Akinari YokoyaProfessor
■Researcher basic information
Organization
- College of Science Department of Sciences Biological Sciences
- Graduate School of Science and Engineering（Master's Program） Major in Quantum Bean Science
- Graduate School of Science and Engineerin（Doctoral Program） Major in Quantum Bean Science
- Faculty of Basic Natural Science Domain of Biological Sciences
Research Areas
Research Keyword
Educational Background
Career
- Apr. 2022 - Present, National Institutes for Quantum Science and Technology, Institute for Quantum Life Science, Quantum Life and Medical Science Directorate, Senior Expert, Special Coordinator of Quantum Life Science Research Center
- Apr. 2021 - Present, Ibaraki University, Graduate School of Science and Engineering Major in Quantum Beam Science, Professor by cross-appointment system
- Jun. 2021 - Mar. 2022, National Institutes for Quantum Science and Technology, Institute for Quantum Life Science, Quantum Life and Medical Science Directorate, Senior principal researcher, Ph.D.
- Apr. 2019 - Mar. 2021, National Institutes for Quantum and Radiological Science and Technology, Institute for Quantum Life Science, Senior Principal Researcher
- Apr. 2010 - Mar. 2021, Ibaraki University, Graduate School of Science and Engineering, 客員教授
- Apr. 2016 - Mar. 2019, National Institutes for Quantum and Radiological Science and Technology, Tokai Quantum Beam Science Center, Senior Principal Researcher
- Apr. 2012 - Mar. 2016, Japan Atomic Energy Agency, 研究主席
- Apr. 2004 - Mar. 2012, Japan Atomic Energy Agency, 先端基礎研究センター, 研究主幹
- Apr. 2008 - Mar. 2010, Ibaraki University, 理学部, 特任教授
- Apr. 2001 - Mar. 2004, 日本原子力研究所, 放射光科学研究センター, 副主任研究員
- Mar. 2000 - Mar. 2001, Medical Research Council, UK, Radiation and Genome Stability Unit, Visiting Scientist
- Apr. 1991 - Mar. 2000, 日本原子力研究所, 大型放射光施設開発推進室, 研究員
Member History
- Apr. 2024 - Present, Strategic and Future Planning Subcommittee, PF User association
- Dec. 2023 - Present, Chair of Quantum Sensing Track of the organizing committee, The International Symposium on Quantum Sciece, Technology and Innovation (Quantum Innovation 2024)
- 2012 - Present, PF-UA 運営委員, Photon Factory User Association
- Dec. 2022 - Nov. 2023, Chair of Quantum Sensing Track of the organizing committee, The International Symposium on Quantum Sciece, Technology and Innovation (Quantum Innovation 2023)
- Jan. 2022 - Nov. 2022, Chair of Quantum Sensing Track of the organizing committee, The International Symposium on Quantum Sciece, Technology and Innovation (Quantum Innovation 2022)
- Jun. 2020 - Jun. 2022, a member of the board of councilors, Japanese Radiation Reseach Society
- May 2021 - Dec. 2021, Track Chair of Quantum Sensing track of the organizing committee, The International Symposium on Quantum Sciece, Technology and Innovation (Quantum Innovation 2021)
- May 2019 - May 2020, Board of Councilors, 一般社団法人量子生命科学会
- 2003 - 2019, Scientific Committee, International Symposium on the Physical, Molecular, Cellular and Medical Aspects of Auger Electron Process
- 2013 - Nov. 2017, Scientific Comimittee, International Symposium on Microdosimetry (MICROS)
- 2011 - 2015, Symposium Chair, International Symposium on the Physical, Molecular, Cellular and Medical Aspects of Auger Electron Process
- Jan. 2012 - Dec. 2013, Board of Councilors, Japanese Radiation Reseach Society
- 2004 - Jun. 2012, Scientific comittee, International Workshop on Radiation Damage to DNA
External link
■Research activity information
Award
- Jun. 2022, 第26回RADIOISOTOPES誌 論文奨励賞, マウス精巣器官培養法を活用した放射線不妊メカニズムの解析, 日本アイソトープ協会
神長 輝一;横谷 明徳;福永 久典 - Dec. 2020, award of excellent presentation, Development of Ca ion dynamics in mammalian cells under stress of X-irradiation, Quantum Life Science Society
Ami Suzuki;Akinari Yokoya - Oct. 2020, The Japanese Radiation Research Society Distinguished Scientist Award, 放射線DNA損傷生成の物理化学的初期過程、及びマイクロビームとライブセル観察を組み合わせた細胞の放射線に対する応答システムの研究, The Japanese Radiation Research Society
Akinari Yokoya - May 2019, award of excellence, Study of process of DNA repair protein (XRCC4) complex formation using X-ray small angle scattering, Quantum Life Science Society
Maho Hasegawa;Kai Nishikubo;Satoru Fujiwara;Tatsuhito Matsuo;Akinari Yokoya
Paper
- X-ray photolysis of a hypervalent iodine compound, 4-carboxy-2-iodosobenzoic acid, via iodine K-shell excitations and ionizations
Yudai Izumi; Maki Ohara; Sho Gakiya; Naoya Ieda; Akinari Yokoya; Mikako Ogawa, Corresponding
Radiation Physics and Chemistry, Dec. 2025, [Reviewed] - Time-lapse imaging of cells in spatially fractionated X-ray fields using a mini beam as an alternative to accelerator-based sub-millimeter beams
Kiichi Kaminaga; Hisanori Fukunaga; Eri Hirose; Ritsuko Watanabe; Keiji Suzuki; Kevin M Prise; Akinari Yokoya, Last
Journal of Radiation Research, 23 May 2025, [Reviewed] - Computational analysis of the spatial distributions of low-energy electrons generated via water photolysis and photoinjection into electrodes in water
Takeshi Kai; Tomohiro Toigawa; Yusuke Matsuya; Yuho Hirata; Hidetsugu Tsuchida; Akinari Yokoya, Last
The Journal of Chemical Physics, 21 Apr. 2025, [Reviewed] - X-Ray Exposed Tubulins During <i>In vitro</i> Polymerization Reactions: A Possible Approach for Radiation-induced Impacts on Microtubules
Noritsugu Abe; Ryosuke Seino; Akinari Yokoya; Hisanori Fukunaga, Japan Radioisotope Association
RADIOISOTOPES, 15 Mar. 2025, [Reviewed] - Multiple DNA damages induced by water radiolysis demonstrated using a dynamic Monte Carlo code
Takeshi Kai; Tomohiro Toigawa; Yusuke Matsuya; Yuho Hirata; Hidetsugu Tsuchida; Yuma Ito; Akinari Yokoya, Last
COMMUNICATIONS CHEMISTRY, 06 Mar. 2025, [Reviewed] - Distribution of the dose response in a silicone-based radio-fluorogenic dosimeter and FWT-60 irradiated with monochromatic low-energy X-rays
Seiko Nakagawa; Takuya Maeyama; Akinari Yokoya; Maki Ohara; Noriko Usami, Elsevier BV
Radiation Measurements, Feb. 2025, [Reviewed] - Super-competition as a Novel Mechanism of the Dose-rate Effect in Radiation Carcinogenesis: A Mathematical Model Study.
Yuya Hattori; Kento Nagata; Ritsuko Watanabe; Akinari Yokoya; Tatsuhiko Imaoka, Data from animal experiments show that the radiation-related risk of cancer decreases if the dose rate is reduced, even though the cumulative dose is unchanged (i.e., a dose-rate effect); however, the underlying mechanism is not well understood. To explore factors underlying the dose-rate effect observed in experimental rat mammary carcinogenesis, we developed a mathematical model that accounts for cellular dynamics during carcinogenesis, and then examined whether the model predicts cancer incidence. A mathematical model of multistage carcinogenesis involving radiation-induced cell death and mutagenesis was constructed using differential equations. The mutation rate was changed depending on the dose rate. The model also considered competition among cells with various mutation levels. The main parameters of the model were determined using previous experimental data. The parameters of the model were consistent with experimental observations. A dose-rate effect on carcinogenesis became apparent when the relationship between dose rate and mutation rate was linear quadratic or quadratic. The dose-rate effect became prominent when cells with more mutations preferentially compensated for the radiation-induced death of cells with fewer mutations. The phenomenon by which mutated cells gain a competitive advantage over normal cells is known as super-competition. Here, we identified super-competition as a novel mechanism underlying the dose-rate effects on carcinogenesis. The data also confirmed the relevance of the shape of the relationship between dose rate and the mutation rate. Thus, this study provides new evidence for the mechanism underlying the dose-rate effect, which is important for predicting the cancer-related risks of low-dose-rate irradiation.
Radiation Research, 20 Jan. 2025, [Reviewed] - Significant role of secondary electrons in the formation of a multi-body chemical species spur produced by water radiolysis
Takeshi Kai; Tomohiro Toigawa; Yusuke Matsuya; Yuho Hirata; Tomoya Tezuka; Hidetsugu Tsuchida; Akinari Yokoya, Last, Abstract
Scientific insights into water photolysis and radiolysis are essential for estimating the direct and indirect effects of deoxyribonucleic acid (DNA) damage. Secondary electrons from radiolysis intricately associated with both effects. In our previous paper, we simulated the femtosecond (1 × 10− 15 s) dynamics of secondary electrons ejected by energy depositions of 11−19 eV into water via high-energy electron transport using a time-dependent simulation code. The results contribute to the understanding of simple “intra-spur” chemical reactions of tree-body chemical species (hydrated electrons, hydronium ion and OH radical) in subsequent chemical processes. Herein, we simulate the dynamics of the electrons ejected by energy depositions of 20−30 eV. The present results contribute to the understanding of complex “inter-spur” chemical reactions of the multi-body chemical species as well as for the formation of complex DNA damage with redox site and strand break on DNA. The simulation results present the earliest formation mechanism of an unclear multi-body chemical species spur when secondary electrons induce further ionisations or electronic excitations. The formation involves electron–water collisions, i.e. ionisation, electronic excitation, molecular excitation and elastic scattering. Our simulation results indicate that (1) most secondary electrons delocalise to ~ 12 nm, and multiple collisions are sometimes induced in a water molecule at 22 eV deposition energy. (2) The secondary electrons begin to induce diffuse band excitation of water around a few nm from the initial energy deposition site and delocalise to ~ 8 nm at deposition energies ~ 25 eV. (3) The secondary electron can cause one additional ionisation or electronic excitation at deposition energies > 30 eV, forming a multi-body chemical species spur. Thus, we propose that the type and density of chemical species produced by water radiolysis strongly depend on the deposition energy. From our results, we discuss formation of complex DNA damage., Springer Science and Business Media LLC
Scientific Reports, 21 Oct. 2024, [Reviewed] - Luminal progenitor and mature cells are more susceptible than basal cells to radiation-induced DNA double-strand breaks in rat mammary tissue.
Kento Nagata; Mayumi Nishimura; Kazuhiro Daino; Yukiko Nishimura; Yuya Hattori; Ritsuko Watanabe; Daisuke Iizuka; Akinari Yokoya; Keiji Suzuki; Shizuko Kakinuma; Tatsuhiko Imaoka, Ionizing radiation promotes mammary carcinogenesis. Induction of DNA double-strand breaks (DSBs) is the initial event after radiation exposure, which can potentially lead to carcinogenesis, but the dynamics of DSB induction and repair are not well understood at the tissue level. In this study, we used female rats, which have been recognized as a useful experimental model for studying radiation effects on the mammary gland. We focused on differences in DSB kinetics among basal cells, luminal progenitor and mature cells in different parts of the mammary duct. 53BP1 foci were used as surrogate markers of DSBs, and 53BP1 foci in each mammary epithelial cell in immunostained tissue sections were counted 1-24 h after irradiation and fitted to an exponential function of time. Basal cells were identified as cytokeratin (CK) 14+ cells, luminal progenitor cells as CK8 + 18low cells and luminal mature cells as CK8 + 18high cells. The number of DSBs per nucleus tended to be higher in luminal cells than basal cells at 1 h post-irradiation. A model analysis indicated that basal cells in terminal end buds (TEBs), which constitute the leading edge of the mammary duct, had significantly fewer initial DSBs than the two types of luminal cells, and there was no significant difference in initial amount among the cell types in the subtending duct. The repair rate did not differ among mammary epithelial cell types or their locations. Thus, luminal progenitor and mature cells are more susceptible to radiation-induced DSBs than are basal cells in TEBs.
Journal of Radiation Research, 05 Sep. 2024, [Reviewed] - 〔Major achievements〕Consideration of the dielectric response for radiation chemistry simulations.
Tomohiro Toigawa; Takeshi Kai; Yuta Kumagai; Akinari Yokoya, Last, The spur reaction, a spatially nonhomogeneous chemical reaction following ionization, is crucial in radiolysis or photolysis in liquids, but the spur expansion process has yet to be elucidated. One reason is the need to understand the role of the dielectric response of the solvating molecules surrounding the charged species generated by ionization. The dielectric response corresponds to the time evolution of the permittivity and might affect the chemical reaction-diffusion of the species in a spur expansion process. This study examined the competitive relationship between reaction-diffusion kinetics and the dielectric response by solving the Debye-Smoluchowski equation while considering the dielectric response. The Coulomb force between the charged species gradually decreases with the dielectric response. Our calculation results found a condition where fast recombination occurs before the dielectric response is complete. Although it has been reported that the primary G-values of free electrons depend on the static dielectric constant under low-linear-energy transfer radiation-induced ionization, we propose that considering the dielectric response can provide a deeper insight into fast recombination reactions under high-linear-energy transfer radiation- or photo-induced ionization. Our simulation method enables the understanding of fast radiation-induced phenomena in liquids.
The Journal of chemical physics, 07 Jun. 2024, [Reviewed] - Ultrafast fragmentation of highly-excited doubly-ionized deoxyribose: role of the liquid water environment.
Marie-Anne Hervé du Penhoat; Alexandre Souchaud; Aashini Rajpal; Rodolphe Vuilleumier; Marie-Pierre Gaigeot; Ivano Tavernelli; Kentaro Fujii; Akinari Yokoya; Sergio Díaz-Tendero; Marie-Françoise Politis, Ab initio molecular dynamics simulations are used to investigate the fragmentation dynamics following the double ionization of 2-deoxy-D-ribose (DR), a major component in the DNA chain. Different ionization scenarios are considered to provide a complete picture. First focusing on isolated DR2+, fragmentation patterns are determined for the ground electronic state, adding randomly distributed excitation energy to the nuclei. These patterns differ for the two isomers studied. To compare thermal and electronic excitation effects, Ehrenfest dynamics are also performed, allowing to remove the two electrons from selected molecular orbitals. Two intermediate-energy orbitals, localized on the carbon chain, were selected. The dissociation pattern corresponds to the most frequent pattern obtained when adding thermal excitation. On the contrary, targeting the four deepest orbitals, localized on the oxygen atoms, leads to selective ultrafast C-O and/or O-H bond dissociation. To probe the role of environment, a system consisting of a DR molecule embedded in liquid water is then studied. The two electrons are removed from either the DR or the water molecules directly linked to the sugar through hydrogen bonds. Although the dynamics onset is similar to that of isolated DR when removing the same deep orbitals localized on the sugar oxygen atoms, the subsequent fragmentation patterns differ. Sugar damage also occurs following the Coulomb explosion of neighboring H2O2+ molecules due to interaction with the emitted O or H atoms.
Physical chemistry chemical physics : PCCP, 29 May 2024, [Reviewed] - Decomposition characteristics of a hypervalent iodine compound, 2-iodosobenzoic acid, exposed to monochromatic X-rays around the iodine L3-edge energy region
Maki Ohara; Yudai Izumi; Hideo Takakura; Shosei Enomoto; Kentaro Fujii; Akinari Yokoya; Mikako Ogawa, Elsevier BV
Radiation Physics and Chemistry, Mar. 2024, [Reviewed] - X-ray photoemission and absorption spectroscopy of a hypervalent iodine compound, 2-iodosobenzoic acid
Yudai Izumi; Maki Ohara; Kentaro Fujii; Akinari Yokoya; Mikako Ogawa, Elsevier BV
Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, Feb. 2024, [Reviewed] - Electronic states of fluorinated DNA components revealed by X-ray photoelectron spectroscopy
S. Onuma; Y. Izumi; M. Ohara; A. Yokoya, Last
Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, Feb. 2024, [Reviewed] - Long-term radiation effects on the genome structure and function, and energy metabolism
Eri Hirose; Akinari Yokoya; Miho Noguchi; Lucie Huar; Keiji Suzuki
Radiation Biology Research Communications, 2024, [Reviewed] - Comparison of core and valence band electronic structures of bulk uracil and 5-halouracils
Yudai Izumi; Maki Ohara; Yuji Baba; Akinari Yokoya, Last
Physical Chemistry Chemical Physics, 2024, [Reviewed] - High linear energy transfer (LET) nature of alanine radical yield by soft X-ray irradiations studied by electron spin resonance (ESR) applications
Seiko Nakagawa; Akinari Yokoya; Maki Ohara; Noriko Usami; Mizue Asada; Motoyasu Fujiwara; Toshikazu Nakamura; Kenji Ishikawa, Elsevier BV
Radiation Physics and Chemistry, Jan. 2024, [Reviewed] - Temporal Dynamic Regulation of Autophagy and Senescence Induction in Response to Radiation Exposure.
Miho Noguchi; Tomokazu Ihara; Keiji Suzuki; Akinari Yokoya, Last, Autophagy and senescence are closely related cellular responses to genotoxic stress, and play significant roles in the execution of cellular responses to radiation exposure. However, little is known about their interplay in the fate-decision of cells receiving lethal doses of radiation. Here, we report that autophagy precedes the establishment of premature senescence in normal human fibroblasts exposed to lethal doses of radiation. Activation of the p53-dependent DNA damage response caused sustained dephosphorylation of RB proteins and consequent cell cycle arrest, concurrently with Ulk1 dephosphorylation at Ser638 by PPM1D, which promoted autophagy induction 1-2 days after irradiation. In addition, mitochondrial fragmentation became obvious 1-2 days after irradiation, and autophagy was further enhanced. However, Ulk1 levels decreased significantly after 2 days, resulting in lower LC3-II levels. An autophagic flux assay using chloroquine (CQ) also revealed that the flux in irradiated cells gradually decreased over 30 days. In contrast, lysosomal augmentation started at 1 day, became significantly upregulated after 5 days, and continued for over 30 days. After a rapid decrease in autophagy, p16 expression increased and senescence was established, but autophagic activity remained reduced. These results demonstrated that X-ray irradiation triggered two processes, autophagy and senescence, with the former being temporary and regulated by DNA damage response and mitophagy, and the latter being sustained and regulated by persistent cell cycle arrest. The interplay between autophagy and senescence seems to be essential for the proper implementation of the cellular response to radiation exposure.
Radiation research, 30 Oct. 2023, [Reviewed] - First-principles simulation of an ejected electron produced by monochromatic deposition energy to water at the femtosecond order.
Takeshi Kai; Tomohiro Toigawa; Yusuke Matsuya; Yuho Hirata; Tomoya Tezuka; Hidetsugu Tsuchida; Akinari Yokoya, Last, This study uses a time-dependent first-principles simulation code to investigate the transient dynamics of an ejected electron produced in the monochromatic deposition energy from 11 to 19 eV in water. The energy deposition forms a three-body single spur comprising a hydroxyl radical (OH˙), hydronium ion (H3O+), and hydrated electron (eaq-). The earliest formation involves electron thermalization and delocalization dominated by the molecular excitation of water. Our simulation results show that the transient electron dynamics primarily depends on the amount of deposition energy to water; the thermalization time varies from 200 to 500 fs, and the delocalization varies from 3 to 10 nm in this energy range. These features are crucial for determining the earliest single-spur formation and facilitating a sequential simulation from an energy deposition to a chemical reaction in water photolysis or radiolysis. The spur radius obtained from the simulation correlates reasonably with the experimental-based estimations. Our results should provide universalistic insights for analysing ultrafast phenomena dominated by the molecular excitation of water in the femtosecond order.
RSC advances, 29 Oct. 2023, [Reviewed] - Quantum processes of radiation damage to DNA and exploring of its repair susceptibility
横谷明徳, Lead, (株)北隆館
Bio Clinica, Aug. 2023, [Invited] - X-ray irradiation-induced ligand cleavage of a phthalocyanine derivative, tin (IV) phthalocyanine dichloride: A potential for X-ray activation of caged compounds
Yudai Izumi; Maki Ohara; Kentaro Fujii; Akinari Yokoya; Mikako Ogawa
Chemical Physics Letters, Jul. 2023, [Reviewed] - 〔Major achievements〕Incorporation of a bromine atom into DNA-related molecules changes their electronic properties.
Misaki Hirato; Akinari Yokoya; Yuji Baba; Seiji Mori; Kentaro Fujii; Shin-Ichi Wada; Yudai Izumi; Yoshinori Haga, Corresponding, To understand the mechanism underlying the high radio-sensitisation of living cells possessing brominated genomic DNA, X-ray photoelectron spectroscopy (XPS) using synchrotron X-rays with energies of 2000 or 2500 eV was used to study brominated and nonbrominated nucleobases, nucleosides and nucleotides. The bromine atom significantly reduced the energy gap between the valence and conduction states, although the core level states were not greatly affected. This finding was supported by quantum chemical calculation for the nucleobases and nucleosides. Our findings strongly indicate that the energy gaps between the valence and conduction levels of the molecules are significantly reduced by bromination. Furthermore, the brominated molecules are more likely to produce inelastic scattering low energy electrons upon exposure to 2000 or 3000 eV X-rays. This modification of electronic properties around the brominated group may both facilitate electron transfer to the brominated site in DNA and increase the probability of reaction with low energy electrons. These processes can induce DNA damage, presumably resulting in debromination of the uracil moiety and a subsequent cytotoxic effect.
Physical chemistry chemical physics : PCCP, 31 May 2023, [Reviewed] - Structural study of wild-type and phospho-mimic XRCC4 dimer and multimer proteins using circular dichroism spectroscopy.
Kai Nishikubo; Maho Hasegawa; Yudai Izumi; Kentaro Fujii; Koichi Matsuo; Yoshihisa Matsumoto; Akinari Yokoya, Last, PURPOSE: To investigate the structural features of wild-type and phospho-mimicking mutated XRCC4 protein, a protein involved in DNA double-strand break repair. MATERIALS AND METHODS: XRCC4 with a HisTag were expressed by E. coli harboring plasmid DNA and purified. Phospho-mimicking mutants in which one phosphorylation site was replaced with aspartic acid were also prepared in order to reproduce the negative charge resulting from phosphorylation. The proteins were separated into dimers and multimers by gel filtration chromatography. Circular dichroism (CD) spectroscopy was performed in the region from ultraviolet to vacuum-ultraviolet. The CD spectra were analyzed with two analysis programs to evaluate the secondary structures of the wild-type and phospho-mimicked dimers and multimers. RESULT AND DISCUSSION: The proportion of β-strand in the wild-type dimers was very low, particularly in their C-terminal region, including the five phosphorylation sites. The secondary structure of the phospho-mimic hardly changed from the monomeric to dimeric forms. In contrast, the β-strand content increased and the α-helix content decreased upon multimerization of the wild-type protein. The structural change of multimers slightly depended on the phospho-mimic site. These results suggest that the β-strand structure stabilizes the multimerization of XRCC4 and it is regulated by phosphorylation at the C-terminal site in living cells. CONCLUSION: An increase in the β-strand content in XRCC4 is essential for stabilization of the multimeric form through C-terminal phosphorylation, allowing formation of the large double-strand break repair machinery.
International journal of radiation biology, 12 May 2023, [Reviewed] - Nature of the physicochemical process in water photolysis uncovered by a computer simulation.
Takeshi Kai; Tomohiro Toigawa; Masatoshi Ukai; Kentaro Fujii; Ritsuko Watanabe; Akinari Yokoya, Last, In this work, we investigate the physicochemical process of water photolysis to bridge physical and chemical processes by a newly developed first-principles calculation code. The deceleration, thermalization, delocalization, and initial hydration of the extremely low-energy electrons ejected by water photolysis are sequentially tracked in the condensed phase. We show herein the calculated results for these sequential phenomena during 300 fs. Our results indicate that the mechanisms heavily depend on the intermolecular vibration and rotation modes peculiar to water and the momentum transfer between the electrons and the water medium. We suggest that using our results for the delocalized electron distribution will reproduce successive chemical reactions measured by photolysis experiments using a chemical reaction code. We expect our approach to become a powerful technique for various scientific fields related to water photolysis and radiolysis.
The Journal of chemical physics, 28 Apr. 2023, [Reviewed] - Secondary structural analyses of histone H2A-H2B proteins extracted from heated cells.
Yudai Izumi; Koichi Matsuo; Akinari Yokoya, Last, Histone proteins, building blocks of chromatins, participate in enzymatic reactions in cells heated at around 45°C though in vitro the denaturation of histones significantly proceeds at a similar temperature. It implies that unidentified mechanisms prevent thermal denaturation of histones in vivo. However, studies on the histone structures in the heated cells have been scarce. Here, we analyzed the secondary structures of histone H2A-H2B proteins originating from the heated cells using circular dichroism spectroscopy. The secondary structure contents of the H2A-H2B extracted from the heated cells differed from those of H2A-H2B both native and denatured in vitro but reverted to the native structures by incubating the heated cells at 37°C within 2 h. Such structural flexibility may play a role in protecting genomic functions governed by chromatin structures from heat stresses.
Chirality, Mar. 2023, [Reviewed] - Initial yield of hydrated electron production from water radiolysis based on first-principles calculation
Takeshi Kai; Tomohiro Toigawa; Yusuke Matsuya; Yuho Hirata; Tomoya Tezuka; Hidetsugu Tsuchida; Akinari Yokoya, Last, For water radiolysis, conventional simulation methods estimate free radical yields based on the cross-sections. Our results indicated that electron dynamic motion must be further solved to predict the initial yields of hydrated electrons., Royal Society of Chemistry (RSC)
RSC Advances, Feb. 2023, [Reviewed] - Mitochondrial Metabolism in X-Irradiated Cells Undergoing Irreversible Cell-Cycle Arrest.
Eri Hirose; Miho Noguchi; Tomokazu Ihara; Akinari Yokoya, Last, Irreversible cell-cycle-arrested cells not undergoing cell divisions have been thought to be metabolically less active because of the unnecessary consumption of energy for cell division. On the other hand, they might be actively involved in the tissue microenvironment through an inflammatory response. In this study, we examined the mitochondria-dependent metabolism in human cells irreversibly arrested in response to ionizing radiation to confirm this possibility. Human primary WI-38 fibroblast cells and the BJ-5ta fibroblast-like cell line were exposed to 20 Gy X-rays and cultured for up to 9 days after irradiation. The mitochondrial morphology and membrane potential were evaluated in the cells using the mitochondrial-specific fluorescent reagents MitoTracker Green (MTG) and 5,5',6,6'-tetraethyl-benzimidazolylcarbocyanine iodide (JC-1), respectively. The ratio of the mean MTG-stained total mitochondrial area per unit cell area decreased for up to 9 days after X-irradiation. The fraction of the high mitochondrial membrane potential area visualized by JC-1 staining reached its minimum 2 days after irradiation and then increased (particularly, WI-38 cells increased 1.8-fold the value of the control). Their chronological changes indicate that the mitochondrial volume in the irreversible cell-cycle-arrested cells showed significant increase concurrently with cellular volume expansion, indicating that the mitochondria-dependent energy metabolism was still active. These results indicate that the energy metabolism in X-ray-induced senescent-like cells is active compared to nonirradiated normal cells, even though they do not undergo cell divisions.
International journal of molecular sciences, 17 Jan. 2023, [Reviewed] - Analysis of differentially expressed genes on human X chromosome harboring large deletion induced by X-rays.
Eri Hirose; Akinari Yokoya; Kasumi Kawamura; Keiji Suzuki, We examined here normal human cells with large deletions encompassing the hypoxanthine-phosphoribosyltransferase 1 (HPRT1) gene on X chromosome. Expression levels of genes on X chromosome were analyzed by microarray and RT-qPCR method, and differentially expressed genes (DEGs) were extracted. We found that DEGs were not limited to the genes flanking deleted regions but spread over the entire X chromosome. Interestingly, the gene regulation patterns were similar to a large extent among independent clones that have similar-sized large deletions involving the HPRT1 gene. Thus, it is indicated that an impact of large deletion on possible epigenetic transcriptional regulation is not limited to the regions proximal to the deletion region.
Journal of radiation research, 06 Jan. 2023, [Reviewed] - Core level ionization or excitation and Auger relaxation induce clustered DNA damage.
Akinari Yokoya; Yui Obata, Lead, Ionizing radiation causes various types of DNA damage, such as single- (SSBs) and double-strand breaks (DSBs), nucleobase lesions, abasic sites (AP sites), and cross-linking between complementary strands of DNA or DNA and proteins. DSBs are among the most harmful type of DNA damage, inducing serious genetic effects such as cell lethality and mutation. Nucleobase lesions and AP sites, on the other hand, may be less deleterious and are promptly repaired by base excision repair (BER) pathways. Recently, biochemical approaches to quantify nucleobase lesions and AP sites have revealed certain types of non-strand break lesions as harmful DNA damage, called clustered DNA damage. Such clusters can retard nucleobase excision repair enzymes, and can sometimes be converted to DSBs by BER catalysis. This unique character of clustered DNA damage strongly depends on the spatial density of ionization or excitation events occurring at the track end of initial radiation or low energy secondary electrons. In particular, the photoelectric effect of elements comprising biological molecules, followed by emission of Auger electrons, are key factors in determining the future fate of each clustered damage site. This chapter describes biological studies of clustered nucleobase lesions with SSBs or AP sites, and mechanistical studies on core level excitation and Auger relaxation giving rise to clustered DNA damage.
The Enzymes, 07 Oct. 2022, [Reviewed], [Invited] - X-ray photoelectron spectroscopy of Thymine and 5-Bromouracil studied by Symmetry-Adapted-Cluster Configuration-Interaction (SAC-CI) theory
Yusaku I. Kurokawa; Hiroshi Nakatsuji; Misaki Hirato; Akinari Yokoya, Last, Elsevier BV
Chemical Physics Letters, Oct. 2022, [Reviewed] - Establishment of a Method for Investigating Direct and Indirect Actions of Ionizing Radiation Using Scavenger-free Plasmid DNA.
Hao Yu; Yusuke Kondo; Kentaro Fujii; Akinari Yokoya; Shinichi Yamashita, In this study, an improved method using scavenger-free plasmid DNA was established to accurately determine yields of DNA damage induced by direct and indirect actions of ionizing radiation. The scavenger-free plasmid DNA was obtained by dialysis over 5-7 days, and the DNA solvent was replaced with phosphate buffer to completely remove impurities, which could be scavengers of radicals produced as a result of water radiolysis. DNA samples of films and dilute aqueous solutions were used to separately evaluate contributions of the direct and indirect actions of X rays (150-160 kVp). The irradiated DNA was analyzed by agarose gel electrophoresis to quantify strand-break yields. The yields of single-strand breaks (SSBs), n(SSB), were determined to be (6.5 ± 2.0) × 10-10 and (3.1 ± 0.9) × 10-7 SSBs/Gy/Da for the film and solution samples, respectively, showing a significant contribution of hydroxyl radicals (•OH) compared with direct energy depositions from ionizing radiation to DNA. As observed in SSBs, the yields of double-strand breaks (DSBs), n(DSB), were (5.6 ± 1.1) × 10-11 and (1.3 ± 0.2) × 10-8 DSBs/Gy/Da for the film and solution samples, respectively. The yield ratio of DSBs to SSBs, that is, n(DSB)/n(SSB), was 0.091 ± 0.026 for the film samples, while it was much lower for the solution samples (0.045 ± 0.010), indicating that direct actions result in more localized strand breaks relative to indirect actions. Base excision repair enzymes, namely, endonuclease III (Nth) and formamidopyrimidine-DNA glycosylase (Fpg), were utilized after irradiations to convert base lesions and apurinic/apyrimidinic (AP) sites into strand breaks. The amounts of Nth and Fpg for the conversion were optimized to a few units per µg of DNA, although the optimal concentrations can differ among conditions.
Radiation Research, 01 Jun. 2022, [Reviewed] - Molecular Interactions of Normal and Irradiated Tubulins During Polymerization
Hisanori Fukunaga; Yuka Kimura; Ami Suzuki; Yuki Kawabata; Akinari Yokoya, Last, Microtubules, one of the cytoskeletons, are highly dynamic structures that play a variety of roles in maintaining cell morphology, cell division and intracellular transport. Microtubules are composed of heterodimers of α- and β-tubulins, which are repeatedly polymerized and depolymerized. To investigate the radiation-induced impacts on the polymerization reaction of tubulins, we evaluated the molecular interactions between normal and irradiated tubulins. First, the polymerization reaction of the tubulins was measured after stepwise irradiation from 0 Gy to 1,000 Gy of X rays. The polymerization was inhibited in a dose-dependent manner. Next, the tubulins' polymerization reaction was then measured after the tubulin that was damaged from the exposure to 1,000 Gy of X rays was mixed with the normal tubulins. Our findings reveal that the radiation dose-dependent change in the degree of overall microtubule polymerization progression depends on the ratio of damaged tubulin. This result is biochemical evidence that non-DNA damage (in this case, cytoskeletal damage) from cytoplasmic radiation exposure may inhibit cell division, suggesting that some cytoskeletal damage may also affect the fate of the entire cell., Radiation Research Society
Radiation Research, 23 May 2022, [Reviewed] - Application of a Mouse Ex Vivo Spermatogenesis Model to Elucidate the Mechanism of Radio- Therapy-Related Male Infertility
Kiichi Kaminaga; Akinari Yokoya; Hisanori Fukunaga, Japan Radioisotope Association
RADIOISOTOPES, 15 Mar. 2022, [Reviewed], [Invited] - A Brief Overview of Radiation-Induced Effects on Spermatogenesis and Oncofertility.
Hisanori Fukunaga; Akinari Yokoya; Kevin M Prise, The genotoxicity of radiation on germ cells may be passed on to the next generation, thus its elucidation is not only a scientific issue but also an ethical, legal, and social issue in modern society. In this article, we briefly overview the effects of radiation on spermatogenesis and its associated genotoxicity, including the latest findings in the field of radiobiology. The potential role of transgenerational effects is still poorly understood, and further research in this area is desirable. Furthermore, from the perspective of oncofertility, we discuss the historical background and clinical importance of preserving male fertility during radiation treatment and the potential of microbeam radiotherapy. We hope that this review will contribute to stimulating further discussions and investigations for therapies for pediatric and adolescent/young adult patients.
Cancers, 04 Feb. 2022, [Reviewed] - No Intercellular Regulation of the Cell Cycle among Human Cervical Carcinoma HeLa Cells Expressing Fluorescent Ubiquitination-Based Cell-Cycle Indicators in Modulated Radiation Fields.
Hisanori Fukunaga; Kiichi Kaminaga; Eri Hirose; Ritsuko Watanabe; Noriko Usami; Kevin M Prise; Akinari Yokoya, Last, The non-targeted effects of radiation have been known to induce significant alternations in cell survival. Although the effects might govern the progression of tumor sites following advanced radiotherapy, the impacts on the intercellular control of the cell cycle following radiation exposure with a modified field, remain to be determined. Recently, a fluorescent ubiquitination-based cell-cycle indicator (FUCCI), which can visualize the cell-cycle phases with fluorescence microscopy in real time, was developed for biological cell research. In this study, we investigated the non-targeted effects on the regulation of the cell cycle of human cervical carcinoma (HeLa) cells with imperfect p53 function that express the FUCCI (HeLa-FUCCI cells). The possible effects on the cell-cycle phases via soluble factors were analyzed following exposure to different field configurations, which were delivered using a 150 kVp X-ray irradiator. In addition, using synchrotron-generated, 5.35 keV monochromatic X-ray microbeams, high-precision 200 μm-slit microbeam irradiation was performed to investigate the possible impacts on the cell-cycle phases via cell-cell contacts. Collectively, we could not detect the intercellular regulation of the cell cycle in HeLa-FUCCI cells, which suggested that the unregulated cell growth was a malignant tumor. Our findings indicated that there was no significant intercellular control system of the cell cycle in malignant tumors during or after radiotherapy, highlighting the differences between normal tissue and tumor characteristics.
International journal of molecular sciences, 26 Nov. 2021, [Reviewed] - 〔Major achievements〕Expression of an X-Ray Irradiated EGFP-Expressing Plasmid Transfected into Nonirradiated Human Cells.
Yui Obata; Hiroki Nakaue; Keishiro Hirasaki; Nobuyoshi Akimitsu; Akinari Yokoya, Last, To investigate the repairability of X-ray induced DNA damage, particularly non-double-strand breaks in living cells, enhanced green fluorescent protein (EGFP)-expressing plasmids X-ray irradiated and then transfected into nonirradiated human cells, MCF7 and MCF10A. Live-cell imaging of EGFP fluorescence was performed to measure the efficiency of plasmid repair in cells. The number of EGFP-expressing cells significantly decreased with increasing X-ray dose for both cell lines. The obtained kinetic curves of EGFP expression indicating plasmid repair were quantitatively compared against algebraically calculated ones based on the values of the transfected plasmids that had been treated with nicking or restriction enzymes. Then, assuming a Poisson distribution of single-strand breaks (SSBs), the number of cells carrying these nicked plasmids that could express EGFP were estimated. Our experimental results revealed considerably fewer cells expressing EGFP compared to the expected values we had calculated. These results suggest that the lower proportion of cells expressing EGFP as a measure of plasmid repair was due not only to the complex chemical structures of termini created by SSBs compared to those created by enzyme treatments, but also that base lesions or AP sites proximately arising at the strand-break termini might compromise EGFP expression. These results emphasize that radiation-induced DNA breaks are less repairable than enzymatically induced DNA breaks, which is not apparent when using conventional gel electrophoresis assays of plasmid DNA.
Radiation research, 01 Sep. 2021, [Reviewed] - 〔Major achievements〕X-ray induced luminescence spectroscopy for DNA damaging intermediates aided by a monochromatic synchrotron radiation
Yusaku Terao; Yoshiaki Kumagai; Issei Suzuki; Takahiro Tsuchiya; Masatoshi Ukai; Akinari Yokoya; Kentaro Fujii; Yoshihiro Fukuda; Yuji Saitoh, Informa UK Limited
International Journal of Radiation Biology, 23 Aug. 2021, [Reviewed] - 〔Major achievements〕Molecular Configuration of Human Genome Neighboring Megabase-Sized Large Deletions Induced by X-Ray Irradiation.
Eri Hirose; Keiji Suzuki; Akinari Yokoya, Last, The genomic landscape neighboring large deletions including the hypoxanthine-guanine phosphoribosyl transferase (HPRT) locus on human X chromosome in 6-thioguanine-resistant mutants originating from immortalized human fibroblast cells exposed to X rays was characterized by real-time quantitative PCR (qPCR)-based analyses. Among the 13 mutant clones with large deletions extending over several Mb, including the HPRT locus, revealed by 10 conventional sequence-tagged site (STS) markers, three clones bearing the largest deletions were selected for further qPCR analysis using another 21 STS markers and 15 newly designed PCR primer pairs. The results indicated that the major deletions were in very specific regions between the 130-Mb and 140-Mb positions containing the HPRT locus on the X chromosome and, contrary to our initial expectations, additional minor deletions were distributed in a patchwork pattern. These findings strongly indicate that the complex deletion patterns in the affected chromosome are related to the radiation track structure with spatially heterogeneous energy deposition and the specific structure of the chromatin-nuclear membrane complex. The uncovered complex deletion patterns are in agreement with the idea of complex chromatin damage, which is frequently associated with carcinogenesis.
Radiation research, 01 Jun. 2021, [Reviewed] - 〔Major achievements〕Targeted Nuclear Irradiation with an X-Ray Microbeam Enhances Total JC-1 Fluorescence from Mitochondria
Kiichi Kaminaga; Ryo Hamada; Noriko Usami; Keiji Suzuki; Akinari Yokoya, Last, Several studies have demonstrated that mitochondria are critically involved in the pleiotropic manifestation of radiation effects. While conventional whole-cell irradiation compromises the function of mitochondria, the effects of subcellular targeted radiation are not yet fully understood. In this study, normal human diploid cells with cell-cycle indicators were irradiated using a synchrotron X-ray microbeam, and mitochondrial membrane potential was quantified by JC-1 over the 72-h period postirradiation. Cytoplasmic irradiation was observed to temporarily enlarge the mitochondrial area with high membrane potential, while the total mitochondrial area did not change significantly. Unexpectedly, cell-nucleus irradiation promoted a similar increase not only in the mitochondrial areas with high membrane potential, but also in those with low membrane potential, which gave rise to the apparent increase in the total mitochondrial area. Augmentation of the mitochondrial area with low membrane potential was predominantly observed among G1 cells, suggesting that nucleus irradiation during the G1 phase regulated the mitochondrial dynamics of the cytoplasm, presumably through DNA damage in the nucleus., Radiation Research Society
Radiation Research, 12 Oct. 2020, [Reviewed] - Spatially Fractionated Microbeam Analysis of Tissue-sparing Effect for Spermatogenesis
Hisanori Fukunaga; Kiichi Kaminaga; Takuya Sato; Karl T. Butterworth; Ritsuko Watanabe; Noriko Usami; Takehiko Ogawa; Akinari Yokoya; Kevin M. Prise, Spatially fractionated radiation therapy (SFRT) has been based on the delivery of a single high-dose fraction to a large treatment area that has been divided into several smaller fields, reducing the overall toxicity and adverse effects. Complementary microbeam studies have also shown an effective tissue-sparing effect (TSE) in various tissue types and species after spatially fractionated irradiation at the microscale level; however, the underlying biological mechanism remains elusive. In the current study, using the combination of an ex vivo mouse spermatogenesis model and high-precision X-ray microbeams, we revealed the significant TSE for maintaining spermatogenesis after spatially fractionated microbeam irradiation. We used the following ratios of the irradiated to nonirradiated areas: 50:50, 150:50 and 350:50 µm-slit, where approximately 50, 75 and 87.5% of the sample was irradiated (using center-to-center distances of 100, 200 and 400 µm, respectively). We found that the 50 and 75% micro-slit irradiated testicular tissues showed an almost unadulterated TSE for spermatogenesis, whereas the 87.5% micro-slit irradiated tissues showed an incomplete TSE. This suggests that the TSE efficiency for spermatogenesis is dependent on the size of the nonirradiated spermatogonial stem cell pool in the irradiated testicular tissues. In addition, there would be a spatiotemporal limitation of stem cell migration/competition, resulting in the insufficient TSE for 87.5% micro-slit irradiated tissues. These stem cell characteristics are essential for the accurate prediction of tissue-level responses during or after SFRT, indicating the clinical potential for achieving better outcomes while preventing adverse effects., Radiation Research Society
Radiation Research, 19 Aug. 2020, [Reviewed] - 〔Major achievements〕Electronic properties of DNA-related molecules containing a bromine atom
Misaki Hirato; Misato Onizawa; Yuji Baba; Yoshinori Haga; Kentaro Fujii; Shin-ichi Wada; Akinari Yokoya, Last, Informa UK Limited
International Journal of Radiation Biology, 12 Aug. 2020, [Reviewed] - Radiation Tissue Biology with Microbeams and Tissue Cultures as an Interface of Health Physics and Radiobiology
Hisanori FUKUNAGA; Akinari YOKOYA, *Japanese, Japan Health Physics Society
Japanese Journal of Health Physics, 20 Jul. 2020, [Reviewed] - The Tissue-Sparing Effect of Spatially Fractionated X-rays for Maintaining Spermatogenesis: A Radiobiological Approach for the Preservation of Male Fertility after Radiotherapy.
Hisanori Fukunaga; Kiichi Kaminaga; Takuya Sato; Ritsuko Watanabe; Takehiko Ogawa; Akinari Yokoya; Kevin M Prise, Radiotherapy can result in temporary or permanent gonadal toxicity in male cancer patients despite the high precision and accuracy of modern radiation treatment techniques. Previous radiobiological studies have shown an effective tissue-sparing response in various tissue types and species following exposure to spatially fractionated radiation. In the present study, we used an ex vivo mouse testicular tissue culture model and a conventional X-ray irradiation device to evaluate the tissue-sparing effect (TSE) of spatially fractionated X-rays for the protection of male fertility from radiotherapy-related adverse effects. We revealed a significant TSE for maintaining spermatogenesis in the ex vivo testes model following spatially fractionated X-ray irradiation. Moreover, we experimentally propose a possible mechanism by which the migration of spermatogonial cells, from the non-irradiated areas to the irradiated ones, in irradiated testicular tissue, is essential for the TSE and maintaining spermatogenesis. Therefore, our findings demonstrate that the control of TSE following spatially fractionated X-rays in the testes has a considerable potential for clinical application. Interdisciplinary research will be essential for further expanding the applicability of this method as an approach for the preservation of male fertility during or after radiotherapy.
Journal of clinical medicine, 11 Apr. 2020, [Reviewed] - 〔Major achievements〕Targeting Specific Sites in Biological Systems with Synchrotron X-Ray Microbeams for Radiobiological Studies at the Photon Factory
Akinari Yokoya; Noriko Usami, Lead
Quantum Beam Science, 09 Jan. 2020, [Reviewed] - 〔Major achievements〕Ab Initio Molecular Dynamics Simulations to Interpret the Molecular Fragmentation Induced in Deoxyribose by Synchrotron Soft X-Rays
Marie-Anne Hervé du Penhoat; Anis Hamila; Marie-Pierre Gaigeot; Rodolphe Vuilleumier; Kentaro Fujii; Akinari Yokoya; Marie-Françoise Politis, It has been suggested that core ionization in DNA atoms could induce complex, irreparable damage. Synchrotron soft X-rays have been used to probe the damage induced by such events in thin films of DNA components. In a complementary approach, we investigate the fragmentation dynamics following a carbon or oxygen K-shell ionization in 2-deoxy-D-ribose (DR), a major component in the DNA chain. Core ionization of the sugars hydration layer is also studied. To that aim, we use state-of-the-art ab initio Density Functional Theory-based Molecular Dynamics (MD) simulations. The ultrafast dissociation dynamics of the core ionized molecule, prior Auger decay, is modeled for about 10 fs. We show that the core-ionization of oxygen atoms within DR or its hydration layer may induce proton transfers towards nearby molecules, before Auger decay. In a second step, we model an Auger effect occurring either at the beginning or at the end of the core–hole dynamics. Two electrons are removed from the deepest valence molecular orbitals localized on the initially core-ionized oxygen atom (O*), and this electronic state is propagated by means of Ehrenfest MD. We show an ultrafast dissociation of the DR2+ molecule C-O* bonds, which, in most cases, seems independent of the time at which Auger decay occurs., MDPI AG
Quantum Beam Science, 10 Dec. 2019, [Reviewed] - 〔Major achievements〕High-precision microbeam radiotherapy reveals testicular tissue-sparing effects for male fertility preservation
Fukunaga Hisanori; Kaminaga Kiichi; Sato Takuya; Butterworth Karl T; Watanabe Ritsuko; Usami Noriko; Ogawa Takehiko; Yokoya Akinari; Prise Kevin M, Corresponding
SCIENTIFIC REPORTS, 01 Oct. 2019, [Reviewed] - VISUALIZATION OF THE DNA REPAIR PROCESS IN MAMMALIAN CELLS TRANSFECTED WITH EGFP-EXPRESSING PLASMID DNA AFTER EXPOSURE TO X-RAYS IN VITRO
Hiroki Nakaue; Yui Obata; Kiichi Kaminaga; Nobuyoshi Akimitsu; Akinari Yokoya, Last
Radiation Protection Dosimetry, 01 May 2019, [Reviewed] - NOVEL ANALYTICAL STUDY FOR REACTION INTERMEDIATES IN THE PRIMARY RADIATION INTERACTION OF DNA USING A SYNCHROTRON RADIATION-INDUCED LUMINESCENCE SPECTROSCOPY
T Kojima; H Aihara; Y Kodashima; H Makishima; S Nakiri; S Takada; H Shimada; M Ukai; C Ozga; X Holzapfel; Ph Schmidt; C Küstner-Wetekam; H Otto; D Bloβ; A Knie; A Ehresmann; A Yokoya; K Fujii; Y Fukuda; Y Saitoh
Radiation Protection Dosimetry, 01 May 2019, [Reviewed] - STRUCTURAL ANALYSIS OF DNA REPAIR PROTEIN XRCC4 APPLYING CIRCULAR DICHROISM IN AN AQUEOUS SOLUTION
Kai Nishikubo; Yudai Izumi; Yoshihisa Matsumoto; Kentaro Fujii; Koichi Matsuo; Akinari Yokoya, Last
Radiation Protection Dosimetry, 01 May 2019, [Reviewed] - MITOCHONDRIAL MEMBRANE POTENTIAL, MORPHOLOGY AND ATP PRODUCTION IN MAMMALIAN CELLS EXPOSED TO X-RAYS
R Hamada; K Kaminaga; K Suzuki; A Yokoya, Last
Radiation Protection Dosimetry, 01 May 2019, [Reviewed] - Precision Radiotherapy and Radiation Risk Assessment: How Do We Overcome Radiogenomic Diversity?
Fukunaga Hisanori; Yokoya Akinari; Taki Yasuyuki; Butterworth Karl T; Prise Kevin M
TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE, Apr. 2019, [Reviewed] - XANES Spectral Changes of Hydrated Deoxyribose Induced by K-Shell Ionization of Oxygen
Fujii Kentaro; Yokoya Akinari
13TH INTERNATIONAL CONFERENCE ON SYNCHROTRON RADIATION INSTRUMENTATION (SRI2018), 2019, [Reviewed] - 〔Major achievements〕Substituent effect on the yield of unpaired electrons in DNA bases studied by electron paramagnetic resonance
Oka Toshitaka; Yokoya Akinari; Fujii Kentaro; Kino Yasushi; Sekine Tsutomu
APPLIED PHYSICS LETTERS, 10 Dec. 2018, [Reviewed] - 〔Major achievements〕Application of an Ex Vivo Tissue Model to Investigate Radiobiological Effects on Spermatogenesis
Hisanori Fukunaga; Kiichi Kaminaga; Takuya Sato; Noriko Usami; Ritsuko Watanabe; Karl T. Butterworth; Takehiko Ogawa; Akinari Yokoya; Kevin M. Prise, Corresponding
Radiation Research, 01 Jun. 2018, [Reviewed] - 〔Major achievements〕Roles of Hydration for Inducing Decomposition of 2-Deoxy-d-ribose by Ionization of Oxygen K-Shell Electrons
Kentaro Fujii; Yudai Izumi; Ayumi Narita; Krishna Kamol Ghose; Pablo López-Tarifa; Alain Touati; Riccardo Spezia; Rodolphe Vuilleumier; Marie-Pierre Gaigeot; Marie-Françoise Politis; Marie-Anne Hervé Du Penhoat; Akinari Yokoya
Radiation Research, 01 Mar. 2018, [Reviewed] - 〔Major achievements〕Circular dichroism spectroscopic study on structural alterations of histones induced by post-translational modifications in DNA damage responses: lysine-9 methylation of H3
Yudai Izumi; Koichi Matsuo; Kentaro Fujii; Akinari Yokoya; Masaki Taniguchi; Hirofumi Namatame
Journal of Radiation Research, 01 Mar. 2018, [Reviewed] - Recent progress of radiation physicochemical process (third part)
甲斐健師; 横谷明徳; 藤井健太郎; 渡邊立子
放射線化学(Web), 2018 - 〔Major achievements〕A significant role of non-thermal equilibrated electrons in the formation of deleterious complex DNA damage
Takeshi Kai; Akinari Yokoya; Masatoshi Ukai; Kentaro Fujii; Tomohiro Toigawa; Ritsuko Watanabe
Physical Chemistry Chemical Physics, 2018, [Reviewed] - Radiobiological Implications of Fukushima Nuclear Accident for Personalized Medical Approach
Hisanori Fukunaga; Akinari Yokoya; Yasuyuki Taki; Kevin M. Prise
TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE, May 2017, [Reviewed] - Reactivity of an antioxidant, edaravone, with reactive oxygen species and its chemical repair properties against oxidative damage on DNA
端邦樹; LIN Mingzhang; 横谷明徳; 藤井健太郎; 山下真一; 室屋裕佐; 勝村庸介
放射線化学(Web), Apr. 2017, [Reviewed] - Efficiency of radiation-induced base lesion excision and the order of enzymatic treatment
Iyo Shiraishi; Naoya Shikazono; Masao Suzuki; Kentaro Fujii; Akinari Yokoya, Corresponding
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, Mar. 2017, [Reviewed] - Dynamic behavior of secondary electrons produced by a high-energy electron in liquid water
甲斐健師; 横谷明徳; 藤井健太郎; 渡邊立子
陽電子科学, 2017 - 〔Major achievements〕DNA damage response induces structural alterations in histone H3-H4
Yudai Izumi; Kentaro Fujii; Satoshi Yamamoto; Koichi Matsuo; Hirofumi Namatame; Masaki Taniguchi; Akinari Yokoya
JOURNAL OF RADIATION RESEARCH, Jan. 2017, [Reviewed] - 〔Major achievements〕Photon-induced Auger effect in biological systems: a review
Akinari Yokoya; Takashi Ito, Lead
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 2017, [Reviewed] - Low-dose radiation-induced risk in spermatogenesis
Hisanori Fukunaga; Karl T. Butterworth; Akinari Yokoya; Takehiko Ogawa; Kevin M. Prise
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 2017, [Reviewed] - The 8th Auger Symposium: Preface
Akinari Yokoya, Lead
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, Nov. 2016, [Reviewed], [Invited] - Enhancement of DNA double-strand break induction and cell killing by K-shell absorption of phosphorus in human cell lines
Masanori Tomita; Munetoshi Maeda; Noriko Usami; Akinari Yokoya; Ritsuko Watanabe; Katsumi Kobayashi
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, Nov. 2016, [Reviewed] - Deceleration processes of secondary electrons produced by a high-energy Auger electron in a biological context
Takeshi Kai; Akinari Yokoya; Masatoshi Ukai; Kentaro Fujii; Ritsuko Watanabe
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, Nov. 2016, [Reviewed] - Cell cycle tracking for irradiated and unirradiated bystander cells in a single colony with exposure to a soft X-ray microbeam
Kiichi Kaminaga; Miho Noguchi; Ayumi Narita; Yuya Hattori; Noriko Usami; Akinari Yokoya, Corresponding
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, Nov. 2016, [Reviewed] - Now Is the Time to Consider Personalized Effective Dose
Hisanori Fukunaga; Akinari Yokoya; Yasuyuki Taki
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, Oct. 2016, [Reviewed] - 〔Major achievements〕Dynamic Behavior of Secondary Electrons in Liquid Water at the Earliest Stage upon Irradiation: Implications for DNA Damage Localization Mechanism
Takeshi Kai; Akinari Yokoya; Masatoshi Ukai; Kentaro Fujii; Ritsuko Watanabe
JOURNAL OF PHYSICAL CHEMISTRY A, Oct. 2016, [Reviewed] - 〔Major achievements〕Structure Change from beta-Strand and Turn to alpha-Helix in Histone H2A-H2B Induced by DNA Damage Response
Yudai Izumi; Kentaro Fujii; Frank Wien; Chantal Houee-Levin; Sandrine Lacombe; Daniela Salado-Leza; Erika Porcel; Rawand Masoud; Satoshi Yamamoto; Matthieu Refregiers; Marie-Anne Herve du Penhoat; Akinari Yokoya
BIOPHYSICAL JOURNAL, Jul. 2016, [Reviewed] - Ultraviolet circular dichroism spectroscopy for protein structural study
Izumi, Yudai; Yamamoto, Satoshi; Fujii, Kentaro; Yokoya, Akinari, Last
Radiation Biology Research Communications, Mar. 2016, [Reviewed], [Invited] - Recent progress of radiation physicochemical process (first part)
甲斐健師; 横谷明徳; 藤井健太郎; 渡邊立子
放射線化学(Web), 2016 - Recent progress of radiation physicochemical process (second part)
甲斐健師; 横谷明徳; 藤井健太郎; 渡邊立子
放射線化学(Web), 2016 - A Spectroscopic Study for the Radiation Damage to Bio-Molecules under the Water Solution
島田紘行; 横谷明徳; 鵜飼正敏
日本物理学会誌, 2016, [Reviewed], [Invited] - 〔Major achievements〕Low-dose radiation risk and individual variation in radiation sensitivity in Fukushima
Hisanori Fukunaga; Akinari Yokoya
JOURNAL OF RADIATION RESEARCH, Jan. 2016, [Reviewed] - 〔Major achievements〕Cellular automaton-based model for radiation-induced bystander effects
Yuya Hattori; Akinari Yokoya; Ritsuko Watanabe
BMC SYSTEMS BIOLOGY, Dec. 2015, [Reviewed] - 〔Major achievements〕Secondary Structure Alterations of Histones H2A and H2B in X-Irradiated Human Cancer Cells: Altered Histones Persist in Cells for at Least 24 Hours
Yudai Izumi; Satoshi Yamamoto; Kentaro Fujii; Akinari Yokoya
RADIATION RESEARCH, Nov. 2015, [Reviewed] - Thermal equilibrium and prehydration processes of electrons injected into liquid water calculated by dynamic Monte Carlo method
Takeshi Kai; Akinari Yokoya; Masatoshi Ukai; Kentaro Fujii; Ritsuko Watanabe
RADIATION PHYSICS AND CHEMISTRY, Oct. 2015, [Reviewed] - Real-time observation of irradiated HeLa-cell modified by fluorescent ubiquitination-based cell-cycle indicator using synchrotron X-ray microbeam
A. Narita; K. Kaminaga; A. Yokoya; M. Noguchi; K. Kobayashi; N. Usami; K. Fujii
RADIATION PROTECTION DOSIMETRY, Sep. 2015, [Reviewed] - Visualisation of cell cycle modifications by X-ray irradiation of single HeLa cells using fluorescent ubiquitination-based cell cycle indicators
K. Kaminaga; M. Noguchi; A. Narita; Y. Sakamoto; Y. Kanari; A. Yokoya, Corresponding
RADIATION PROTECTION DOSIMETRY, Sep. 2015, [Reviewed] - A mathematical model of radiation-induced responses in a cellular population including cell-to-cell communications
Yuya Hattori; Michiyo Suzuki; Tomoo Funayama; Yasuhiko Kobayashi; Akinari Yokoya; Ritsuko Watanabe
RADIATION PROTECTION DOSIMETRY, Sep. 2015, [Reviewed] - LIVE-CELL IMAGING STUDY OF MITOCHONDRIAL MORPHOLOGY IN MAMMALIAN CELLS EXPOSED TO X-RAYS
M. Noguchi; Y. Kanari; A. Yokoya; A. Narita; K. Fujii
RADIATION PROTECTION DOSIMETRY, Sep. 2015, [Reviewed] - 〔Major achievements〕Nitrogen K-edge x-ray absorption near edge structure of pyrimidine-containing nucleotides in aqueous solution
Hiroyuki Shimada; Hirotake Minami; Naoto Okuizumi; Ichiro Sakuma; Masatoshi Ukai; Kentaro Fujii; Akinari Yokoya; Yoshihiro Fukuda; Yuji Saitoh
JOURNAL OF CHEMICAL PHYSICS, May 2015, [Reviewed] - Cross sections, stopping powers, and energy loss rates for rotational and phonon excitation processes in liquid water by electron impact
Takeshi Kai; Akinari Yokoya; Masatoshi Ukai; Ritsuko Watanabe
RADIATION PHYSICS AND CHEMISTRY, Mar. 2015, [Reviewed] - 〔Major achievements〕Investigation of the fragmentation of core-ionised deoxyribose: a study as a function of the tautomeric form
Marie-Anne Herve du Penhoat; Krishna Kamol Ghose; Marie-Pierre Gaigeot; Rodolphe Vuilleumier; Kentaro Fujii; Akinari Yokoya; Marie-Francoise Politis
PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 2015, [Reviewed] - 〔Major achievements〕Live-cell imaging study of radiation effect on cell cycles of three-dimensional cultured cells exposed to synchrotron soft X-ray microbeam
Sakamoto, Y; Kaminaga, K; Kanari, Y; Usami, N; Noguchi, M; Yokoya, A, Last
乳癌基礎研究, 2015, [Reviewed] - 〔Major achievements〕Chemical repair activity of free radical scavenger edaravone: reduction reactions with dGMP hydroxyl radical adducts and suppression of base lesions and AP sites on irradiated plasmid DNA
Kuniki Hata; Ayumi Urushibara; Shinichi Yamashita; Mingzhang Lin; Yusa Muroya; Naoya Shikazono; Akinari Yokoya; Haiying Fu; Yosuke Katsumura
JOURNAL OF RADIATION RESEARCH, Jan. 2015, [Reviewed] - Dynamics of low-energy electrons in liquid water with consideration of Coulomb interaction with positively charged water molecules induced by electron collision
Takeshi Kai; Akinari Yokoya; Masatoshi Ukai; Kentaro Fujii; Mariko Higuchi; Ritsuko Watanabe
RADIATION PHYSICS AND CHEMISTRY, Sep. 2014, [Reviewed] - Nitrogen K-edge X-ray absorption near edge structure (XANES) spectra of purine-containing nucleotides in aqueous solution
Hiroyuki Shimada; Taishi Fukao; Hirotake Minami; Masatoshi Ukai; Kentaro Fujii; Akinari Yokoya; Yoshihiro Fukuda; Yuji Saitoh
JOURNAL OF CHEMICAL PHYSICS, Aug. 2014, [Reviewed] - 〔Major achievements〕Induction of genetic instability by transfer of a UV-A-irradiated chromosome
Ayumi Urushibara; Seiji Kodama; Akinari Yokoya
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, May 2014, [Reviewed] - Localization of DNA damage induced by innershell ionization
横谷明徳; 鵜飼正敏; 岡壽崇; 甲斐健師; 渡邊立子; 藤井健太郎, Lead
原子衝突学会誌「しょうとつ」, Mar. 2014, [Reviewed], [Invited] - Single-cell tracking and dynamical analysis of cellular population based on systems biology
Akinari Yokoya; Kiichi Kaminaga, Lead, 放射線生物研究会
Radiation Biology Research Communications, 2014, [Reviewed], [Invited] - 〔Major achievements〕Structural changes of nucleic acid base in aqueous solution as observed in X-ray absorption near edge structure (XANES)
Hiroyuki Shimada; Taishi Fukao; Hirotake Minami; Masatoshi Ukai; Kentaro Fujii; Akinari Yokoya; Yoshihiro Fukuda; Yuji Saitoh
CHEMICAL PHYSICS LETTERS, Jan. 2014, [Reviewed] - Bond cleavages of adenosine 5 '-triphosphate induced by monochromatic soft X-rays
K. Fujii; A. Narita; A. Yokoya
1ST CONFERENCE ON LIGHT AND PARTICLE BEAMS IN MATERIALS SCIENCE 2013 (LPBMS2013), 2014, [Reviewed] - DNA damage by soft X-ray exposure at oxygen K-edge
Y. Sugaya; A. Narita; K. Fujii; A. Yokoya, Corresponding
1ST CONFERENCE ON LIGHT AND PARTICLE BEAMS IN MATERIALS SCIENCE 2013 (LPBMS2013), 2014, [Reviewed] - Significance of DNA polymerase I in in vivo processing of clustered DNA damage
Naoya Shikazono; Ken Akamatsu; Momoko Takahashi; Miho Noguchi; Ayumi Urushibara; Peter O'Neill; Akinari Yokoya
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, Sep. 2013, [Reviewed] - 〔Major achievements〕Chemical repair of base lesions, AP-sites, and strand breaks on plasmid DNA in dilute aqueous solution by ascorbic acid
Kuniki Hata; Ayumi Urushibara; Shinichi Yamashita; Naoya Shikazono; Akinari Yokoya; Yosuke Katsumura
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, May 2013, [Reviewed] - 〔Major achievements〕Induction of DNA damage, including abasic sites, in plasmid DNA by carbon ion and X-ray irradiation
Takuya Shiina; Ritsuko Watanabe; Iyo Shiraishi; Masao Suzuki; Yuki Sugaya; Kentaro Fujii; Akinari Yokoya, Corresponding
RADIATION AND ENVIRONMENTAL BIOPHYSICS, Mar. 2013, [Reviewed] - Lifetime of the unpaired electron species in calf thymus DNA thin films induced by nitrogen and oxygen K-shell photoabsorption
Toshitaka Oka; Akinari Yokoya; Kentaro Fujii
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, Dec. 2012, [Reviewed] - Observation of cleavage in DNA and nucleotides following oxygen K-shell ionization by measuring X-ray absorption near edge structure
Kentaro Fujii; Yoshihiro Fukuda; Akinari Yokoya
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, Dec. 2012, [Reviewed] - Development of a simulation method for dynamics of electrons ejected from DNA molecules irradiated with X-rays
Takeshi Kai; Mariko Higuchi; Kentaro Fujii; Ritsuko Watanabe; Akinari Yokoya
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, Dec. 2012, [Reviewed] - 〔Major achievements〕Unpaired Electron Species in Thin Films of Calf-Thymus DNA Molecules Induced by Nitrogen and Oxygen K-Shell Photoabsorption
T. Oka; A. Yokoya; K. Fujii; Y. Fukuda; M. Ukai
PHYSICAL REVIEW LETTERS, Nov. 2012, [Reviewed] - 〔Major achievements〕Yield of Single- and Double-Strand Breaks and Nucleobase Lesions in Fully Hydrated Plasmid DNA Films Irradiated with High-LET Charged Particles
Takeshi Ushigome; Naoya Shikazono; Kentaro Fujii; Ritsuko Watanabe; Masao Suzuki; Chizuru Tsuruoka; Hiroshi Tauchi; Akinari Yokoya, Corresponding
RADIATION RESEARCH, May 2012, [Reviewed] - 〔Major achievements〕The mutagenic potential of 8-oxoG/single strand break-containing clusters depends on their relative positions
Miho Noguchi; Ayumi Urushibara; Akinari Yokoya; Peter O'Neill; Naoya Shikazono
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, Apr. 2012, [Reviewed] - 〔Major achievements〕Electron paramagnetic resonance study of unpaired electron species in thin films of pyrimidine bases induced by nitrogen and oxygen K-shell photoabsorption
T. Oka; A. Yokoya; K. Fujii
APPLIED PHYSICS LETTERS, Mar. 2011, [Reviewed] - A MODEL FOR ANALYSIS OF THE YIELD AND THE LEVEL OF CLUSTERING OF RADIATION-INDUCED DNA-STRAND BREAKS IN HYDRATED PLASMIDS
N. Shikazono; A. Yokoya; A. Urushibara; M. Noguchi; K. Fujii
RADIATION PROTECTION DOSIMETRY, Feb. 2011, [Reviewed] - A NOVEL TECHNIQUE USING DNA DENATURATION TO DETECT MULTIPLY INDUCED SINGLE-STRAND BREAKS IN A HYDRATED PLASMID DNA MOLECULE BY X-RAY AND He-4(2+) ION IRRADIATION
Akinari Yokoya; Naoya Shikazono; Kentaro Fujii; Miho Noguchi; Ayumi Urushibara, Lead
RADIATION PROTECTION DOSIMETRY, Feb. 2011, [Reviewed] - Protective effects of silybin and analogues against X-ray radiation-induced damage
Haiying Fu; Mingzhang Lin; Yosuke Katsumura; Akinari Yokoya; Kuniki Hata; Yusa Muroya; Kentaro Fujii; Naoya Shikazono
ACTA BIOCHIMICA ET BIOPHYSICA SINICA, Jul. 2010, [Reviewed] - 〔Major achievements〕X-ray absorption spectra of nucleotides (AMP, GMP, and CMP) in liquid water solutions near the nitrogen K-edge
Masatoshi Ukai; Akinari Yokoya; Kentaro Fujii; Yuji Saitoh
CHEMICAL PHYSICS LETTERS, Jul. 2010, [Reviewed] - Spectral change in X-ray absorption near edge structure of DNA thin films irradiated with monochromatic soft X-rays
Kentaro Fujii; Akinari Yokoya
RADIATION PHYSICS AND CHEMISTRY, Dec. 2009, [Reviewed] - Free radical scavenging and radioprotective effects of carnosine and anserine
Haiying Fu; Yosuke Katsumura; Mingzhang Lin; Yusa Muroya; Kuniki Hata; Kentaro Fujii; Akinari Yokoya; Yoshihiko Hatano
RADIATION PHYSICS AND CHEMISTRY, Dec. 2009, [Reviewed] - Synchrotron radiation photoelectron studies for primary radiation effects using a liquid water jet in vacuum: Total and partial photoelectron yields for liquid water near the oxygen K-edge
Masatoshi Ukai; Akinari Yokoya; Yusuke Nonaka; Kentaro Fujii; Yuji Saitoh
RADIATION PHYSICS AND CHEMISTRY, Dec. 2009, [Reviewed] - EPR study of radiation damage to DNA irradiated with synchrotron soft X-rays around nitrogen and oxygen K-edge
A. Yokoya; K. Fujii; Y. Fukuda; M. Ukai, Lead
RADIATION PHYSICS AND CHEMISTRY, Dec. 2009, [Reviewed] - Nucleobase Lesions and Strand Breaks in Dry DNA Thin Film Selectively Induced by Monochromatic Soft X-rays
Kentaro Fujii; Naoya Shikazono; Akinari Yokoya
JOURNAL OF PHYSICAL CHEMISTRY B, Dec. 2009, [Reviewed] - 〔Major achievements〕Induction of DNA Strand Breaks, Base Lesions and Clustered Damage Sites in Hydrated Plasmid DNA Films by Ultrasoft X Rays around the Phosphorus K Edge
Akinari Yokoya; Siobhan M. T. Cunniffe; Ritsuko Watanabe; Katsumi Kobayashi; Peter O' Neill, Lead
RADIATION RESEARCH, Sep. 2009, [Reviewed] - The Yield, Processing, and Biological Consequences of Clustered DNA Damage Induced by Ionizing Radiation
Naoya Shikazono; Miho Noguchi; Kentaro Fujii; Ayumi Urushibara; Akinari Yokoya
JOURNAL OF RADIATION RESEARCH, Jan. 2009, [Reviewed] - UNREPAIRABLE DNA DAMAGE SITE COMPOSED OF CLUSTERED LESIONS ALONG INON PARTICLE TRACKS
Akinari Yokoya; Naoya Shikazono; Fujii Kentaro; Takeshi Ushigome; Masao Suzuki; Ayumi Urushibara; Ritsuko Watanabe, Lead
REPORT OF RESEARCH CENTER OF ION BEAM TECHNOLOGY, HOSEI UNIVERSITY, 2009, [Reviewed] - Free radical scavenging reactions and antioxidant activities of silybin: Mechanistic aspects and pulse radiolytic studies
Haiying Fu; Mingzhang Lin; Yusa Muroya; Kuniki Hata; Yosuke Katsumura; Akinari Yokoya; Naoya Shikazono; Yoshihiko Hatano
FREE RADICAL RESEARCH, 2009, [Reviewed] - Studies of soft X-ray-induced Auger effect on the induction of DNA damage
A. Yokoya; K. Fuji; N. Shikazono; K. Akamatsu; A. Urushibara; R. Watanabe
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, Dec. 2008, [Reviewed] - Characterization of lesions induced in linear-formed plasmid DNA by valence ionization and Auger decay at carbon, nitrogen and oxygen
Ken Akamatsu; Kentaro Fujii; Akinari Yokoya
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, Dec. 2008, [Reviewed] - Induction of single strand breaks, and base lesions in plasmid DNA films induced by carbon, nitrogen, and oxygen KLL Auger process
Kentaro Fujii; Akinari Yokoya; Naoya Shikazono
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, Dec. 2008, [Reviewed] - ASR2007 - International symposium on "Charged Particle and Photon Interactions with Matter", November 6-9, 2007
Y. Katsumura; M. Lin; A. Yokoya; Y. Hatano
RADIATION PHYSICS AND CHEMISTRY, Oct. 2008, [Reviewed], [Invited] - X-ray absorption spectrum for guanosine-5 '-monophosphate in water solution in the vicinity of the nitrogen K-edge observed in free liquid jet in vacuum
Masatoshi Ukai; Akinari Yokoya; Kentaro Fujii; Yuji Saitoh
RADIATION PHYSICS AND CHEMISTRY, Oct. 2008, [Reviewed] - DNA damage induced by the direct effect of radiation
A. Yokoya; N. Shikazono; K. Fujii; A. Urushibara; K. Akamatsu; R. Watanabe, Lead
RADIATION PHYSICS AND CHEMISTRY, Oct. 2008, [Reviewed] - 〔Major achievements〕LET dependence of the yield of single-, double-strand breaks and base lesions in fully hydrated plasmid DNA films by He-4(2+) ion irradiation
Ayumi Urushibara; Naoya Shikazono; Peter O'Neill; Kentaro Fujii; Seiichi Wada; Akinari Yokoya
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, Jan. 2008, [Reviewed] - DNA damage induced by the direct effect of HE ion particles
Ayumi Urushibara; Naoya Shikazono; Ritsuko Watanabe; Kentaro Fujii; Peter O'Neill; Akinari Yokoya
RADIATION PROTECTION DOSIMETRY, Dec. 2006, [Reviewed] - Yields of strand breaks and base lesions induced by soft X-rays in plasmid DNA
A. Yokoya; K. Fujii; T. Ushigome; N. Shikazono; A. Urushibara; R. Watanabe, Lead
RADIATION PROTECTION DOSIMETRY, Dec. 2006, [Reviewed] - Natural circular dichroism of amino acid films observed in soft X-ray and VUV region using polarizing undulator
K Nakagawa; F Kaneko; Y Ohta; M Tanaka; T Kitada; A Agui; F Fujii; A Yokoya; K Yagi-Watanabe; T Yamada
JOURNAL OF ELECTRON SPECTROSCOPY AND RELATED PHENOMENA, Jun. 2005, [Reviewed] - Chemical evolution of amino acid induced by soft X-ray with synchrotron radiation
F Kaneko; M Tanaka; S Narita; T Kitada; T Matsui; K Nakagawa; A Agui; K Fujii; A Yokoya
JOURNAL OF ELECTRON SPECTROSCOPY AND RELATED PHENOMENA, Jun. 2005, [Reviewed] - 〔Major achievements〕First observation of natural circular dichroism for biomolecules in soft x-ray region studied with a polarizing undulator
Masahito Tanaka; Kazumichi Nakagawa; Akane Agui; Kentaro Fujii; Akinari Yokoya
PHYSICA SCRIPTA, 2005, [Reviewed] - 〔Major achievements〕DNA strand breaks by direct energy deposition by Auger and photo-electrons ejected from DNA constituent atoms following K-shell photoabsorption
R Watanabe; A Yokoya; K Fujii; K Saito
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, Nov. 2004, [Reviewed] - "In situ" observation of guanine radicals induced by ultrasoft X-ray irradiation around the K-edge regions of nitrogen and oxygen
A Yokoya; K Akamatsu; K Fujii; M Ukai, Lead
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, Nov. 2004, [Reviewed] - Low-energy Auger- and photo-electron effects on the degradation of thymine by ultrasoft X-irradiation
K Akamatsu; K Fujii; A Yokoya
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, Nov. 2004, [Reviewed] - Decomposition of 2-deoxy-D-ribose by irradiation with 0.6 keV electrons and by 0.5 keV ultrasoft X-rays
K Fujii; K Akamatsu; A Yokoya
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, Nov. 2004, [Reviewed] - 〔Major achievements〕EPR studies of 5-bromouracil crystal after irradiation with X rays in the bromine K-edge region
A Yokoya; K Takakura; R Watanabe; K Akamatsu; T Ito, Lead
RADIATION RESEARCH, Oct. 2004, [Reviewed] - Near-edge X-ray absorption fine structure of DNA nucleobases thin film in the nitrogen and oxygen K-edge region
K Fujii; K Akamatsu; A Yokoya
JOURNAL OF PHYSICAL CHEMISTRY B, Jun. 2004, [Reviewed] - 〔Major achievements〕Ion desorption from DNA components irradiated with 0.5 keV ultrasoft X-ray photons
K Fujii; K Akamatsu; A Yokoya
RADIATION RESEARCH, Apr. 2004, [Reviewed] - Qualitative and quantitative analyses of the decomposition products that arise from the exposure of thymine to monochromatic ultrasoft X rays and Co-60 gamma rays in the solid state
K Akamatsu; K Fujii; A Yokoya
RADIATION RESEARCH, Apr. 2004, [Reviewed] - The measurement of molecular fragments from DNA components using synchrotron radiation
K Fujii; K Akamatsu; A Yokoya
SURFACE SCIENCE, Mar. 2003, [Reviewed] - 〔Major achievements〕Effects of hydration on the induction of strand breaks, base lesions, and clustered damage in DNA films by alpha-radiation
A Yokoya; SMT Cunniffe; DL Stevens; P O'Neill, Lead
JOURNAL OF PHYSICAL CHEMISTRY B, Jan. 2003, [Reviewed] - X-ray absorption near edge structure of DNA bases around oxygen and nitrogen K-edge
K Fujii; K Akamatsu; Y Muramatsu; A Yokoya
NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS, Jan. 2003, [Reviewed] - Infrared spectral change in 2-deoxy-D-ribose by irradiation with monochromatic photons around oxygen K-edge
K Akamatsu; K Fujii; A Yokoya
NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS, Jan. 2003, [Reviewed] - 〔Major achievements〕Electron paramagnetic resonance induced by K-shell resonance excitation in DNA bases in solid state
A Yokoya; K Akamatsu; K Fujii, Lead
NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS, Jan. 2003, [Reviewed] - 〔Major achievements〕Effect of hydration on the induction of strand breaks and base lesions in plasmid DNA films by gamma-radiation
A Yokoya; SMT Cunniffe; P O'Neill, Lead
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Jul. 2002, [Reviewed] - First results from the actinide science beamline BL23SU at SPring-8
Y Saitoh; T Nakatani; T Matsushita; A Agui; A Yoshigoe; Y Teraoka; A Yokoya
NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT, Dec. 2001, [Reviewed] - Reparability of lethal lesions produced by phosphorus photoabsorption in yeast cells
N Usami; A Yokoya; S Ishizaka; K Kobayashi
JOURNAL OF RADIATION RESEARCH, Sep. 2001, [Reviewed] - First operation of circular dichroism measurements with periodic photon-helicity switching by a variably polarizing undulator at BL23SU at SPring-8
A Agui; A Yoshigoe; T Nakatani; T Matsushita; Y Saitoh; A Yokoya; H Tanaka; Y Miyahara; T Shimada; M Takeuchi; T Bizen; S Sasaki; M Takao; H Aoyagi; TP Kudo; K Satoh; S Wu; Y Hiramatsu; H Ohkuma
REVIEW OF SCIENTIFIC INSTRUMENTS, Aug. 2001, [Reviewed] - Synchronous beam diagnostic system using cordless telephones at SPring-8
TP Kudo; H Aoyagi; K Sato; S Wu; H Tanaka; S Sasaki; T Nakatani; M Takeuchi; T Shimada; Y Hiramatsu; A Yokoya; A Agui; A Yoshigoe; H Ohkuma; Y Miyahara; T Ishikawa; H Kitamura
NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT, Jul. 2001, [Reviewed] - EPR spectrometer installed in a soft X-ray beamline at SPring-8 for biophysical studies
A Yokoya; K Akamatsu, Lead
NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT, Jul. 2001, [Reviewed] - X-ray absorption near-edge structure (XANES) spectral changes of 2-deoxy-D-ribose by irradiation within the energy region around the oxygen K-shell absorption edge
K Akamatsu; A Yokoya
JOURNAL OF SYNCHROTRON RADIATION, Mar. 2001, [Reviewed] - A grating monochromator of BL23SU at SPring-8 covering silicon and oxygen K-edges
A Yoshigoe; A Agui; T Nakatani; T Matsusita; Y Saitoh; A Yokoya
JOURNAL OF SYNCHROTRON RADIATION, Mar. 2001, [Reviewed] - X-ray absorption near edge structures of DNA or its components around the oxygen K-shell edge
K Akamatsu; A Yokoya
RADIATION RESEARCH, Mar. 2001, [Reviewed] - Oxygen K-edge X-ray absorption near edge structures (XANES) of sublimated films of amino acids
Masahito Tanaka; Kazumichi Nakagawa; Toshiyuki Koketsu; Akane Agui; Akinari Yokoya
Journal of Synchrotron Radiation, 01 Mar. 2001, [Reviewed] - Photoionization of Ne3+ ions in the region of the 1s -> 2p autoionizing resonance
M Oura; H Yamaoka; K Kawatsura; J Kimata; T Hayaishi; T Takahashi; T Koizumi; T Sekioka; M Terasawa; Y Itoh; Y Awaya; A Yokoya; A Agui; A Yoshigoe; Y Saitoh
PHYSICAL REVIEW A, Jan. 2001, [Reviewed] - 〔Major achievements〕Single- and double-strand breaks in solid pBR322 DNA induced by ultrasoft X-rays at photon energies of 388, 435 and 573 eV
A Yokoya; R Watanabe; T Hara, Lead
JOURNAL OF RADIATION RESEARCH, Jun. 1999, [Reviewed] - Construction of the JAERI soft X-ray beamline for actinide material sciences
T Nakatani; Y Saitoh; Y Teraoka; T Okane; A Yokoya
JOURNAL OF SYNCHROTRON RADIATION, May 1998, [Reviewed] - 〔Major achievements〕Soft X-ray beamline specialized for actinides and radioactive materials equipped with a variably polarizing undulator
A Yokoya; T Sekiguchi; Y Saitoh; T Okane; T Nakatani; T Shimada; H Kobayashi; M Takao; Y Teraoka; Y Hayashi; S Sasaki; Y Miyahara; T Harami; TA Sasaki, Lead
JOURNAL OF SYNCHROTRON RADIATION, Jan. 1998, [Reviewed] - Single- and double-strand breaks in pBR322 plasmid DNA by monochromatic X-rays on and off the K-absorption peak of phosphorus
K Hieda; T Hirono; A Azami; M Suzuki; Y Furusawa; H Maezawa; N Usami; A Yokoya; K Kobayashi
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, Oct. 1996, [Reviewed] - Synchrotron radiation beamline to study radioactive materials at the photon factory
H Konishi; A Yokoya; H Shiwaku; H Motohashi; T Makita; Y Kashihara; S Hashimoto; T Harami; TA Sasaki; H Maeta; H Ohno; H Maezawa; S Asaoka; N Kanaya; K Ito; N Usami; K Kobayashi
NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT, Mar. 1996, [Reviewed] - Lethal effect of K-shell absorption of intracellular phosphorus on wild-type and radiation sensitive mutants of Escherichia coli
H Maezawa; Y Furusawa; K Kobayashi; K Hieda; M Suzuki; N Usami; A Yokoya; T Mori
ACTA ONCOLOGICA, 1996, [Reviewed] - INACTIVATION ACTION SPECTRA OF BACILLUS-SUBTILIS SPORES WITH MONOCHROMATIC SOFT X-RAYS (0.1-0.6 NM) OF SYNCHROTRON RADIATION
N MUNAKATA; K HIEDA; N USAMI; A YOKOYA; K KOBAYASHI
RADIATION RESEARCH, Jul. 1992, [Reviewed] - MUTAGENIC AND TRANSFORMING EFFECTS OF SOFT-X-RAYS WITH RESONANCE ENERGY OF PHOSPHORUS K-ABSORPTION EDGE
M WATANABE; M SUZUKI; K WATANABE; K SUZUKI; N USAMI; A YOKOYA; K KOBAYASHI
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, Feb. 1992, [Reviewed] - RADIOLYTIC DEGRADATION OF CYSTATHIONINE IRRADIATED WITH MONOCHROMATIC SOFT X-RAYS AT THE K-SHELL RESONANCE-ABSORPTION OF SULFUR
A YOKOYA; K KOBAYASHI; N USAMI; S ISHIZAKA, Lead
JOURNAL OF RADIATION RESEARCH, Jun. 1991, [Reviewed] - TARGET SIZE FOR A FIBRONECTIN-CELL ADHESION SYSTEM DETERMINED BY THE X-RAY INACTIVATION METHOD
A YOKOYA; K KOBAYASHI; Y MIYAMOTO; S ISHIZAKA, Lead
CELL STRUCTURE AND FUNCTION, Feb. 1991, [Reviewed] - INTERACTION BETWEEN CELL-BINDING DOMAIN AND EXTRACELLULAR MATRIX-BINDING DOMAIN OF FIBRONECTIN DETERMINED BY FLUORESCENCE DEPOLARIZATION
Y MIYAMOTO; A YOKOYA; S ISHIZAKA
BIOCHIMICA ET BIOPHYSICA ACTA, Apr. 1988, [Reviewed]
MISC
- Decomposition characteristics of hypervalent iodine compounds induced by X-ray core excitation for the development of X-ray activated caged compounds
M. Ohara; Y. Izumi; H. Takakura; S. Enomoto; K. Fujii; A. Yokoya; M. Ogawa
Photon Factory Highlights 2023, 2024, [Reviewed], [Invited] - Cross-linking of PDMS by irradiation of soft X-rays and dependence of X-ray energy
中川清子; 大原麻希; 横谷明徳; 宇佐美徳子
応用物理学会秋季学術講演会講演予稿集(CD-ROM), 2024 - Invitation to the project “A near-edge x-ray absorption fine structure study of products in ice film by monochromic soft x-ray irradiation”
中川清子; 横谷明徳; 馬場祐治
放射線化学討論会講演要旨集, 2024 - NMR and UV-visible absorption spectroscopy analyses of electronic structures of halogenated DNA-related molecules
阿住弥玖; 木村奨; 山口央; 徳永陽; 神戸振作; 横谷明徳
放射線化学討論会講演要旨集, 2024
Corresponding - Modeling the heat generation and the heat flow in a cell exposed to radiation stress
花澤恵子; 横谷明徳
アイソトープ・放射線研究発表会(Web), 2024
Last - Distribution of a noncoding RNA, MALAT1, in a nucleus of cancer or normal human cells in responding to X-ray irradiation.
竹下敬祐; 横谷明徳
アイソトープ・放射線研究発表会(Web), 2024
Last - The study of metabolism mechanisms specific to radiation-induced senescence cells
三浦颯; 野口実穂; 横谷明徳
アイソトープ・放射線研究発表会(Web), 2024
Last - The change in electronic state of bromouracil by soft X-ray irradiation
小沼草太; 大原麻希; 泉雄大; 横谷明徳
アイソトープ・放射線研究発表会(Web), 2024
Last - Decomposition of the target molecules for photoimmunotherapy by X-ray core excitation
横谷明徳; 泉雄大; 大原麻希; 小河原浩輝; 我喜屋祥; 家田直弥; 小川美香子
アイソトープ・放射線研究発表会(Web), 2024
Lead - Alteration of the cell-migration rate by non-uniform X-irradiation of human monolayer cultured cell populations
山口海希; 横谷明徳
アイソトープ・放射線研究発表会(Web), 2024
Last - In vivo and In vitro rejoining of enzymatically induced double-strand breaks in EGFP expressing plasmid DNA
江田脩真; 伊東裕真; 小畑結衣; 廣瀬エリ; 横谷明徳
アイソトープ・放射線研究発表会(Web), 2024
Last - Cellular Temperature Changes with Irreversibly Arrested Cell Cycle by Ionizing Irradiation
伊原智一; 伊原智一; 伊原智一; 花澤恵子; 横谷明徳
Thermal Medicine, 2024
Last - Effects of soft X-ray irradiation to DNA related molecules detected by changes of photoelectron spectra
Sota ONUMA; Akinari YOKOYA
Photon Factory Activity Report 2023 #41, 2024
Last - X-ray Photoelectron Spectroscopy Analysis of Electron States in Fluorinated DNA components
小沼草太; 泉雄大; 大原麻希; 横谷明徳
量子ビームサイエンスフェスタ(Web), 2024
Last - X-ray absorption and photoemission spectra of a hypervalent iodine compound, 2-iodosobenzoic acid
泉雄大; 大原麻希; 藤井健太郎; 横谷明徳; 小川美香子
量子ビームサイエンスフェスタ(Web), 2024 - First-principles electronic structure calculations of surface states of uracil halide
関川卓也; 甲斐健師; 小沼草太; 芳賀芳範; 横谷明徳
量子ビームサイエンスフェスタ(Web), 2024
Last - ESR imaging of radicals produced in alanine by soft X-ray irradiation
中川清子; 横谷明徳; 大原麻希; 宇佐美徳子; 浅田瑞枝; 藤原基靖; 中村敏和; 石川健治
電子スピンサイエンス学会年会講演要旨集, 2023 - Analysis of early cellular dynamics leading to radiation carcinogenesis in rat mammary gland
永田健斗; 西村まゆみ; 臺野和広; 臺野和広; 飯塚大輔; 飯塚大輔; 西村由希子; 西村由希子; 服部佑哉; 渡邊立子; 横谷明徳; 柿沼志津子; 柿沼志津子; 今岡達彦; 今岡達彦
日本癌学会学術総会抄録集(Web), 2023 - Electric properties of fluorinated DNA related molecules revealed by XPS
Sota ONUMA; Maki OHARA; Akinari YOKOYA
Photon Factory Activity Report 2022 #40 (2023), 2023
Last - Does sparse radiation exposure affect rat mammary cell competition?
西村由希子; 神長輝一; 宇佐美徳子; 横谷明徳; 今岡達彦
KEK Progress Report (Web), 2023 - EGFP plasmid DNA damage induced by phosphorus K-resonance excitation and its cellular repair
小畑結衣; 小畑結衣; 木名瀬暁理; 横谷明徳; 横谷明徳
量子ビームサイエンスフェスタ(Web), 2023
Last - Efficiency of alanine radical yield on radiation energy of X-rays
中川清子; 横谷明徳; 大原麻希; 宇佐美徳子
量子ビームサイエンスフェスタ(Web), 2023 - Decomposition of hypervalent iodine compounds induced by monochromatic X-ray irradiation
大原麻希; 泉雄大; 高倉栄男; 榎本将聖; 藤井健太郎; 横谷明徳; 小川美香子
量子ビームサイエンスフェスタ(Web), 2023 - マイクロビーム放射線治療における組織代償効果のメカニズム(A Possible Mechanism for the Tissue-Sparing Effect of Microbeam Radiotherapy)
福永 久典; 横谷 明徳
日本放射線影響学会大会講演要旨集, Sep. 2022
Last - 電子状態の物理学的理解による放射線生体分子変異プロセスの探索(Radiation damage processes explored based on physical property of electronic states of biological molecules)
横谷 明徳
日本放射線影響学会大会講演要旨集, Sep. 2022, [Invited]
Lead - 放射線はラット乳腺の内腔細胞の分化を線量率依存的に阻害する(Radiation inhibits differentiation of luminal cells in the rat mammary gland in a dose-rate-dependent manner)
永田 健斗; 西村 まゆみ; 臺野 和宏; 飯塚 大輔; 西村 由希子; 服部 佑哉; 渡邊 立子; 横谷 明徳; 柿沼 志津子; 今岡 達彦
日本放射線影響学会大会講演要旨集, Sep. 2022 - ヒト細胞中に導入された線形プラスミドDNAは遺伝子発現をするのか?(Does linear plasmid DNA express genes in it after transfected into human cells)
小畑 結衣; 木名瀬 暁理; 伊東 祐真; 秋光 信佳; 横谷 明徳
日本放射線影響学会大会講演要旨集, Sep. 2022
Last - 軟X線を照射したEGFP発現プラスミドDNAの非照射細胞内におけるDNA修復の難易性(DNA repair susceptibility in non-irradiated cells transfected with EGFP expressing plasmid DNA irradiated with various soft X-rays)
木名瀬 暁理; 小畑 結衣; 横谷 明徳
日本放射線影響学会大会講演要旨集, Sep. 2022
Last - Brから放出される低エネルギー二次電子がプラスミドDNAの鎖切断に与える効果(Effect of low-energy secondary electrons emitted from bromine atoms on the strand breaks of plasmid DNA)
伊東 祐真; 小畑 結衣; 木名瀬 暁理; 横谷 明徳
日本放射線影響学会大会講演要旨集, Sep. 2022
Last - 放射線誘発老化様増殖停止を起こした細胞は二相性のオートファジー活性化を示す(Biphasic activation of autophagy in X-irradiated cells undergoing senescence-like growth arrest)
野口 実穂; 伊原 智一; 鈴木 啓司; 横谷 明徳
日本放射線影響学会大会講演要旨集, Sep. 2022
Last - ヨウ素L吸収端近傍の単色X線照射による超原子価ヨウ素化合物の分解特性(Decomposition characteristics of caged compounds harboring a hypervalent iodine atom exposed to monochromatic X-rays around iodine L-edge)
大原 麻希; 泉 雄大; 高倉 栄男; 榎本 将聖; 藤井 健太郎; 横谷 明徳; 小川 美香子
日本放射線影響学会大会講演要旨集, Sep. 2022 - 不均一なX線照射野での細胞移動を視覚化するためのFucci化および非Fucci化ヒト線維芽細胞の共培養(Co-culture of the Fucci and non-Fucci human fibroblast cells for visualizing cell migration in a heterogeneously X-ray-exposed field)
松本 萌; 福永 久典; 鈴木 啓司; 横谷 明徳
日本放射線影響学会大会講演要旨集, Sep. 2022
Last - Application of a Mouse Ex Vivo Spermatogenesis Model to Elucidate the Mechanism of Radio- Therapy-Related Male Infertility
Kiichi Kaminaga; Akinari Yokoya; Hisanori Fukunaga
RADIOISOTOPES, 15 Mar. 2022, [Reviewed] - Dense radical formation in L-alanine-3,3,3-d3 and L-alanine-d4 by 1.5 keV soft X-ray irradiation
Seiko Nakagawa; Toshitaka Oka; Kentaro Fujii; Akinari Yokoya
Radiation Physics and Chemistry, Mar. 2022
Last - X-ray Photoemission Spectroscopy of Hypervalent Iodine Compound 2-Iodosobenzoic Acid (IBA)
泉雄大; 大原麻希; 横谷明徳
KEK Progress Report (Web), 2022
Last - Beam position adjustment required in X-ray microbeam irradiation of two-dimensionally cultured rat mammary cells expressing fluorescent proteins
西村由希子; 神長輝一; 宇佐美徳子; 横谷明徳; 今岡達彦
KEK Progress Report (Web), 2022 - X-ray Photoemission Spectroscopy of Halogenated Uracils
泉雄大; 大原麻希; 馬場祐治; 横谷明徳
KEK Progress Report (Web), 2022
Last - Radiation-induced damage to plasmid DNA: 1. Dose evaluation for samples of film and aqueous solution
YU Hao; 篠原俊輔; 横谷明徳; 横谷明徳; 山下真一
アイソトープ・放射線研究発表会(Web), 2022 - Change of NADH contents in X-ray irradiated cells
山野下佳輝; 山野下佳輝; 横谷明徳; 横谷明徳
アイソトープ・放射線研究発表会(Web), 2022
Last - Ca2+ concentration dynamics and morphological change of Endoplasmic reticulum in irradiated cells
斉藤智幸; 鈴木碧海; 鈴木碧海; 横谷明徳; 横谷明徳
アイソトープ・放射線研究発表会(Web), 2022
Last - Radiation suppresses differentiation of rat mammary luminal cells depending on dose rate
永田健斗; 西村まゆみ; 臺野和広; 飯塚大輔; 西村由希子; 服部佑哉; 渡辺立子; 横谷明徳; 柿沼志津子; 今岡達彦
アイソトープ・放射線研究発表会(Web), 2022 - Radiation-induced Damage to Plasmid DNA: Absorbed Doses of Films and Dilute Aqueous Solutions
YU H.; YU H.; 篠原俊輔; 横谷明徳; 横谷明徳; 山下真一
放射線化学討論会講演要旨集, 2022 - Efficiency of alanine radical yield and spin relaxation time dependence on radiation energy of X-rays
中川清子; 横谷明徳; 大原麻希; 宇佐美徳子
放射線化学討論会講演要旨集, 2022 - 光免疫がん治療のための超原子価ヨウ素化合物のXANES測定による評価
大原麻希; 泉雄大; 高倉栄男; 榎本将聖; 藤井健太郎; 横谷明徳; 小川美香子
日本放射光学会年会・放射光科学合同シンポジウム(Web), 2022 - 内殻空孔緩和に伴う水和ヌクレオチドからの発光
寺尾優作; 熊谷嘉晃; 鈴木一世; 土屋貴寛; 鵜飼正敏; 横谷明徳; 藤井健太郎; 福田義博; 斎藤祐児
日本放射光学会年会・放射光科学合同シンポジウム(Web), 2022 - 軟X線XPSによるBr-ヌクレオチド分子の価電子状態計測とDNA分子内電荷移動機構
平戸未彩紀; 平戸未彩紀; 横谷明徳; 横谷明徳; 馬場祐治; 和田真一; 芳賀芳範; 藤井健太郎; 藤井健太郎
日本放射光学会年会・放射光科学合同シンポジウム(Web), 2022
Last - Iodine L3-edge XANES spectroscopy of hypervalent iodine compounds
大原麻希; 泉雄大; 高倉栄男; 榎本将聖; 藤井健太郎; 横谷明徳; 小川美香子
量子ビームサイエンスフェスタ(Web), 2022 - X-ray photoemission spectroscopy of 5-halouracils
泉雄大; 大原麻希; 馬場祐治; 馬場祐治; 横谷明徳
量子ビームサイエンスフェスタ(Web), 2022
Last - Ion mass spectrometry for studying the radiation effect of aqueous molecules
熊谷嘉晃; 土屋貴寛; 宮後海帆; 寺尾優作; 鈴木一世; 金井唯; 黒瀬研二; 鵜飼正敏; 横谷明徳; 藤井健太郎; 福田義博; 斎藤祐児
日本物理学会講演概要集(CD-ROM), 2022 - Structural analysis of DNA repair protein XRCC4 and its mutated proteins by SAXS
長谷川真保; 西久保開; 藤原悟; 松尾龍人; 松本義久; 横谷明徳
Photon Factory Activity Report 2020, Apr. 2021, [Reviewed]
Last - Ca2+ waves as stress signals in X-irradiated cells
鈴木碧海; 鈴木碧海; 大塚将太郎; 大塚将太郎; 横谷明徳; 横谷明徳
アイソトープ・放射線研究発表会(Web), 2021
Last - Selective Protection Effects of Additives against Radiation-induced DNA Damage and their Differences with Moisture Contents
YU Hao; 近藤勇佑; 藤井健太郎; 横谷明徳; 山下真一
アイソトープ・放射線研究発表会(Web), 2021 - Small-Angle X-Ray Scattering Measurements of α-Synuclein, a Protein Related to the Pathogenesis of Parkinson’s Disease, under Various Conditions
藤原悟; 西久保開; 長谷川真保; 横谷明徳
KEK Progress Report (Web), 2021
Last - Beam position adjustment required in X-ray microbeam irradiation of two-dimensional cultured rat mammary gland cells
西村由希子; 西村由希子; 神長輝一; 宇佐美徳子; 横谷明徳; 今岡達彦
KEK Progress Report (Web), 2021 - Study on radiation damaging intermediates of DNA by measuring x-ray induced luminescence
寺尾優作; 熊谷嘉晃; 鈴木一世; 土屋貴寛; 鵜飼正敏; 横谷明徳; 藤井健太郎; 福田義博; 斎藤祐児
日本物理学会講演概要集(CD-ROM), 2021 - Influence of moisture contents on radiation damage to DNA: 2. Yields of base lesions and AP sites
YU Hao; 近藤勇佑; 山下真一; 藤井健太郎; 横谷明徳
放射線化学(Web), 2021, [Reviewed]
Last - 水和DNAに対する放射線効果解明のための飛行時間型イオン質量分析法の開発
土屋貴寛; 熊谷嘉晃; 熊谷嘉晃; 宮後海帆; 寺尾優作; 鈴木一世; 金井唯; 黒瀬研二; 鵜飼正敏; 鵜飼正敏; 横谷明徳; 藤井健太郎; 福田義博; 斎藤祐児
原子衝突学会年会講演概要集, 2021 - 液相における内殻空孔緩和に伴う水分子解離プロセス
宮後海帆; 熊谷嘉晃; 土屋貴寛; 寺尾優作; 鈴木一世; 金井唯; 鵜飼正敏; 横谷明徳; 藤井健太郎; 福田義博; 斎藤祐児
原子衝突学会年会講演概要集, 2021 - 活性化XRCC4のSAXS構造解析とDNA修復
長谷川真保; 西久保開; 西久保開; 藤原悟; 松尾龍人; 松本義久; 横谷明徳
日本放射光学会年会・放射光科学合同シンポジウム(Web), 2021
Last - Influence of Water Content on Radiation Damage to DNA: Separation by Damage Types and their Yield Evaluation
YU H.; 近藤勇佑; 藤井健太郎; 横谷明徳; 横谷明徳; 山下真一
放射線化学討論会講演要旨集, 2021 - X-ray induced luminescence of hydrated nucleotide molecules
寺尾優作; 熊谷嘉晃; 鈴木一世; 土屋貴寛; 鵜飼正敏; 横谷明徳; 藤井健太郎; 福田義博; 斎藤祐児
放射線化学討論会講演要旨集, 2021 - 放射線損傷DNAの細胞内修復ダイナミクス可視化のための新たなベクターDNA系の開発(Development of a vector DNA system for visualization of intracellular repair dynamics of DNA damage by ionizing radiation)
小畑 結衣; 平嵜 敬志朗; 秋光 信佳; 鈴木 雅雄; 横谷 明徳
日本放射線影響学会大会講演要旨集, Oct. 2020
Last - X線照射による広範囲ゲノム欠失の様式解析(Genome signature analysis of Megabase-sized large deletions induced by X-irradiation)
廣瀬 エリ; 鈴木 啓司; 横谷 明徳
日本放射線影響学会大会講演要旨集, Oct. 2020
Last - X線により老化した細胞内の温度計測の試み(An approach of intracellular measurements of temperature in senescent cells after X-ray exposure)
伊原 智一; 野口 実穂; 岡部 弘基; 横谷 明徳
日本放射線影響学会大会講演要旨集, Oct. 2020
Last - 放射線損傷DNAの細胞内修復ダイナミクス可視化のための新たなベクターDNA系の開発(Development of a vector DNA system for visualization of intracellular repair dynamics of DNA damage by ionizing radiation)
小畑 結衣; 平嵜 敬志朗; 秋光 信佳; 鈴木 雅雄; 横谷 明徳
日本放射線影響学会大会講演要旨集, Oct. 2020
Last - 水和水に対するX線エネルギー付与により誘発されたEGFPプラスミドDNA損傷の修復のライブセルイメージング(Live cell imaging of repair of EGFP plasmid DNA damage induced by X-ray energy deposition on hydrated waters)
平嵜 敬志朗; 小畑 結衣; 横谷 明徳
日本放射線影響学会大会講演要旨集, Oct. 2020
Last - DNA損傷と細胞応答に対する線量率効果のシミュレーション(Simulation of dose-rate effect on DNA damage and cellular responses)
渡辺 立子; 服部 佑哉; 横谷 明徳
日本放射線影響学会大会講演要旨集, Oct. 2020
Last - DNA修復タンパク質XRCC4多量体のリン酸化による構造変化(Structural changes of DNA repair protein XRCC4 due to phosphorylation and its role for multimerization)
西久保 開; 長谷川 真保; 泉 雄大; 藤井 健太郎; 松尾 光一; 松本 義久; 横谷 明徳
日本放射線影響学会大会講演要旨集, Oct. 2020
Last - X線照射された細胞内部の温度測定(Measurement of the temperature inside X-ray irradiated cells)
重清 壯登; 宇佐美 徳子; 岡部 弘基; 横谷 明徳
日本放射線影響学会大会講演要旨集, Oct. 2020 - X線照射された細胞内におけるストレス応答シグナルとしてのCa2+濃度変化(Ca2+ waves as stress signals in X-irradiated cells)
鈴木 碧海; 横谷 明徳
日本放射線影響学会大会講演要旨集, Oct. 2020 - X線照射による広範囲ゲノム欠失の様式解析(Genome signature analysis of Megabase-sized large deletions induced by X-irradiation)
廣瀬 エリ; 鈴木 啓司; 横谷 明徳
日本放射線影響学会大会講演要旨集, Oct. 2020 - 放射線誘発老化細胞におけるオートファジー関連タンパク質の経時的な発現変動(Temporal expression analysis of autophagy-related proteins in radiation-induced senescence)
野口 実穂; 伊原 智一; 鈴木 啓司; 横谷 明徳
日本放射線影響学会大会講演要旨集, Oct. 2020 - X線により老化した細胞内の温度計測の試み(An approach of intracellular measurements of temperature in senescent cells after X-ray exposure)
伊原 智一; 野口 実穂; 岡部 弘基; 横谷 明徳
日本放射線影響学会大会講演要旨集, Oct. 2020 - 光免疫治療に資するX線誘導による生体深部腫瘍での選択的分子解離の探索(Explore of X-ray induced selective molecular degradation for photoimmuno-therapy targeting deep tissues)
横谷 明徳; 藤井 健太郎; 渡辺 立子; 平戸 未彩紀; 中川 桂一; 稲波 修; 武次 徹也; 小川 美香子
日本放射線影響学会大会講演要旨集, Oct. 2020 - X線マイクロビーム照射及び非照射細胞の化学プローブを用いた温度計測の試み
重清壯登; 重清壯登; 清野晃平; 清野晃平; 神長輝一; 宇佐美徳子; 横谷明徳; 横谷明徳
日本放射光学会年会・放射光科学合同シンポジウム(Web), 2020 - 軟X線分光法を用いたハロゲン化DNA関連分子の電子状態の研究
平戸未彩紀; 平戸未彩紀; 馬場祐治; 和田真一; 藤井健太郎; 本田充紀; 横谷明徳; 横谷明徳
日本放射光学会年会・放射光科学合同シンポジウム(Web), 2020 - Radiation Protection by a Tiny Amount of Additives: Yields Measurements of Radiation Damage to DNA without Protective Agents
近藤勇佑; YU Hao; 横谷明徳; 藤井健太郎; 山下真一
日本原子力学会春の年会予稿集(CD-ROM), 2020 - Cell dynamics of two-dimensional cultured rat mammary cells irradiated with an X-ray microbeam
西村由希子; 西村由希子; 神長輝一; 宇佐美徳子; 横谷明徳; 今岡達彦
KEK Progress Report (Web), 2020 - VUV-CDで見えてきたリン酸化によるXRCC4会合体の構造変化解析
西久保開; 西久保開; 長谷川真保; 長谷川真保; 泉雄大; 藤井健太郎; 松尾光一; 松本義久; 横谷明徳; 横谷明徳
日本放射光学会年会・放射光科学合同シンポジウム(Web), 2020 - X線小角散乱法を用いたリン酸化XRCC4の活性化構造解析
長谷川真保; 長谷川真保; 西久保開; 西久保開; 藤原悟; 松尾龍人; 松本義久; 横谷明徳; 横谷明徳
日本放射光学会年会・放射光科学合同シンポジウム(Web), 2020 - Influence of Moisture Contents on Radiation Damage to DNA: 2. Yields of Base Lesions and AP Sites
YU H.; 近藤勇佑; 藤井健太郎; 横谷明徳; 山下真一
放射線化学討論会講演要旨集, 2020 - Influence of Moisture Content on Radiation Damage to DNA: 1. Improvement of Measurement Accuracy and Strand Break Yields
近藤勇佑; YU H.; 藤井健太郎; 横谷明徳; 山下真一
放射線化学討論会講演要旨集, 2020 - Role of hydration water in DNA damage formation by heavy ion beams
山下真一; YU H.; 近藤勇佑; 永井菜月; 横谷明徳; 平山亮一
量子科学技術研究開発機構研究報告書(Web), 2020 - Micro-slit X-ray irradiation reveals testicular tissue-sparing effects: an attempt for high-precision radiotherapy for male fertility preservation
Hisanori Fukunaga; Kevin M. Prise; Akinari Yokoya
PF Highlights 2019, 2020, [Invited]
Last - コルヒチン投与またはX線照射によって阻害される哺乳動物細胞におけるミトコンドリア動態(Mitochondrial Dynamics in Mammalian Cells Modified by Colchicine Administration or X-irradiation)
木村 由佳; 大内 則幸; 横谷 明徳
日本放射線影響学会大会講演要旨集, Nov. 2019 - 非照射ヒト細胞におけるin vitro X線照射プラスミドDNAのEGFP発現のライブセル観察(Live cell observation of EGFP expression of in vitro X-irradiated plasmid DNA in non-irradiated human cells)
小畑 結衣; 平嵜 敬志朗; 横谷 明徳
日本放射線影響学会大会講演要旨集, Nov. 2019 - 正常ヒト線維芽細胞における放射線照射後のオートファジー及び老化誘導の分子的プロセスについて(Molecular processes of Radiation induced autophagy and senescence of a normal human fibroblast)
野口 実穂; 伊原 智一; 横谷 明徳
日本放射線影響学会大会講演要旨集, Nov. 2019 - ヒト細胞中に移入されたX線照射水和EGFP発現プラスミドDNAの修復感受性(Repair susceptibility of hydrated EGFP-expressing plasmid DNA transfected into human cells after exposure to X-rays)
平嵜 敬志朗; 小畑 結衣; 横谷 明徳
日本放射線影響学会大会講演要旨集, Nov. 2019 - X線照射後の老化誘発における細胞内環境及びオートファジー活性の変化(Changes of intracellular environment and autophagy activity during senescence induction after X-ray exposure)
伊原 智一; 野口 実穂; 横谷 明徳
日本放射線影響学会大会講演要旨集, Nov. 2019 - 最先端の研究開発 量子科学技術研究開発機構 第4回「量子生命科学」の発進
藤巻秀; 五十嵐龍治; 高草木洋一; 安達基泰; 横谷明徳; 玉田太郎; 河野秀俊; 鹿園直哉; 今岡達彦; 赤松憲; 小西輝昭; 山田真希子; 八幡憲明
ΑΤΟΜΟΣ, 01 Jun. 2019 - XANESスペクトルによる放射線DNA鎖切断の観測
藤井健太郎; 横谷明徳; DU PENHOAT M.A. Herve; POLITIS M.F.
日本放射光学会年会・放射光科学合同シンポジウム(Web), 2019 - CDスペクトル測定を用いたリン酸化XRCC4タンパク質の活性化構造の探索
西久保開; 西久保開; 長谷川真保; 長谷川真保; 泉雄大; 藤井健太郎; 松尾光一; 松本義久; 横谷明徳; 横谷明徳
日本分子生物学会年会プログラム・要旨集(Web), 2019 - DNA修復タンパク質複合体形成過程に関する小角散乱研究の試み
長谷川真保; 長谷川真保; 西久保開; 西久保開; 横谷明徳; 横谷明徳
日本放射光学会年会・放射光科学合同シンポジウム(Web), 2019 - VUV-CDで見えてきたXRCC4活性中心に対するリン酸化の分子内遠隔制御
西久保開; 西久保開; 長谷川真保; 長谷川真保; 泉雄大; 藤井健太郎; 松尾光一; 松本義久; 横谷明徳
日本放射光学会年会・放射光科学合同シンポジウム(Web), 2019 - SAXS analysis of a phosphorylated DNA repair protein
長谷川真保; 長谷川真保; 西久保開; 西久保開; 松尾龍人; 藤原悟; 横谷明徳; 横谷明徳
量子ビームサイエンスフェスタ(Web), 2019 - Electronic states of DNA related molecules containing a Br atom
平戸未彩紀; 平戸未彩紀; 横谷明徳; 横谷明徳; 馬場祐治; 藤井健太郎
量子ビームサイエンスフェスタ(Web), 2019 - structural analysis of phosphorylated XRCC4 with VUV-CD
西久保開; 西久保開; 長谷川真保; 長谷川真保; 泉雄大; 藤井健太郎; 松尾光一; 松本義久; 横谷明徳; 横谷明徳
量子ビームサイエンスフェスタ(Web), 2019 - 器官培養したマウス精巣に対するすだれ状X線マイクロビーム照射と精子形成に与える影響
福永久典; 神長輝一; BUTTERWORTH Karl T.; 佐藤卓也; 渡辺立子; 宇佐美徳子; 小川毅彦; 横谷明徳; PRISE Kevin M.
KEK Progress Report (Web), Jul. 2019 - DNA放射線損傷中間体分析のための発光測定
寺尾優作; 百鬼壮大; 高田秀一郎; 小島拓也; 相原大樹; 小田島嘉孝; 槇島煕; 島田紘行; 鵜飼正敏; OZGA C.; HOLZAPFEL X.; SCHIMIDT Ph.; KUESTNER-WETEKAMM C.; OTTO H.; KNIE A.; EHRESMANN A.; 横谷明徳; 藤井健太郎; 福田義博; 斎藤祐児
放射線化学討論会講演要旨集, 2018 - 酸素K殻イオン化によって起こるデオキシリボースの分解過程
藤井健太郎; HERVE DU PENHOAT Marie-Anne; POLITIS Marie-Francoise; 横谷明徳
分子科学討論会講演プログラム&要旨(Web), 2018 - 水和ヌクレオチドの放射線誘起反応経路分析のための発光励起関数測定
寺尾優作; 百鬼壮大; 高田秀一郎; 小島拓也; 相原大樹; 小田島嘉孝; 槇島煕; 島田紘行; 鵜飼正敏; OZGA C.; HOLZAPFEL X.; SCHIMIDT Ph.; KUESTNER-WETEKAMM C.; OTTO H.; KNIE A.; EHRESMANN A.; 横谷明徳; 藤井健太郎; 福田義博
原子衝突学会年会講演概要集, 2018 - 電離放射線によって生じるDNA鎖切断に対する水和水分子の役割
藤井健太郎; 横谷明徳; DU PENHOAT M-A Herve; POLITIS M-F
日本放射光学会年会・放射光科学合同シンポジウム(Web), 2018 - ライブセルイメージングで観るX線マイクロビーム照射・非照射細胞の細胞周期変調
神長輝一; 神長輝一; 野口美穂; 宇佐美徳子; 横谷明徳; 横谷明徳
応用物理学会春季学術講演会講演予稿集(CD-ROM), 2018 - 蛍光ナノダイヤによるマウス受精卵内環境変化のリアルタイム計測に向けた試み
神長輝一; 塚本智史; 相澤竜太郎; 藤咲貴大; 横谷明徳; 柿沼志津子; 白川昌弘; 白川昌弘; 五十嵐龍治
日本分子生物学会年会プログラム・要旨集(Web), 2018 - VUV-CDスペクトル測定によるDNA修復タンパク質XRCC4の二次構造解析
西久保開; 泉雄大; 藤井健太郎; 松本義久; 横谷明徳
日本放射光学会年会・放射光科学合同シンポジウム(Web), 2018 - Application of an ex vivo organ culture method to investigate impacts on spermatogenesis following exposure to intensity- and distribution-modulated radiation fields
福永久典; 神長輝一; 宇佐美徳子; 小川毅彦; PRISE Kevin; 横谷明徳
量子ビームサイエンスフェスタ(Web), 2018 - Live-cell imaging of cell cycle modification started by DNA damage using X-ray microbeam
神長輝一; 宇佐美徳子; 横谷明徳
量子ビームサイエンスフェスタ(Web), 2018 - (量子物理学+生化学)×生物学=?～"量子生物学"とは何か～ シンクロトロン放射をツールとする放射線によるDNA損傷と細胞学的応答の研究
横谷 明徳; 藤井 健太郎; 島田 紘行; 鵜飼 正敏; 神長 輝一; 大和田 謙二; 町田 晃彦; 西村 由希子; 今岡 達彦
生命科学系学会合同年次大会, Dec. 2017 - 精巣組織器官培養法を用いた放射線照射影響の検討と治療への応用
福永 久典; 神長 輝一; 佐藤 卓也; Butterworth Karl; 横谷 明徳; 小川 毅彦; Prise Kevin
生命科学系学会合同年次大会, Dec. 2017 - 正常ヒト細胞へのX線照射によるミトコンドリア量及びATP産生量の変化
浜田涼; 浜田涼; 小野莉菜; 小野莉菜; 神長輝一; 神長輝一; 木村由佳; 木村由佳; 鈴木啓司; 横谷明徳; 横谷明徳
日本放射線影響学会大会抄録(Web), 2017 - シンクロトロン放射を用いたCDスペクトル測定によるDNA修復タンパク質XRCC4の溶液中での構造解析
西久保開; 泉雄大; 藤井健太郎; 松本義久; 横谷明徳
日本放射線影響学会大会抄録(Web), 2017 - 非照射細胞への放射線誘発DNA損傷の導入とライブセル観察による修復動態の観察
中上裕貴; 中上裕貴; 小畑結衣; 神長輝一; 神長輝一; 横谷明徳; 横谷明徳
日本放射線影響学会大会抄録(Web), 2017 - Ca2+オシレーションを含む細胞内ネットワークシステムの変化をパラメータとした放射線適応応答誘導経路のモデル化に向けた取組み
杉本理峻; 杉本理峻; 小林涼香; 服部佑哉; 渡辺立子; 立花章; 横谷明徳; 横谷明徳
日本放射線影響学会大会抄録(Web), 2017 - 放射線による細胞競合を解析するための蛍光タンパク発現ラット乳腺細胞培養技術
西村由希子; 横谷明徳; 横谷明徳; 神長輝一; 神長輝一; 工藤健一; 宇佐美徳子; 柿沼志津子; 今岡達彦; 今岡達彦
日本放射線影響学会大会抄録(Web), 2017 - 放射光円二色性分光によるDNA損傷誘起ヒストン二次構造変化の観測
泉雄大; 山本悟史; 藤井健太郎; 松尾光一; 横谷明徳; 横谷明徳
日本放射光学会年会・放射光科学合同シンポジウム(Web), 2017 - 水溶液中ピリミジン塩基の軟X線光電子およびオージェ電子スペクトル
島田紘行; 武田泰明; 三浦亮介; 篠澤柚衣; 柏田拓臣; 村井龍司; 鵜飼正敏; 横谷明徳; 藤井健太郎; 福田義博; 斎藤祐児; KNIE A.; OZGA C.; EHRESMANN A.
日本放射光学会年会・放射光科学合同シンポジウム(Web), 2017 - Live-cell imaging of cell cycle modification started by DNA damage using X-ray microbeam
神長輝一; 神長輝一; 宇佐美徳子; 横谷明徳; 横谷明徳
量子ビームサイエンスフェスタ(Web), 2017 - 水溶液中ヌクレオチドのオージェ崩壊のpH依存性
島田紘行; 武田泰明; 三浦亮介; 柏田拓臣; 篠澤柚衣; 村井龍司; 鵜飼正敏; 横谷明徳; 藤井健太郎; 福田義博; 斎藤祐児; OZGA C.; KNIE A.
日本物理学会講演概要集(CD-ROM), 2016 - 内殻励起された水溶液中ヌクレオチドからの発光の観測
島田紘行; 柏田拓臣; 篠澤柚衣; 村井龍司; 小田島嘉孝; 槇島熙; 鵜飼正敏; 横谷明徳; 藤井健太郎; 福田義博; 斎藤祐児
日本物理学会講演概要集(CD-ROM), 2016 - 放射線生体影響のメカニズム解明に向けた放射光利用研究
横谷明徳; 横谷明徳; 神長輝一; 神長輝一; 渡辺立子; 服部佑哉; 福永久典; 福永久典; 鈴木啓司; 泉雄大; 藤井健太郎
KEK Proceedings (Web), 2016 - Soft X-ray irradiation effect of SAM-DNA bilayer on solid surface as an irradiation sample
成田あゆみ; 藤井健太郎; 横谷明徳; 馬場祐治; 下山巖
量子ビームサイエンスフェスタ(Web), 2016 - Live-cell imaging of cell cycle modification started by DNA damage using X-ray microbeam
神長輝一; 神長輝一; 野口実穂; 宇佐美徳子; 横谷明徳; 横谷明徳
量子ビームサイエンスフェスタ(Web), 2016 - スフェロイドに対するX線マイクロビームを用いたバイスタンダー効果の研究
坂本由佳; 坂本由佳; 嘉成由紀子; 嘉成由紀子; 神長輝一; 神長輝一; 成田あゆみ; 野口実穂; 宇佐美徳子; 小林克己; 藤井健太郎; 横谷明徳; 横谷明徳
物構研サイエンスフェスタ要旨集, 2015 - バイスタンダー効果が細胞周期に与える影響の解明
神長輝一; 神長輝一; 成田あゆみ; 野口実穂; 嘉成由紀子; 嘉成由紀子; 坂本由佳; 坂本由佳; 宇佐美徳子; 横谷明徳; 横谷明徳
物構研サイエンスフェスタ要旨集, 2015 - 放射光X線マイクロビームを利用した細胞部分照射によるミトコンドリア活性への影響
嘉成由紀子; 嘉成由紀子; 神長輝一; 神長輝一; 坂本由佳; 坂本由佳; 成田あゆみ; 野口実穂; 宇佐美徳子; 小林克己; 鈴木啓司; 横谷明徳; 横谷明徳; 藤井健太郎
物構研サイエンスフェスタ要旨集, 2015 - 水溶液中ヌクレオチドからのN1sオージェ電子スペクトル
島田紘行; 鵜飼正敏; 武田泰明; 三浦亮介; 篠澤柚衣; 柏田拓臣; 村井龍司; 横谷明徳; 藤井健太郎; 福田義博; 斎藤祐児; KNIE A.; OZGA C.; EHRESMANN A.
日本物理学会講演概要集(CD-ROM), 2015 - 水溶液中ピリミジン塩基の軟X線吸収スペクトルに現れるpHおよび水和の影響
島田紘行; 佐久間一郎; 奥泉直人; 武田泰明; 三浦亮介; 横谷明徳; 藤井健太郎; 福田義博; 斎藤祐児; 鵜飼正敏
日本放射光学会年会・放射光科学合同シンポジウム予稿集, 2015 - Visualization of cell-cycle modification by ionizing irradiation in single HeLa cells using fluorescent ubiquitination-based cell-cycle indicator
K. Kaminaga; Y. Sakamoto; Y. Kanari; M. Noguchi; A. Yokoya
Journal of Radiation Research, 01 Mar. 2014
Last - Three-dimensional culture of HeLa-FUCCI cells for study of bystander cell-cycle effect of high LET particles
Y. Sakamoto; K. Kaminaga; Y. Kanari; M. Noguchi; A. Yokoya
Journal of Radiation Research, 01 Mar. 2014
Last - Live-cell imaging study of mitochondrial morphology in mammalian cells irradiated
Y. Kanari; M. Noguchi; K. Kaminaga; Y. Sakamoto; A. Yokoya
Journal of Radiation Research, 01 Mar. 2014
Last - Order effect of repair processes to clustered DNA damage
I. Shiraishi; M. Suzuki; N. Shikazono; K. Fujii; A. Yokoya
Journal of Radiation Research, 01 Mar. 2014
Last - Dependence of the yields of AP sites and AP clusters produced in plasmid DNA on scavenging capacity and LET
T. Shiina; R. Watanabe; M. Suzuki; A. Yokoya
Journal of Radiation Research, 01 Mar. 2014
Last - X線マイクロビームを用いた細胞周期影響観察
成田あゆみ; 神長輝一; 神長輝一; 横谷明徳; 野口実穂; 小林克己; 宇佐美徳子; 藤井健太郎
日本放射光学会年会・放射光科学合同シンポジウム予稿集, 2014 - 水和デオキシリボース分子の軟X線による分解過程
藤井健太郎; 泉雄大; 成田あゆみ; 横谷明徳; HERVE DU PENHOAT M. A.; TOUATI A.; VUILLEUMIOER R.; GAIGEOT M. P.; POLITIS M. F.
日本放射光学会年会・放射光科学合同シンポジウム予稿集, 2014 - 水溶液中のプリンヌクレオチドの軟X線吸収スペクトルおよびそのpH依存性
島田紘行; 深尾太志; 南寛威; 佐久間一郎; 奥泉直人; 横谷明徳; 藤井健太郎; 福田義博; 斎藤祐児; 鵜飼正敏
日本放射光学会年会・放射光科学合同シンポジウム予稿集, 2014 - タイムラプスイメージング法で観察したFucci発現細胞へのX線マイクロビーム照射の影響
神長輝一; 神長輝一; 成田あゆみ; 野口実穂; 嘉成由紀子; 坂本由佳; 横谷明徳; 嘉成由紀子; 坂本由佳; 横谷明徳
物構研サイエンスフェスタ要旨集, 2014 - X線照射によるミトコンドリアの動態変化と膜電位の関係
嘉成由紀子; 嘉成由紀子; 野口実穂; 神長輝一; 坂本由佳; 横谷明徳; 神長輝一; 坂本由佳; 横谷明徳; 鈴木啓司
物構研サイエンスフェスタ要旨集, 2014 - スフェロイドに対するX線マイクロビーム照射及び細胞応答の観察
坂本由佳; 嘉成由紀子; 神長輝一; 坂本由佳; 嘉成由紀子; 神長輝一; 野口実穂; 横谷明徳; 横谷明徳
物構研サイエンスフェスタ要旨集, 2014 - X線マイクロビームを用いた細胞周期に依存した照射影響のリアルタイム観察
成田あゆみ; 神長輝一; 神長輝一; 横谷明徳; 野口実穂; 小林克己; 宇佐美徳子; 藤井健太郎
物構研サイエンスフェスタ要旨集, 2014 - マイクロビームを用いた細胞核照射と細胞質照射によるミトコンドリアへの影響
嘉成由紀子; 嘉成由紀子; 神長輝一; 神長輝一; 成田あゆみ; 宇佐美徳子; 鈴木啓司; 横谷明徳; 横谷明徳
日本放射線影響学会大会講演要旨集, 2014 - X線マイクロビーム照射・非照射細胞の細胞分裂のライブセルイメージング
神長輝一; 成田あゆみ; 嘉成由紀子; 坂本由佳; 嘉成由紀子; 坂本由佳; 宇佐美徳子; 小林克己; 野口実穂; 横谷明徳; 横谷明徳
日本放射線影響学会大会講演要旨集, 2014 - 内殻イオン化による水和デオキシリボースの分解初期物理過程
藤井健太郎; 泉雄大; 成田あゆみ; 横谷明徳; ペンホート マリーアンハーベ; グース クリスナ; ブレモア ロドルフ; ガイゴー マリーピエール; ポリティス マリーフランソア
日本放射線影響学会大会講演要旨集, 2014 - X線マイクロビーム照射細胞のライブイメージング追跡
横谷明徳; 横谷明徳; 成田あゆみ; 神長輝一; 神長輝一; 嘉成由紀子; 嘉成由紀子; 坂本由佳; 坂本由佳; 野口実穂; 藤井健太郎; 宇佐美徳子; 小林克己; 鈴木啓司
日本放射線影響学会大会講演要旨集, 2014 - ELECTROANALYSIS OF RADIATION-INDUCED ATP DAMAGE USING A NANOCARBON FILM ELECTRODE
加藤大; 藤井健太郎; 藤井紳一郎; 月本光俊; 秋光信佳; 成田あゆみ; 小島周二; 横谷明徳; 丹羽修
Chemical Sensors, 2014 - Circular Dichroism Study on Structural Change of Proteins Triggering DNA Repair
IZUMI YUDAI; YAMAMOTO SATOSHI; YAMAMOTO SATOSHI; FUJII KENTARO; YOKOYA AKINARI
放射線化学討論会講演要旨集, 2014 - Substituent Effect for Pyrimidine DNA-base Induced by Soft X-ray Irradiation
OKA TOSHITAKA; YOKOYA AKINARI; FUJII KENTARO; KINO YASUSHI; SEKINE TSUTOMU
放射線化学討論会講演要旨集, 2014 - VUV-CD Measurements of Modified Histone Proteins
IZUMI YUDAI; MATSUO KOICHI; FUJII KENTARO; YOKOYA AKINARI
Proc Hiroshima Int Symp Synchrotron Radiat, 2014 - Unpaired electrons of pyrimidine-base induced by high intense soft X-ray irradiation studied by ESR
OKA TOSHITAKA; YOKOYA AKINARI; FUJII KENTARO; KINO YASUSHI; SEKINE TSUTOMU
原子衝突学会年会講演概要集, 2014 - Initial Process of DNA Base Damage Induction Explored by Soft X-ray Spectroscopies
SHIMADA HIROYUKI; TAKEDA YASUAKI; MIURA RYOSUKE; KASHIWADA TAKUMI; SHINOZAWA YUI; MURAI RYUJI; FUJII KENTARO; YOKOYA AKINARI; FUKUDA YOSHIHIRO; SAITOH YUJI; UKAI MASATOSHI
原子衝突学会年会講演概要集, 2014 - Destruction of Deoxyribose Induced by Core-ionization-Experimental and Theoretical Approach to Reveal Physical Processes of DNA Strand Breakage-
FUJII KENTARO; IZUMI YUDAI; NARITA AYUMI; YOKOYA AKINARI; HERVE DU; PENHOAT MARIE-ANNE; GHOSE K; VUILLEUMIER RODOLPHE; GAIGEOT MARIE-PIERRE; POLITIS MARIE-FRANCOISE
放射線化学討論会講演要旨集, 2014 - 酸素K殼XANES領域の軟X線照射によるDNA損傷の収率変化
菅谷雄基; 菅谷雄基; 成田あゆみ; 椎名卓也; 椎名卓也; 白石伊世; 白石伊世; 藤井健太郎; 横谷明徳; 横谷明徳
日本放射光学会年会・放射光科学合同シンポジウム予稿集, 2013 - タイムラプスイメージング法で観察したFucci発現細胞へのX線照射の影響
神長輝一; 神長輝一; 成田あゆみ; 野口美穂; 嘉成由紀子; 嘉成由紀子; 坂本由佳; 坂本由佳; 横谷明徳; 横谷明徳
日本原子力学会秋の大会予稿集(CD-ROM), 2013 - 窒素K吸収端近傍X線吸収スペクトルのpH依存性にみる水溶液ヌクレオチドの構造変化
島田紘行; 深尾太志; 南寛威; 佐久間一郎; 奥泉直人; 横谷明徳; 藤井健太郎; 福田義博; 斎藤祐児; 鵜飼正敏
放射線化学討論会講演要旨集, 2013 - X線吸収スペクトルに見る水溶液中のプリンヌクレオチドの構造変化
奥泉直人; 島田紘行; 深尾大志; 南寛威; 佐久間一郎; 鵜飼正敏; 横谷明徳; 藤井健太郎; 福田義博; 斎藤祐児
原子衝突学会年会講演概要集, 2013 - ピリミジンヌクレオチドの窒素K殻吸収端近傍におけるX線吸収スペクトル
佐久間一郎; 島田紘行; 南寛威; 奥泉直人; 鵜飼正敏; 横谷明徳; 藤井健太郎; 福田義博; 斉藤裕児
原子衝突学会年会講演概要集, 2013 - 軟X線を用いた水溶液中のヌクレオチドの幾何・電子構造の研究
島田紘行; 深尾太志; 南寛威; 佐久間一郎; 奥泉直人; 横谷明徳; 藤井健太郎; 福田義博; 斎藤祐児; 鵜飼正敏
原子衝突学会年会講演概要集, 2013 - 単色軟X線を用いたリンK殻吸収によるDNA2重鎖切断生成・修復効率と細胞致死効果の解析
冨田雅典; 前田宗利; 宇佐美徳子; 横谷明徳; 渡辺立子; 小林克己
日本分子生物学会年会プログラム・要旨集(Web), 2013 - 低線量放射線の健康影響 初期過程から細胞応答まで 放射線トラック構造に依存したクラスターDNA損傷の誘発(Dependence of induction of clustered DNA damage on radiation track structure)
横谷 明徳; O'Neill Peter
日本放射線影響学会大会講演要旨集, Sep. 2012 - タイムラプス法で観測したFucci発現細胞の細胞周期へのX線照射の影響
横谷明徳; 横谷明徳; 野口実穂; 神長輝一; 神長輝一; 坂本由佳; 坂本由佳; 嘉成由紀子; 嘉成由紀子; 成田あゆみ; 藤井健太郎
日本放射線影響学会大会講演要旨集, 2012 - DNA分子上の放射線損傷分布とDNA損傷修復経路干渉の相関
白石伊世; 白石伊世; 椎名卓也; 椎名卓也; 菅谷雄基; 菅谷雄基; 鹿園直哉; 鹿園直哉; 横谷明徳; 横谷明徳
日本放射線影響学会大会講演要旨集, 2012 - APサイト及びこれを含むクラスターDNA損傷収率の放射線の線質およびLET依存性
椎名卓也; 椎名卓也; 白石伊世; 白石伊世; 菅谷雄基; 菅谷雄基; 渡邊立子; 鈴木雅雄; 横谷明徳; 横谷明徳
日本放射線影響学会大会講演要旨集, 2012 - 水溶液アデニンヌクレオチドの軟X線吸収スペクトルのpH依存性と構造変化
島田紘行; 深尾太志; 南寛威; 佐久間一郎; 奥泉直人; 横谷明徳; 藤井健太郎; 福田義博; 斎藤祐児; 鵜飼正敏
放射線化学討論会講演要旨集, 2012 - 酸素K殻共鳴励起によりプラスミドDNA中に生成する鎖切断,塩基変異及びAPサイト
菅谷雄基; 菅谷雄基; 白石伊世; 白石伊世; 椎名卓也; 椎名卓也; 藤井健太郎; 横谷明徳; 横谷明徳
日本放射光学会年会・放射光科学合同シンポジウム予稿集, 2011 - 抗酸化物質エダラボンによるDNA損傷前駆体の化学回復
端邦樹; 端邦樹; 端邦樹; 漆原あゆみ; 山下真一; 山下真一; 鹿園直哉; 横谷明徳; 室屋裕佐; 勝村庸介
日本放射線影響学会大会講演要旨集, 2011 - モンテカルロ飛跡計算に基づくBNCTにおけるDNA損傷評価
冠城雅晃; 冠城雅晃; 渡邊立子; 佐藤達彦; 横谷明徳; PINAK Miroslav; 勝村庸介; 上坂充
日本放射線影響学会大会講演要旨集, 2011 - APサイト及びこれを含むクラスターDNA損傷収率の放射線線質およびLET依存性
椎名卓也; 椎名卓也; 菅谷雄基; 菅谷雄基; 白石伊世; 白石伊世; 渡邊立子; 渡邊立子; 横谷明徳; 鶴岡千鶴; 鈴木雅雄
日本放射線影響学会大会講演要旨集, 2011 - クラスターDNA損傷に対する塩基除去修復酵素の作用順序の効果 II
白石伊世; 白石伊世; 椎名卓也; 椎名卓也; 菅谷雄基; 菅谷雄基; 鹿園直哉; 鹿園直哉; 横谷明徳
日本放射線影響学会大会講演要旨集, 2011 - 酸素K殻イオン化エネルギー領域の軟X線照射によるDNA損傷の収率変化
菅谷雄基; 菅谷雄基; 椎名卓也; 椎名卓也; 白石伊世; 白石伊世; 藤井健太郎; 横谷明徳
日本放射線影響学会大会講演要旨集, 2011 - Development of a Synchrotron Radiation Aided PES/SIMS under a High Ambient Vapor Pressure as the Spectroscopy for the Induction and Repair Processes of Radiation Damage
鵜飼正敏; 住谷亮輔; 安廣哲; 横谷明徳; 藤井健太郎; 斎藤祐児
日本原子力研究開発機構JAEA-Review(Web), 2011 - 22aEE-8 Analysis of DNA damage by soft X-rays irradiation using a molecular dynamics method
Kai Takeshi; Higuchi Mariko; Fujii Kentato; Watanabe Ritsuko; Yokoya Akinari
Meeting abstracts of the Physical Society of Japan, 24 Aug. 2011 - Research Group for Radiation and Biomolecular Sciences
YOKOYA AKINARI; FUJII KENTARO; NOGUCHI MIHO; URUSHIBARA AYUMI; OKA TOSHITAKA; SUGAYA YUKI; SHIRAISHI IYO; SHIINA TAKUYA
Ann Rep ASRC, 2011
Lead - AP site及びこれを含むクラスターDNA損傷収率の放射線の線質及びスキャベンジャー能に対する依存性
椎名卓也; 菅谷雄基; 白石伊世; 椎名卓也; 菅谷雄基; 白石伊世; 渡辺立子; 横谷明徳; 横谷明徳; 横谷明徳; 鶴岡千鶴; 鈴木雅雄
日本放射線影響学会大会講演要旨集, 2010 - 軟X線及び電子線照射によりプラスミドDNA中に生成する塩基損傷及びAPサイト
菅谷雄基; 白石伊世; 椎名卓也; 横谷明徳; 菅谷雄基; 白石伊世; 椎名卓也; 藤井健太郎; 横谷明徳
日本放射線影響学会大会講演要旨集, 2010 - 希簿プラスミドDNA水溶液へのガンマ線照射:放射線誘起損傷の抗酸化剤エダラボンによる化学回復
端邦樹; 漆原あゆみ; 山下真一; 鹿園直哉; 横谷明徳; 勝村庸介
日本放射線影響学会大会講演要旨集, 2010 - クラスターDNA損傷に対する塩基除去修復酵素の作用順序の効果
白石伊世; 椎名卓也; 菅谷雄基; 鹿園直哉; 横谷明徳; 白石伊世; 椎名卓也; 菅谷雄基; 鹿園直哉; 横谷明徳
日本放射線影響学会大会講演要旨集, 2010 - A new technique for determination of DNA strand breaks using DNA denaturation
横谷明徳
Notes on basic science, Feb. 2010 - シリビンの抗酸化作用とラジカル捕捉作用に関する研究
端邦樹; FU Haiying; LIN Mingzhang; 室屋裕佐; 勝村庸介; 勝村庸介; 横谷明徳; 籏野嘉彦
アイソトープ・放射線研究発表会要旨集, 2009 - Development of a Synchrotron Radiation Aided PES/SIMS under a High Ambient Vapor Pressure as the Spectroscopy for the Induction and Repair Processes of Radiation Damage
鵜飼正敏; 野中裕介; 住谷亮輔; 横谷明徳; 藤井健太郎; 斎藤祐児
日本原子力研究開発機構JAEA-Review, 2009 - イオンビーム照射により高水和DNAフィルム中に誘発されるDNA鎖切断及び塩基損傷収率のLET依存性
横谷明徳; 牛込剛史; 牛込剛史; 田内広; 鈴木雅雄; 鶴岡千鶴; 野口実穂; 藤井健太郎; 鹿園直哉; 渡邊立子
日本放射線影響学会大会講演要旨集, 2009 - X線誘発損傷に対するシリビンとその類似体のin vitroでのDNA防護効果
FU Haiying; LIN Mingzhang; 端邦樹; 室屋裕佐; 藤井健太郎; 勝村庸介; 勝村庸介; 横谷明徳; 鹿園直哉; 籏野嘉彦
日本放射線影響学会大会講演要旨集, 2008 - 21pTC-4 Soft X-ray synchrotron radiation spectroscopy for nucleotides in water solution using a liquid water jet technique.
Ukai Masatoshi; Yokoya Akinari; Fujii Kentaro; Saitoh Yuji
Meeting abstracts of the Physical Society of Japan, 28 Feb. 2007 - Installation of Refocusing Mirrors in JAEA Soft X-ray Beamline BL23SU at Spring-8
福田義博; 福田義博; 斎藤祐児; 横谷明徳; 寺岡有殿
日本原子力研究開発機構JAEA-Technology, 2007 - アミノ酸の軟X線自然二色性スペクトル(SXNCD):初測定とその後の発展
中川和道; 田中真人; 泉雄大; 安居院あかね; 横谷明徳; 藤井健太郎; 室隆桂之; 松下智裕
分子科学討論会講演要旨集(CD-ROM), 2007 - 光子及びイオン粒子照射により生じるDNA鎖切断及び塩基損傷の収率のLET依存性
横谷明徳; 牛込剛史; 牛込剛史; 鹿園直哉; 藤井健太郎; 漆原あゆみ; 鈴木雅雄; 田内広; 渡邊立子
日本放射線影響学会大会講演要旨集, 2006 - 8 Chemical evolution of diglycine to oligopeptide induced by VUV irradiation at 77K(General Contribution,The 31th annual meeting of the SSOEL-JAPAN (Abstracts))
Matsui Takahiro; Nakagawa Kazumichi; Izumi Yudai; Kamohara Masumi; Yokaya Akinari
Viva origino, 2006 - A novel technique using DNA denaturation to detect multiply induced single-strand breaks in a hydrated plasmid DNA molecule by X-ray and 4He 2+ ion irradiation
Akinari Yokoya; Naoya Shikazono; Kentaro Fujii; Miho Noguchi; Ayumi Urushibara
Radiation Protection Dosimetry, 2006 - Synchrotron-radiation photoelectron study for bio-solution using liquid water jet
UKAI MASATOSHI; YOKOYA AKINARI; FUJII KENTARO; SAITOH YUJI
日本原子力研究開発機構JAEA-Review, Jan. 2006 - Unstable radical in evaporated DNA-bases onto surface irradiated with soft X-rays around nitrogen and oxygen K-edge region
YOKOYA AKINARI; FUJII KENTARO
日本原子力研究開発機構JAEA-Review, Jan. 2006 - Circular dichroism and Asymmetric reaction of amino acid films in vacuum ultraviolet and soft X-ray region(Chemical Evolution, International Symposium on Origins of Life and Astrobiology) :
Kodama Yoko; Ohta Yoshimi; Tanaka Masahito; Kaneko Fusae; Kitada Tomo; Nakagawa Kazumichi; Yagi (Watanabe) Kazutoshi; Yamada Toru; Onuki Hideo; Agui Akane; Fujii Kentaro; Yokoya Akinari
Viva origino, 2005 - Chemical evolution of amino acid induced by soft X-ray with Synchrotron Radiation(Chemical Evolution, International Symposium on Origins of Life and Astrobiology) :
Kaneko F.; Tanaka M.; Matsui T.; Nakagawa K.; Agui A.; Fujii K.; Yokoya A.
Viva origino, 2005 - CHEMICAL EVOLUTION TO OLIGOPEPUTIDE IN SOLID PHASE IRRADIATED WITH VACUUM ULTRAVIOLET LIGHT AND SOFT X-RAY(Chemical Evolution, International Symposium on Origins of Life and Astrobiology) :
Matsui T.; Nakagawa K.; Kaneko F.; Tanaka M.; Kitada T.; Izumi Y.; Kamohara M.; Yokoya A.
Viva origino, 2005 - First observation of natural circular dichroism for biomolecules in soft x-ray region studied with a polarizing undulator
Masahito Tanaka; Kazumichi Nakagawa; Akane Agui; Kentaro Fujii; Akinari Yokoya
Physica Scripta T, 2005 - 26pXP-13 アミノ酸(アラニン)蒸着膜の軟X線自然円二色性スペクトル測定(領域5, 領域3, 領域8合同招待講演,領域5(光物性))
北田 朋; 中川 和道; 田中 真人; 安居院 あかね; 藤井 健太郎; 横谷 明徳
日本物理学会講演概要集, 2005 - 13pTE-14 Soft-Xray absorption spectrum of liquid water by means of synchrotron radiation excitaton combined with liquid water jet
Ukai M; Takahata H; Ohtsuka H; Mitsuya D; Fujii K; Yokoya A
Meeting abstracts of the Physical Society of Japan, 25 Aug. 2004 - First Observation of Circular Dichroism of Amino Acid Films from Vacuum Ultraviolet to Soft X-ray Region
NAKAGAWA K; TANAKA M; KANEKO F; KITADA T; AGUI A; FUJII K; YOKOYA A; YAMADA T; WATANABE K
Viva origino, 28 Feb. 2004 - 軟X線照射により水和プラスミドDNA中に生じる鎖切断,塩基損傷及びクラスター損傷
横谷明徳; CUNNIFFE S M T; 渡辺立子; 小林克己; O’NEILL P
日本放射線影響学会大会講演要旨集, 2004 - 放射線物理・化学による放射線生物学のブレークスルー 放射線エネルギーの直接付与によって生じるDNA損傷の実体とは?-酸化的DNA損傷との相違点と類似点-
赤松憲; 藤井健太郎; 横谷明徳
日本放射線影響学会大会講演要旨集, 2004 - 29pXF-1 Natural Ciroular Diohroism of Biomoleoules in Soft X-ray Region
田中 真人; 中川 和道; 安居院 あかね; 藤井 健太郎; 横谷 明徳
Meeting Abstracts of the Physical Society of Japan, 2004 - Chemical evolution of amino acid induced by soft X-ray irradiation with synchrotron radisation
NARITA Satoru; ZHAOHUI Jin; TANAKA Masahito; KITADA Tomo; KANEKO Fusae; NAKAGAWA Kazumichi; AGUI Akane; FUJII Kentaro; YOKOYA Akinari
Viva origino, 30 Mar. 2003 - Present Status of Synchrotron Radiation Study on Chemical Evolution of Amino Acids
NAKAGAWA K; TANAKA M; ZHAOHUI Jin; NARITA S; KITADA T; KANEKO F; AGUI A; FUJII K; YOKOYA A; YAMADA T; ONUKI H
Viva origino, 30 Mar. 2003 - Track structure of ionizing radiation and DNA damage
Watanabe Ritsuko; Saito Kimiaki; Yokoya Akinari
Meeting abstracts of the Physical Society of Japan, 06 Mar. 2003 - 190 HPLC and EPR Analysis of Thymine Derivatives produced by Ultrasoft X- and ^<60>Co γ-irradiation(Environmental effects of radiation, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society) :
AKAMATSU Ken; FUJII Kentaro; YOKOYA Akinari
Journal of radiation research, 2003 - 142 In situ observation of DNA base radical using an EPR spectrometer combined with a synchrotron soft X-ray beamline in SPring-8(Redox regulation, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society) :
YOKOYA Akinari; AKAMATSU Ken; FUJII Kentaro
Journal of radiation research, 2003 - W-1-3 Electronic States of DNA and Radiation Damage to DNA(Theoretical and Experimental Approaches Relative to DNA Structure and DNA Damage Production, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society) :
FUJII Kentaro; YOKOYA Akinari
Journal of radiation research, 2003 - Chemical Evolution of Amino Acid Induced by Soft X-ray Irradiation with Synchrotron Radiation
Kaneko Fusae; Narita S.; Nakagawa K.; Tanaka M.; Jin Zhaohui; Kitada T.; Agui A.; Yokoya A.; Fujii K.
Meeting abstracts of the Physical Society of Japan, 15 Aug. 2003 - First Observation of Natural Circular Dichroism Spectra in Soft X-ray region using polarizing undulator
Tanaka M; Nakagawa K; Kitada T; Kaneko F; Agui A; Yokoya A; Fujii K
Meeting Abstracts of the Physical Society of Japan, 2003 - 実験ステーション(原研ビームライン) BL23SU 原研 重元素科学
寺岡有殿; 吉越章隆; 藤井健太郎; 横谷明徳; 安居院あかね; 中谷健; 岡本淳; 間宮一敏; 村松康司
SPring-8年報, Dec. 2002 - 偏光放射光軟X線を用いた5-bromouracil単結晶に対するBr-K殻X線吸収及びこれにより誘発される分子損傷
横谷明徳; 高倉かほる; 渡辺立子; 赤松憲; 恵恒雄; 伊藤隆
日本放射線影響学会大会講演要旨集, 2002 - 軟X線領域におけるアミノ酸,ペプチド薄膜のXANESおよび軟X線化学反応
田中真人; 成田悟; JIN Z; 北田朋; 三宅康之; 中川和道; 安居院あかね; 藤井健太郎; 横谷明徳
放射線化学討論会講演要旨集, 2002 - グリシン蒸着膜への軟X線照射によるグリシン二量体の生成
成田悟; ZHAOHUI J; 田中真人; 三宅康之; 北田朋; 中川和道; 安居院あかね; 横谷明徳; 藤井健太郎
放射線化学討論会講演要旨集, 2002 - Polarized Bromine K-shell X-ray Absorption of 5-bromouracil Crystal and Induced Molecular Damage :
YOKOYA Akinari; TAKAKURA Kaoru; WATANABE Ritsuko; AKAMATSU Ken; MEGUMI Tsuneo; ITO Takashi
Journal of radiation research, 2002 - Clustering of DNA damage due to Auger process induced by photoabsorption :
WATANABE Ritsuko; SAITO Kimiaki; YOKOYA Akinari
Journal of radiation research, 2002 - A Basic Approach for Radiation Chemical Dose-Response Estimation for Thymine Derivatives :
AKAMATSU Ken; FUJII Kentaro; YOKOYA Akinari
Journal of radiation research, 2002 - The Observation of DNA Fragmentation using Desorbed Ion Detection Technique :
FUJII Kentaro; AKAMATSU Ken; YOKOYA Akinari
Journal of radiation research, 2002 - Operation of Circular Dichroism Measurements with Reiodic Photon-Helicity Switching by an APPLE-2 type Undulator at BL23SU in SPring-8
AGUI Akane; YOSHIGOE Akitaka; NAKATANI Takeshi; MATSUSHITA Tomohiro; SAITOH Yuji; MIZUMAKI Masaichiro; YOKOYA Akinari; TANAKA Hitoshi; MIYAHARA Yoshikazu; SHIMADA Taihei; TAKEUCHI Masao; TAKAO Masaru; SASAKI Shigeki; AOYAGI Hideki; KUDO Tougo; SATO Kazumichi; WU Syukui; OHKUMA Haruo
放射光, 01 Nov. 2001 - γ線及びα線照射により水和したプラスミドDNAに生じる鎖切断とNthとFpgにより除去される塩基損傷の収率
横谷明徳; CUNNIFFE S; STEVENS D; O’NEILL P
日本放射線影響学会大会講演要旨集, 2001 - XANES measurement of amino acid and peptide films around nitrogen and oxygen K-edge.
田中真人; 古結俊行; 児玉洋子; 中川和道; 安居院あかね; 赤松憲; 横谷明徳
放射線化学討論会講演要旨集, 2001 - X-ray Absorption Near Edge Structure of DNA Bases :
FUJII Kentaro; AKAMATSU Ken; YOKOYA Akinari; MURAMATSU Yasuji
Journal of radiation research, 2001 - Modelling of DNA damage following K-shell photoabsorption of DNA constituent atoms :
WATANABE Ritsuko; YOKOYA Akinari; SAITO Kimiaki
Journal of radiation research, 2001 - Characterization of Chemical Changes in DNA Components by Energy Deposition from monochromatic Photons :
AKAMATSU Ken; FUJII Kentaro; YOKOYA Akinari
Journal of radiation research, 2001 - Highlights of SPring-8 BL23SU in 2000.
安居院あかね; 吉越章隆; 中谷健; 斎藤祐児; 寺岡有殿; 横谷明徳
日本原子力研究所JAERI-Tech, Jul. 2001 - NEXAFS measurement of amino acid sublimated films around nitrogen and oxygen K-edge.
Tanaka Masahito; Koketsu Toshiyuki; Kodama Yoko; Nakagawa Kazumichi; Akamatsu Ken; Agui Akane; Yokoya Akinari
Meeting Abstracts of the Physical Society of Japan, 2001 - Design and Manufacture of a Testing Device for the Evaluation of Optical Elements.
清水雄一; 依田修; 貴家恒男; 寺岡有殿; 横谷明徳; 柳原美広
日本原子力研究所JAERI-Tech, 2000 - X-ray absorption near edge structures (XANES) of DNA or its components around oxygen K-edge and the application for radiation biology :
AKAMATSU Ken; YOKOYA Akinari
Journal of radiation research, 2000 - Role of X-ray absorotion near edge structures (XANES) on investigating basic prccesses of ionizing radiation toxicity
Akamatsu Ken; Yokoya Akinari
日本環境変異原学会大会プログラム・要旨集, 2000 - 25pYK-11 ネオンイオン及び酸素イオンの内殻光励起・電離実験
山岡 人志; 伊藤 陽; 粟屋 容子; 横谷 明徳; 安居院 あかね; 吉越 章隆; 大浦 正樹; 川面 澄; 木俣 潤一; 早石 達司; 高橋 武寿; 小泉 哲夫; 関岡 嗣久; 寺澤 倫孝
日本物理学会講演概要集, 2000 - 22aPS-98 First operation of circular dichroism measurements with high-frequency phase switching of a variable polarizing undulator
Agui A; Takao M; Saotome K; Ohkuma H; Aoyagi H; Kudo T; Wu S; Satoh K; Takeuchi M; Bizen T; Yoshigoe A; Yokoya A; Saitoh Y; Nakatani T; Matsushita T; Shimada T; Miyahara Y; Tanaka H
Meeting Abstracts of the Physical Society of Japan, 2000 - SPring-8軟X線光化学ビームラインBL27SUの建設
大橋治彦; 石黒英治; 田中隆次; 岸本輝; 大浦正樹; 横谷明徳; 為則雄祐; 金島岳; 石川哲也
日本放射光学会年会・放射光科学合同シンポジウム予稿集, 1999 - Current Status of JAERI Soft X-ray BL23SU.
横谷明徳; 寺岡有殿; 島田太平; 平松洋一; 斎藤祐児; 中谷健; 宮原義一; 岡根哲夫
SPring-8利用者情報, 1999 - Modeling of Production Process of DNA Damage by X-ray Induced Inner-Shell Photoabsorrpion :
WATANABE Ritsuko; YOKOYA Akinari; SAITO Kimiaki
Journal of radiation research, 1999 - 24pYC-15 MCD in the JAERI soft X-ray BL23SU at SPring-8
Saitoh Y; Mizumaki M; Matsushita T; Nakatani T; Agui A; Teraoka Y; Yokoya A
Meeting Abstracts of the Physical Society of Japan, 1999 - Biological irradiation effects in ultra-soft X-ray region gained with undulator radiation.
横谷明徳
日本放射線影響学会大会講演要旨集, 1998 - Facts revealed by test data of repairability of chromatin cutting by inner shell ionization of phosphorus K-shell.
鈴木雅雄; 前沢博; 加瀬陽子; 横谷明徳; 宇佐美徳子; 小林克己
日本放射線影響学会大会講演要旨集, 1998 - Induction of non-rejoining chromatin breaks by the inner shell absorption of phosphorus in DNA. :
SUZUKI Masao; MAESAWA Hiroshi; KASE Yoko; YOKOYA Akinari; Usami Noriko; KOBAYASHI Katsumi
Journal of radiation research, 1998 - Radiobiological Study in Ultrasoft X-ray Region Using Undulator Synchrotron Radiation :
YOKOYA Akinari
Journal of radiation research, 1998 - XANES Spectra for DNA in Ultrasoft X-ray Region :
AKAMATSU Ken; YOKOYA Akinari
Journal of radiation research, 1998 - JAERI Soft X-ray Beamline Specialized for Radioactive Materials Equipped with Variably-polarizing Undulator.
横谷明徳; 関口哲弘; 斎藤祐児; 岡根哲夫; 中谷健; 寺岡有殿; 島田太平; 高雄勝; 大野英雄
SPring-8利用者情報, 1997 - Soft X-ray Spectroscopy for Biology in SPring-8 : Soft X-ray Spectroscopy for Biology in SPring-8
YOKOYA Akinari
Journal of radiation research, 1997 - Chromatin-break induction in V79 cells by monochromatic soft X rays near K-shell absorption edge of phosphorus. : Chromatin-break induction in V79 cells by monochromatic soft X rays near K-shell absorption edge of phosphorus.
SUZUKI Masao; MAESAWA Hiroshi; KASE Yoko; YOKOYA Akinari; Usami Noriko; KOBAYASHI Katsumi
Journal of radiation research, 1997 - Optical absorption spectrum of DNA in soft x-ray region.
横谷明徳; 原岳広; 渡辺立子; 桧枝光太郎; 小林克己
日本放射光学会年会予稿集, 1996 - Development of monochromatic ultrasoft X-ray irradiation device for wet biological samples. II.
桧枝光太郎; 冨田雅典; 小林克己; 宇佐美徳子; 横谷明徳; 渡辺立子; 前沢博; 伊藤敦; 高倉かほる
日本放射線影響学会大会講演要旨集, 1996 - Conceptual Design of EPR Cryotip Specialized for Irradiation Experiment with Synchrotron Soft X-rays.
横谷明徳; 渡辺立子; 高倉かほる; 恵恒雄; 伊藤隆
放射線化学討論会講演要旨集, 1996 - Optical absorption spectrum of DNA in soft X-ray region.
横谷明徳; 渡辺立子; 原岳広; 桧枝光太郎; 小林克己
日本放射線影響学会大会講演要旨集, 1996 - Magnetic Field Calculation of Variably Polarizing Undulator (APPLE-type) for SX Beamline in the SPring-8.
小林秀樹; 佐々木茂美; 島田太平; 高雄勝; 横谷明徳; 宮原義一
日本原子力研究所JAERI-Tech, 1996 - Photoabsorption Spectrum of DNA in Ultrasoft X-ray Region : Photoabsorption Spectrum of DNA in Ultrasoft X-ray Region
YOKOYA Akinari; WATANABE Ritsuko; HARA Takehiro; HIEDA Kotaro; KOBAYASHI Katsumi
Journal of radiation research, 1996 - Irradiation System of Monochromatic Ultrasoft X-Rays for Wet Biological Samples. : Irradiation System of Monochromatic Ultrasoft X-Rays for Wet Biological Samples.
HIEDA Kotaro; KOBAYASHI Katsumi; USAMI Noriko; YOKOYA Akinari; WATANABE Ritsuko; MAEZAWA Hiroshi; IT0 Atsushi; TAKAKURA Kaoru; TOMITA Masanori
Journal of radiation research, 1996 - Design of an Irradiation System of Monochromatic Ultrasoft X-rays for Wet Samples : Design of an Irradiation System of Monochromatic Ultrasoft X-rays for Wet Samples
HIEDA Kotaro; KOBAYASHI Katsumi; USAMI Noriko; YOKOYA Akinari; MAEZAWA Hiroshi; Ito Atsushi; TAKAKURA Kaoru
Journal of radiation research, 1995 - SOS-induction in Salmonella typhimurium TA1535/pSK1002 by Monochromatic Soft X-ray from Synchrotron Radiation.
中村清一; 恵恒雄; 宇佐美徳子; 横谷明徳; 小林克巳
大阪府立公衆衛生研究所研究報告 労働衛生編, 1994 - Single- and double-strand breaks induced by monochromatic ultra-soft X-rays from 60 to 550 eV. : Single- and double-strand breaks induced by monochromatic ultra-soft X-rays from 60 to 550 eV.
HIEDA Kotaro; SUZUKI Keiji; YOKOYA Akinari; KOBAYASHI Katsumi
Journal of radiation research, 1994 - Development of Synchrotron Radiation Beam Line for Researches of Radioactive Materials.
小西啓之; 本橋治彦; 横谷明徳; 藤田利明; 大野英雄
日本原子力学会春の年会要旨集, 1993 - Degradation of Amino Acid Irradiated with Monochromatized Soft X-rays in Aqueous Solution : Degradation of Amino Acid Irradiated with Monochromatized Soft X-rays in Aqueous Solution
YOKOYA Akinari; KOBAYASHI Katsumi; USAMI Noriko
Journal of radiation research, 1993 - Mode of decomposition of amino acid which is depended on ionized atom of inner electron orbit.
横谷明徳; 宇佐美徳子; 小林克己
Photon Factory News, 1992 - マウス線維芽細胞における単色軟X線による潜在致死損傷の回復
横谷 明徳
日本放射線影響学会大会講演要旨集, Aug. 1989 - LETHAL EFFECT OF SYNCHROTRON SOFT X-RAYS AROUND K-SHELL ABSORPTION-EDGE OF PHOSPHORUS ON MOUSE 10T1/2 CELLS
A YOKOYA; K KOBAYASHI; H MAEZAWA; K HIEDA; S ISHIZAKA
JOURNAL OF RADIATION RESEARCH, Mar. 1988 - INACTIVATION OF REPAIR DEFICIENT YEAST-CELLS IRRADIATED WITH MONOCHROMATIC SOFT X-RAYS OF THE RESONANCE-ABSORPTION OF PHOSPHORUS
K KOBAYASHI; N USAMI; A YOKOYA; H MAEZAWA; Y FURUSAWA; K HIEDA; T ITO
JOURNAL OF RADIATION RESEARCH, Mar. 1988 - INACTIVATION OF CELL-ADHESION ACTIVITY MEDIATED WITH FIBRONECTIN WITH X-RAYS
A YOKOYA; K KOBAYASHI; S ISHIZAKA
JOURNAL OF RADIATION RESEARCH, Mar. 1987 - マイクロスフィアを用いた細胞接着機能に対する放射線効果の測定
横谷 明徳
日本放射線影響学会大会講演要旨集, Oct. 1986
Books and other publications
- 2-6. Explore of stabilization mechanisms of genome against radiation-stress based on quantum effects
Akinari Yokoya; Kentaro Fujii, Contributor
The Photon Factory, High Energy Accelerator Research Organization (KEK), 31 Oct. 2016 - Spectroscopic study of radiation-induced DNA lesions and their susceptibility to enzymatic repair
Akinari Yokoya; Kentaro Fujii; Naoya Shikazono; Masatoshi Ukai, Joint work
CRC Press, 01 Jan. 2010, [Reviewed]
Lectures, oral presentations, etc.
- Studies on X-ray Induced Biomolecular Effecs Using Multibeams: Fundamental Biological Analysis and Applications to Advanced Drug Discovery
Akinari YOKOYA
The 6th IMSS Colloquium in 2024, 04 Apr. 2025, [Invited]
20250404, 20250404 - A plasmid DNA construct encoding dual fluorescent proteins developed to quantitatively assess the rate of cellular DNA repair following radiation-induced damage
櫻井滉也; 江田脩真; 小畑結衣; 伊東祐真; 秋光信佳; 横谷明徳
The 6th IMSS Colloquium in 2024, 09 Feb. 2025, [Invited]
20250209, 20250209 - In situ measurements of X-ray-induced biomolecular modulation realized by twin-X-ray beams; X-ray re
Akinari Yokoya
PF研究会「放射光２ビーム利用と広波長域実験が 切り拓く学術フロンティア」, 17 Nov. 2024, [Invited]
20241117, 20241118 - Heat generation in a cell exposed to radiation stress
HANAZAWA Keiko; YOKOYA Akinari
The 67th Annual Meeting of the Japanese Radiation Research Society, 27 Sep. 2024, [Invited]
20240925, 20240928 - State transition to senescence of irradiated cells as a non-equilibrium open system
Akinari YOKOYA
The 67th Annual Meeting of the Japanese Radiation Research Society, 25 Sep. 2024, [Invited]
20240925, 20240928 - Theoretical and experimental approach to investigate change of heat-flux in a cell exposed to radiation stress
Keiko Hanazawa; Akinari Yokoya
Quantum Innovation 2023, 16 Nov. 2023
20231115, 20231117 - Electronic states of a fluorinated DNA base, nucleoside and nucleotide revealed by synchrotron X-ray photoemission spectroscopy
Photon Factory Activity Rep
Photon Factory Activity Report 2022 #40 (2023), 16 Nov. 2023
20231115, 20231117 - X-ray photoemission and absorption spectroscopy of a hypervalent iodine compound, 2-iodosobenzoic acid, for developments of X-ray activated caged compounds
Y. Izumi; M. Ohara; K. Fujii; A. Yokoya; M. Ogawa
The 21st International Conference on Radiation Effects in Insulators (REI-21), 05 Sep. 2023
20230903, 20230908 - 〔Major achievements〕Electronic states of Fluorinated DNA component molecules revealed by X-ray Photoemission Spectroscopy
S. Onuma; Y. Izumi; M. Ohara; A. Yokoya
The 21st International Conference on Radiation Effects in Insulators (REI-21), 05 Sep. 2023
20230903, 20230908 - Title: Luminal cell differentiation in the rat mammary gland is regulated in a dose-rate dependent manner after gamma-ray irradiation
Kento Nagata; Mayumi Nishimura; Kazuhiro Daino; Daisuke Iizuka; Yukiko Nishimura; Yuya Hattori; Ritsuko Watanabe; Akinari Yokoya; Shizuko Kakinuma; Tatsuhiko Imaoka
The 17th International Congress for Radiation Research, Aug. 2023
20230827, 20230830 - Towards a comprehensive understanding of initial processes of radiobiologicla effects and resulting cellular responses
Akinari Yokoya
2023 Tokyo RBC New Year Symposium, 11 Feb. 2023, [Invited]
20230211, 20230211 - Novel sciences of raddiation biology using two beams (Radiation Biology User Group)
Akinari Yokoya
Beamline for R&D: Construction and Use, 05 Jan. 2023, [Invited]
20230105, 20230106 - DNA repair response of mammary gland cells to EGFP plasmid DNA exposed to various ionizing radiations or treated with restriction enzymes
Yui Obata; Akari Kinase; Keishiro Hirasaki; Nobuyoshi Akimitsu; Akinari Yokoy
68th Annual International Meeting of Radiation Research Society, 17 Oct. 2022
20221016, 20221019 - Structural change in DNA repair protein XRCC4 by multimerization revealed by CD and SAXS
Kai Nishikubo; Maho Hasegawa; Yoshihisa Matsumoto; Akinari Yokoy
68th Annual International Meeting of Radiation Research Society, 17 Oct. 2022
20221016, 20221019 - Radiation damage processes explored based on physical property of electronic states of biological molecules
Akinari Yokoya
日本放射線影響学会第65回大会, 16 Sep. 2022, [Invited]
20220915, 20220917 - Clustered DNA damage
Akinari Yokoya
Workshop on Auger Therapy, 05 Sep. 2022, [Invited]
20220905, 20220905 - Exploring active structures of DNA repair protein XRCC4 using CD and SAXS
Akinari Yokoya; Kai Nishikubo; Maho Hasegawa
The 26th Hiroshima International Symposium on Synchrotron Radiation, 18 Feb. 2022, [Invited]
20220217, 20220218 - Chemical repairing effects of additives on early radiation-induced DNA damage
于暠; 藤井健太郎; 横谷明徳; 山下真一
日本放射線影響学会第64回大会, 23 Sep. 2021, [Invited]
20210922, 20210924 - Radiation, Life Science and Physics with wisdoms of giants
Akinari Yokoya
日本放射線影響学会第64回大会, 23 Sep. 2021, [Invited]
20210922, 20210924 - Targeting of single cells and population of cells using X-ray microbeam with various geometric patterns
Akinari Yokoya
日本放射線影響学会若手部会第1回総会・日本マイクロビーム生物研究会第11回連絡会議（総会）・高LET研究会, 14 Oct. 2020, [Invited]
20201014, 20201014 - Mitochondrial dynamics with ATP production change in a mammalian culture cell exposed to ionizing radiation and medication stress
Yuka Kimura; Noriyuki Ouchi; Keiji Suzuki; Akinari Yokoya
The 13th Quantum Medicine Workshop, an Open symposium of College of Sciece in Ibaraki University, 23 Feb. 2020, [Invited]
20200223, 20200223 - Do bromine atoms incorporated into DNA obscure the photon-induced Auger effect on damage induction?
Akinari Yokoya
The 9th International Symposium on Physical, Molecular, Cellular, and Medical Aspects of Auger Processes, 23 Aug. 2019, [Invited]
20190822, 20190824 - Fluorescent Nanodiamonds for Intracellular Measurements
Ryuji Igarashi; Kiichi Kaminaga; Daiki Terada; Takahiro Fujisaku; Takuya Genjo; Takuya F. Segawa; Akinari Yokoya; Masahiro Shirakawa
PhotonIcs & Electromagnetics Research Symposium also known as Progress In Electromagnetics Research Symposium (PIERS 2019), 17 Jun. 2019, [Invited]
20190617, 20190620 - 生体に対する放射線効果研究のための量子ツール
Akinari Yokoya
PhotonIcs & Electromagnetics Research Symposium also known as Progress In Electromagnetics Research Symposium (PIERS 2019), 17 Jun. 2019, [Invited]
20190617, 20190620 - Live-cell imaging of the cells transfected with plasmid DNA exposed to ionizing radiation
Yui Obata; Akinari Yokoya
The 12th Quantum Medicine Workshop, an Open symposium of College of Sciece in Ibaraki University, 17 Feb. 2019, [Invited]
20190217, 20190217 - Live-cell imaging of mitochondrial activity change induced by X-ray microbeam
Akinari Yokoya; Kiichi Kaminaga; Ryo Hamada; Noriko Usami; Keiji Suzuki
若⼿放射線⽣物学研究会 平成 30 年度専⾨研究会, 01 Sep. 2018, [Invited]
20180901, 20180902 - Bio-Medical researches using synchrotron radiation as quantum tools
Akinari Yokoya
JAEA-QST Symposium of Synchrotron Radiation Sciences 2018, 12 Mar. 2018, [Invited]
20180312, 20180314 - Physicochemical study on the initial process of complex radiation damate to DNA
Akinari Yokoya
長崎原研研究会, 28 Feb. 2018, [Invited]
20180228, 20180228 - Development of the ex vivo spermatogenesis technique for advanced radiotherapeutic science
Hisanori Fukunaga; Kiichi Kaminaga; Takuya Sato; Karl T. Butterworth; Akinari Yokoya; Takehiko Ogawa; Kevin M. Prise
Consortium of Biological Sciences 2017 (ConBio2017), 30 Nov. 2017, [Invited]
20171128, 20171130 - シンクロトロン放射をツールとする放射線によるDNA損傷と細胞学的応答の研究
Akinari Yokoya; Kentaro Fujii; Hiroyuki Shimada; Masatoshi Ukai; Kiichi Kaminaga; Kenji Ohwada; Akihiko Machida; Tatsuhiko Imaoka; Yukiko Nishimura
Consortium of Biological Sciences 2017 (ConBio2017), 29 Nov. 2017, [Invited]
20171128, 20171130 - Novel analytical study for reaction intermediates in the primary radiation interaction of DNA using a synchrotron radiation induced luminescence spectroscopy
T.Kojima; H.Aihara; Y.Kodashima; H.Makishima; S.Nakiri; S.Takada; H.Shimada; C.Ozga; X.Holzapfel; Ph.Schimid; C.Küstner-Wetekamm; H.Otto; A.Knie; A.Ehresmann; A.Yokoya; K.Fujii; Y.Fukuda; M.Ukai
17th International Symposium on Microdosimetry (MICROS 2017), 07 Nov. 2017
20171105, 20171110 - Visualization of DNA Repair Process in Mammalian Cells Transformed by Plasmid DNA Exposed to X-rays in vitro
Hiroki Nakaue; Yui Obata; Kiichi Kaminaga; Akinari Yokoy
17th International Symposium on Microdosimetry (MICROS2017), 07 Nov. 2017
20171105, 20171110 - Study of electronic property of a halogenated pyrimidine causing radiosensitization effects on DNA
Misato Onizawa; Yoshinori Haga; Shigenori Tanaka; Seiya Koibuchi; Akinari Yokoya
The 60th Annual meeting of Japanease Radiation Research Society, 28 Oct. 2017, [Invited]
20171025, 20171028 - Change of mitochondorial activity of the cell irradiated with X-ray a microbeam
Akinari Yokoya; Kiichi Kaminaga; Ryo Hamada; Noriko Usami; Keiji Suzuki
The 60th Annual meeting of Japanease Radiation Research Society, 26 Oct. 2017, [Invited]
20171025, 20171028 - Dynamic behavior of electrons deposited energy in water
T. Kai; T. Toigawa; M. Ukai; K. Fujii; R. Watanabe; A. Yokoy
The 60th annual meeting of the Japan Society of Radiation Chemistry, 28 Sep. 2017, [Invited]
20170927, 20170929 - Fragmentation of Doubly-Ionized Deoxyribose. Ab Initio Molecular Dynamics Simulations
Marie Anne Hervé du Penhoa; Alexandre Souchaud; Rodolphe Vuilleumier; Ivano Tavernelli; Marie Pierre Gaigeo; Kentaro Fujii; Akinari Yokoya; Marie Françoise Politis
The first International Symposium of QST - Quantum Life Sciences -, 25 Jul. 2017, [Invited]
20170725, 20170726 - High Brilliance Synchrotron Radiation as a Tool for Studies of Radiation Damage to DNA and resulting cellular responses
Akinari Yokoya
The first International Symposium of QST - Quantum Life Sciences -, 25 Jul. 2017, [Invited]
20170725, 20170726 - Live imaging of cells exposed to ionizing radiation
Akinari Yokoya; Kiichi Kaminaga; Tatsuhiko Imaoka; Takeshi Ohshima; Ryuji Igarashi
QUANTUM SENSING IN BIOLOGY WORKSHOP in University of Melbourne, 28 Mar. 2017, [Invited]
20170328, 20170328 - Fate of cells exposed to X-ray microbeam and their mitochondrial activity
Akinari Yokoya; Kiichi Kaminaga; Ryo Hamada; Noriko Usami; Keiji Suzuki
The 13th Quantum Medicine Workshop, an Open symposium of College of Sciece in Ibaraki University, 12 Feb. 2017, [Invited]
20170212, 20170212 - Various modes of DNA damage formation by the direct effect of radiation
YOKOYA Akinari
The 56th Annual Meeting of Radiation Research Society, 25 Sep. 2010, [Invited]
Affiliated academic society
Research Themes
- The role of "interfacial water" in radiation damage to DNA
Grant-in-Aid for Scientific Research (A)
The University of Tokyo
01 Apr. 2024 - 31 Mar. 2028 - Mechanism and regulation of of testicular tissue-sparing effect following exposure to spacially fractionated radiation
Grant-in-Aid for Scientific Research (B)
Hokkaido University
01 Apr. 2024 - 31 Mar. 2027 - Compound activation in the human body using light（Research Director: Mikako Ogawa)
CREST
[Innovative optics and photonics] Creating innovative optics and photonics based on creative principles
Oct. 2019 - Mar. 2025 - Quantum mechanism and regulation of radiation damage to DNA
Grant-in-Aid for Scientific Research (B)
National Institutes for Quantum Science and Technology
01 Apr. 2020 - 31 Mar. 2024 - Biological Significance of DNA-PK in the Orchestration of Cellular Response to DNA Double-strand Breaks
Grant-in-Aid for Scientific Research (B)
Tokyo Institute of Technology
01 Apr. 2020 - 31 Mar. 2023 - Role of Hydration Water in Radiation Damage to DNA
Grant-in-Aid for Scientific Research (A)
The University of Tokyo
01 Apr. 2018 - 31 Mar. 2022 - Systems biology for cellular responses to radiation stress
Grant-in-Aid for Scientific Research (B)
National Institutes for Quantum and Radiological Science and Technology
19 Jul. 2016 - 31 Mar. 2019 - Mechanism of cluster DNA damage induction and its repair processes in vivo
Grant-in-Aid for Scientific Research (B)
01 Apr. 2015 - 31 Mar. 2018 - Explore of molecular aerials sensitizing radiobiological effects
Grant-in-Aid for Challenging Exploratory Research
01 Apr. 2015 - 31 Mar. 2017 - Development of a spectroscopic study for radiation damage induction by thermal relaxation
Grant-in-Aid for Scientific Research (A)
Tokyo University of Agriculture and Technology
01 Apr. 2013 - 31 Mar. 2016 - Synergy effect of subcellular organelles in radiation responses
Grant-in-Aid for Challenging Exploratory Research
Japan Atomic Energy Agency
01 Apr. 2013 - 31 Mar. 2015 - Control of Biological Effect by Altered ATP induced with Synchrotron Soft X-rays
Grant-in-Aid for Scientific Research (B)
Japan Atomic Energy Agency
01 Apr. 2012 - 31 Mar. 2015 - Research on molecular structure and repair of complex DNA damage
Grant-in-Aid for Scientific Research (B)
Japan Atomic Energy Agency
01 Apr. 2010 - 31 Mar. 2015 - Study of Biological Effect induced by Radiation Damage of non-DNA Molecules
Grant-in-Aid for Challenging Exploratory Research
独立行政法人日本原子力研究開発機構
01 Apr. 2012 - 31 Mar. 2014 - Study of radiation-induced cluster DNA damage- its structure and repair susceptibility
Grant-in-Aid for Scientific Research (B)
Japan Atomic Energy Agency
01 Apr. 2009 - 31 Mar. 2014 - 複雑損傷の分子構造と修復に関する研究
Apr. 2010 - Mar. 2014 - 非ＤＮＡに対する放射線損傷に伴う生物影響の検討
Apr. 2012 - Mar. 2013 - 放射線によるクラスターＤＮＡ損傷の構造と難修復特性の研究
Apr. 2009 - Mar. 2013 - Non-linear DNA repair responses caused by interference between competitive repair pathways
Grant-in-Aid for Challenging Exploratory Research
Japan Atomic Energy Agency
2011 - 2012 - DEVELOPMENT OF A TIME-DEPENDENT LIQUID MICRO-JET SPECTROSCOPY FOR RADIATION-INDUCED ANORMALY IN MIMETIC BIO-CELL MOLECULES
Grant-in-Aid for Scientific Research (A)
Tokyo University of Agriculture and Technology
2009 - 2011 - Isolation of repair-deficient mutants for clustered DNA damage
Grant-in-Aid for Scientific Research (C)
Japan Atomic Energy Agency
2007 - 2009 - Physicochemical and biochemical study of radiation induced DNA damage
Grant-in-Aid for Scientific Research (B)
Japan Atomic Energy Agency
2006 - 2008 - Development of a Time Correlation Spectroscopy for Liquid Phase Reactions using a Liquid Micro Jet in Combination with a Synchrotron Radiation
Grant-in-Aid for Scientific Research (A)
Tokyo University of Agriculture and Technology
2005 - 2007 - Synchrotron-Radiation Electron-Spectroscopy for Chemical Analysis on molecules in solution
Grant-in-Aid for Scientific Research (A)
Tokyo University Agriculture And Technology
2001 - 2003 - Development of an irradiation system of monochromatic photons (50-1000 eV) for wet biological samples
Grant-in-Aid for Scientific Research (A)
RIKKYO UNIVERSITY
1995 - 1996
