2014年03月, ベストポスター賞, Formation of neuronal circuits by interactions between neuronal populations derived from different origins in the Drosophila visual center, 動く細胞と場のクロストーク 若手の会
国内学会・会議・シンポジウム等の賞

bHLH family proteins control the timing and completion of transition from neuroepithelial cells into neural stem cells
Chika Akiba; Aya Takezawa; Yuanchang Tsai; Mire Hirose; Takumi Suzuki, ラスト(シニア)オーサー, ABSTRACT

The number of neural stem cells reflects the total number of neurons in the mature brain. As neural stem cells arise from neuroepithelial cells, the neuroepithelial cell population must be expanded to secure a sufficient number of neural stem cells. However, molecular mechanisms that regulate timely differentiation from neuroepithelial to neural stem cells are largely unclear. Here, we show that TCF4/Daughterless is a key factor that determines the timing of the differentiation in Drosophila. The neuroepithelial cells initiated but never completed the differentiation in the absence of TCF4/Daughterless. We also found that TCF4/Daughterless binds to the Notch locus, suggesting that Notch is one of its downstream candidate genes. Consistently, Notch expression was ectopically induced in the absence of TCF4/Daughterless. Furthermore, ectopic activation of Notch signaling phenocopied loss of TCF4/Daughterless. Our findings demonstrate that TCF4/Daughterless directly inactivates Notch signaling pathway, resulting in completion of the differentiation from neuroepithelial cells into neural stem cells with optimal timing. Thus, the present results suggest that TCF4/Daughterless is essential for determining whether to move to the next state or stay in the current state in differentiating neuroepithelial cells., The Company of Biologists
Development, 2024年09月, ［査読有り］

Steroid hormone-dependent changes in trehalose physiology in the silkworm, Bombyx mori
Suzuki; T.; Akiba; C.; Izawa; M. and Iwami; M., 筆頭著者, Holometabolous insects undergo metamorphosis to reconstruct their body to the adult form during pupal period. Since pupae cannot take any diets from the outside because of a hard pupal cuticle, those insects stock up on nutrients sufficient for successful metamorphosis during larval feeding period. Among those nutrients, carbohydrates are stored as glycogen or trehalose, which is the major blood sugar in insects. The hemolymph trehalose is constantly high during the feeding period but suddenly decreases at the beginning of the prepupal period. It is believed that trehalase, which is a trehalose-hydrolyzing enzyme, becomes highly active to reduce hemolymph trehalose level during prepupal period. This change in the hemolymph trehalose level has been interpreted as the physiological shift from storage to utilization of trehalose at that stage. Although this shift in trehalose physiology is indispensable for energy production required for successful metamorphosis, little is known on the regulatory mechanisms of trehalose metabolism in accordance with developmental progress. Here, we show that ecdysone, an insect steroid hormone, plays essential roles in the regulation of soluble trehalase activity and its distribution in the midgut of silkworm, Bombyx mori. In the end of larval period, soluble trehalase was highly activated in the midgut lumen. This activation was disappeared in the absence of ecdysone and also restored by ecdysone administration. Our present results suggest that ecdysone is essentially required for the changes in the function of the midgut on trehalose physiology as development progresses., Springer Nature
Journal of Comparative Physiology B, 2023年05月, ［査読有り］

Cutting edge technologies expose the temporal regulation of neurogenesis in the Drosophila nervous system
M. Sato and T. Suzuki, Informa UK Limited
Fly, 2022年05月, ［査読有り］

NanoDam identifies Homeobrain and Scarecrow as conserved temporal factors in the Drosophila central brain and visual system　　　　　　　　　　　　　　　
Tang; J.; Hakes; A.; Krautz; R.; Suzuki; T.; Contreras; E.G.; Fox; P.; and Brand; A.H.
Developmental Cell, 2022年05月, ［査読有り］

Sequential changes in the regulatory mechanism of carbohydrate digestion in larvae of the silkworm, Bombyx mori
Takumi Suzuki; Masafumi Iwami, 筆頭著者, Nutritional signals strictly control post-embryonic development in insects. Dietary carbohydrates are hydrolyzed to monosaccharides in the gut and then transported into the hemolymph. These monosaccharides in hemolymph are rapidly taken up by tissues and utilized in glycolysis, the pentose phosphate shunt, and glycogen or trehalose synthesis. These metabolic pathways are essential for nutrient metabolism; therefore, the control of carbohydrate digestion is indispensable for maintaining energy supply during development. Carbohydrate digestion was believed to be controlled by dietary mechanisms. We previously reported that hormonal and developmental controls participate in the regulation of carbohydrate digestion during larval–pupal metamorphosis. However, it is unclear whether this regulatory mechanism also works during larval–larval molting and inter-molt feeding period. Here, we show that control mechanisms of the carbohydrate digestion show sequential changes that are controlled by different mechanisms. In the penultimate larval instar, carbohydrate hydrolysis activity changed depending on developmental progress and dietary state. Maltose- and sucrose-hydrolysis activity were suppressed by ecdysteroid, an insect steroid hormone. During the inter-molt feeding period, carbohydrate hydrolysis activities were grouped as either nutrient-sensitive or nutrient-insensitive. Although the activity in both groups was suppressed by ecdysteroid, this hormonal regulatory machinery remains in an “off-state” because ecdysteroid is scarce during the feeding period, suggesting that the carbohydrate digestion system is exclusively regulated by the dietary state during inter-molt feeding period.
Journal of Comparative Physiology B, 2021年05月, ［査読有り］

Ecdysteroid ingestion suppresses carbohydrate hydrolysis in larvae of the silkworm Bombyx mori
Takumi Suzuki; Masafumi Iwami, 筆頭著者, Springer Science and Business Media LLC
Naturwissenschaften, 2020年08月, ［査読有り］

Netrin Signaling Defines the Regional Border in the Drosophila Visual Center.
Suzuki T; Liu C; Kato S; Nishimura K; Takechi H; Yasugi T; Takayama R; Hakeda-Suzuki S; Suzuki T; Sato M, The brain consists of distinct domains defined by sharp borders. So far, the mechanisms of compartmentalization of developing tissues include cell adhesion, cell repulsion, and cortical tension. These mechanisms are tightly related to molecular machineries at the cell membrane. However, we and others demonstrated that Slit, a chemorepellent, is required to establish the borders in the fly brain. Here, we demonstrate that Netrin, a classic guidance molecule, is also involved in the compartmental subdivision in the fly brain. In Netrin mutants, many cells are intermingled with cells from the adjacent ganglia penetrating the ganglion borders, resulting in disorganized compartmental subdivisions. How do these guidance molecules regulate the compartmentalization? Our mathematical model demonstrates that a simple combination of known guidance properties of Slit and Netrin is sufficient to explain their roles in boundary formation. Our results suggest that Netrin indeed regulates boundary formation in combination with Slit in vivo.
iScience, 2018年10月, ［査読有り］

Inter-progenitor pool wiring: An evolutionarily conserved strategy that expands neural circuit diversity
Takumi Suzuki; Makoto Sato, Diversification of neuronal types is key to establishing functional variations in neural circuits. The first critical step to generate neuronal diversity is to organize the compartmental domains of developing brains into spatially distinct neural progenitor pools. Neural progenitors in each pool then generate a unique set of diverse neurons through specific spatiotemporal specification processes. In this review article, we focus on an additional mechanism, 'inter-progenitor pool wiring', that further expands the diversity of neural circuits. After diverse types of neurons are generated in one progenitor pool, a fraction of these neurons start migrating toward a remote brain region containing neurons that originate from another progenitor pool. Finally, neurons of different origins are intermingled and eventually form complex but precise neural circuits. The developing cerebral cortex of mammalian brains is one of the best examples of inter-progenitor pool wiring. However, Drosophila visual system development has revealed similar mechanisms in invertebrate brains, suggesting that inter-progenitor pool wiring is an evolutionarily conserved strategy that expands neural circuit diversity. Here, we will discuss how inter-progenitor pool wiring is accomplished in mammalian and fly brain systems., ACADEMIC PRESS INC ELSEVIER SCIENCE
DEVELOPMENTAL BIOLOGY, 2017年11月, ［査読有り］

Wnt Signaling Specifies Anteroposterior Progenitor Zone Identity in the Drosophila Visual Center
Takumi Suzuki; Olena Trush; Tetsuo Yasugi; Rie Takayama; Makoto Sato, During brain development, various types of neuronal populations are produced from different progenitor pools to produce neuronal diversity that is sufficient to establish functional neuronal circuits. However, the molecular mechanisms that specify the identity of each progenitor pool remain obscure. Here, we show that Wnt signaling is essential for the specification of the identity of posterior progenitor pools in the Drosophila visual center. In the medulla, the largest component of the visual center, different types of neurons are produced from two progenitor pools: the outer proliferation center (OPC) and glial precursor cells (GPCs; also known as tips of the OPC). We found that OPC-type neurons are produced from the GPCs at the expense of GPC-type neurons when Wnt signaling is suppressed in the GPCs. In contrast, GPC-type neurons are ectopically induced when Wnt signaling is ectopically activated in the OPC. These results suggest that Wnt signaling is necessary and sufficient for the specification of the progenitor pool identity. We also found that Homothorax (Hth), which is temporally expressed in the OPC, is ectopically induced in the GPCs by suppression of Wnt signaling and that ectopic induction of Hth phenocopies the suppression ofWntsignaling in the GPCs. Thus, Wntsignaling is involved in regionalization of the fly visual center through the specification of the progenitor pool located posterior to the medulla by suppressing Hth expression., SOC NEUROSCIENCE
JOURNAL OF NEUROSCIENCE, 2016年06月, ［査読有り］

Formation of Neuronal Circuits by Interactions between Neuronal Populations Derived from Different Origins in the Drosophila Visual Center
Takumi Suzuki; Eri Hasegawa; Yasuhiro Nakai; Masako Kaido; Rie Takayama; Makoto Sato, A wide variety of neurons, including populations derived from different origins, are precisely arranged and correctly connected with their partner to establish a functional neural circuit during brain development. The molecular mechanisms that orchestrate the production and arrangement of these neurons have been obscure. Here, we demonstrate that cell-cell interactions play an important role in establishing the arrangement of neurons of different origins in the Drosophila visual center. Specific types of neurons born outside the medulla primordium migrate tangentially into the developing medulla cortex. During their tangential migration, these neurons express the repellent ligand Slit, and the two layers that the neurons intercalate between express the receptors Robo2 and Robo3. Genetic analysis suggests that SlitRobo signaling may control the positioning of the layer cells or their processes to form a path for migration. Our results suggest that conserved axon guidance signaling is involved in the interactions between neurons of different origins during brain development., CELL PRESS
CELL REPORTS, 2016年04月, ［査読有り］

eyeless/Pax6 controls the production of glial cells in the visual center of Drosophila melanogaster
Takumi Suzuki; Rie Takayama; Makoto Sato, Pax6 is known as a neurogenic factor in the development of the central nervous system and regulates proliferation of neuronal progenitor cells and promotes neuronal differentiation. In addition to neurogenesis, Pax6 is also involved in the specification and maturation of glial cells. Here, we show that Eyeless (Ey), Drosophila homolog of Pax6, regulates the production of glial cells in the brain. In the developing fly visual center, the production of neurons and glial cells are controlled by the temporal transcription factors that are sequentially expressed in neuroblasts (NBs). Among them, NBs of the last temporal window produce astrocyte-like glial cells. Ey is strongly expressed in the middle aged NBs, whose temporal window is earlier compared with glia producing older NBs. Weak Ey expression is also detected in the glia producing NBs. Our results suggest that Ey expression in the middle aged NBs indirectly control gliogenesis from the oldest NBs by regulating other temporal transcription factors. Additionally, weak Ey expression in the NBs of last temporal window may directly control gliogenesis. Ey is also expressed in neurons produced from the NBs of Ey-positive temporal window. Interestingly, neuron specific overexpression of Ey causes significant increase in glial cells suggesting that neuronal expression of Ey may also contribute to gliogenesis. Thus, Pax6-dependent regulation of astrocyte-like glial development is conserved throughout the animal kingdom. (C) 2015 Elsevier Inc. All rights reserved., ACADEMIC PRESS INC ELSEVIER SCIENCE
DEVELOPMENTAL BIOLOGY, 2016年01月, ［査読有り］

Neurogenesis and neuronal circuit formation in the Drosophila visual center
Takumi Suzuki; Makoto Sato, The Drosophila optic lobe is composed of a wide variety of neurons that form laminar structures and columnar units. The fly optic lobe shares structural features with the mammalian brain, and fly genetics allow precise genetic manipulations. Thus, the Drosophila visual center is an excellent model for studying the mechanisms underlying the establishment of a functional neuronal circuit during brain development. However, little is understood about the developmental mechanisms that produce neuronal diversity and establish neuronal circuits in the medulla, the largest component of the optic lobe. Our recent research revealed key features of medulla development, such as birth-order-dependent specification of neuronal types and the subdivision of the medulla primordium into concentric zones, which is characterized by the expression of four transcription factors. Here, we review recent investigations into the development of the medulla and discuss the mechanisms that establish functional neuronal circuits., WILEY-BLACKWELL
DEVELOPMENT GROWTH & DIFFERENTIATION, 2014年09月, ［査読有り］

Waves of differentiation in the fly visual system
Makoto Sato; Takumi Suzuki; Yasuhiro Nakai, Sequential progression of differentiation in a tissue or in multiple tissues in a synchronized manner plays important roles in development. Such waves of differentiation are especially important in the development of the Drosophila visual system, which is composed of the retina and the optic lobe of the brain. All of the components of the fly visual system are topographically connected, and each ommatidial unit in the retina corresponds to a columnar unit in the optic lobe, which is composed of lamina, medulla, lobula and lobula plate. In the developing retina, the wave of differentiation follows the morphogenetic furrow, which progresses in a posterior-to-anterior direction. At the same time, differentiation of the lamina progresses in the same direction, behind the lamina furrow. This is not just a coincidence: differentiated photoreceptor neurons in the retina sequentially send axons to the developing lamina and trigger differentiation of lamina neurons to ensure the progression of the lamina furrow just like the furrow in the retina. Similarly, development of the medulla accompanies a wave of differentiation called the proneural wave. Thus, the waves of differentiation play important roles in establishing topographic connections throughout the fly visual system. In this article, we review how neuronal differentiation and connectivity are orchestrated in the fly visual system by multiple waves of differentiation. (c) 2013 Elsevier Inc. All rights reserved., ACADEMIC PRESS INC ELSEVIER SCIENCE
DEVELOPMENTAL BIOLOGY, 2013年08月, ［査読有り］

A temporal mechanism that produces neuronal diversity in the Drosophila visual center
Takumi Suzuki; Masako Kaido; Rie Takayama; Makoto Sato, The brain consists of various types of neurons that are generated from neural stem cells; however, the mechanisms underlying neuronal diversity remain uncertain. A recent study demonstrated that the medulla, the largest component of the Drosophila optic lobe, is a suitable model system for brain development because it shares structural features with the mammalian brain and consists of a moderate number and various types of neurons. The concentric zones in the medulla primordium that are characterized by the expression of four transcription factors, including Homothorax (Hth), Brain-specific homeobox (Bsh), Runt (Run) and Drifter (Drf), correspond to types of medulla neurons. Here, we examine the mechanisms that temporally determine the neuronal types in the medulla primordium. For this purpose, we searched for transcription factors that are transiently expressed in a subset of medulla neuroblasts (NBs, neuronal stem cell-like neural precursor cells) and identified five candidates (Hth, Klumpfuss (Klu), Eyeless (Ey), Sloppy paired (Sip) and Dichaete (D)). The results of genetic experiments at least explain the temporal transition of the transcription factor expression in NBs in the order of Ey, Sip and D. Our results also suggest that expression of Hth, Klu and Ey in NBs trigger the production of Hth/Bsh-, Run- and Drf-positive neurons, respectively. These results suggest that medulla neuron types are specified in a birth order-dependent manner by the action of temporal transcription factors that are sequentially expressed in NBs. (c) 2013 Elsevier Inc. All rights reserved., ACADEMIC PRESS INC ELSEVIER SCIENCE
DEVELOPMENTAL BIOLOGY, 2013年08月, ［査読有り］

Steroidal regulation of hydrolyzing activity of the dietary carbohydrates in the silkworm, Bombyx mori
Takumi Suzuki; Sho Sakurai; Masafumi Iwami, Blood sugar is an essential energy source for growth and development and is maintained at a constant level through precise regulation of formation and utilization. Sugars are produced from dietary carbohydrates by enzymatic hydrolysis in the digestive tract, which are under the homeostatic control of paracrine and prandial mechanisms in mammals. Here, we show that dietary carbohydrates hydrolyzing activity of the digestive tract is developmentally regulated by the steroid hormone ecdysone in the silkworm, Bombyx mori. The dietary carbohydrates hydrolyzing activity remained high throughout the last larval period and then decreased to negligible levels until the pupal period. However, dietary carbohydrates digestive activities were constitutively high when the steroidogenic organ, prothoracic glands were ablated. The prothoracic glands produced and released a large amount of ecdysone at the end of the larval period, suggesting that ecdysone is responsible for the decrease in dietary carbohydrates hydrolyzing activity. In fact, ecdysone decreased the activity to negligible levels in silkworms lacking the prothoracic glands. The present results indicate that the dietary carbohydrates hydrolyzing activity is regulated by ecdysone and that an increase in ecdysone titer decreases that activity at the end of the larval period, suggesting that ecdysone is essential for metabolic coordination during development. (C) 2011 Elsevier Ltd. All rights reserved., PERGAMON-ELSEVIER SCIENCE LTD
JOURNAL OF INSECT PHYSIOLOGY, 2011年09月, ［査読有り］

Juvenile hormone delays the initiation of rectal sac distention by disrupting ecdysteroid action in the silkworm, Bombyx mori
Takumi Suzuki; Sho Sakurai; Masafumi Iwami, Holometabolous insects develop without feeding and excreting during the pupal period and thus require repository organs for metabolic waste, or meconium. The rectal sac is an organ for storing meconium during pupal-adult development of holometabolous insects. Although the rectal sac has an essential function, hormonal and developmental regulation of waste-accumulation and the consequences of rectal sac distention are still unknown. In the silkworm, Bombyx mori, the rectal sac distends with meconium in the middle pupal period under the regulation of ecdysteroid. Here, we show that juvenile hormone analog (JHA) delayed rectal sac distention and disturbed adult emergence. Distention was not restored completely by an injection of 20-hydroxyecdysone (20E) into pupae applied with JHA, suggesting that JHA suppresses 20E action and delays the timing of ecdysteroid elevation. Thus the "status quo" action of JHA may function in two different ways during pupal-adult development. (C) 2010 Elsevier Inc. All rights reserved., ACADEMIC PRESS INC ELSEVIER SCIENCE
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, 2010年07月, ［査読有り］

Physiological requirements for 20-hydroxyecdysone-induced rectal sac distention in the pupa of the silkworm, Bombyx mori
Takumi Suzuki; Sho Sakurai; Masafumi Iwami, Successful insect development is achieved via appropriate fluctuation of ecdysteroid levels. When an insect's ecdysteroid level is disrupted, physiological and developmental defects occur. In the pupa of the silkworm, Bombyx mori, the rectal sac is an essential organ that operates as a repository for degraded ecdysteroids, and it can be distended by administration of 20-hydroxyecdysone (20E). Our previous study showed that rectal sac distention appears 4 days after 20E administration. Hemolymph ecdysteroid levels, however, decrease to lower level during this period. Thus, the timing of the rectal sac distention does not match with that of ecdysteroid elevation. Here, we examine how 20E induces rectal sac distention. A ligature experiment and ecdysteroid quantification showed that continuous 20E stimulation induces rectal sac distention. Thorax tissue contributed to the continuous 20E stimulation needed to induce distention. Ecdysteroid released from the thorax tissue may be converted to 20E by ecdysone 20-hydroxylase to produce continuous 20E stimulation. Thus, the ecdysone metabolic pathway plays a critical role in rectal sac distention. (C) 2010 Elsevier Ltd. All rights reserved., PERGAMON-ELSEVIER SCIENCE LTD
JOURNAL OF INSECT PHYSIOLOGY, 2010年06月, ［査読有り］

Rectal sac distention is induced by 20-hydroxyecdysone in the pupa of Bombyx mori
Takumi Suzuki; Sho Sakurai; Masafumi Iwami, Holometabolous insects do not excrete but store metabolic wastes during the pupal period. The waste is called meconium and is purged after adult emergence. Although the contents of meconium are well-studied, the developmental and physiological regulation of meconium accumulation is poorly understood. In Bombyx mori, meconium is accumulated in the rectal sac; thereby, the rectal sac distends at the late pupal stage. Here, we show that rectal sac distention occurs between 4 and 5 days after pupation. The distention is halted by brain-removal just after larval-pupal ecdysis but not by brain-removal I day after pupation. In the pupae, brain-removal just after ecdysis kept the hemolymph ecdysteroid titer low during early and mid-pupal stages. An injection of 20-hydroxyecdysone (20E) evoked the distention that was halted by brain-removal in a dose-dependent manner. Therefore, brain-removal caused the lack of ecdysteroid, and rectal sac distention did not appear in the brain-removed pupae because of the lack of ecdysteroid. We conclude that rectal sac distention is one of the developmental events regulated by 20E during the pupal period in B. mori. (C) 2008 Elsevier Ltd. All rights reserved., PERGAMON-ELSEVIER SCIENCE LTD
JOURNAL OF INSECT PHYSIOLOGY, 2009年03月, ［査読有り］

進化的に保存された神経回路形成機構inter-progenitor pool wiringによって神経回路が飛躍的に多様化する
佐藤 純; 鈴木 匠
生化学, 2017年12月

Hemolymph Proteins and Functional Peptides: Recent Advances in Insects and Other Arthropods　　　　　　　　　　　　　　　
鈴木 匠; 岩見 雅史, 分担執筆
Bentham Science Publishers, 2012年

Studeies on the regulation mechanism of sugar metabolism during the larval-pupal transition of the silkworm, Bombyx mori.
鈴木 匠
[Takumi Suzuki], 2011年

Daughterless is essential to complete differentiation from neuroepithelial cells into neural stem cells　　　　　　　　　　　　　　　
Chika Akiba; Yuanchang Tsai; Aya Takezawa; Mire Hirose; Takumi Suzuki
APDNC3, 2024年02月
202402, 202403

Molecular mechanisms that regulate neuronal differentiation by Extramacrochaete　　　　　　　　　　　　　　　
Gensyo Sai; Aya Takezawa; and Takumi Suzuki
第45回 日本分子生物学会, 2022年12月

Identifying genes that regulate the production of neurogenesis diversity in fly visual center　　　　　　　　　　　　　　　
Akiba Chika; Izawa Misaki; Saito Anna; Aya Takezawa and Takumi Suzuki
第45回 日本分子生物学会, 2022年12月

Klumpfuss guarantees neuronal differentiation in two different stem cell pools in Drosophila visual center　　　　　　　　　　　　　　　
Takumi Suzuki
The 7th Visual System Neuron Meeting, 2022年11月

Snail family transcription factors are involved in the transition from neuroepithelial to neural stem cells　　　　　　　　　　　　　　　
Anna Saito and Takumi Suzuki
The 7th Visual System Neuron Meeting, 2022年11月

Identifying genes that regulate the production of neuronal diversity in Drosophila visual center　　　　　　　　　　　　　　　
Yuanchang Tsai; Akiba Chika; Izawa Misaki; Saito Anna; *Takumi Suzuki
第55回 日本発生生物学会, 2022年06月

Identifying genes that regulate neuronal diversity in Drosophila visual system　　　　　　　　　　　　　　　
Akari Tanaka; Yuanchang Tsai; Naho Tsubota; Takumi Suzuki
第44回 日本分子生物学会年会, 2021年12月

Identifying genes that regulate neural stem cell quiescence　　　　　　　　　　　　　　　
Takumi Suzuki; Andrea H. Brand
第43回 日本分子生物学会年会, 2020年12月

Reactivation of quiescent neural stem cell via cholinergic signaling　　　　　　　　　　　　　　　
Takumi Suzuki; Andrea H. Brand
5th Visual System Neuron Meeting, 2020年11月, Makoto Sato
202011, 202011

Identifying genes that regulate neural stem cell quiescence　　　　　　　　　　　　　　　
第42回 日本分子生物学会年会, 2019年12月

Roles of unfolded protein response signaling in the regulation of neural stem cell reactivation　　　　　　　　　　　　　　　
Takumi Suzuki; Andrea Brand
25th European Drosophila Research Conference, 2017年09月

Formation of neuronal circuits by interactions between neuronal populations derived from different origins in the Drosophila visual center　　　　　　　　　　　　　　　
Takumi Suzuki; Eri Hasegawa; Yasuhiro Nakai; Masako Kaido; Rie Takayama; Makoto Sato
24th European Drosophila Research Conference, 2015年09月

Formation of neuronal circuits by interactions between neuronal populations derived from different origins in the Drosophila visual center.　　　　　　　　　　　　　　　
鈴木匠、海道雅子、高山理恵、佐藤純
発生生物学会第48回大会, 2015年06月

Neuronal expression of eyeless/Pax6 controls the production of glial cells　　　　　　　　　　　　　　　
鈴木匠、高山理恵、佐藤純
日本分子生物学会第37回大会, 2014年11月

Establishment of neural circuit by interaction between cells of different origins　　　　　　　　　　　　　　　
鈴木匠、海道雅子、高山理恵、佐藤純
Japanese Drosophila Research Conference 11, 2014年06月

Molecular basis of the production of neuronal diversity in the Drosophila visual center　　　　　　　　　　　　　　　
Takumi Suzuki; Masako Kaido; Rie Takayama; Makoto Sato
53rd Annual Drosophila Research Conference, 2012年03月

2011年08月, 日本分子生物学会

2011年04月, 日本発生生物学会

2011年04月, 国際発生生物学会

神経幹細胞が多種多様な神経を一つ一つ作り分ける分子機構の解明　　　　　　　　　　　　　　　
2022年08月 - 2027年07月

神経上皮細胞から神経幹細胞への分化時期を決定する分子基盤の理解　　　　　　　　　　　　　　　
基盤研究（C）
2024年04月 - 2027年03月

ゲノム上の疾病原因箇所を迅速に特定する技術の開発　　　　　　　　　　　　　　　
2024年01月 - 2026年03月

グリア細胞由来の栄養シグナルによる神経の細胞死抑制機構を理解する　　　　　　　　　　　　　　　
2023年12月 - 2025年09月

神経上皮細胞の増殖期を終結させる分子機構の理解　　　　　　　　　　　　　　　
2023年10月 - 2024年09月

Temporal Factorsが神経の運命を決定する分子基盤の理解　　　　　　　　　　　　　　　
基盤研究（C）
2021年04月 - 2024年03月

神経幹細胞が多種多様な神経細胞を作り分ける分子メカニズムの解明　　　　　　　　　　　　　　　
2021年04月 - 2024年03月

神経幹細胞が多様な神経を生み出す分子メカニズムの理解　　　　　　　　　　　　　　　
2021年12月 - 2023年08月

神経回路の多様性を飛躍的に増加させる分子メカニズム　　　　　　　　　　　　　　　
2022年08月 - 2023年03月

神経産生期からグリア産生期への切り替えスイッチをONにする神経由来の生理活性物質の探索　　　　　　　　　　　　　　　
2022年04月 - 2023年03月

ゲノムDNA上の疾病原因領域を迅速に特定する新規技術の開発　　　　　　　　　　　　　　　
2022年03月 - 2023年03月

ゲノムDNAの3次元的な高次構造情報を任意の細胞で取得する新規手法の開発　　　　　　　　　　　　　　　
2022年01月 - 2023年03月

迅速にエンハンサーを同定し疾病原因領域を特定する技術の開発　　　　　　　　　　　　　　　
2021年12月 - 2023年03月

神経幹細胞が多種多様な神経細胞を作り分ける分子メカニズムの解明　　　　　　　　　　　　　　　
2021年04月 - 2022年03月

Understanding of the molecular mechanisms that regulate production of neuronal diversity　　　　　　　　　　　　　　　
2021年04月 - 2022年03月

遺伝子の発現調節領域の同定により疾病の原因箇所を迅速に特定する新規技術の開発　　　　　　　　　　　　　　　
2021年04月 - 2022年03月

多様な神経を必要な数だけ生み出すメカニズムを解明する　　　　　　　　　　　　　　　
2020年12月 - 2022年03月

神経幹細胞が多種多様な神経を過不足なく生み出す分子メカニズムの解明　　　　　　　　　　　　　　　
2020年11月 - 2022年03月

新規手法DamIDによる神経多様性創出機構の解明　　　　　　　　　　　　　　　
2020年01月 - 2021年04月

神経細胞の多様性を生み出す分子機構の解明　　　　　　　　　　　　　　　
2020年04月 - 2021年03月

新たな手法DamIDを用いた多様な神経細胞を作り分けるメカニズムの解明　　　　　　　　　　　　　　　
研究活動スタート支援
2019年08月 - 2021年03月

神経幹細胞の休眠制御による脳神経系修復メカニズムの解明　　　　　　　　　　　　　　　
2019年12月 - 2020年11月

Understanding molecular mechanisms that regulate production of neuronal diversity by DamID, a newly established technique　　　　　　　　　　　　　　　
2019年10月 - 2020年10月

神経多様性を創出する分子機構の解明　　　　　　　　　　　　　　　
2019年08月 - 2020年07月

動体認識の神経回路とその動作機構
基盤研究(B)
金沢大学
2012年04月01日 - 2016年03月31日