Takahide YamaguchiAssistant Professor
■Researcher basic information
Organization
Educational Background
■Research activity information
Paper
- Unraveling the unfolding mechanism of pseudoazurin: Insights into stabilizing cupredoxin fold as a common domain of Cu-containing proteins
Takahide Yamaguchi; Attila Taborosi; Kiyokazu Tsugane; Kathleen Wood; Andrew E. Whitten; Seiji Mori; Takamitsu Kohzuma, Lead, Elsevier BV
Journal of Inorganic Biochemistry, Jul. 2025, [Reviewed] - 〔Major achievements〕Systematic elucidation of the second coordination sphere effect on the structure and properties of a blue copper protein, pseudoazurin
Takahide Yamaguchi; Attila Taborosi; Chihiro Sakai; Kohei Akao; Seiji Mori; Takamitsu Kohzuma, Lead
https://doi.org/10.1016/j.jinorgbio.2023.112292, 15 May 2023, [Reviewed] - Syntheses, Characterizations, Crystal Structures, and Protonation Reactions of Dinitrogen Chromium Complexes Supported with Triamidoamine Ligands
Yoshiaki Kokubo; Kazuki Tsuzuki; Hikari Sugiura; Shunsuke Yomura; Yuko Wasada-Tsutsui; Tomohiro Ozawa; Sachiko Yanagisawa; Minoru Kubo; Tomoyuki Takeyama; Takahide Yamaguchi; Yuichi Shimazaki; Shinichi Kugimiya; Hideki Masuda; Yuji Kajita, American Chemical Society (ACS)
Inorganic Chemistry, 27 Mar. 2023, [Reviewed] - Effect of structural iron on nanoscroll formation via exfoliation of a high iron-content kaolin.
Balázs Zsirka; Katalin Győrfi; Takahide Yamaguchi; Attila Táborosi; Veronika Vágvölgyi; Clara Parameswary; Zoltán Homonnay; Ernő Kuzmann; Erzsébet Horváth & János Kristóf
Journal of Materials Research, 20 Oct. 2022, [Reviewed] - Open-Bundle Structure as the Unfolding Intermediate of Cytochrome c′ Revealed by Small Angle Neutron Scattering
Takahide Yamaguchi; Kouhei Akao; Alexandros Koutsioubas; Henrich Frielinghaus; Takamitsu Kohzuma, Lead
Biomolecules, 07 Jan. 2022, [Reviewed] - 2.85 and 2.99 Å resolution structures of 110 kDa nitrite reductase determined by 200 kV cryogenic electron microscopy
Naruhiko Adachi; Takahide Yamaguchi; Toshio Moriya; Masato Kawasaki; Kotaro Koiwai; Akira Shinoda; Yusuke Yamada; Fumiaki Yumoto; Takamitsu Kohzuma; ToshiyaSenda, Lead, Elsevier BV
Journal of Structural Biology, 16 Jul. 2021, [Reviewed] - Unusual Protein Stability of the Met16Leu Pseudoazurin Variant
Takahide Yamaguchi; Miyu Akatsu; Attila Taborosi; Takamitsu Kohzuma, Lead
Chemistry Letters, Dec. 2020, [Reviewed] - Effect of Cavity Size of Mesoporous Silica on Type 1 Copper Site Geometry in Pseudoazurin
Akira Yamaguchi; Yurie Edanami; Takahide Yamaguchi; Yuuta Shibuya; Norihisa Fukaya; Takamitsu Kohzuma
Bulletin of the Chemical Society of Japan, May 2020, [Reviewed] - The Role for the Weak Interaction on the Stabilization of Copper-Containing Complex: DFT Investigation of Noncovalent Interactions in Ternary-Cu(II) (DA)(AA) Complexes (DA = Diamine and AA = Amino Acids) as a Model of Metalloprotein
Attila Taborosi; Takahide Yamaguchi; Akira Odani; Osamu Yamauchi; Takamitsu Kohzuma
Bulletin of the Chemical Society of Japan, Nov. 2019, [Reviewed] - Computational Modelling Study on the Pseudoazurin Type 1 Cu Site
Attila Taborosi; Takahide Yamaguchi; Seiji Mori; Takamitsu Kohzuma
JPS Conference Proceedings, Proceedings of the 3rd International Symposium of Quantum Beam Science at Ibaraki University "Quantum Beam Science in Biology and Soft Materials (ISQBSS2018)", Mar. 2019, [Reviewed] - Solution structure determination of a copper-containing nitrite reductase of achromobacter cycloclastes by small angle neutron scattering
Takahide Yamaguchi; Kathleen Wood; Attila Taborosi; Kouhei Akao; Takamitsu Kohzuma, Chemical Society of Japan
Chemistry Letters, 2018, [Reviewed] - Stabilization of protein structure through - interaction in the second coordination sphere of pseudoazurin
Takahide Yamaguchi; Yuko Nihei; Duncan E. K. Sutherland; Martin J. Stillman; Takamitsu Kohzuma
PROTEIN SCIENCE, Oct. 2017, [Reviewed] - The pH Dependent Protein Structure Transitions and Related Spin State Transition of Cytochrome c’ from Alcaligenes xylosoxidans NCIMB 11015
Akiko Takashina; Michael T. Tiedemann; Masaki Unno; Takahide Yamaguchi; Martin J. Stillman; Takamitsu Kohzuma
Bulletin of the Chemical Society of Japan, Feb. 2017, [Reviewed] - Molecular Science in Biology(3),– Quantum Beam, Synchrotron Radiation and X-ray Absorption Spectroscopy –
Takahide Yamaguchi and Takamitsu Kohzuma,The 70 years have been passed from the first observation of synchrotron radiation. Recently, synchrotron radiation light source has been developped by new type of accelerator, and modern syncrtron has been dedicated and utilized to analyze the strucutres and properties of many variety of materials involving biomolecules. The histrical features of synchrtron radiation are overlooked, and synchrotron based X-ray absorption spectroscopy and related computational chemistry of metallo-protein are also introduced in this issue.
, Society of Computer Chemistry, Japan
Journal of Computer Chemistry, Japan, Dec. 2016, [Reviewed] - X-ray crystallographic evidence for the simultaneous presence of axial and rhombic sites in cupredoxins: atomic resolution X-ray crystal structure analysis of pseudoazurin and DFT modelling
Takahide Yamaguchi; Kohei Akao; Akiko Takashina; Sayaka Asamura; Masaki Unno; Robert K. Szilagyi and Takamitsu Kohzuma, Lead
RSC Advances, Sep. 2016, [Reviewed] - The Allosteric Regulation of Axial/Rhombic Population in a “Type 1” Copper Site: Multi-Edge X-ray Absorption Spectroscopic and Density Functional Studies of Pseudoazurin
Takahide Yamaguchi; Junko Yano; Vittal K. Yachandra; Yuko Nihei; Hiromi Togashi; Robert K. Szilagyi; Takamitsu Kohzuma, Lead
Bulletin of the Chemical Society of Japan, Dec. 2015, [Reviewed] - Influence of Ligand Flexibility on the Electronic Structure of Oxidized NiIII-Phenoxide Complexes
Minoru Kawai; Takahide Yamaguchi; Shigeyuki Masaoka; Fumito Tani; Takamitsu Kohzuma; Linus Chiang; Tim Storr; Kaoru Mieda; Takashi Ogura; Robert K. Szilagyi; and Yuichi Shimazaki
Inorganic Chemistry, Oct. 2014, [Reviewed] - The type 1 copper site of pseudoazurin: Axial and rhombic
Peter Gast; Freek G.J. Broeren; Silvia Sottini; Risa Aoki; Akiko Takashina; Takahide Yamaguchi; Takamitsu Kohzuma; Edgar J.J. Groenen
Journal of Inorganic Biochemistry, Aug. 2014, [Reviewed]
MISC
- 金属タンパク質の構造・電子状態を制御する外圏の弱い相互作用
高妻孝光; 山口峻英; 高階明子; 海野昌喜
茨城大学iFRC年報 平成26年度, Sep. 2015 - X-ray crystallographic structure analyses and characterization of a blue copper protein, pseudoazurin, Met16Ile variant
Kana Gunji; Takahide Yamaguchi; Akiko Takashina; Masaki Unno; Takamitsu Kohzuma
JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY, Aug. 2014 - Geometry and electronic structures of axial/rhombic site in pseudoazurin Met16 variants: XAS and DFT investigations
Takahide Yamaguchi; Junko Yano; Vittal K. Yachandra; Robert K. Szilagyi; Takamitsu Kohzuma
JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY, Aug. 2014
Books and other publications
Lectures, oral presentations, etc.
- ラッカーゼのアミノ酸修飾 Au(111)電極へのエナンチオ選択的 吸着と酸素還元活性
加藤優; 岡紗雪; 大橋龍人; 松島永佳; 山口峻英; 菅井碧宙; 星野翔吾; 八木一三
日本表面真空学会東北・北海道支部 令和6年度学術講演会, Mar. 2025
20250310, 20250311 - シュウドアズリンMet16Gly変異体の構造と性質
菅井 碧宙; 山口 峻英; 高妻 孝光
第50回 生体分子科学討論会, 22 Jun. 2024
20240621, 20240622 - 亜硝酸還元酵素Met56Phe変異体の性質
篠塚 花音; 稲葉 直人; 山口 峻英; 高妻 孝光
第50回 生体分子科学討論会, 22 Jun. 2024
20240621, 20240622 - 中性子準弾性散乱によるシュウドアズリンMet16変異体のナノ・ピコ秒ダイナミクス解析
橋本 将太; 山口 峻英; Kathleen Wood; Alice Klapproth; 高妻 孝光
第50回 生体分子科学討論会, 22 Jun. 2024
20240621, 20240622 - 中性子小角散乱と MD 計算によるシュウドアズリン Met16 変 異体の変性過程の解析
山口 峻英; Taborosi Attil; 津金 聖和; Wood Kathleen; Andrew Whitte; 森 聖治; 高妻 孝光
第50回 生体分子科学討論会, 21 Jun. 2024
20240621, 20240622 - ブルー銅タンパク質シュウドアズリンMet16X変異体を用いたタンパク質内弱い相互作用の系統的研究
高妻 孝光、山口 峻英、Taborosi Attila、森 聖治
日本薬学会第143年会, Mar. 2023
20230325, 20230328 - Tuning of the Cu Site Properties and Protein Stability by the Noncovalent Interactions in Second Coordination Sphere of Pseudoazurin
Takahide Yamaguchi; Attila Taborosi; Wood Kathleen; Whitten Andrew; Seiji Mori; Takamitsu Kohzuma
10th Asian Biological Inorganic Chemistry (AsBIC10), Nov. 2022
20221128, 20221203 - Second Coordination Sphere Effects on the Stability and Unfolding of Pseudoazurin
山口 峻英・Taborosi Attila・津金 聖和・Wood Kathleen・Whitten Andrew・高妻 孝光
錯体化学会第72回討論会, 27 Sep. 2022
20220926, 20220928 - クライオ電子顕微鏡による亜硝酸還元酵素のパッキングフリー構造解析
山口 峻英; 安達 成彦; 守屋 俊夫; 川崎 政夫; 小祝 孝太郎; 篠田 晃; 山田 悠介; 湯本 史明; 高妻 孝光; 千田 俊哉
第48回生体分子科学討論会, 30 Jun. 2022
20220630, 20220701 - Small angle X-ray scattering of lactase and stellacyanin from Okukuji lacquer sap
菅井碧宙、中山綾乃、山口峻英、高妻孝光
第３１回金属の関与する生体関連反応シンポジウム, 18 Jun. 2022
20220618, 20220619 - Effect of Noncovalent Weak Interaction in Pseudoazurin Met16Glu variant
第３１回金属の関与する生体関連反応シンポジウム, 18 Jun. 2022
20220618, 20220619 - Rational Elucidation of the Structure and Function for the Weak Interaction in Protein through a Pseudoazuin Met16X Variants
Takahide Yamaguchi; Attila Taborosi; Seiji Mori; Takamitsu Kohzuma
第２２回日本蛋白質科学会年会, 08 Jun. 2022
20220607, 20220609 - 還元型Cytochrome c'のX線結晶構造解析
2021年度量子ビームサイエンスフェスタ, 09 Mar. 2022
20220307, 20220309 - 量子ビームによる絹の染色機構に関する研究
2021年度量子ビームサイエンスフェスタ, 08 Mar. 2022
20220307, 20220309 - Alcaligenes xylosoxidans由来のAzurin IIの結晶構造解析
2021年度量子ビームサイエンスフェスタ, 08 Mar. 2022
20220307, 20220309 - Structural Stability and X-ray Crystal Structure of Met16Glu Mutant
2021年度量子ビームサイエンスフェスタ, 08 Mar. 2022
20220307, 20220309 - SAXSによるウルシ由来ステラシアニンの構造解析
2021年度量子ビームサイエンスフェスタ, 08 Mar. 2022
20220307, 20220309 - SAXSによる奥久慈産漆由来ラッカーゼの溶液構造
2021年度量子ビームサイエンスフェスタ, 08 Mar. 2022
20220307, 20220308 - 弱い相互作用によるシュウドアズリンの構造安定性と変性状態の変化
津金 聖和; 山口 峻英; Attila Taborosi; Kathleen Wood; Andrew Whitten; 高妻 孝光
第30回金属の関与する生体関連反応シンポジウム, 18 Jun. 2021
20210618, 20210619 - 奥久慈漆由来ラッカーゼ、ステラシアニンの単離と性質
菅井碧宙; 山口 峻英; 高妻 孝光
第30回金属の関与する生体関連反応シンポジウム, 18 Jun. 2021
20210618, 20210619 - Alcaligenes xylosoxidans由来のAzurin I, Azurin IIの精製と結晶構造解析
稲葉 直登; 山口 峻英; 高妻 孝光
第30回金属の関与する生体関連反応シンポジウム, 18 Jun. 2021
20210618, 20210619 - シュウドアズリン Met16Phe 変異体の還元型 X 線結晶構造解析
青山 雄亮; 山口 峻英; 高妻 孝光
第30回金属の関与する生体関連反応シンポジウム, 18 Jun. 2021
20210618, 20210619 - 還元型 Cytochrome c’の X 線結晶構造解析
鶴野 湧哉; 山口 峻英; 高妻 孝光
第30回金属の関与する生体関連反応シンポジウム, 18 Jun. 2021
20210618, 20210619 - Second Coordination Effects in Blue Copper Protein with Combined Experimental and Computational Chemistry
Takahide Yamaguchi; Attila Taborosi; Seiji Mori; Takamitsu Kohzuma
The 24th International Annual Symposium on Computational Science and Engineering (ANSCSE24), 30 Apr. 2021, [Invited]
20210428, 20210430 - Tuning of type 1 copper site and stability through the non-covalent weak interaction in second coordination sphere of blue copper protein
Takahide Yamaguchi; Taborosi Attila; Takamitsu Kohzuma
The 5th International Symposium of Quantum Beam Science, 19 Nov. 2020, [Invited]
20201119, 20201121 - SANSによるブルー銅タンパク質シュウドアズリンのpH構造転移の解明
津金 聖和; 山口 峻英; Attila Taborosi; Kathleen Wood; Andrew Whitten; 高妻 孝光
錯体化学会 第70回討論会, 30 Sep. 2020
20200928, 20200930 - QENS Studies on the Detection of Domain Dynamics of Pseudoazurin Met16Ile Variant
Shota HASHIMOTO; Takahide YAMAGUCHI; Attila TABOROSI; Kathleen WOOD; Alice KLAPPROTH; Takamitsu KOHZUMA
錯体化学会 第70回討論会, 30 Sep. 2020
20200928, 20200930 - Structure Determination of the Open-Bundle Unfolding Intermediate of Cytochrome c’ by Small Angle Neutron Scattering
Takahide Yamaguchi
The 70th JSCC Conference,"New Era of Bioinorganic Chemistry Developed by the Quantum Beam and,High Performance Computational Science", 28 Sep. 2020, [Invited]
20200928, 20200930 - シュウドアズリンMet16変異体のpH構造転移
津金聖和; 山口峻英; Taborosi Attila; Kathleen Wood; Andrew Whitten; 高妻孝光
第３０回日本化学会関東支部茨城地区研究交流会, 20 Dec. 2019 - シュウドアズリンMet16Leu変異体の構造安定性
赤津美結; 山口峻英; 高妻孝光
第３０回日本化学会関東支部茨城地区研究交流会, 20 Dec. 2019 - QENSによるシュウドアズリンの構造ダイナミクス測定
橋本将太; 山口峻英; Taborosi Attila; Kathleen Wood; Alice Klapproth; 高妻孝光
第３０回日本化学会関東支部茨城地区研究交流会, 20 Dec. 2019 - The Strong Weak Interaction in Blue Copper Protein
高妻孝光; 山口峻英; Taborosi Attila
第３０回日本化学会関東支部茨城地区研究交流会, 20 Dec. 2019 - Elucidation of the weak interactions at the second coordination sphere of protein molecule: Structural and energetic studies of S-π, π-π, and CH-π interactions in Met16X Pseudoazurin.
Attila Taborosi; Takahide Yamaguchi; Chihiro Sakai; Kohei Akao; Seiji Mori; Takamitsu Kohzuma
4th International Symposium of Quantume Beam Science, Oct. 2019 - Computational chemistry study on the effect of noncovalent interactions in ternary-Cu(II) complexes, and on the blue copper protein Pseudoazurin Cu(II) active site.
Attila Taborosi; Takahide Yamaguchi; Seiji Mori; Takamitsu Kohzuma
IMS Supercomputer Workshop 2018, Jan. 2019 - Solution Structure Analysis of Nitrite Reductase by Small Angle Neutron Scattering
Takahide Yamaguchi; Kathleen Wood; Takamitsu Kohzuma
第28回金属の関与する生体関連反応シンポジウム, Jun. 2018 - Met16Ali(Ali=Aliphatic amino acids)シュウドアズリン変異体における弱い相互作用の効果
高妻孝光; 酒井千尋; 山口峻英
第28回金属の関与する生体関連反応シンポジウム, Jun. 2018 - Solution Structure Analysis of Blue Copper Protein by Small Angle Neutron Scattering
Takahide Yamaguchi; kathleen Wood; Takamitsu Kohzuma
3rd International Symposium of Quantum Beam Science at Ibaraki University, 31 May 2018 - The Structure and Function of Weak Interaction in Blue Copper Protein
Takamitsu Kohzuma; Chihiro Sakai; Takahide Yamaguchi
3rd International Symposium of Quantum Beam Science at Ibaraki University, 31 May 2018 - Solution Structure of Nitrite Reductase from Achromobacter cycloclasetes by Small Angle Neutron Scattering Method
3rd International Symposium of Quantum Beam Science at Ibaraki University, 31 May 2018 - タンパク質中の電子移動反応における活性中心近傍の弱い相互作用の効果
山口 峻英; 赤尾 康平; 高妻 孝光
日本化学会第９８春季年会, Mar. 2018 - In silico examination of non-bonding interactions in proteins
Attila Taborosi; Takahide Yamaguchi; Takehiro Sato; Seiji Mori; Takamitsu Kohzuma
日本化学会第９８春季年会, Mar. 2018 - Structure and Properties of a Side-Loop Variant, Met16Gly Pseudoazurin
6th International Symposium on Metallomics, Aug. 2017 - Additivity of the Structure and Properties in Protein Molecule
2016年度量子ビームサイエンスフェスタ, Mar. 2017 - Re-Investigation of Blue Copper Protein: Allosteric Structural Regulation of Type 1 Cu Site
Thai-Japan Symposium in Chemistry, 15 Nov. 2016, [Invited] - 弱い相互作用によるブルー銅タンパク質活性中心のアロステリック制御
錯体化学会第66回討論会, 10 Sep. 2016
Affiliated academic society
