 達郎; 堀端 大路; 鏡 朋和; 豊田 淳
第72回日本栄養・食糧学会大会, 12 May 2018

社会的ストレスへのレジリエンスに関わる代謝産物の探索研究
豊田淳; 後藤達彦; 友永省三
日本畜産学会第124回大会, 29 Mar. 2018

Identification of the metabolites linked to stress resilience using a chronic social defeat model of mice
豊田 淳; 後藤達彦; 友永省三
ConBio2017, 08 Dec. 2017

幼若期社会的敗北モデルマウスの開発と評価
大澤夏樹; 豊田 淳
第23回Hindgut Club Japanシンポジウム, 02 Dec. 2017

未熟フクレミカン果皮成分の給与が慢性社会的敗北モデルマウスの ストレス脆弱性におよぼす影響
佐藤瑞穂; 鈴木一徳; 大澤夏樹; 井上栄一; 宮口右二; 豊田 淳
第23回Hindgut Club Japanシンポジウム, 02 Dec. 2017

Diet purity impacts on the cecum microbiome but not depressive-like behaviors and plasma corticosterone levels in C57Bl/6J mice
Atsushi Toyoda; Hikari Shimonishi; Mizuho Sato; Kento Usuda; Kentaro Nagaoka
Neuroscience 2017, 13 Nov. 2017

Nutritional and metabolic studies on chronic social defeat models
ATSUSHI TOYODA
第60回日本神経化学会大会, 08 Sep. 2017, [Invited]

飼育下のオオアリクイの行動は季節によって変わるのか？　　　　　　　　　　　　　　　
中山 侑; 小針大助; 豊田 淳; 木村隆司; 奥山絵里; 中根建宣; 武田 梓
KOUDOU2017, 31 Aug. 2017

Effects of dietary intake of Lactobacillus gasseri CP2305 (CP2305) on the depressive-like behaviours in subchronic mild social defeat stress (sCSDS) model of mice
Atsushi Toyoda; Tatsuhiko Goto; Takahiro Kawase; Takamitsu Tsukahara; Shigeru Fujiwara
NeuroGASTRO2017, 26 Aug. 2017

Effects of dietary supplementation of peels of immature Citrus tumida on social behavior in subchronic mild social defeat model of mice
Mizuho Sato; Eiichi Inoue; Yuji Miyaguchi; Atsushi Toyoda
第40回日本神経科学大会, 22 Jul. 2017

Effects of diet purity on the behaviors, plasma corticosterone, and caecum microbiome in mice
Atsushi Toyoda; Hikari Shimonishi; Kento Usuda; Kentaro Nagaoka
第40回日本神経科学大会, 20 Jul. 2017

Antagonist for 5-HT2a receptor partially rescued the delayed nesting behavior in mice subjected to acute social defeat stress
Hikari Otabi; Tsuyoshi Okayama; Daisuke Kohari; Atsushi Toyoda
第40回日本神経科学大会, 20 Jul. 2017

Effects of constant light exposure on the body weight gain in C57BL/6J mice
佐藤 瑞穂; 豊田 淳
第71回日本栄養・食糧学会大会, 20 May 2017

Peels of immature Citrus tumida as dietary supplements affect plasma and liver metabolites in mice
豊田 淳; 佐藤 瑞穂; 井上 栄一
第71回日本栄養・食糧学会大会, 20 May 2017

うつ病モデルマウスを用いた 栄養・代謝研究　　　　　　　　　　　　　　　
豊田 淳
第71回日本栄養・食糧学会大会・ハインドガットサテライト, 20 May 2017, [Invited]

家畜とのふれあいを含む農作業活動が精神疾患者の心理・生理的状態に及ぼす効果
安江 健; 竹村; 紀穂; 高橋; 弘美; 柴沼; 沙織; 下西 ひかり; 水野; 高昌; 小松崎; 将一; 山川; 百合子; 小針; 大助; 岡山; 毅; 佐々木; 誠一; 豊田 淳
日本畜産学会第122回大会, 28 Mar. 2017

飼育下のオオアリクイの常同行動と個体維持行動に及ぼす影響
中山侑; 小針大助; 豊田淳; 中根建宜; 武田梓; 前外間利奈
日本家畜管理学会・応用動物行動学会２０１７年度春季合同研究発表会, 27 Mar. 2017

社会的敗北ストレスモデルを用いた増体および摂食行動に関する研究　　　　　　　　　　　　　　　
飯尾 恒; 塚原 隆充; 小川 恭喜; 長南 茂; 豊田 淳
2017年度家畜栄養生理研究会春季集談会, 26 Mar. 2017, [Invited]

5-HT2a receptor antagonist partially rescued the nesting-building deficit in acute social defeat model of mice
大給日香里; 豊田 淳
atoyoda, 16 Mar. 2017

うつ病モデル動物のメタボローム研究
豊田 淳
第一回茨城大学重点研究シンポジウム つながる微生物の不思議：農と医も？, 09 Mar. 2017

社会的敗北モデルマウスのメタボローム解析
豊田 淳; 後藤達彦; 友永省三
国際タウリン研究会inいばらき, 12 Feb. 2017

タウリン欠乏モデルネコの作製
宮崎照雄; 佐々木誠一; 豊田淳; 白井睦; 池上正; 松崎靖司; 本多彰
第三回国際タウリン研究会日本部会inいばらき, 11 Feb. 2017

うつ病予防機能を持つ食品探索プラットフォーム
豊田 淳
第16回 産総研・産技連LS-BT合同研究発表会, 31 Jan. 2017

うつ病モデルマウスを用いた栄養・代謝研究
豊田 淳
第22回Hindgut Club Japanシンポジウム, 03 Dec. 2016, [Invited]

フクレミカンの未熟果皮粉末が慢性社会的敗北モデルマウスのストレス脆弱性におよぼす影響
佐藤 瑞穂; 豊田 淳
第22回Hindgut Club Japanシンポジウム, 03 Dec. 2016

動物の健康モニタリングを目的とした超小型低消費電力ワイヤレスセンサノードの開発
芹澤 弘一; 魯 健; 前田 龍太郎; 佐藤 瑞穂; 豊田 淳; 早瀬 仁則; 新井 恵美
第22回Hindgut Club Japanシンポジウム, 03 Dec. 2016

Behavioral and metabolic characterization in subchronic social defeat model of mice
A. TOYODA; T. GOTO; H. OTABI; S. TOMONAGA; D. KOHARI; T. OKAYAMA
Neuroscience 2016, 16 Nov. 2016, Society for neuroscience

社会的敗北モデルマウスの栄養・代謝研究
豊田 淳
2016年度行動遺伝学研究会, 13 Oct. 2016

Effect of farming activity included horticulture and interacting with domestic animals on person with mental disorders
Takeshi Yasue; Nozomi Sakamoto; Masakazu Komatsuzaki; Hikari Shimonishi; Yuriko Yamakawa; Daisuke Kohari; Tsuyoshi Okayama; Seiichi Sasaki; Atsushi Toyoda
The 17th Asian-Australasian Association of Animal Production Societies Animal Science Congress, 25 Aug. 2016

Effects of diet quality and psychosocial stress on the metabolic profiles in mice
Atsushi Toyoda; Tatsuhiko Goto; Shozo Tomonaga
第39回日本神経科学大会, 15 Jul. 2016

Behavioural and metabolome characterization in socially defeated mice for understanding psychiatric disorders
Atsushi Toyoda; Tatsuhiko Goto; Hikari Otabi; Shozo Tomonaga; Daisuke Kohari; Tsuyoshi Okayama
ISAE2016, 13 Jul. 2016

こころの健康と食の関係　　　　　　　　　　　　　　　
豊田 淳
茨城大学公開講座「オトナのための食育講座」, 01 Jul. 2016

飼料組成および社会心理ストレスがマウスの血漿、肝臓および盲腸代謝産物におよぼす影響
後藤 達彦; 友永 省三; 豊田 淳
日本畜産学会第121回大会, 29 Mar. 2016

ウシの飼育管理作業が健常者の心理・生理的状態に及ぼす効
安江 健; 平山 望; 武田 愛生; 小針 大助; 岡山 毅; 小松崎 将一; 山川 百合子; 佐々木 誠一; 豊田 淳
日本畜産学会第121回大会, 29 Mar. 2016

こころと栄養―うつ病モデルマウスが教えてくれること―　　　　　　　　　　　　　　　
豊田 淳
第4回 かみね・おもしろZOOサロン, 20 Feb. 2016

慢性社会的敗北ストレスがマウス大腸のタイト結合構成蛋白質の遺伝子発現に与える効果
山岸 直子; 青木-吉田 綾子; 守谷 直子; 後藤 達彦; 豊田 淳; 青木 玲二; 鈴木 チセ; 高山 喜晴
第38回日本分子生物学会年会（BMB2015), 02 Dec. 2015

社会的敗北ストレスモデルマウスにおける巣作り行動障害のメカニズム
大給 日香里; 後藤 達彦; 岡山 毅; 小針 大助; 豊田 淳
第38回日本分子生物学会年会（BMB2015), 01 Dec. 2015

社会的敗北モデルマウスを用いた栄養・代謝研究
豊田 淳
第18回日本補完代替医療学会学術集会, 28 Nov. 2015, [Invited]

社会心理的ストレスモデルマウスの腸内細菌叢プロファイル
山岸直子; 守谷直子; 青木綾子; 後藤達彦; 豊田淳; 青木玲二; 鈴木チセ; 高山喜晴
臨床ストレス応答学会, 07 Nov. 2015

Development of the objective method for evaluating nest building behaviors in mice using a 3-D depth camera
A. TOYODA; T. GOTO; T. OKAYAMA
Society for Neuroscience 2015, 18 Oct. 2015

Effects of diet quality on stress-vulnerability and metabolomic profiles in chronic mild social defeat stress model of mice
T. GOTO; S. TOMONAGA; Y. KUBOTA; A. TOYODA
Society for Neuroscience 2015, 18 Oct. 2015

Auto-detecting cattle behaviour using IR depth-sensor camera
D.Kohari; T.Okayama; H.Sato; K.Matsuo; T.Kosako; T.Goto; A.Toyoda
ISAE2015, 15 Sep. 2015, The Congress of the International Society for Applied Ethology (ISAE)

赤外線深度センサによるマウス巣作り行動の3D 解析
豊田淳; 後藤達彦; 大給日香里; 岡山毅
日本畜産学会第120回大会, 12 Sep. 2015

社会的敗北ストレスモデルマウスの新たな行動評価法の開発巣作り行動の遅延について
大給日香里; 後藤達彦; 岡山毅; 小針大助; 豊田淳
日本畜産学会第120回大会, 11 Sep. 2015

社会心理ストレスに暴露されたマウスの肝臓および血漿代謝産物の変化
後藤達彦; 久保田祥史; 豊田淳
日本畜産学会第120回大会, 11 Sep. 2015

3-D analysis systems for nest building behaviors in mice using a depth sensor
Atsushi Toyoda; Tatsuhiko Goto; Tsuyoshi Okayama
第38回日本神経科学会大会, 29 Jul. 2015

Metabolomic analyses of plasma and liver in chronic mild social defeat stress model of mice
Tatsuhiko Goto; Yoshifumi Kubota; Atsushi Toyoda
第38回日本神経科学大会, 29 Jul. 2015

精製および非精製飼料がマウスの社会心理ストレスに対する脆弱性におよぼす影響　　　　　　　　　　　　　　　
後藤 達彦; 久保田 祥史; 豊田 淳
第119回日本畜産学会大会, 29 Mar. 2015

慢性的な社会的敗北ストレスはC57BL/6Jマウスの消化管機能に影響をおよぼす　　　　　　　　　　　　　　　
守谷直子; 山岸直子; 木元広実; 大森英之; 青木綾子; 後藤達彦; 豊田淳; 鈴木チセ
第119回日本畜産学会大会, 29 Mar. 2015

赤外線深度センサを活用したマウス巣作り行動の解析　　　　　　　　　　　　　　　
豊田淳; 後藤達彦; 岡山毅
第119回日本畜産学会大会, 29 Mar. 2015

ウシの飼育管理作業がヒトの精神的・生理的状態に及ぼす影響　　　　　　　　　　　　　　　
安江 健; 武田 愛生; 小針 大助; 岡山 毅; 小松崎 将一; 豊田 淳
第119回日本畜産学会大会, 29 Mar. 2015

社会的敗北ストレス負荷がマウスの胆汁酸産生に及ぼす影響　　　　　　　　　　　　　　　
麻生 愛花; 一法師 克成; 山岸 直子; 守谷 直子; 青木(吉田) 綾子; 後藤 達彦; 豊田 淳; 山本(前田) 万里; 鈴木 チセ
日本農芸化学会 2015 年度大会, 26 Mar. 2015

茨城大学農医連携プロジェクトでの取組について　　　　　　　　　　　　　　　
豊田 淳
食と健康・新たな機能性表示制度に関する講演会, 19 Feb. 2015, いばらき成長産業振興協議会食品研究会, [Invited]

社会心理的ストレス暴露によるマウスの行動および血液性状への影響
後藤達彦; 久保田祥文; 豊田 淳
第20回Hindgut Club Japanシンポジウム, 06 Dec. 2014

20日間の慢性社会的敗北ストレス暴露がマウスの行動および体水分率におよぼす影響
大給 日香里; 後藤 達彦; 守谷 直子; 豊田 淳
第37回日本分子生物学会年会, 26 Nov. 2014

Monitoring Nest Building in Mice and Leaf Movement of Kidney Beans using an Infrared Range Camera　　　　　　　　　　　　　　　
Tsuyoshi Okayama; Tatsuhiko Goto; Takeshi Suzuki; Atsushi Toyoda
International Conference on Agro-industry, 24 Nov. 2014, [Invited]

Effects of chronic mild social defeat stress on characteristics of behaviors and serum components in mice
T. GOTO; Y. KUBOTA; Y. TANAKA; W. IIO; A. TOYODA
Neuroscience 2014, 19 Nov. 2014, Society for neuroscience

Three-dimensional (3-D) behavior analysis for mice using the commercial depth sensor
A. TOYODA; T. GOTO; T. OKAYAMA
Neuroscience 2014, 15 Nov. 2014, Society for neuroscience

ラクトフェリンの慢性的投与が社会的敗北ストレスモデルマウスの行動におよぼす影響
後藤 達彦; 久保田祥史; 豊田淳
日本ラクトフェリン学会第6回学術集会, 08 Nov. 2014

3D センサを用いたマウスの巣作り行動の解析 －遺伝的な影響の検討－
後藤達彦; 岡山毅; 豊田淳
日本動物遺伝育種学会第 15 回大会, 01 Nov. 2014

赤外線深度センサを利用した動物、植物の動きの解析
豊田 淳; 後藤 達彦; 荒川 俊也; 小針 大助; 鈴木 丈詞; 岡山 毅
第87回日本生化学会大会, 18 Oct. 2014, 日本生化学会, [Invited]

慢性社会的敗北ストレス負荷がC57BL/6Jマウスの腸管における 遺伝子発現、腸内細菌叢および腸内代謝産物に及ぼす影響　　　　　　　　　　　　　　　
青木(吉田) 綾子; 青木 玲二; 髙山 喜晴; 守谷 直子; 後藤 達彦; 豊田 淳; 鈴木 チセ
第10回日本食品免疫学会学術大会, 16 Oct. 2014

3次元深度センサを用いたマウス行動解析システムの開発
豊田淳; 後藤達彦; 岡山毅
第37回日本神経科学学会, 13 Sep. 2014

慢性的な軽度の社会的敗北ストレスがマウスの行動特性におよぼす影響
後藤 達彦; 久保田 祥史; 田中 勇気; 飯尾 恒; 豊田 淳
第37回日本神経科学学会, 12 Sep. 2014

ストレスは脳、行動、遺伝子、栄養に何をもたらすか？
豊田 淳
日本科学飼料協会 第431月例研究会, 30 Jul. 2014, [Invited]

動物のこころと遺伝子
豊田 淳
茨城大学農学部オープンキャンパス模擬授業, 19 Jul. 2014

心身の健康を維持・改善する農医連携研究の推進　　　　　　　　　　　　　　　
豊田 淳
茨城大学農学部後援会, 12 Jul. 2014

腸管オルガノイド及び社会的ストレス負荷マウスを用いた精神的ストレス評価系の構築
青木(吉田)綾子; 濱田晃弘; 後藤達彦; 青木玲二; 高山喜晴; 守谷直子; 豊田淳; 鈴木チセ; 園山慶
第６８回日本栄養・食糧学会シンポジウム, 31 May 2014

Effects of chronic taurine administration on the gene and protein expression and the phosphorylation in rat hippocampus
Atsushi Toyoda; Hiroaki Koike; Kouichiro Nishihata; Wataru Iio; Tatsuhiko Goto
XIX international Taurine meeting, 23 May 2014

赤外線深度センサを用いた動物行動解析システムの開発
豊田 淳; 後藤 達彦; 岡山 毅
第118回日本畜産学会, 28 Mar. 2014, 畜産草地研究所

胎生期および乳子期のラットへのタウリン強化が成長や行動、中枢神経系遺伝子発現におよぼす影響
小池 広明; 飯尾 恒; 豊田 淳
第118回日本畜産学会, 27 Mar. 2014, 畜産草地研究所

慢性社会的敗北ストレスがマウスの行動および血液生化学性状におよぼす影響
後藤 達彦; 久保田 祥史; 吉田 綾子; 青木 玲二; 高山 喜晴; 守谷 直子; 鈴木 チセ; 豊田 淳
第118回日本畜産学会, 27 Mar. 2014, 畜産草地研究所

慢性社会的敗北ストレスがマウスの増体、摂食量、および肝臓 CoAレベルにおよぼす影響
久保田 祥史; 後藤 達彦; 萩谷 友稀; 長南 茂; 豊田 淳
第118回日本畜産学会, 27 Mar. 2014, 畜産草地研究所

C57BL/6J マウスの慢性社会的敗北ストレス負荷による腸内細菌叢の変動
吉田 綾子; 後藤 達彦; 青木 玲二; 高山 喜晴; 守谷 直子; 豊田 淳; 鈴木 チセ
第118回日本畜産学会, 27 Mar. 2014, 畜産草地研究所

Introduction of Ibaraki University Cooperation between Agriculture and Medicine (IUCAM)　　　　　　　　　　　　　　　
ATSUSHI TOYODA
Ibaraki University-Kasetsart University Symposium on "Integrative Molecular Biosciences", 13 Dec. 2013, [Invited]

社会心理的ストレス暴露によるマウス消化管への影響
後藤達彦; 久保田祥史; 鈴木健太; 塚原隆充; 豊田 淳
Hindgut Club Japanシンポジウム, 07 Dec. 2013

赤外線深度センサを用いたマウス行動解析システムの開発　　　　　　　　　　　　　　　
後藤 達彦; 岡山 毅; 豊田 淳
日本分子生物学会, 04 Dec. 2013

Effects of chronic taurine administration on the protein expression and phosphorylation in rat hippocampus
A. TOYODA; W. IIO; H. KOIKE
Society for neuroscience, 13 Nov. 2013

Body surface temperature measurement in the mouse using an infrared thermometer installed on the ceiling of a shelter
T. OKAYAMA; T. GOTO; H. KOIKE; W. IIO; A. TOYODA
Society for neuroscience, 10 Nov. 2013

妊娠期のタウリン給与が産仔に与える影響の解明
小池 広明; 飯尾 恒; 豊田 裕子; 豊田 淳
日本畜産学会 第116回大会, 28 Mar. 2013

タウリンの長期給与がラットの行動と海馬のシグナル伝達におよぼす影響
豊田 淳; 飯尾 恒
関東畜産学会, 10 Nov. 2012

慢性的社会性ストレスモデル動物における摂食量および体重の変化
田中勇気; 飯尾 恒; 豊田 淳
関東畜産学会, 10 Nov. 2012

慢性的社会性ストレスによる摂食不振は視床下部マロニル-CoA濃度の 上昇によっておこる
飯尾 恒; 小池広明; 徳竹由華; 松川典子; 塚原隆充; 長南 茂; 豊田 淳
関東畜産学会, 10 Nov. 2012

Anorexia and hypothalamic malonyl- CoA signaling pathway in chronic social defeated rats
Wataru Iio; Yuka Tokutake; Noriko Matsukawa; Takamitsu Tsukahara; Shigeru Chohnan; Atsushi Toyoda
Neuroscience 2012, 17 Oct. 2012

Chronic taurine administration and its antidepressant-like action in rats
ATSUSHI TOYODA; Wataru Iio; Noriko Matsukawa; Takamitsu Tsukahara
Neuroscience 2012, 16 Oct. 2012

高脂肪食がラット組織内CoAプー ルに及ぼす影響　　　　　　　　　　　　　　　
徳竹 由華; 飯尾 恒; 豊田 淳; 長南 茂
第33回肥満学会, 11 Oct. 2012

動物のこころと遺伝子　　　　　　　　　　　　　　　
豊田 淳
茨城大学農学部サテライト公開授業（柏）, 06 Oct. 2012

Anorexic behavior and elevation of hypothalamic malonyl-CoA in socially defeated rats
Wataru Iio; Yuka Tokutake; Noriko Matsukawa; Takamitsu Tsukahara; Shigeru Chohnan; Atsushi Toyoda
第35回日本神経科学大会, 18 Sep. 2012

実験小動物用飼育環境の計測制御装置の試作　　　　　　　　　　　　　　　
岡山 毅; 田中勇気; 飯尾 恒; 豊田 淳
日本生物環境工学会, Sep. 2012

実験小動物用飼育環境計測制御装置の開発　　　　　　　　　　　　　　　
田中 勇気; 飯尾; 恒; 豊田; 淳; 岡山 毅
日本農業環境工学関連学会2012年合同大会, Sep. 2012

Modification of the Acyl-CoA Cycling Method for Analysis of CoA Pools　　　　　　　　　　　　　　　
Y. TOKUTAKE; A. SAIJO; W. IIO; Y. OGATA; A. TOYODA; S. CHOHNAN
American Society for Microbiology, 112th General Meeting, 19 Jun. 2012

Behavioral and biochemical studies of antidepressant-like effects of taurine
ATSUSHI TOYODA; WATARU IIO
18th International Taurine Meeting, Apr. 2012

社会的慢性ストレスがラット白色脂肪および脾臓の TNF-α、IL-6、レプチンの遺伝子発現に及ぼす影響　　　　　　　　　　　　　　　
高木 良治; 飯尾 恒; 瀬尾 優太; 松川 典子; 塚原 隆充; 豊田 淳; 宮口 右二; 小川 恭喜
日本畜産学会第115回大会, Mar. 2012

社会的慢性ストレスモデルにおける増体抑制メカニズムの解明　　　　　　　　　　　　　　　
飯尾 恒; 徳竹; 由華; 松川 典子; 塚原 隆充; 長南 茂; 豊田 淳
日本畜産学会第115回大会, Mar. 2012

タウリンの長期間投与がWistarラットの行動および海馬のシグナル伝達に及ぼす影響　　　　　　　　　　　　　　　
飯尾 恒; 松川 典子; 塚原 隆充; 豊田 淳
第17回Hindgut Club Japan, Dec. 2011

タウリンの長期給与が海馬におけるグルタミン酸脱炭酸酵素GAD65およびGAD67の発現に及ぼす影響　　　　　　　　　　　　　　　
飯尾 恒; 松川 典子; 塚原 隆充; 豊田 淳
第34回日本分子生物学会年, Dec. 2011

食餌の質がラット組織内CoAプールに及ぼす影響　　　　　　　　　　　　　　　
徳竹 由華; 鬼澤 直樹; 飯尾 恒; 豊田 淳; 長南 茂
第32回日本肥満学会, Sep. 2011

Wistarラットにおける慢性的タウリン投与の行動学的および生化学的評価　　　　　　　　　　　　　　　
飯尾 恒; 豊田 淳
日本神経科学会, Sep. 2011

未熟フクレミカン皮の給与がマウスのうつ様および不安様行動に与える影響　　　　　　　　　　　　　　　
武本 智嗣; 高野 幸恵; 真泉 蘇代子; 豊田 淳
日本栄養食糧学会, May 2011

ラットへの2週間のタウリン給与がうつ様行動に与える影響　　　　　　　　　　　　　　　
飯尾 恒; 豊田 淳
日本栄養食糧学会, May 2011

慢性的社会性ストレスと急性ストレスラットでの小腸消化吸収能の違い　　　　　　　　　　　　　　　
松川 典子; 飯尾 恒; 豊田 淳; 中山 啓三; 原 博; 塚原 隆充
日本栄養食糧学会, May 2011

飼料中リジン濃度の低減によるブタ筋肉内脂肪の畜積促進機構の解明　　　　　　　　　　　　　　　
京谷隆侍; 石田藍子; 中島一喜; 中島郁世; 豊田淳; 中村豊; 勝俣昌也
家畜栄養生理研究会, May 2011

社会的ストレス誘導型うつ病モデルラットにおける増体抑制機序の解明　　　　　　　　　　　　　　　
松川 典子; 飯尾 恒; 豊田 淳; 中山 啓三; 原 博; 塚原 隆充
日本農芸化学会, Mar. 2011

4週間のタウリン給与における抗うつ効果の行動学的評価　　　　　　　　　　　　　　　
飯尾 恒; 豊田 淳
日本農芸化学会, Mar. 2011

絶食および飽食ラットにおける組織内CoAプールの動態解析　　　　　　　　　　　　　　　
徳竹 由華; 鬼澤 直樹; 村田 恵; 渡辺 央好; 角田 梨奈; 豊田 淳; 長南 茂
日本農芸化学会, Mar. 2011

社会的ストレスによるうつ病モデルラットの増体抑制はなぜ起こるのか？　　　　　　　　　　　　　　　
松川典子; 飯尾恒; 豊田淳; 原博; 塚原隆充
第16回Hindgut Club Japanシンポジウム, Dec. 2010

飼料としてのスイートソルガム残さの品質に及ぼす蒸煮・爆砕処理の影響　　　　　　　　　　　　　　　
石井照章; 中村豊; 宮口右二; 豊田淳; 本間貴史; 長谷川守文; 新田洋司; 久留主泰朗
関東畜産学会, Nov. 2010

成長および低リジン飼料給与に伴う豚筋肉内脂肪細胞の数と大きさの変化　　　　　　　　　　　　　　　
京谷隆侍; 石田藍子; 中島一喜; 豊田淳; 中村豊; 勝俣昌也
日本畜産学会第112回大会, Mar. 2010

クレアチンの経口給与が脳内CoA分子種に及ぼす影響　　　　　　　　　　　　　　　
鬼澤直樹; 徳竹由華; 長南茂; 中村豊; 豊田淳
日本畜産学会第112回大会, Mar. 2010

アシル‐CoAサイクリング法によるラット組織内CoAプールの解析　　　　　　　　　　　　　　　
徳竹由華; 鬼澤直樹; 豊田淳; 長南茂
日本農芸化学会, Mar. 2010

機能性食品の評価により適した、社会的ストレス誘導によるうつ病モデルラットの確立　　　　　　　　　　　　　　　
松川典子; 飯尾恒; 岸野恵理子; 藤田孝輝; 中山啓三; 塚原隆充; 豊田淳
第15回Hindgut Club Japanシンポジウム, Dec. 2009

酢酸カルシウム給与は鶏ヒナ社会的隔離ストレスによる血漿中コルチコステロン濃度の上昇を抑制する　　　　　　　　　　　　　　　
菅原諭; 豊田淳; 滝川裕美; 畠山雅彦
日本畜産学会第111回大会, Sep. 2009

同系統ラットを用いた社会的慢性ストレスモデルの確立および生化学的評価　　　　　　　　　　　　　　　
飯尾恒; 鬼澤直樹; 和知弘朗; 豊田淳
日本畜産学会第111回大会, Sep. 2009

反芻動物のルーメン内容物に含まれるセルロース結合タンパク質に対する抗体ライブラリーの作製　　　　　　　　　　　　　　　
豊田淳; 飯尾恒; 湊 一
日本畜産学会, Mar. 2009

クレアチンが摂食リズムに及ぼす影響　　　　　　　　　　　　　　　
鬼澤直樹; 藤森水絵; 中村豊; 豊田淳
日本畜産学会第110回大会, Mar. 2009

納豆添加飼料給与とニワトリ脾臓中の炎症性サイトカイン遺伝子の発現　　　　　　　　　　　　　　　
杉田歩; 西野景知; 五島恵; 藤田真弓; 豊田淳; 宮口右二; 小川恭喜; 藤原謙一郎; 山崎信; 大津晴彦; 矢ヶ部陽子; 阿部啓之
日本畜産学会第110回大会, Mar. 2009

低リジン飼料を豚に給与したときの筋肉内脂肪の蓄積は筋肉の種類によって異なる　　　　　　　　　　　　　　　
京谷隆侍; 石田藍子; 中島一喜; 豊田淳; 中村豊; 勝俣昌也
日本畜産学会第110回大会, Mar. 2009

反芻動物のルーメン内容物に含まれるセルロース結合タンパク質に対する抗体ライブラリーの作製　　　　　　　　　　　　　　　
豊田淳; 飯尾恒; 湊 一
第81回日本生化学会、第31回日本分子生物学会合同大会, Dec. 2008

Sweet sorghum cultivation as a bio-fuel crop in the suburbs of Tokyo Metropolitan area.　　　　　　　　　　　　　　　
Akinori Kamiyama; Youji Nitta; Toshiaki Matsuda; Satoshi Nakamura; Yusuke Goto; Eiichi Inoue; Kazuhiko Narisawa; Yasuro Kurusu; Hiroyuki Ohta; Shigeru Chonan; Atsushi Toyoda; Tasuku Kato; Hisashi Kobayashi; Masakazu Komatsuzaki; Tatsuo Sato
5th International Crop Science Congress & Exhibition, Apr. 2008

反芻動物のルーメン内容物に含まれるセルロース結合タンパク質の分離と同定　　　　　　　　　　　　　　　
豊田淳; 飯尾恒; 湊 一
日本畜産学会, Mar. 2008

Sweet sorghum cultivation as a bio-fuel crop in Ibaraki prefecture.　　　　　　　　　　　　　　　
Nitta Y; Kamiyama A; Matsuda T; Nakamura S; Goto S; Inoue E; Narisawa K; Kurusu Y; Ohta H; Chonan S; Toyoda A; Kato T; Kobayashi H; Komatsuzaki M; Sato T
日本作物学会, Mar. 2008

クレアチンの脳室投与がラットの摂食行動に及ぼす影響　　　　　　　　　　　　　　　
鬼澤直樹; 中村豊; 豊田淳
日本畜産学会第109回大会, Mar. 2008

同系統ラットを用いた社会的慢性ストレスモデルの確立　　　　　　　　　　　　　　　
飯尾恒; 豊田淳
日本畜産学会第109回大会, Mar. 2008

反芻動物のルーメン内容物に含まれるセルロース結合性タンパク質の分離と同定　　　　　　　　　　　　　　　
豊田淳; 飯尾恒; 湊 一
日本分子生物学会, Dec. 2007

ミトコンドリア外膜タンパク質Voltage-dependent anion channel (VDAC)と微小管結合タンパク質Microtubule-associated protein 2 (MAP2)の結合様式　　　　　　　　　　　　　　　
西村結; 中條潤; 豊田淳
第30回日本分子生物学会、第80回日本生化学会大会, Dec. 2007

乳酸発酵残さの給与が産卵鶏のヒナの飼養成績および盲腸内環境に及ぼす影響　　　　　　　　　　　　　　　
藤原 謙一; 加藤 由紀乃; 御幡 寿; 礒 政男; 宮口 右二; 豊田 淳; 小川 恭喜; 中村 豊; 山崎 信; 矢ヶ部 陽子; 中島 一喜; 阿部 啓之; 稲葉 陸太; 山田 正人; 井 上 雄三
日本畜産学会第108回大会, Sep. 2007

納豆給与が筑波地鶏の肉質に及ぼす影響　　　　　　　　　　　　　　　
宮口 右二; 馮 暁寒; 西野 景知; 藤田 真弓; 豊田 淳; 小川 恭喜; 中村 豊; 藤原 謙一郎; 加藤 由紀乃; 御幡 寿; 礒 政男; 山崎 信; 中島 一喜; 阿部 啓之; 金子 謙 一郎
日本畜産学会第108回大会, Sep. 2007

ルーメン内セルロース分解菌Eubacterium cellulosolvens 5のセルラーゼCel9Dの遺伝子解析　　　　　　　　　　　　　　　
矢野由梨; 吉松美帆; 豊田淳
日本畜産学会第108回大会, Sep. 2007

Biochemical characterization of cellulose-binding proteins (CBPA and CBPB) from the rumen cellulolytic bacterium Eubacterium cellulosolvens 5.　　　　　　　　　　　　　　　
Miho Yoshimatsu; Atsushi Toyoda; Yutaka Nakamura; Hajime Minato
The 6th Joint Symposium of Japan-Korea-China on Rumen Metabolism and Physiology – Improvement of rumen function for efficient animal production, Jul. 2007

Creatine経口投与がラットの学習行動に及ぼす影響　　　　　　　　　　　　　　　
佐藤朱里; 鬼澤直樹; 豊田淳
日本栄養食糧学会第61回大会, May 2007

Creatineの経口投与がラットの自発行動、摂食行動に与える影響　　　　　　　　　　　　　　　
鬼澤直樹; 佐藤朱里; 豊田淳
日本栄養食糧学会第61回大会, May 2007

乾燥納豆給与が産卵鶏および肉用鶏の脾臓のサイトカイン遺伝子発現へ及ぼす影響　　　　　　　　　　　　　　　
阿部啓之; 矢ヶ部陽子; 山崎信; 中島一喜; 藤原謙一郎; 加藤由紀乃; 御幡寿; 礒政男; 宮口右二; 豊田淳; 小川恭喜; 中村豊; 金子謙一郎
日本畜産学会第107大会, Mar. 2007

納豆の給与が産卵鶏の飼養成績、卵質および盲腸内環境に及ぼす影響　　　　　　　　　　　　　　　
藤原謙一郎; 加藤由紀乃; 御幡寿; 礒政男; 山崎信; 中島一喜; 矢ヶ部陽子; 阿部啓之; 豊田淳; 宮口右二; 小川恭喜; 中村豊; 金子謙一郎
日本畜産学会第107大会, Mar. 2007

ニワトリ肝臓中のコレステロール関連遺伝子の発現に及ぼす乾燥納豆給与の影響　　　　　　　　　　　　　　　
藤田真弓; 宮口右二; 豊田淳; 小川恭喜; 中村豊; 藤原謙一郎; 加藤由紀乃; 御幡寿; 礒政男; 山崎信; 中島一喜; 矢ヶ部陽子; 阿部啓之; 金子謙一郎
日本畜産学会第107大会, Mar. 2007

ルーメン内繊維分解細菌Eubacterium cellulosolvens 5のセルロース結合性タンパク質CBPAおよびCBPBの性状比較　　　　　　　　　　　　　　　
吉松美帆; 鬼澤直樹; 豊田淳
日本畜産学会第107大会, Mar. 2007

クレアチンの経口投与がラットの自発行動、摂食行動に及ぼす影響　　　　　　　　　　　　　　　
鬼澤直樹; 豊田淳
日本畜産学会第107大会, Mar. 2007

Effect of high temperature on a pig growth performance and its future prediction　　　　　　　　　　　　　　　
Atsuko Izutsu; Ryozo Takada; Makoto Otsuka; Masaya Katsumata; Atsushi Toyoda; Yutaka Nakamura
International student workshop in Ami consideration to food, life and environment in Asia, Proposals for issues from the new generation in Asia, Oct. 2006

The cellulose-binding proteins in rumen cellulolytic bacterium Eubacterium cellulosolvens 5　　　　　　　　　　　　　　　
ATSUSHI TOYODA
XIIth AAAP Animal Science Congress 2006 Busan, Jun. 2006, [Invited]

ルーメン内繊維分解細菌Eubacterium cellulosolvens 5セルロース結合性タンパク質CBPBの性状解析　　　　　　　　　　　　　　　
吉松美帆; 鬼澤直樹; 豊田淳
日本畜産学会第106大会, Mar. 2006

Eubacterium cellulosolvens 5のセルロース結合性タンパク質Aのモジュール構造が酵素活性に及ぼす影響　　　　　　　　　　　　　　　
鬼澤直樹; 吉松美帆; 豊田淳
日本畜産学会第106大会, Mar. 2006

カンショ皮の給与が肉用鶏の品質及ぼす影響　　　　　　　　　　　　　　　
宮口右二; 永山理恵; 馬 暁寒; 豊田淳; 中村豊; 藤原謙一郎; 加藤由紀乃; 御幡 寿; 礒 政男; 山崎 信; 中島一喜; 阿部啓之
日本畜産学会第106大会, Mar. 2006

カンショ皮の給与が筑波地鶏の血漿脂質成分および抗酸化能に及ぼす影響　　　　　　　　　　　　　　　
山崎 信; 阿部啓之; 中島一喜; 矢ヶ部陽子; 藤原謙一郎; 加藤由紀乃; 御幡 寿; 礒 政男; 豊田淳; 宮口右二; 中村豊; 金子謙一郎; 鬼澤文夫; 鬼澤宏幸
日本畜産学会第106大会, Mar. 2006

カンショ皮および納豆残さの給与が筑波地鶏の飼養成績および盲腸内環境に及ぼす影響　　　　　　　　　　　　　　　
藤原謙一郎; 加藤由紀乃; 御幡 寿; 礒 政男; 山崎 信; 阿部啓之; 中島一喜; 永山理恵; 豊田淳; 宮口右二; 中村豊; 金子謙一郎; 鬼澤文夫; 鬼澤宏幸
日本畜産学会第106大会, Mar. 2006

Lysobacter sp. IB-9374由来endoglucanase(Cel8A)遺伝子のクローニング　　　　　　　　　　　　　　　
小倉治朗; 鐘 愛玲; 豊田 淳; 長南 茂; 正木武治
日本農芸化学会, Mar. 2006

ミトコンドリア外膜タンパク質Voltage-dependent anion channel (VDAC)結合タンパク質の探索　　　　　　　　　　　　　　　
中條潤; 向山佳宏; 鬼澤直樹; 豊田淳
第28回日本分子生物学会, Dec. 2005

Ruminal cellulose degradation: a molecular and biochemical approach　　　　　　　　　　　　　　　
ATSUSHI TOYODA
Food and environmental preservation in Asian agriculture, International symposium on academic exchange cooperation Udayana University and Ibaraki University, Nov. 2005

採卵鶏への納豆残さの給与が卵質に及ぼす影響　　　　　　　　　　　　　　　
豊田 淳; 宮口右二; 永山理恵; 中村 豊; 藤原謙一郎; 加藤由紀乃; 大林康信; 生井和夫; 山崎 信; 阿部啓之; 中島一喜; 金子謙一郎
日本畜産学会, Sep. 2005

納豆残さの給与が肉用鶏の品質に及ぼす影響　　　　　　　　　　　　　　　
宮口右二; 豊田 淳; 永山理恵; 中村 豊; 藤原謙一郎; 加藤由紀乃; 大林康信; 生井和夫; 山崎 信; 阿部啓之; 中島一喜; 金子謙一郎
日本畜産学会第105回大会, Sep. 2005

納豆残さの給与が採卵鶏および筑波地鶏の血漿脂質成分および抗酸化能に及ぼす影響　　　　　　　　　　　　　　　
山崎 信; 阿部啓之; 中島一喜; 藤原謙一郎; 大林康信; 加藤由紀乃; 生井和夫; 豊田 淳; 宮口右二; 中村 豊; 金子謙一郎
日本畜産学会第105回大会, Sep. 2005

納豆残さの給与が採卵鶏および筑波地鶏の飼養成績および盲腸内環境に及ぼす影響　　　　　　　　　　　　　　　
藤原謙一郎; 加藤由紀乃; 大林康信; 生井和夫; 礒 政男; 山崎 信; 阿部啓之; 中島一喜; 石田藍子; 大塚 誠; 豊田 淳; 宮口右二; 中村 豊; 金子謙一
日本畜産学会第105回大会, Sep. 2005

Utitlization of plant materials in grass carp, Ctenopharyngodon idella　　　　　　　　　　　　　　　
Masayuki Asada; Atsushi Toyoda; Makoto Ohtsuka; Ryozo Takada; Yutaka Nakamura
The 5th Joint Symposium of Japan-Korea-China on Rumen Metabolism and Physiology – Improvement of rumen function for efficient animal production, Jul. 2005

Cloning of a gene encoding endoglucanase (Cel5A) with novel carbohydrate-binding modules of Eubacterium cellulosolvens 5, and properties of Cel5A　　　　　　　　　　　　　　　
Kazutoyo Yoda; Atsushi Toyoda; Yoshihiro Mukoyama; Yutaka Nakamura; Hajime Minato
The 5th Joint Symposium of Japan-Korea-China on Rumen Metabolism and Physiology – Improvement of rumen function for efficient animal production, Jun. 2005

PCR detection of bovine mitochondrial DNA derived from meat and bone meal in feed　　　　　　　　　　　　　　　
Atsushi Toyoda; Mitsuru Nakajyo; Hiroyuki Kawachi; Tohru Matsui; Hideo Yano
日本分子生物学会, Dec. 2004

Technological Development for Detection of Animal Materials in Feed in Japan　　　　　　　　　　　　　　　
T. Kawashima; O. Enishi; K. Tajima; M. Amari; T. Hosokawa-Kanai; K. Tuchiya; A. Toyoda; H. Kawachi; T. Matsui; H. Yano
International symposium food and feed safety in the context of prion diseases, Jun. 2004

「ルーメン内主要セルロース分解菌、Eubacterium cellulosolvens 5、のセルロースへの付着機構　　　　　　　　　　　　　　　
豊田淳
家畜栄養生理研究会春季集談会, May 2004, [Invited]

PCR detection of bovine mitochondrial DNA derived from meat and bone meal in feed　　　　　　　　　　　　　　　
Atsushi Toyoda; Mitsuru Nakajyo; Hiroyuki Kawachi; Tohru Matsui; Hideo Yano
Ibaraki - Wageningen Young Investigators’ Symposium on Gut Microbiology (IWASM), Apr. 2004

Cloning, sequencing and expression of a gene encoding endoglucanase (Cel5A) of Eubacterium cellulosolvens 5　　　　　　　　　　　　　　　
Kazutoyo Yoda; Atsushi Toyoda; Yutaka Nakamura; Hajime Minato
Ibaraki - Wageningen Young Investigators’ Symposium on Gut Microbiology (IWASM), Apr. 2004

Analysis of gene cluster for the cellulose degradation in Eubacterium cellulosolvens 5　　　　　　　　　　　　　　　
Miho Yoshimatsu; Atsushi Toyoda; Akio Ichihara; Yutaka Nakamura; Hajime Minato
Ibaraki - Wageningen Young Investigators’ Symposium on Gut Microbiology (IWASM), Apr. 2004

Bacterial diversity of grass carp (Ctenopharyngodon idella) intestine by sequence analysis of 16S rDNA libraries　　　　　　　　　　　　　　　
Masayuki Asada; Atsushi Toyoda; Kiyoshi Tajima; Makoto Ohtsuka; Yutaka Nakamura
Ibaraki - Wageningen Young Investigators’ Symposium on Gut Microbiology (IWASM), Apr. 2004

Eubacterium cellulosolvens 5のセルロース分解酵素Cel5A遺伝子クローニングおよび発現解析　　　　　　　　　　　　　　　
依田一豊; 豊田 淳; 中村 豊
日本畜産学会第103回大会, Mar. 2004

Analysis of the gene cluster for cellulose degradation in rumen cellulolytic bacterium Eubacterium cellulosolvens 5　　　　　　　　　　　　　　　
Miho Yoshimatsu; Atsushi Toyoda; Akio Ichihara; Yutaka Nakamura; Hajime Minato
第26回日本分子生物学会年会, Dec. 2003

The cell wall-anchoring module of cellulose-binding protein A from rumen cellulolytic bacterium Eubacterium cellulosolvens 5　　　　　　　　　　　　　　　
Akio Ichihara; Atsushi Toyoda; Miho Yoshimatsu; Yutaka Nakamura; Hajime Minato
第26回日本分子生物学会年会, Dec. 2003

A possible role of cellulose-binding protein A (CBPA) in adhesion of Eubacterium cellulosolvens 5 to cellulose　　　　　　　　　　　　　　　
Atsushi Toyoda; Kazunori Takano; Akio Ichihara; Miho Yoshimatsu; Hajime Minato
MIE BIOFORUM 2003 - Biotechnology of lignocellulose degradation and biomass utilization -, Oct. 2003

The cell wall-anchoring module of cellulose-binding protein A from rumen cellulolytic bacterium Eubacterium cellulosolvens 5　　　　　　　　　　　　　　　
Akio Ichihara; Atsushi Toyoda; Miho Yoshimatsu; Yutaka Nakamura; Hajime Minato
MIE BIOFORUM 2003 - Biotechnology of lignocellulose degradation and biomass utilization -, Oct. 2003

Gene cluster for the cellulose degradation in rumen cellulolytic bacterium Eubacterium cellulosolvens 5　　　　　　　　　　　　　　　
Miho Yoshimatsu; Atsushi Toyoda; Akio Ichihara; Yutaka Nakamura; Hajime Minato
MIE BIOFORUM 2003 - Biotechnology of lignocellulose degradation and biomass utilization -, Oct. 2003

高い組織選択性を有するPCR法による飼料中ウシ肉骨粉の検出　　　　　　　　　　　　　　　
豊田 淳; 中條 潤; 河内 浩行; 松井 徹; 矢野秀雄
日本畜産学会, Sep. 2003

Eubacterium cellulosolvens 5のセルロース分解系遺伝子の解析　　　　　　　　　　　　　　　
吉松 美帆; 豊田 淳; 市原 朗雄; 中村 豊; 湊 一
日本畜産学会第101回大会, Mar. 2003

反芻胃内繊維分解菌Eubacterium cellulosolvens 5のセルロース結合性タンパク質(CBPA)の菌体細胞壁への結合様式の解析　　　　　　　　　　　　　　　
市原 朗雄; 豊田 淳; 吉松 美帆; 中村 豊; 湊 一
日本畜産学会第101回大会, Mar. 2003

反芻胃内セルロース分解菌Eubacterium cellulosolvens 5の新規セルロース結合性タンパク質の同定と機能解析　　　　　　　　　　　　　　　
豊田 淳; 吉松美帆; 市原朗雄; 湊 一
日本分子生物学会, Dec. 2002

反芻胃内セルロース分解菌Eubacterium cellulosolvens 5のセルロース結合タンパク質(CBPA)の新規モジュール　　　　　　　　　　　　　　　
市原朗雄; 豊田 淳; 吉松美帆; 中村 豊; 湊 一
第25回日本分子生物学会年会, Dec. 2002

Eubacterium cellulosolvens 5のセルロース分解系遺伝子の解析　　　　　　　　　　　　　　　
吉松美帆; 豊田 淳; 市原朗雄; 中村 豊; 湊 一
ルーメン研究会, Oct. 2002

ルーメン内セルロース分解菌Eubacterium cellulosolvens 5のセルロース結合性タンパク質(CBPA)のC末端側の機能解析　　　　　　　　　　　　　　　
市原朗雄; 豊田 淳; 高野和儀; 吉松美帆; 中村 豊; 湊 一
ルーメン研究会, Oct. 2002

Eubacterium cellulosolvens 5のセルロース結合性蛋白質CBPAは菌体のセルロース付着に必要である　　　　　　　　　　　　　　　
豊田淳; 湊一
日本畜産学会, Mar. 2002

ルーメン細菌Wolinella succinogenesにおける亜硝酸還元酵素の特性について　　　　　　　　　　　　　　　
佐藤泰章; 豊田 淳; 湊 一
日本畜産学会第100回大会, Mar. 2002

セルロース分解菌Eubacterium cellulosolvens由来セルロース結合性蛋白質(CBPE1)の新規セルロース結合モジュール　　　　　　　　　　　　　　　
豊田淳; 湊一
日本畜産学会第99回, Sep. 2001

ルーメン細菌Eubacterium cellulosolvens由来のセルロース結合性蛋白質をコードする遺伝子のクローニング　　　　　　　　　　　　　　　
豊田淳; 湊一
日本畜産学会第98回, Mar. 2001

Eubacterium cellulosolvensの繊維分解機構　　　　　　　　　　　　　　　
豊田淳
ルーメン研究会, Mar. 2001, [Invited]

ルーメン細菌（Selenomonas ruminantium subsp. Lactilytica）の硝酸還元酵素の精製　　　　　　　　　　　　　　　
藤田和政; 豊田 淳; 湊 一
日本畜産学会第98回大会, Mar. 2001

ルーメン細菌Eubacterium cellulosolvens 由来のセルロース結合性タンパク質の検出　　　　　　　　　　　　　　　
豊田 淳; 湊 一
日本畜産学会第97回, Mar. 2000

豚腸管内微生物叢に及ぼすユッカ･サポニン投与の影響　　　　　　　　　　　　　　　
勝沼 優; 豊田 淳; 湊 一
日本畜産学会第97回大会, Mar. 2000

ルーメン細菌（Selenomonas ruminantium subsp. Lactilytica）の硝酸還元酵素の精製　　　　　　　　　　　　　　　
藤田和政; 豊田 淳; 湊 一
日本畜産学会第97回大会, Mar. 2000

ユッカ抽出物およびサポニンの家畜腸管内由来細菌の発育に及ぼす影響　　　　　　　　　　　　　　　
勝沼 優; 豊田 淳; 湊 一
日本畜産学会第96回大会, Mar. 1999

in vitro ルーメン内におけるメタン生成と繊維質消化性に及ぼす硝酸塩の影響　　　　　　　　　　　　　　　
井手順子; 豊田 淳; 湊 一
日本畜産学会第94回大会, Mar. 1998

通常飼育豚舎および低臭気豚舎内における豚新鮮糞便中微生物構成の比較　　　　　　　　　　　　　　　
長峰 泉; 豊田 淳; 湊 一
日本畜産学会第94回大会, Mar. 1998

温細胞は加温でカチオン透過性を上昇させ脱分極する　　　　　　　　　　　　　　　
右京久美子; 豊田 淳; 小林茂雄; その他
第17回日本神経科学大会, Nov. 1997

神経細胞接着因子NeuroliginとPSD-95/SAP90の結合　　　　　　　　　　　　　　　
入江美奈; 豊田淳; 高井義美; その他
日本生化学会, 1997

PSD-95/SAP90に結合する新しい蛋白質のクローニングとその性状解析　　　　　　　　　　　　　　　
竹内勝一; 豊田 淳; 高井義美; その他
第69回日本生化学会大会・第19回日本分子生物学会年会合同年会, 1996

PSD-95/SAP90関連遺伝子のクローニングとその性状解析　　　　　　　　　　　　　　　
入江 美奈; 豊田 淳; 高井義美; その他
第69回日本生化学会大会・第19回日本分子生物学会年会合同年会, 1996

孤束核ニューロンに対するアンギオテンシンII(AII)の作用機構　　　　　　　　　　　　　　　
豊田 淳; 小林茂雄
日本神経科学会, Nov. 1994

視床下部温受容ニューロンの温度感受性カチオンコンダクタンス　　　　　　　　　　　　　　　
堀あいこ; 豊田 淳; 小林茂雄; その他
第18回日本神経科学大会, Nov. 1994

亜鉛欠乏がラットの脳内亜鉛濃度に与える影響　　　　　　　　　　　　　　　
豊田 淳; 白木琢磨; 矢野史子; 松井徹; 矢野秀雄
微量栄養素研究会, Jul. 1993

Oct. 2020 - Present
東京農工大学大学院連合農学研究科

Oct. 2019 - Present
茨城大学

Apr. 2019 - Present
茨城大学

Apr. 2019 - Present
茨城大学

〔Major achievements〕Special lecture on regional sustainability science II　　　　　　　　　　　　　　　
Dec. 2016 - Present
Ibaraki University

茨城大学農学部

茨城大学大学院農学研究科

東京農工大学大学院連合農学研究科

新潟大学農学部

茨城大学大学院農学研究科

茨城大学大学院農学研究科

茨城大学大学院農学研究科

茨城大学農学部

茨城大学農学部

茨城大学農学部

茨城大学農学部

茨城大学農学部

茨城大学農学部

茨城大学農学部

茨城大学大学院農学研究科

つくば国際大学

茨城大学農学部

九州大学大学院生物資源環境科学府

東京大学大学院農学生命科学研究科

茨城大学農学部

茨城大学農学部

茨城大学農学部

茨城大学農学部

茨城大学農学部

麻布大学大学院

茨城大学

茨城大学

茨城大学

茨城大学

茨城大学

茨城大学

茨城大学

茨城大学

茨城大学

Jan. 2020 - Present, ヘスペリジン研究会

国際タウリン研究会

ルーメン研究会

Society for Neuroscience

JAPANESE SOCIETY OF NUTRITION AND FOOD SCIENCE

THE JAPAN NEUROSCIENCE SOCIETY

THE MOLECULAR BIOLOGY SOCIETY OF JAPAN

JAPAN SOCIETY FOR BIOSCIENCE, BIOTECHNOLOGY, AND AGROCHEMISTRY

JAPANESE SOCIETY OF ANIMAL SCIENCE

JAPANESE SOCIETY FOR ANIMAL NUTRITION AND METABOLISM