Sep. 2023, アグリテックグランプリ2023 ニップン賞, 株式会社リバネス

Aug. 2022, 第9回 日本時間栄養学会学術大会 優秀発表賞

Mar. 2020, 2020年度 日本畜産学会奨励賞, 日本畜産学会

Mar. 2020, 2019年度 生物資源環境科学府賞, 九州大学大学院

Mar. 2019, 優秀発表賞 (第125回大会), 日本畜産学会

Mar. 2019, English Presentation Award (第125回大会), 日本畜産学会

Sep. 2017, 優秀発表賞 (第123回大会), 日本畜産学会

Sep. 2017, English Presentation Award (第123回大会), 日本畜産学会

Large-scale animal model study uncovers altered brain pH and lactate levels as a transdiagnostic endophenotype of neuropsychiatric disorders involving cognitive impairment
Hideo Hagihara; Hirotaka Shoji; Satoko Hattori; Giovanni Sala; Yoshihiro Takamiya; Mika Tanaka; Masafumi Ihara; Mihiro Shibutani; Izuho Hatada; Kei Hori; Mikio Hoshino; Akito Nakao; Yasuo Mori; Shigeo Okabe; Masayuki Matsushita; Anja Urbach; Yuta Katayama; Akinobu Matsumoto; Keiichi I Nakayama; Shota Katori; Takuya Sato; Takuji Iwasato; Haruko Nakamura; Yoshio Goshima; Matthieu Raveau; Tetsuya Tatsukawa; Kazuhiro Yamakawa; Noriko Takahashi; Haruo Kasai; Johji Inazawa; Ikuo Nobuhisa; Tetsushi Kagawa; Tetsuya Taga; Mohamed Darwish; Hirofumi Nishizono; Keizo Takao; Kiran Sapkota; Kazutoshi Nakazawa; Tsuyoshi Takagi; Haruki Fujisawa; Yoshihisa Sugimura; Kyosuke Yamanishi; Lakshmi Rajagopal; Nanette Deneen Hannah; Herbert Y Meltzer; Tohru Yamamoto; Shuji Wakatsuki; Toshiyuki Araki; Katsuhiko Tabuchi; Tadahiro Numakawa; Hiroshi Kunugi; Freesia L Huang; Atsuko Hayata-Takano; Hitoshi Hashimoto; Kota Tamada; Toru Takumi; Takaoki Kasahara; Tadafumi Kato; Isabella A Graef; Gerald R Crabtree; Nozomi Asaoka; Hikari Hatakama; Shuji Kaneko; Takao Kohno; Mitsuharu Hattori; Yoshio Hoshiba; Ryuhei Miyake; Kisho Obi-Nagata; Akiko Hayashi-Takagi; Léa J Becker; Ipek Yalcin; Yoko Hagino; Hiroko Kotajima-Murakami; Yuki Moriya; Kazutaka Ikeda; Hyopil Kim; Bong-Kiun Kaang; Hikari Otabi; Yuta Yoshida; Atsushi Toyoda; Noboru H Komiyama; Seth GN Grant; Michiru Ida-Eto; Masaaki Narita; Ken-ichi Matsumoto; Emiko Okuda-Ashitaka; Iori Ohmori; Tadayuki Shimada; Kanato Yamagata; Hiroshi Ageta; Kunihiro Tsuchida; Kaoru Inokuchi; Takayuki Sassa; Akio Kihara; Motoaki Fukasawa; Nobuteru Usuda; Tayo Katano; Teruyuki Tanaka; Yoshihiro Yoshihara; Michihiro Igarashi; Takashi Hayashi; Kaori Ishikawa; Satoshi Yamamoto; Naoya Nishimura; Kazuto Nakada; Shinji Hirotsune; Kiyoshi Egawa; Kazuma Higashisaka; Yasuo Tsutsumi; Shoko Nishihara; Noriyuki Sugo; Takeshi Yagi; Naoto Ueno; Tomomi Yamamoto; Yoshihiro Kubo; Rie Ohashi; Nobuyuki Shiina; Kimiko Shimizu; Sayaka Higo-Yamamoto; Katsutaka Oishi; Hisashi Mori; Tamio Furuse; Masaru Tamura; Hisashi Shirakawa; Daiki X Sato; Yukiko U Inoue; Takayoshi Inoue; Yuriko Komine; Tetsuo Yamamori; Kenji Sakimura; Tsuyoshi Miyakawa, Increased levels of lactate, an end-product of glycolysis, have been proposed as a potential surrogate marker for metabolic changes during neuronal excitation. These changes in lactate levels can result in decreased brain pH, which has been implicated in patients with various neuropsychiatric disorders. We previously demonstrated that such alterations are commonly observed in five mouse models of schizophrenia, bipolar disorder, and autism, suggesting a shared endophenotype among these disorders rather than mere artifacts due to medications or agonal state. However, there is still limited research on this phenomenon in animal models, leaving its generality across other disease animal models uncertain. Moreover, the association between changes in brain lactate levels and specific behavioral abnormalities remains unclear. To address these gaps, the International Brain pH Project Consortium investigated brain pH and lactate levels in 109 strains/conditions of 2294 animals with genetic and other experimental manipulations relevant to neuropsychiatric disorders. Systematic analysis revealed that decreased brain pH and increased lactate levels were common features observed in multiple models of depression, epilepsy, Alzheimer’s disease, and some additional schizophrenia models. While certain autism models also exhibited decreased pH and increased lactate levels, others showed the opposite pattern, potentially reflecting subpopulations within the autism spectrum. Furthermore, utilizing large-scale behavioral test battery, a multivariate cross-validated prediction analysis demonstrated that poor working memory performance was predominantly associated with increased brain lactate levels. Importantly, this association was confirmed in an independent cohort of animal models. Collectively, these findings suggest that altered brain pH and lactate levels, which could be attributed to dysregulated excitation/inhibition balance, may serve as transdiagnostic endophenotypes of debilitating neuropsychiatric disorders characterized by cognitive impairment, irrespective of their beneficial or detrimental nature., eLife Sciences Publications, Ltd
eLife, 26 Mar. 2024, [Reviewed]

Characterization of taste sensitivities to amino acids and sugars by conditioned taste aversion learning in chickens
Yuta Yoshida; Shu Fujishiro; Ryota Kawai; Fuminori Kawabata, Lead, Elsevier BV
animal, Feb. 2024, [Reviewed]

Metabolic profiles of saliva in male mouse models of chronic sleep disorders induced by psychophysiological stress.
Katsutaka Oishi; Yuhei Yajima; Yuta Yoshida; Hideo Hagihara; Tsuyoshi Miyakawa; Sayaka Higo-Yamamoto; Atsushi Toyoda, Disordered sleep is a global social problem and an established significant risk factor for psychological and metabolic diseases. We profiled non-targeted metabolites in saliva from mouse models of chronic sleep disorder (CSD). We identified 288 and 55 metabolites using CE-FTMS and LC-TOFMS, respectively, among which concentrations of 58 (CE-FTMS) and three (LC-TOFMS) were significantly changed by CSD. Pathway analysis revealed that CSD significantly suppressed glycine, serine and threonine metabolism. Arginine and proline metabolic pathways were among those that were both upregulated and downregulated. Pathways of alanine, aspartate and glutamate metabolism, genetic information processing, and the TCA cycle tended to be downregulated, whereas histidine metabolism tended to be upregulated in mice with CSD. Pyruvate, lactate, malate, succinate and the glycemic amino acids alanine, glycine, methionine, proline, and threonine were significantly decreased, whereas 3-hydroxybutyric and 2-hydroxybutyric acids associated with ketosis were significantly increased, suggesting abnormal glucose metabolism in mice with CSD. Increases in the metabolites histamine and kynurenic acid that are associated with the central nervous system- and decreased glycine, might be associated with sleep dysregulation and impaired cognitive dysfunction in mice with CSD. Our findings suggested that profiling salivary metabolites could be a useful strategy for diagnosing CSD.
Scientific reports, 10 Jul. 2023, [Reviewed]

Impacts of Subchronic and Mild Social Defeat Stress on Plasma Putrefactive Metabolites and Cardiovascular Structure in Male Mice
Atsushi Toyoda; Kina Kawakami; Yuto Amano; Hideaki Nishizawa; Shin-ichi Nakamura; Takahiro Kawase; Yuta Yoshida; Hodaka Suzuki; Takamitsu Tsukahara, Psychosocial stress precipitates mental illnesses, such as depression, and increases the risk of other health problems, including cardiovascular diseases. In this study, we observed the effects of psychosocial stress on the histopathological features of systemic organs and tissues in a mouse psychosocial stress model, namely the subchronic and mild social defeat stress (sCSDS) model. There were several pathological findings in the tissues of both sCSDS and control mice. Mild fibrosis of the heart was observed in sCSDS mice but not in control mice. Extramedullary hematopoiesis in the spleen and hemorrhage in the lungs were observed in both the control and sCSDS mice. Focal necrosis of the liver was seen only in control mice. Furthermore, putrefactive substances in the blood plasma were analyzed because these metabolites originating from intestinal fermentation might be linked to heart fibrosis. Among them, plasma p-cresyl glucuronide and p-cresyl sulfate concentrations significantly increased owing to subchronic social defeat stress, which might influence cardiac fibrosis in sCSDS mice. In conclusion, several pathological features such as increased cardiac fibrosis and elevated plasma putrefactive substances were found in sCSDS mice. Thus, sCSDS mice are a potential model for elucidating the pathophysiology of psychosocial stress and heart failure., MDPI AG
International Journal of Molecular Sciences, 08 Jan. 2023, [Reviewed]

Identification of salivary microRNA profiles in male mouse model of chronic sleep disorder
Yuta Yoshida; Yuhei Yajima; Yuri Fujikura; Haotong Zhuang; Sayaka Higo-Yamamoto; Atsushi Toyoda; Katsutaka Oishi, Lead, Chronic sleep disorders (CSD) comprise a potential risk factor for metabolic and cardiovascular diseases, obesity and stroke. Thus, the identification of biomarkers for CSD is an important step in the early prevention of metabolic dysfunctions induced by sleep dysfunction. Diagnostic saliva samples can be easily and noninvasively collected. Thus, we aimed to identify whole microRNA (miRNA) profiles of saliva in control and psychophysiologically stressed CSD mouse models and compare them at Zeitgeber time (ZT) 0 (lights on) and ZT12 (lights off). The findings of two-way ANOVA revealed that the expression of 342 and 109 salivary miRNAs was affected by CSD and the time of day, respectively. Interactions were found in 122 miRNAs among which, we identified 197 (ZT0) and 62 (ZT12) upregulated, and 40 (ZT0) and seven (ZT12) downregulated miRNAs in CSD mice. We showed that miR-30c-5p, which is elevated in the plasma of patients with hypersomnia, was upregulated in the saliva of CSD mice collected at ZT0. The miRNAs, miR-10a-5p, miR-146b-5p, miR-150-5p, and miR-25-3p are upregulated in the serum of humans with poor sleep quality, and these were also upregulated in the saliva of CSD mice collected at ZT0. The miRNAs miR-30c, miR146b-5p, miR150, and miR-25-5p are associated with cardiovascular diseases, and we found that plasma concentrations of brain natriuretic peptides were significantly increased in CSD mice. The present findings showed that salivary miRNA profiles could serve as useful biomarkers for predicting CSD., Informa UK Limited
Stress, 02 Jan. 2023, [Reviewed]

Salivary microRNA and Metabolic Profiles in a Mouse Model of Subchronic and Mild Social Defeat Stress
Yuta Yoshida; Yuhei Yajima; Kina Kawakami; Shin-ichi Nakamura; Takamitsu Tsukahara; Katsutaka Oishi; Atsushi Toyoda, Lead, Identification of early biomarkers of stress is important for preventing mood and anxiety disorders. Saliva is an easy-to-collect and non-invasive diagnostic target. The aim of this study was to characterize the changes in salivary whole microRNAs (miRNAs) and metabolites in mice subjected to subchronic and mild social defeat stress (sCSDS). In this study, we identified seven upregulated and one downregulated miRNAs/PIWI-interacting RNA (piRNA) in the saliva of sCSDS mice. One of them, miR-208b-3p, which is reported as a reliable marker for myocardial infarction, was upregulated in the saliva of sCSDS mice. Histological analysis showed frequent myocardial interstitial fibrosis in the heart of such mice. In addition, gene ontology and pathway analyses suggested that the pathways related to energy metabolism, such as the oxidative phosphorylation and the pentose phosphate pathway, were significantly related to the miRNAs affected by sCSDS in saliva. In contrast, salivary metabolites were not significantly changed in the sCSDS mice, which is consistent with our previous metabolomic study on the plasma of sCSDS mice. Taken in the light of previous studies, the present study provides novel potential stress biomarkers for future diagnosis using saliva., MDPI AG
International Journal of Molecular Sciences, 21 Nov. 2022, [Reviewed]

Oral expressions and functional analyses of the extracellular calcium-sensing receptor (CaSR) in chicken
Hikaru Omori; Yuko Kawabata; Yuta Yoshida; Yutaro Nagamoto; Fuminori Kawabata; Shotaro Nishimura; Shoji Tabata, Abstract

In vertebrates, the extracellular calcium-sensing receptor (CaSR) plays a key role in calcium homeostasis by sensing slight changes in extracellular Ca²⁺. CaSR is also expressed in mammals including rodent taste cells and is involved in sensing kokumi, a rich, savory quality that enhances the intensities of salty, sweet, and umami tastes. In this study, we focused on chicken CaSR (cCaSR) since calcium is an essential nutrient that is necessary for making eggshell and for the extremely rapid initial growth of bones. First we confirmed that cCaSR is expressed in taste cells. Next we cloned the cCaSR gene from kidney and transiently transfected human embryonic kidney 293 T (HEK293T) cells with the recombinant cCaSR, or empty vector and looked for the agonists and allosteric modulators (including kokumi substances) of cCaSR by Ca²⁺ imaging. We found that cCaSR was activated by extracellular Ca²⁺ and Mg²⁺ in a dose dependent manner. Several L-amino acids and kokumi substances such as glutathione enhanced the response of cCaSR. In addition, NPS2143 as a negative allosteric modulator of human CaSR negatively modulated the response of cCaSR. These results suggest that cCaSR can sense extracellular Ca²⁺ and Mg²⁺ as well as positive and negative allosteric modulators. Taken together, the results imply that CaSR might be a multifunctional receptor for calcium, amino acids, and kokumi substances in chicken. The present finding that functional CaSR is expressed in the chicken oral tissues will allow us to further elucidate the physiological role of CaSR in the chickens' taste sense, and to create new feeds that will contribute to the poultry industry., Springer Science and Business Media LLC
Scientific Reports, 22 Oct. 2022, [Reviewed]

Periostin Contributes to Fibrocartilage Layer Growth of the Patella Tendon Tibial Insertion in Mice
Hirotaka Mutsuzaki; Yuta Yoshida; Hiromi Nakajima, Background and Objectives: The influence of periostin on the growth of the patella tendon (PT) tibial insertion is unknown. The research described here aimed to reveal the contribution of periostin to the growth of fibrocartilage layers of the PT tibial insertion using periostin knockout mice. Materials and Methods: In both the wild-type (WD; C57BL/6N, periostin +/+; n = 54) and periostin knockout (KO; periostin −/−; n = 54) groups, six mice were euthanized on day 1 and at 1, 2, 3, 4, 6, 8, 10, and 12 weeks of age. Chondrocyte proliferation and apoptosis, number of chondrocytes, safranin O-stained glycosaminoglycan (GAG) area, staining area of type II collagen, and length of the tidemark were investigated. Results: Chondrocyte proliferation and apoptosis in KO were lower than those in WD on day 1 and at 1, 4, and 8 weeks and on day 1 and at 4, 6, and 12 weeks, respectively. Although the number of chondrocytes in both groups gradually decreased, it was lower in KO than in WD on day 1 and at 8 and 12 weeks. In the extracellular matrix, the GAG-stained area in KO was smaller than that in WD on day 1 and at 1, 4, 8, 10, and 12 weeks. The staining area of type II collagen in KO was smaller than that in WD at 8 weeks. The length of the tidemark in KO was shorter than that in WD at 4 and 6 weeks. Conclusion: Loss of periostin led to decreased chondrocyte proliferation, chondrocyte apoptosis, and the number of chondrocytes in the growth process of the PT tibial insertion. Moreover, periostin decreased and delayed GAG and type II collagen production and delayed tidemark formation in the growth process of the PT tibial insertion. Periostin can, therefore, contribute to the growth of fibrocartilage layers in the PT tibial insertion. Periostin deficiency may result in incomplete growth of the PT tibial insertion., MDPI AG
Medicina, 19 Jul. 2022, [Reviewed]

Behavioral responses to sweet compounds via T1R2-independent pathways in chickens
Momoko Higashida; Yuta Yoshida; Yuko Kawabata; Yuki Matsui; Shotaro Nishimura; Shoji Tabata; Fuminori Kawabata, Elsevier BV
Poultry Science, Jul. 2022, [Reviewed]

Conditioned Taste Aversion to L-Amino Acid Taste Stimuli and Oral Transcriptional Changes to Type 1 Taste Receptors T1R1 and T1R3 on Chronic Exposure to L-Alanine Solution in Chickens
Yuta Yoshida; Ryota Tanaka; Shu Fujishiro; Shotaro Nishimura; Shoji Tabata; Fuminori Kawabata, Lead, Japan Poultry Science Association
The Journal of Poultry Science, Apr. 2022, [Reviewed]

Chicken taste receptors and perception: recent advances in our understanding of poultry nutrient-sensing systems
Yuta Yoshida; Shotaro Nishimura; Shoji Tabata; Fuminori Kawabata, Lead, Informa UK Limited
World's Poultry Science Journal, 02 Jan. 2022, [Reviewed]

Identification of Ligands for Chicken Transient Receptor Potential Ankyrin 1 Channel and Chemosensory Perception of Herbal Compounds in Chickens
Fuminori Kawabata; Kana Murayama; Yuta Yoshida; Ruojun Liang; Shotaro Nishimura; Shoji Tabata, Japan Poultry Science Association
The Journal of Poultry Science, Jan. 2022, [Reviewed]

Fatty Acid Taste Receptor GPR120 Activation by Arachidonic Acid, Eicosapentaenoic Acid, and Docosahexaenoic Acid in Chickens
Fuminori Kawabata; Yuta Yoshida; Seiga Kuba; Yuko Kawabata; Shotaro Nishimura; Shoji Tabata, Japan Poultry Science Association
The Journal of Poultry Science, Nov. 2021, [Reviewed]

Subchronic and mild social defeat stress downregulates peripheral expression of sweet and umami taste receptors in male mice
Yuta Yoshida; Misa Miyazaki; Yuhei Yajima; Atsushi Toyoda, Lead, Elsevier BV
Biochemical and Biophysical Research Communications, Nov. 2021, [Reviewed]

Overlapping distributions of mammalian types I, II, and III taste cell markers in chicken taste buds
Yuta Yoshida; Fuminori Kawabata; Shotaro Nishimura; Shoji Tabata, Lead, Elsevier BV
Biochemical and Biophysical Research Communications, Sep. 2021, [Reviewed]

The umami receptor T1R1–T1R3 heterodimer is rarely formed in chickens
Yuta Yoshida; Fuminori Kawabata; Shotaro Nishimura; Shoji Tabata, Lead, Abstract

The characterization of molecular mechanisms underlying the taste-sensing system of chickens will add to our understanding of their feeding behaviors in poultry farming. In the mammalian taste system, the heterodimer of taste receptor type 1 members 1/3 (T1R1/T1R3) functions as an umami (amino acid) taste receptor. Here, we analyzed the expression patterns of T1R1 and T1R3 in the taste cells of chickens, labeled by the molecular markers for chicken taste buds (vimentin and α-gustducin). We observed that α-gustducin was expressed in some of the chicken T1R3-positive taste bud cells but rarely expressed in the T1R1-positive and T2R7-positive taste bud cells. These results raise the possibility that there is another second messenger signaling system in chicken taste sensory cells. We also observed that T1R3 and α-gustducin were expressed mostly in the vimentin-positive taste bud cells, whereas T1R1 and bitter taste receptor (i.e., taste receptor type 2 member 7, T2R7) were expressed largely in the vimentin-negative taste bud cells in chickens. In addition, we observed that T1R1 and T1R3 were co-expressed in about 5% of chickens' taste bud cells, which express T1R1 or T1R3. These results suggest that the heterodimer of T1R1 and T1R3 is rarely formed in chickens’ taste bud cells, and they provide comparative insights into the expressional regulation of taste receptors in the taste bud cells of vertebrates., Springer Science and Business Media LLC
Scientific Reports, 10 Jun. 2021, [Reviewed]

Evolvement of taste sensitivity and taste buds in chickens during selective breeding
Yuta Yoshida; Fuminori Kawabata; Shoji Tabata; Samuel E. Aggrey; Romdhane Rekaya; Hong-Xiang Liu, Lead, Elsevier BV
Poultry Science, Jun. 2021, [Reviewed]

Taste buds are not derived from neural crest in mouse, chicken, and zebrafish
Wenxin Yu; Zhonghou Wang; Brett Marshall; Yuta Yoshida; Renita Patel; Xiaogang Cui; Rebecca Ball; Linlin Yin; Fuminori Kawabata; Shoji Tabata; Wenbiao Chen; Robert N. Kelsh; James D. Lauderdale; Hong-Xiang Liu, Elsevier BV
Developmental Biology, Mar. 2021, [Reviewed]

A review of taste sense in chickens : behavioral responses to umami taste and expression of umami taste receptor
Yuta YOSHIDA; Fuminori KAWABATA; Shotaro NISHIMURA; Shoji TABATA, Lead, Japanese Society of Animal Science
Nihon Chikusan Gakkaiho, Feb. 2021, [Reviewed], [Invited]

Research Note: Behavioral preference and conditioned taste aversion to oleic acid solution in chickens
Fuminori Kawabata; Yuta Yoshida; Yuki Inoue; Yuko Kawabata; Shotaro Nishimura; Shoji Tabata, Elsevier BV
Poultry Science, Jan. 2021, [Reviewed]

Bitter Taste Receptor Antagonists Inhibit the Bitter taste of Canola Meal Extract in Chickens
Fuminori Kawabata; Bapon Dey; Yuta Yoshida; Shotaro Nishimura; Shoji Tabata, Japan Poultry Science Association
The Journal of Poultry Science, 2020, [Reviewed]

Abundant proliferating cells within early chicken taste buds indicate a potentially "built-in" progenitor system for taste bud growth during maturation in hatchlings.
Wang Z; Yoshida Y; Kramer NE; Kawabata F; Tabata S; Kim WK; Liu HX
Histology and histopathology, May 2019, [Reviewed]

Bitter taste receptor T2R7 and umami taste receptor subunit T1R1 are expressed highly in Vimentin-negative taste bud cells in chickens
Yuta Yoshida; Zhonghou Wang; Kayvan F. Tehrani; Emily G. Pendleton; Ryota Tanaka; Luke J. Mortensen; Shotaro Nishimura; Shoji Tabata; Hong-Xiang Liu; Fuminori Kawabata, Lead, Elsevier BV
Biochemical and Biophysical Research Communications, Apr. 2019, [Reviewed]

Short-term perception of and conditioned taste aversion to umami taste, and oral expression patterns of umami taste receptors in chickens
Yuta Yoshida; Fuminori Kawabata; Yuko Kawabata; Shotaro Nishimura; Shoji Tabata, Lead, Elsevier BV
Physiology & Behavior, Jul. 2018, [Reviewed]

Expression levels of taste-related genes in palate and tongue tip, and involvement of transient receptor potential subfamily M member 5 (TRPM5) in taste sense in chickens
Yuta Yoshida; Fuminori Kawabata; Yuko Kawabata; Shotaro Nishimura; Shoji Tabata, Lead, Wiley
Animal Science Journal, Feb. 2018, [Reviewed]

Identification of functional bitter taste receptors and their antagonist in chickens
Bapon Dey; Fuminori Kawabata; Yuko Kawabata; Yuta Yoshida; Shotaro Nishimura; Shoji Tabata, Elsevier BV
Biochemical and Biophysical Research Communications, Jan. 2017, [Reviewed]

Expressions of multiple umami taste receptors in oral and gastrointestinal tissues, and umami taste synergism in chickens
Yuta Yoshida; Yuko Kawabata; Fuminori Kawabata; Shotaro Nishimura; Shoji Tabata, Lead, Elsevier BV
Biochemical and Biophysical Research Communications, Oct. 2015, [Reviewed]

家禽の味覚受容体に関する研究　　　　　　　　　　　　　　　
川端二功; 川端由子; 廣瀬のぞみ; 澤村亮; 吉田悠太; 西村正太郎; 田畑正志
栄養生理研究会報, Apr. 2015, [Reviewed], [Invited]

⼼理社会的なストレスが味蕾に及ぼす影響の検討　　　　　　　　　　　　　　　
宮崎 美沙; 豊田 淳; 吉田 悠太
第46回 日本分子生物学会年会, 07 Dec. 2023

The effect of subchronic and mild social defeat stress on salt preference in male mice　　　　　　　　　　　　　　　
門脇 崇; 湯澤 亜利沙; 豊田 淳; 吉田 悠太
第46回 日本分子生物学会年会, 07 Dec. 2023

A study on the relationship between salivary miR-208b-3p and stress-induced cardiac fibrosis in male mice subjected to sub-chronic and mild social defeat stress (sCSDS)　　　　　　　　　　　　　　　
Finandya Fatihasari Yuta; Yoshida Yuhei; Yajima Kina; Kawakami; Shin-ichi Nakamura; Takamitsu Tsukahara; Katsutaka Oishi; Atsushi Toyoda
第46回 日本分子生物学会年会, 06 Dec. 2023

〔Major achievements〕ニワトリが味覚を感じるアミノ酸と糖のプロファイリング　　　　　　　　　　　　　　　
吉田悠太; 藤代柊; 河合亮汰; 川端二功
日本家禽学会 2023年度秋季大会, 21 Sep. 2023

〔Major achievements〕食性の異なる動物における新規味覚受容体候補遺伝子の発現　　　　　　　　　　　　　　　
吉田悠太; 宮口右二; 宮﨑照雄; 冨田和秀; 佐々木誠一
日本畜産学会 第131回大会, 20 Sep. 2023

〔Major achievements〕食性の異なる動物における長鎖脂肪酸受容体の応答性の比較　　　　　　　　　　　　　　　
藤代柊; 久保田未優; 川端二功; 吉田悠太
日本畜産学会 第131回大会, 19 Sep. 2023

慢性的な睡眠障害モデルマウスの唾液におけるmiRNA-seq解析　　　　　　　　　　　　　　　
吉田悠太; 谷島優平; 藤倉祐里; 庄皓桐; 山本明花; 豊田淳; 大石勝隆
第29回 日本時間生物学会学術大会, 03 Dec. 2022

ニワトリが味覚を感じるL-アミノ酸のプロファイリング　　　　　　　　　　　　　　　
藤代柊; 川端二功; 吉田悠太
日本畜産学会 第130回大会, 16 Sep. 2022
20220914, 20220917

慢性的な睡眠障害モデルマウスにおける唾液microRNAプロファイルの解析　　　　　　　　　　　　　　　
吉田悠太; 谷島優平; 藤倉祐里; 庄皓桐; 山本明花; 豊田淳; 大石勝隆
第9回 日本時間栄養学会学術大会, 26 Aug. 2022

塩味の嗜好性を制御する脳神経基盤の解明　　　　　　　　　　　　　　　
吉田悠太
ソルトサイエンス研究財団 第34回助成研究発表会, 26 Jul. 2022

動物の食性と味覚の研究　　　　　　　　　　　　　　　
吉田悠太
第24回日本畜産学会若手企画シンポジウム, 30 Mar. 2022, [Invited]

Systematic analysis of brain lactate and pH levels in 73 animal models related to neuropsychiatric conditions　　　　　　　　　　　　　　　
Hideo Hagihara; Hirotaka Shoji; International Brain pH Project Consortium; Tsuyoshi Miyakawa
ACNP Annual Meeting 2021
20211205, 20211208

畜産動物の味覚研究について　　　　　　　　　　　　　　　
吉田悠太
第63回茨城県畜産研究会シンポジウム, Mar. 2021, [Invited]

動物の味覚研究の将来展望　　　　　　　　　　　　　　　
吉田悠太
第21回日本畜産学会若手企画シンポジウム, 13 Nov. 2020, [Invited]

ニワトリ脂肪酸受容体GPR120の新規アゴニストの同定　　　　　　　　　　　　　　　
川端二功; 久場星河; 吉田悠太; 川端由子; 西村正太郎; 田畑正志
第13回日本暖地畜産学会 沖縄大会, 25 Oct. 2020

Expression of umami taste receptors in the taste bud cells of chickens, and behavioral responses to umami taste in chickens　　　　　　　　　　　　　　　
Yoshida Y; Wang Z; Tehrani KF; Pendleton EG; Mortensen LJ; Nishimura S; Tabata S; Liu HX; Kawabata F
The 18th International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Perception, 02 Nov. 2019

Taste receptors and taste behaviors in chickens　　　　　　　　　　　　　　　
Kawabata F; Kawabata Y; Yoshida Y; Omori H; Higashida M; Dey B; Liang R; Murayama K; Hayase Y; Araki M; Nishimura S; Liu HX; Tabata S
THE 48th NAITO CONFERENCE on Integrated Sensory Sciences-Pain, Itch, Smell and Taste, 10 Oct. 2019

Bitter Taste Receptor T2R7 and Umami Taste Receptor Subunit T1R1 are Expressed Largely in Vimentin-Negative Taste Bud Cells of Chickens　　　　　　　　　　　　　　　
Yoshida Y; Wang Z; Tehrani KF; Pendleton EG; Tanaka R; Mortensen LJ; Nishimura S; Tabata S; Liu HX; Kawabata F
The Association for Chemoreception Sciences 41th annual meeting, 15 Apr. 2019

Bitter Taste Receptor T2R7 and Umami Taste Receptor Subunit T1R1 are Expressed in the Taste Bud Cells of Chickens　　　　　　　　　　　　　　　
吉田悠太; Wang Z; Tehrani KF; Pendleton EG; 田中崚太; Mortensen LJ; 西村正太郎; 田畑正志; Liu HX; 川端二功
日本畜産学会 第125回大会, 28 Mar. 2019

Analysis of mRNA expressions and functions of sour taste receptor candidate PKD2L1 in chickens　　　　　　　　　　　　　　　
Araki M; Kawabata F; Kawabata Y; Yoshida Y; Nishimura S; Tabata S
The 17th International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Perception, 01 Dec. 2018

Taste systems in chickens　　　　　　　　　　　　　　　
Kawabata F; Kawabata F; Yoshida Y; Dey B; Hirose N; Sawamura R; Omori H; Higashida M; Nishimura S; Tabata S
English Poster Session “Meet the Professor”, 121th Annual meeting of Japan Poultry Science Association, 06 Sep. 2018

Umami taste sense in chickens characterized by the receptor expression and behavioral responses　　　　　　　　　　　　　　　
吉田悠太; 川端二功; 川端由子; 西村正太郎; 田畑正志
日本畜産学会 第123回大会, 06 Sep. 2017

Expression of Umami Taste Receptors and Behavioral Reactions to Umami Taste in Chickens　　　　　　　　　　　　　　　
Yoshida Y; Kawabata F; Kawabata Y; Nishimura S; Tabata S
The Association for Chemoreception Sciences 39th annual meeting, 27 Apr. 2017

Expression patterns of multiple umami taste receptors in chickens; metabotropic glutamate receptor type 4 is not involved in umami receptor systems of chickens　　　　　　　　　　　　　　　
Yoshida Y; Kawabata F; Nishimura S; Tabata S
The 15th International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Perception, 04 Dec. 2016

Expression patterns of taste sensors in oral and gastrointestinal tissues of chickens　　　　　　　　　　　　　　　
Kawabata F; Kawabata Y; Yoshida Y; Higashida M; Ohmori H; Nishimura S; Tabata S
The 17th AAAP Animal Science Congress, 25 Aug. 2016

ニワトリにおけるうま味の相乗効果とうま味受容体遺伝子発現解析　　　　　　　　　　　　　　　
吉田悠太; 川端二功; 川端由子; 西村正太郎; 田畑正志
日本畜産学会 第121回大会, 28 Mar. 2016

The receptors for fat, bitter, and umami tastes in chickens　　　　　　　　　　　　　　　
Kawabata F; Yoshida Y; Kawabata Y; Nishimura S; Tabata S
The 13th International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Perception, 04 Nov. 2015

ニワトリにおけるうま味の相乗効果とうま味受容体群の発現解析　　　　　　　　　　　　　　　
吉田悠太; 川端二功; 川端由子; 西村正太郎; 田畑正志
日本味と匂学会 第49回大会, 26 Sep. 2015

ニワトリのうま味に対する嗜好性およびうま味受容体遺伝子の発現解析　　　　　　　　　　　　　　　
吉田悠太; 川端二功; 川端由子; 西村正太郎; 田畑正志
日本畜産学会 第119回大会, 29 Mar. 2015

Apr. 2024 - Present

Apr. 2024 - Present

Apr. 2024 - Present

Apr. 2024 - Present

Apr. 2024 - Present

Apr. 2024 - Present

Apr. 2024 - Present

2021 - Present

2021 - Present

2021 - Present

2021 - Present

2021 - Present

2021 - Present

2021 - Present

2021 - Present

Apr. 2024 - Mar. 2025

日本家禽学会

日本味と匂学会

日本畜産学会

反芻動物の味覚：ルーメン発酵産物の反芻を介した新奇栄養素受容機構の解明
基盤研究(B)
茨城大学
Apr. 2024 - Mar. 2028

精神ストレスを介した塩味嗜好性の新規制御メカニズムの解明　　　　　　　　　　　　　　　
公益財団法人ロッテ財団 奨励研究助成 (A)
Apr. 2023 - Mar. 2026

ウズラの苦味受容特性の理解と飼養への応用　　　　　　　　　　　　　　　
2024年度 旗影会研究助成
Apr. 2024 - Mar. 2025

畜産動物の脂肪酸味覚受容体の機能解析 (II)　　　　　　　　　　　　　　　
公益財団法人伊藤記念財団 令和5年度研究助成
Apr. 2023 - Mar. 2024

ニワトリの口腔内アミノ酸センサーの同定とそれらを介した食行動調節機構の解明
基盤研究(B)
弘前大学
Apr. 2021 - Mar. 2024

畜産動物における苦味受容特性の分子基盤の解明
若手研究
茨城大学
Apr. 2021 - Mar. 2024

畜産動物の脂肪酸味覚受容体の機能解析　　　　　　　　　　　　　　　
公益財団法人伊藤記念財団 令和4年度研究助成
Apr. 2022 - Mar. 2023

塩味嗜好性を制御する脳神経回路の解明　　　　　　　　　　　　　　　
2022年度 笹川科学研究助成
Apr. 2022 - Mar. 2023

畜産動物の有郭乳頭からの味蕾オルガノイド培養系の構築　　　　　　　　　　　　　　　
2022年度 旗影会研究助成
Apr. 2022 - Mar. 2023

塩味の嗜好性を制御する脳神経基盤の解明　　　　　　　　　　　　　　　
公益財団法人ソルト・サイエンス研究財団 研究助成
Apr. 2021 - Mar. 2022

ブタの味蕾における味覚受容体レパートリーの解明　　　　　　　　　　　　　　　
2021年度 旗影会研究助成
Apr. 2021 - Mar. 2022

ニワトリの味蕾における味覚シグナル伝達機構の解明　　　　　　　　　　　　　　　
Apr. 2020 - Mar. 2021

Comprehensive analyses of fat-taste sensing in chickens
Grant-in-Aid for Scientific Research (B)
Kyushu University
Apr. 2018 - Mar. 2021

ニワトリのうま味受容機構の解明：畜産学と比較生理学への貢献
特別研究員奨励費
九州大学
Apr. 2017 - Mar. 2020

ニワトリのうま味受容機構の解明：畜産学と比較生理学への貢献　　　　　　　　　　　　　　　
若手研究者海外挑戦プログラム
Mar. 2018 - Jan. 2019

ニワトリにおけるうま味の相乗効果とうま味受容体機能の解明　　　　　　　　　　　　　　　
平成28年度 笹川科学研究助成
Apr. 2016 - Mar. 2017