Nov. 2019, 日本放射線影響学会賞, DNA二重鎖切断修復機構に基づく放射線誘発突然変異および放射線感受性の研究, 一般社団法人 日本放射線影響学会
田内 広
Japan society

2018, 平成29年度特別研究員等審査会専門委員（書面担当）表彰, 日本学術振興会
Others

2003, （財）放射線影響協会奨励賞

2002, 日本癌学会奨励賞

1999, 日本放射線影響学会奨励賞

Possible existence of dose-rate threshold for mutation induction by chronic low-dose-rate gamma-rays
Haruki Nagashima; Kenshi Komatsu; Hiroshi Tauchi, Last, Abstract

To assess the biological effects of low-dose and low-dose-rate radiation, we established a sensitive assay system for detecting somatic mutations in hypoxanthine-phosphoribosyltransferase 1 (HPRT1) gene. In this study, we investigated the dose-rate effects of mutagenesis by gamma irradiation at dose-rates of 6.6, 20 and 200 mGy d−1. We identified a potential inflection point in the gamma-induced mutant frequency, which ranged between 6.6 and 20 mGy d−1. In addition, the mutant spectrum was not different from that of the non-irradiated control at all dose-rates. Compared with previous studies with low-concentration HTO exposure, mutant frequencies were similar, but mutant spectrum showed different trends, especially at high-dose-rates (200 mGy d−1). These observations indicate the presence of potential mechanistic differences in mutagenic events between tritium beta and gamma-rays., Oxford University Press (OUP)
Radiation Protection Dosimetry, 13 Nov. 2024, [Reviewed]

Effect of PI3-kinase inhibitors on DNA double strand break repair pathways: observations using a site specific DSB induction system
Tomoki Myodo; Yuki Sakamoto; Keita Sato; Honami Kobayashi; Kenta Iijima; Kenshi Komatsu; Shinya Matsuura; Hiroshi Tauchi, Last, Abstract

We established two types of site-specific DNA double strand breaks (DSB) induction systems to elucidate factors which affect the efficiency or quality of DSB repair. For mutation assays, a site specific DSB was generated by the transient expression of a zinc finger nuclease which targets the human HPRT1 gene. A cell line in which time and site specific DSBs can be generated in a HR reporter construct was used for homology-directed repair (HR) analysis. By using these two systems, we investigated the effects of PI3-kinase inhibitors on the efficiency and quality of DSB repair. Ataxia telangiectasia mutated (ATM) kinase inhibition resulted a decrease in mutant frequency and a slight increase in deletion-type mutations accompanied by microhomology. Furthermore, the HR frequency increased significantly when ATM kinase activity was inhibited. Thus, ATM kinase activity might be involved in the suppression of DSB end resection, and this may promote DSB repair through canonical non-homologous end joining., Oxford University Press (OUP)
Radiation Protection Dosimetry, 13 Nov. 2024, [Reviewed]

Phosphorylation dynamics and kinase interaction in mRNA transcription-associated kinases: Autophosphorylation of CDK12 and its modulation by CDK7 and CDK9.　　　　　　　　　　　　　　　
Yamakawa H.; Ebara S.; Yoshida M.; Yamamoto K.; Hayashi K.; Shimokawa K.; Araki S.; Tauchi H.; Morishita D., Corresponding
BPB Reports, Sep. 2024, [Reviewed]

〔Major achievements〕Interaction of CDK12 with NXF1 is a new node for the linking mechanism between transcription and transportation of mRNA
Shunsuke Ebara; Misaki Yoshida; Hiroko Yamakawa; Kenichiro Shimokawa; Yasumichi Inoue; Hiroshi Tauchi; Daisuke Morishita, Corresponding, Elsevier BV
Biochemical and Biophysical Research Communications, Aug. 2024, [Reviewed]

Establishment and activity of the planning and acting network for low dose radiation research in Japan (PLANET): 2016–2023
Yutaka Yamada; Tatsuhiko Imaoka; Toshiyasu Iwasaki; Junya Kobayashi; Munechika Misumi; Kazuo Sakai; Takashi Sugihara; Keiji Suzuki; Hiroshi Tauchi; Hiroshi Yasuda; Shinji Yoshinaga; Megumi Sasatani; Satoshi Tanaka; Kazutaka Doi; Masanori Tomita; Daisuke Iizuka; Shizuko Kakinuma; Michiya Sasaki; Michiaki Kai, Abstract

The Planning and Acting Network for Low Dose Radiation Research in Japan (PLANET) was established in 2017 in response to the need for an all-Japan network of experts. It serves as an academic platform to propose strategies and facilitate collaboration to improve quantitative estimation of health risks from ionizing radiation at low-doses and low-dose-rates. PLANET established Working Group 1 (Dose-Rate Effects in Animal Experiments) to consolidate findings from animal experiments on dose-rate effects in carcinogenesis. Considering international trends in this field as well as the situation in Japan, PLANET updated its priority research areas for Japanese low-dose radiation research in 2023 to include (i) characterization of low-dose and low-dose-rate radiation risk, (ii) factors to be considered for individualization of radiation risk, (iii) biological mechanisms of low-dose and low-dose-rate radiation effects and (iv) integration of epidemiology and biology. In this context, PLANET established Working Group 2 (Dose and Dose-Rate Mapping for Radiation Risk Studies) to identify the range of doses and dose rates at which observable effects on different endpoints have been reported; Working Group 3 (Species- and Organ-Specific Dose-Rate Effects) to consider the relevance of stem cell dynamics in radiation carcinogenesis of different species and organs; and Working Group 4 (Research Mapping for Radiation-Related Carcinogenesis) to sort out relevant studies, including those on non-mutagenic effects, and to identify priority research areas. These PLANET activities will be used to improve the risk assessment and to contribute to the revision of the next main recommendations of the International Commission on Radiological Protection., Oxford University Press (OUP)
Journal of Radiation Research, 15 Jul. 2024, [Reviewed]

Mechanistic insights into the survival curve of HeLa cells with a short shoulder and their S phase-specific sensitivity
Kenshi Komatsu; Hiroshi Tauchi, Abstract

HeLa cells are a cell line with two unique cellular features: a short-shouldered survival curve and two peaks of radioresistance during the cell cycle phase, while their underlying mechanisms remain unclear. We herein proposed that these radiobiological features are due to a common mechanism by which radiation suppresses homologous recombination repair (HRR) in a dose-dependent manner. This radio-suppression of HRR is mediated by an intra-S checkpoint and reduces survivals of cells in S phase, especially early S phase, resulting in both short shoulder and radioresistance with two peaks in the cell cycle. This new explanation may not be limited to HeLa cells since a similar close association of these features is also observed in other type of cells., Oxford University Press (OUP)
Journal of Radiation Research, 26 Dec. 2023, [Reviewed]

Prediction of late adverse events in pelvic cancer patients receiving definitive radiotherapy using radiation-induced gamma-H2AX foci assay
Masanori Someya; Tomokazu Hasegawa; Asako J Nakamura; Takaaki Tsuchiya; Mio Kitagawa; Toshio Gocho; Sho Mafune; Yutaro Ikeuchi; Hiroshi Tauchi; Koh-ichi Sakata, Abstract

Radiation can induce DNA double-stranded breaks, which are typically detected by the fluorescence of phosphorylated histone H2AX. In this study, we examined the usefulness of the dynamics of radiation-induced gamma-H2AX foci of peripheral blood lymphocytes (PBLs), as a marker of DNA repair ability, in predicting late adverse events from radiotherapy. A total of 46 patients with cervical, vaginal and anal canal cancers treated with radical radiotherapy between 2014 and 2019 were included in this analysis. Concurrent chemotherapy was administered in 36 cases (78.3%). Peripheral blood was obtained before treatment, and then irradiated ex vivo with 1 Gy X-ray. The ratio of radiation-induced gamma-H2AX foci in PBLs measured at 30 min and at 4 h was defined as the foci decay ratio (FDR). With a median follow-up of 54 months, 9 patients (19.6%) were observed to have late genitourinary or gastrointestinal (GU/GI) toxicity. The FDR ranged from 0.51 to 0.74 (median 0.59), with a significantly higher incidence of Grade 1 or higher late adverse events in the FDR ≥ 0.59 group. In multivariate analysis, FDR ≥ 0.59 and hypertension also emerged as significant factors associated with the development of late toxicities. Overall, our results suggest that measurement of radiation-induced gamma-H2AX foci in PBLs may predict the risk of late GU/GI toxicities from chemoradiotherapy, which can enable tailoring the radiation dose to minimize adverse effects., Oxford University Press (OUP)
Journal of Radiation Research, 15 Oct. 2023, [Reviewed]

Dose and dose-rate dependence of DSB-type mutants induced by X-rays or tritium beta-rays: An approach using a hyper-sensitive system
Nagashima H.; Hayashi Y.; Tanimoto S.; Tauchi H., Last, Oxford University Press
Radiation Protection Dosimetry, Sep. 2022, [Reviewed]

NBS1 I171V variant underlies individual differences in chromosomal radiosensitivity within human populations
Tomioka K.; Miyamoto T.; Akutsu S.N.; Yanagihara H.; Fujita K.; Royba E.; Tauchi H.; Yamamoto T.; Koh I.; Hirata E.; Kudo Y.; Kobayashi M.; Okada S.; Matsuura S., Genetic information is protected against a variety of genotoxins including ionizing radiation (IR) through the DNA double-strand break (DSB) repair machinery. Genome-wide association studies and clinical sequencing of cancer patients have suggested that a number of variants in the DNA DSB repair genes might underlie individual differences in chromosomal radiosensitivity within human populations. However, the number of established variants that directly affect radiosensitivity is still limited. In this study, we performed whole-exome sequencing of 29 Japanese ovarian cancer patients and detected the NBS1 I171V variant, which is estimated to exist at a rate of approximately 0.15% in healthy human populations, in one patient. To clarify whether this variant indeed contributes to chromosomal radiosensitivity, we generated NBS1 I171V variant homozygous knock-in HCT116 cells and mice using the CRISPR/Cas9 system. Radiation-induced micronucleus formation and chromosomal aberration frequency were significantly increased in both HCT116 cells and mouse embryonic fibroblasts (MEFs) with knock-in of the NBS1 I171V variant compared with the levels in wild-type cells. These results suggested that the NBS1 I171V variant might be a genetic factor underlying individual differences in chromosomal radiosensitivity., Springer Nature
Scientific Reports, Dec. 2021, [Reviewed]

〔Major achievements〕Induction of somatic mutations by low concentrations of tritiated water (HTO): evidence for the possible existence of a dose-rate threshold
Nagashima; H.; Hayashi; Y.; Sakamoto; Y.; Komatsu; K.; Tauchi; H., Last,
Tritium is a low energy beta emitter and is discharged into the aquatic environment primarily in the form of tritiated water (HTO) from nuclear power plants or from nuclear fuel reprocessing plants. Although the biological effects of HTO exposures at significant doses or dose rates have been extensively studied, there are few reports concerning the biological effects of HTO exposures at very low dose rates. In the present study using a hyper-sensitive assay system, we investigated the dose rate effect of HTO on the induction of mutations. Confluent cell populations were exposed to HTO for a total dose of 0.2 Gy at dose rates between 4.9 mGy/day and 192 mGy/day by incubating cells in medium containing HTO. HTO-induced mutant frequencies and mutation spectra were then investigated. A significant inflection point for both the mutant frequency and mutation spectra was found between 11 mGy/day and 21.6 mGy/day. Mutation spectra analysis revealed that a mechanistic change in the nature of the mutation events occurred around 11 mGy/day. The present observations and published experimental results from oral administrations of HTO to mice suggest that a threshold dose-rate for HTO exposures might exist between 11 mGy/day and 21.6 mGy/day where the nature of the mutation events induced by HTO becomes similar to those seen in spontaneous events., Oxford University Press
Journal of Radiation Research, 24 Apr. 2021, [Reviewed]

Health Effects Triggered by Tritium: How do we get public understanding based on scientifically supported evidence?　　　　　　　　　　　　　　　
Matsumoto; H.; Shimada; Y.; Nakamura; A.J.; Usami; N.; Ojima; M.; Kakinuma; S.; Shimada; M.; Sunaoshi; M.; Hirayama; R.; Tauchi; H., Corresponding, Oxford University Press
Journal of Radiation Research, Apr. 2021, [Reviewed]

〔Major achievements〕Mitotic cells can repair DNA double strand breaks via a homology-directed pathway
Yuki Sakamoto; Tetsuya Kokuta; Ai Teshigahara; Kenta Iijima; Hiroyuki Kitao; Minoru Takata; Hiroshi Tauchi, Last, The choice of repair pathways of DNA double-strand breaks (DSBs) is dependent upon the cell cycle phases. While homologous recombination repair (HRR) is active between the S and G2 phases, its involvement in mitotic DSB repair has not been examined in detail. In the present study, we developed a new reporter assay system to detect homology-directed repair (HDR), a major pathway used for HRR, in combination with an inducible DSB-generation system. As expected, the maximal HDR activity was observed in the late S phase, along with minimal activity in the G1 phase and at the G1/S boundary. Surprisingly, significant HDR activity was observed in M phase, and the repair efficiency was similar to that observed in late S phase. HDR was also confirmed in metaphase cells collected with continuous colcemid exposure. ChIP assays revealed the recruitment of RAD51 to the vicinity of DSBs in M phase. In addition, the ChIP assay for gamma-H2AX and phosphorylated DNA-PKcs indicated that a part of M-phase cells with DSBs could proceed into the next G1 phase. These results provide evidence showing that a portion of mitotic cell DSBs are undoubtedly repaired through action of the HDR repair pathway., Oxford University Press
Journal of Radiation Research, Jan. 2021, [Reviewed]

Discussions on Tritiated Water Treatment for Fukushima Daiichi Nuclear Power Station　　　　　　　　　　　　　　　
Yamanishi; T.; Kakiuchi; H.; Tauchi; H.; Yamamoto; T.; Yamamoto; I
Fusion Science and Technology, Nov. 2020, [Reviewed], [Invited]

放射線感受性の遺伝的個人差を規定する候補素因としてのNBS1遺伝子I171V多型の定量的評価　　　　　　　　　　　　　　　
冨岡 啓太; 藤田 和将; Akutsu Silvia Natsuko; 柳原 啓見; 田内 広; 山本 卓; 小林 正夫; 工藤 美樹; 宮本 達雄; 松浦 伸也, 広島医学会
広島医学, Apr. 2020

Induction of somatic mutations by low-dose X-rays: The challenge in recognizing radiation-induced events
Haruki Nagashima; Kumiko Shiraishi; Saori Ohkawa; Yuki Sakamoto; Kenshi Komatsu; Shinya Matsuura; Akira Tachibana; Hiroshi Tauchi, Oxford University Press
Journal of Radiation Research, 01 Apr. 2018, [Reviewed]

Tritium Biology in Japan: A search for a new approach.　　　　　　　　　　　　　　　
Tauchi; H.; Toyoshima-Sasatani; M.; Nagashima; H.; Shimura; T.; Umata; T.; Tachibana; A., Lead
Fusion Engineering and Design, Feb. 2018, [Reviewed], [Invited]

放射線感受性個人差を規定する遺伝素因の定量的評価としてのヒト培養細胞株におけるゲノム編集　　　　　　　　　　　　　　　
宮本達雄; Ekaterina Royba; Silvia Natsuko Akutsu; 細羽康介; 田内広; 山本卓; 工藤美樹; 田代聡; 松浦伸也
広島医学, 2018

Evaluation of ATM heterozygous mutations underlying individual differences in radiosensitivity using genome editing in human cultured cells.
Royba; E.; Miyamoto; T.; Akutsu; S.N.; Hosoba; K.; Tauch; H.; Kudo; Y.; Tashiro; S.; Yamamoto; T.; Matsuura; S.
Scientific Reports, 2017, [Reviewed]

〔Major achievements〕Mutations in the FHA-domain of ectopically expressed NBS1 lead to radiosensitization and to no increase in somatic mutation rates via a partial suppression of homologous recombination
Ohara; M.; Funyu; Y.; Ebara; S.; Sakamoto; Y.; Seki; R.; Iijima; K.; Ohishi; A.; Kobayashi; J.; Komatsu; K.; Tachibana; A.; Tauchi; H., Last
Journal of Radiation Research, Mar. 2014, [Reviewed]

Histone chaperone FACT regulates homologous recombination by chromatin remodeling through interaction with RNF20.
Oliveira; D.V.; Kato; A.; Nakamura; K.; Ikura; T.; Okada; M.; Kobayashi; J.; Yanagihara; H.; Saito; Y.; Tauchi; H.; Komatsu; K.
Journal of Cell Science, 2014, [Reviewed]

The combination of hyperthermia or chemotherapy with Gimeracil for effective radiosensitization.
Takagi; M.; Sakata; K.; Someya; M.; Matsumoto; Y.; Tauchi; H.; Hareyama; M.; Fukusima; M.
Strahlentherapie und Onkologie, 2012, [Reviewed]

Yield of single-, double-strand breaks and nucleobase lesions in fully hydrated plasmid DNA films irradiated with high-LET charged particles.
Ushigome; T.; Shikazono; N.; Fujii; K.; Watanabe; R.; Suzuki; M.; Takakura; C.; Tauchi; H.; Yokoya A.
Radiation Research, 2012, [Reviewed]

Effects of depletion of dihydropyrimidine dehydrogenase on focus formation and RPA phosphorylation.
Someya; M; Sakata; K.; Matsumoto; Y.; Tauchi; H.; Kai; M.; Hareyama; M.; Fukushima; M.
Journal of Radiation Research, 2012, [Reviewed]

〔Major achievements〕Regulation of homologous recombination by RNF20-dependent H2B ubiquitination
Nakamura; K.; Kato; A.; Kobayashi; J.; Yanagihara; H.; Sakamoto; S.; Oliveira; D. V.N.P.; Shimada; M.; Tauchi; H.; 他4名
Molecular Cell, 05 Mar. 2011, [Reviewed]

H2B Ubiquitination-mediated chromatin remodeling in response to double-stranded DNA breaks in vertebrates　　　　　　　　　　　　　　　
Kenshi Komatsu; Kyosuke Nakamura; Akihiro Kato; Junya Kobayashi; Hiromi Yanagihara; Shuichi Sakamoto; Douglas V.N.P. Oliveira; Mikio Shimada; Satoshi Tashiro; Hiroshi Tauchi
日本分子生物学会，パシフイコ横浜,2011 年12 月15 日（招待講演）, 2011, [Reviewed]

The Induction of Radioadaptive Response by 3H-Thymidine in Mouse Fibroblast Cells.　　　　　　　　　　　　　　　
Tachibana, A; Ito, K; Fujii, N; Saotome, S; Tauchi, H
Fusion Science and Technology, 2011, [Reviewed]

Assessment of biological effect of tritiated water by using hypersensitive system.
Tauchi; H.; Imamura; H.; Inoue; M.; Komatsu; K.; Tachibana; A, Lead
Fusion Science and Technology, 2011, [Reviewed], [Invited]

Gimeracil, an inhibitor of dihydropyrimidine dehydrogenase, inhibits the early step in homologous recombination.
Sakata; K.; Someya; M.; Matsumoto; Y.; Tauchi; H.; Kai; M.; Toyota; M.; Takagi; M.; Hareyama; M.; Fukushima; M.
Cancer Science, 2011, [Reviewed]

NBS1 recruits RAD18 via a RAD6-like motif and regulates Pol -dependent translesion DNA synthesis.
Yanagihara; H.; Kobayashi; J.; Tateishi; S.; Kato; A.; Matsuura; S.; Tauchi; H.; Yamada; K.; Takezawa; J.; Sugasawa; K.; Masutani; C.; Hanaoka; F.; Weemaes; C. M.; Mori; T.; Zou; L.; Komatsu; K., Translesion DNA synthesis, a process orchestrated by monoubiquitinated PCNA, is critical for DNA damage tolerance. While the ubiquitin-conjugating enzyme RAD6 and ubiquitin ligase RAD18 are known to monoubiquitinate PCNA, how they are regulated by DNA damage is not fully understood. We show that NBS1 (mutated in Nijmegen breakage syndrome) binds to RAD18 after UV irradiation and mediates the recruitment of RAD18 to sites of DNA damage. Disruption of NBS1 abolished RAD18-dependent PCNA ubiquitination and Polη focus formation, leading to elevated UV sensitivity and mutation. Unexpectedly, the RAD18-interacting domain of NBS1, which was mapped to its C terminus, shares structural and functional similarity with the RAD18-interacting domain of RAD6. These domains of NBS1 and RAD6 allow the two proteins to interact with RAD18 homodimers simultaneously and are crucial for Polη-dependent UV tolerance. Thus, in addition to chromosomal break repair, NBS1 plays a key role in translesion DNA synthesis.
Molecular Cell, 2011, [Reviewed]

Gimeracil sensitizes cells to radiation via inhibition of homologous recombination.
Takagi; M.; Sakata; K.; Someya; M.; Tauchi; H.; Iijima; K.; Matsumoto; Y.; Torigoe; T.; Takahashi; A.; Hareyama; M.; Fukushima; M.
Radiotherapy and Oncology, 2010, [Reviewed]

DNA修復応答とゲノム不安定性 ヒストンH2Bユビキチン化による相同組換え修復の制御(DNA damage and cancer Control of homologous recombination by H2B ubiquitination)　　　　　　　　　　　　　　　
小松 賢志; 加藤 晃弘; 小林 純也; 田内 広; 田代 聡, 日本癌学会
日本癌学会総会記事, Aug. 2009

Corrigendum to "Histone H2AX participates the DNA damage-induced ATM activation through interaction with NBS1" [Biochem. Biophys. Res. Commun. 380 (2009) 752-757] (DOI:10.1016/j.bbrc.2009.01.109)
J. Kobayashi; H. Tauchi; B. Chen; S. Burma; S. Tashiro; S. Matsuura; K. Tanimoto; D.J. Chen; K. Komatsu
Biochemical and Biophysical Research Communications, 2009, [Reviewed]

〔Major achievements〕Two major factors involved in the reverse dose-rate effect for somatic mutation induction are the cell cycle position and LET value
Tauchi; H.; Waku; H.; Matumoto; E.; Yara; S.; Okumura; S.; Iwata; Y.; Komatsu; K.; Frusawa; Y.; Eguchi-Kasai; K.; Tachibana; A., Lead
Journal of Radiation Research, 2009, [Reviewed]

Histone H2AX participates the DNA damage-induced ATM activation through interaction with NBS1
Kobayashi; J.; Tauchi; H.; Chen; B.; Bruma; S.; Tashiro; S.; Matsuura; S.; Tanimoto; K.; Chen; D. J.; Komatsu; K.
Biochemical and Biophysical Research Communications, 2009, [Reviewed]

Homologous recombination but not nucleotide excision repair plays a pivotal role in tolerance to DNA-protein crosslinks in mammalian cells
Nakano; T.; Katafuchi; A.; Matsubara; M.; Terato; H.; Tsuboi; T.; Masuda; T.; Tatsumoto; M.; Pack; S.-P. Makino; K.; Croteau; D. L.; Van Houten; B.; Iijima; K.; Tauchi; H.; Ide; H
Journal of Biological Chemistry, 2009, [Reviewed]

Rapid myeloid recovery as a possible mechanism of whole-body radioadaptive response
Ohtsuka; K.; Koana; T.; Tomita; M.; Ogata; H.; Tauchi; H.
Radiation Research, Sep. 2008, [Reviewed]

NBS1 Prevents Chromatid-Type Aberrations through ATM-Dependent Interactions with SMC1
Antoccia; A.; Sakamoto; S.; Matsuura; S.; Tauchi; H.; Komatsu; K.
Radiation Research, Sep. 2008, [Reviewed]

〔Major achievements〕NBS1 regulates a novel apoptotic pathway through Bax activation
Iijima; K.; Muranaka; C.; Kobayashi; J.; Sakamoto; S.; Komatsu; K.; Matsuura; S.; Kubota; N.; Tauchi; H., Corresponding
DNA Repair, 2008, [Reviewed]

「Functional interaction between histone H2A χ and NBS1 on ATM-dependent DNA damage response. 」　　　　　　　　　　　　　　　
Kobayashi J; Tauchi H; Matsuura S; Chen DJ; Komatsu K
13th International Congress of Radiation Research 2007 年7 月 San Francisco, 2007, [Reviewed]

Human NBS1 and MRE11 associate for regulation of checkpoints and for homologous recombination repair.
K. Komatsu; A. Antoccia; S. Sakamoto; J. Kobayashi; S.Matsuura; H. Tauchi
International Congress Series 1299:158-163, ELSEVIER, Amsterdam., 2007, [Reviewed]

NBS1 and MRE11 associate for responses to DNA double-strand breaks
K. Komatsu; A. Antoccia; S. Sakamoto; J. Kobayashi; S. Matsuura; H. Tauchi
International Congress Series, 2007, [Reviewed]

Characterization of the plant homolog of Nijmegen breakage syndrome 1: involvement in DNA repair and recombination.　　　　　　　　　　　　　　　
Noriyuki Akutsu; Kenta Iijima; Takeo Hinata; Hiroshi Tauchi, Corresponding
Biochemical and Biophysical Research Communications, Jan. 2007, [Reviewed]

Homologous recombination repair is regulated by domains at the N- and C-terminus of NBS1 and is dissociated with ATM functions
Sakamoto; S.; Iijima; K.; Mochizuki; D.; Nakamura; K.; Teshigawara; K.; Kobayashi; J.; Matsuura; S.; Tauchi; H.; Komatsu; K., Corresponding
Oncogene, 2007, [Reviewed]

TopBP1 associates with NBS1 and is involved in homologous recombination repair
Morishima; K.; Sakamoto; S.; Kobayashi; J; Izumi; H.; Suda; T.; Matsumoto; Y.; Tauchi; H.; Ide; H.; Komatsu; K.; Matsuura; S
Biochemical and Biophysical Research Communications, 2007, [Reviewed]

Association of DNA-PK activity and radiation-induced NBS1 foci formation in lymphocytes with clinical malignancy in breast cancer patients
Someya; M.; Sakata; K.; Matsumoto; Y.; Tauchi; H.; Narimatsu; H.; Hareyama; M.
Oncology Report, 2007, [Reviewed]

NBS1 regulates DNA-damage induced apoptosis independent of p53.　　　　　　　　　　　　　　　
H. Tauchi; K. Iijima; C. Muranaka; J. Kobayashi; K. Komatsu; S. Matsuura; Y. Ichimasa
20th IUBMB International Congress of Biochemistry and molecular Biology and 11th FAOBMB Congress. Kyoto, Japan., 2006, [Reviewed]

Nijmegen breakage syndrome and functions of the responsible protein, NBS1.
A. Antoccia; J. Kobayashi; H. Tauchi; S. Matsuura; K. Komatsu
Genome dynamics, 2006, [Reviewed]

BUB1B mutations and defective mitotic-spindle checkpoint in seven families with premature chromatid separation (PCS) syndrome
) Matsuura; S.; Matsumoto; Y.; Morishima; K.; Izumi; H.; Matsumoto; H.; Ito; E.; Tsutsui; K.; Kobayashi; J.; Tauchi; H.; Kajiwara; K.; Hama; S.; Kurisu; K.; Tahara; H.; Oshimura; M.; Komatsu; K.; Ikeuchi; T.; Kajii; T.
American Journal of Medical Genetics, 2006, [Reviewed]

53BP1 contributes to survival of cells irradiated with X-ray during G1 without Ku70 or Artemis
Iwabuchi; K.; Hashimoto; M.; Matsui; T.; Kurihara; T.; Shimizu; H.; Adachi; N.; Ishiai; M.; Yamamoto; K.; Tauchi; H.; Takata; M.; Koyama; H.; Date; T.
Genes to Cells, 2006, [Reviewed]

Association of Ionizing Radiation-Induced Foci of NBS1 with Chromosomal Instability and Breast Cancer Susceptibility
Someya; M.; Sakata; K.; Tauchi; H.; Matsumoto; Y.; Nakamura; A.; Komatsu; K.; Hareyama; M.
Radiation Research, 2006, [Reviewed]

ATM activation by a sulfhydryl-reactive inflammatory cyclopentenone prostaglandin
Kobayashi; M.; Ono; H.; Mihara; K.; Tauchi; H.; Komatsu; K.; Shibata; T.; Shimizu; H.; Uchida; K.; Yamamoto; K.
GENES TO CELLS, 2006, [Reviewed]

Activation of Antioxidative Enzymes Induced by Low-Dose-Rate Whole-Body gamma Irradiation: Adaptive Response in Terms of Initial DNA Damage
Otsuka; K.; Koana; T.; Tauchi; H.; Sakai; K.
Radiation Research, 2006, [Reviewed]

Repair activity of base and nucleotide excision repair enzymes for guanine lesions induced by nitrosative stress
Nakano; T.; Katafuchi; A.; Shimizu; R.; Terato; H.; Suzuki; T.; Tauchi; H.; Makino; K.; Skorvaga; M.; Van Houten; B.; Ide; H.:
Nucleic Acids Research, 2005, [Reviewed]

Uptake of heavy water and loss bay tangerine in the heavy water vapor release experiment in a greenhouse as a substitute for tritiated water
Ichimasa Y.; Sasajima; E.; Makihara; H.; Tauchi; H.; Uda; T.; Ichimasa; M.
Fusion Science and Technology, 2005, [Reviewed]

Recognition of DNA damage by NBS1/hMRE11/hRAD50 complex
Kobayashi Junya; Tauchi Hiroshi; Chen Benjamin; Sakamoto Shuichi; Matsuura Shinya; Chen David; Komatsu Kenshi
CELL STRUCTURE AND FUNCTION, May 2004, [Reviewed]

Analysis of cells from the patients with PCS (premature chromatid separation) syndrome
Matsumoto Yoshiyuki; Morishima Ken-ichi; Kobayashi Junya; Tauchi Hiroshi; Komatsu Kenshi; Ikeuchi Tatsuro; Kajii Tadashi; Matsuura Shinya, PCS syndrome is the human mitotic-spindle checkpoint disorder, characterized by mosaic variegated aneuploidy (MVA) and premature chromatid separation (PCS). The clinical manifestations include severe microcephaly, Dandy-Walker anomaly, and development of Wilms tumor. To determine the molecular basis of the disorder, we established immortalized skin fibroblast cell lines from Japanese patients. We found that the expression level of BubR1 protein was remarkably decreased in PCS cells, and only faint BubR1 signals were detected on kinetochores by immunofluorescence analysis. In PCS cells, p55cdc also failed to associate with the kinetochores. These abnormal features were normalized after introduction of BubR1 cDNA. Sequence analysis of the patients' cells detected no mutations in the BubR1 gene. These results indicated that the reduced expression of BubR1 protein might result in abolished kinetochore localization of p55cdc, and cause the mitotic checkpoint defects in PCS cells., Journal of Radiation Research Editorial Committee
The Japan Radiation Research Society Annual Meeting Abstracts, 2004

NBS1を中心とした放射線DNA二重鎖切断修復遺伝子の機能解析　　　　　　　　　　　　　　　
田内 広; 飯島健太; 坂本修一; 小松賢志
茨城大・理・地球生命環境科学，京大放生研, 2004, [Reviewed]

Nijmegen breakage syndrome and DNA double strand break repair by NBS1 complex
Matsuura; S.; Kobayashi; J.; Tauchi; H.; Komatsu; K
Advances in Biophysics, 2004

The Nijmegen breakage syndrome gene and its role in genome stability
Iijima; K.; Komatsu; K.; Matsuura; S.; Tauchi; H., Corresponding
Chromosoma, 2004

NBS1 and its functional role in the DNA damage response
Kobayashi; J.; Antoccia; A.; Tauchi; H.; Matsuura; S.; Komatsu; K.
DNA Repair, 2004

242 Analysis of apoptosis induction in Nbs1 deficient cells(Apoptosis related, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
OGATA Hiromi; MURANAKA Chizuko; SAKAMOTO Shuichi; KOBAYASHI Junya; ICHIMASA Michiko; ICHIMASA Yusuke; MATSUURA Shinya; KOMATSU Kenshi; TAUCHI Hiroshi, The Japan Radiation Research Society
Journal of radiation research, 15 Dec. 2003

206 Functional Domain Analysis of NBS1 Gene in Homologous Recombinational Repair(Physics, chemistry and DNA damage, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
IIJIMA Kenta; SAKAMOTO Shuichi; MATSUURA Shinya; KOMATSU Kenshi; ICHIMASA Yusuke; TAUCHI Hiroshi, The Japan Radiation Research Society
Journal of radiation research, 15 Dec. 2003

98 Localization of Rad51 protein in cells from patients with Fanconi Anemia D1 group(Repair of radiation damage, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
MORISHIMA Kenichi; NAKAMURA Asako; SAKAMOTO Syuichi; TAUCHI Hiroshi; ANTOCCIA Antonio; MATSUURA Shinya; KOMATSU Kenshi, The Japan Radiation Research Society
Journal of radiation research, 15 Dec. 2003

S-3-1 Mechanisms of DNA double-strand break repair(Biological Effects of Low Dose and Low Dose-rate Irradiations, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
TAUCHI Hiroshi; KOBAYASHI Junya; MURANAKA Chizuko; SAKAMOTO Shuichi; GENT Dik; ICHIMASA Yusuke; MATSUURA Shinya; KOMATSU Kenshi, The Japan Radiation Research Society
Journal of radiation research, 15 Dec. 2003

Effect of gravity stress on fidelity of DNA double-strand break repair.
H. Tauchi; E. Matsumoto; K. Iijima; D. Mochizuki; K. Komatsu; Y. Ichimasa, DNA double strand break (DSB) causes many cytotoxic effects such as cellular lethality, somatic mutation, and carcinogenesis. Fidelity of DSB repair is a important factor that determines the quality of genomic stability. It is known that the most of DSBs are properly repaired on the earth, however, little is known whether those are rejoined at the same fidelity even under the space environment. One of the DSB repair pathway, homologous recombination (HR), allows the cells to repair their DSBs with error free. Therefore, the efficiency of HR is a good index to assess the fidelity of DSB repair. In order to clarify the effect of gravity stress on HR pathway, we established a cell line that can detect a site-specific DNA repair via HR. The cells carrying a reporter construct for HR were incubated under hypergravity condition after induction of site specific DSB. Our preliminary results suggest that the gravity stress may affect the HR efficiency.
Biological sciences in space, 2003, [Reviewed]

p16 gene transfer increases cell killing with abnormal nucleation after ionizing radiation in glioma cells
Hama; S.; Matsuura; S.; Tauchi; H.; Yamasaki; F.; Kajiwara; Y.; Arita; K.; Yoshioka; H.; Heike; Y.; Mandai; K.; Kurisu; K
British Journal of Cancer, 2003

DNA二重鎖切断の相同組換えによる修復 － 関連するタンパクをめぐる最近の話題 －
飯島健太; 松本英悟; 望月大輔; 田内 広, 放射線生物研究会
放射線生物研究, 2003

Mutation screening for a novel cancer-predisposition syndrome of total PCS
MATSUURA Shinya; TAUCHI Hiroshi; KOBAYASHI Junya; Antoccia Antonio; SHINOHARA Miki; KOMATSU Kenshi; IKEUCHI Tatsuro; KAJII Tadashi, The Japan Radiation Research Society
Journal of radiation research, Dec. 2002

Analysis of the function of NBS1 in DNA double-strand break repair
TAUCHI Hiroshi; KOBAYASHI Junya; Gent an Dik; MATSUURA Shinya; ICHIMASA Michiko; ICHIMASA Yusuke; TAKEDA Shunichi; KOMATSU Kenshi, The Japan Radiation Research Society
Journal of radiation research, Dec. 2002

Histone H2AX regulates the formation of NBS1 foci on DNA damage sites
KOBAYASHI Junya; TAUCHI Hiroshi; MATSUURA Shinya; NAKAMURA Asako; MORISHIMA Ken-ichi; SAKAMOTO Shuchi; TANIMOTO Keiji; KOMATSU Kenshi, The Japan Radiation Research Society
Journal of radiation research, Dec. 2002

Dissociation of ATM/NBS1 functions in telomere maintenance
NAKAMURA Asako; TAUCHI Hiroshi; KOBAYASHI Junya; MATSUURA Shinya; IDE Toshinori; KOMATSU Kenshi, The Japan Radiation Research Society
Journal of radiation research, Dec. 2002

NBS1 is involved in recognition of DNA damage and initiation of homologous recombination.
KOMATSU Kenshi; KOBAYASHI Jyunya; TAUCHI Hiroshi; SAKAMOTO Shuichi; NAKAMURA Asako; MORISIMA Kenichi; MATSUURA Shinya, The Japan Radiation Research Society
Journal of radiation research, Dec. 2002

p53結合蛋白質1(53BP1)はDNA二重鎖切断の修復に関与する　　　　　　　　　　　　　　　
岩淵 邦芳; 栗原 孝行; 柴田 昌夫; 曹 永恒; 濱田 富美男; 小林 純也; 田内 広; 青木 秀年; 本山 昇; 小松 賢志; 今村 幸治; 伊達 孝保, (一社)日本放射線影響学会
日本放射線影響学会大会講演要旨集, Sep. 2002

Studies of mutagenesis caused by low dose rate tritium radiation using a novel hyper-sensitive detection system
Tauchi; H.; Ichimasa; M.; Ichimasa; Y.; Shiraishi; T.; Morishima; K.; Matsuura; S.; Komatsu; K, Lead
Fusion Science and Technology, 2002

〔Major achievements〕Nbsl is essential for DNA repair by homelogous recombination in hygher vertebrate cells
H Tauchi; J Kobayashi; K Morishima; DC van Gent; T Shiraishi; NS Verkaik; D vanHeems; E Ito; A Nakamura; E Sonodo; M Takata; S Takeda; S Matsuura; K Komatsu, Lead
Nature, 2002

NBSl localizes to γ-H2AX foci through interaction with FHA/BRCT domain
J Kobayashi; H Tauchi; S Sakamoto; A Nakamura; K Morishima; S Matsuura; T Kobayashi; K Tamai; K Tanimoto; K Komatsu
Current Biology, 2002

Nijmegen breakage syndrome gene, NBS1, and molecular links to factors for genome stability
Tauchi; H.; Matsuura; S.; Kobayashi; J.; Sakamoto; S.; Komatsu; K., Lead
Oncogene, 2002

Bystander mutagenic effect of alpha particle in human-hamster hybrid cells
SHIRAISHI Takahiro; TAUCHI Hiroshi; SHINOHARA Miki; MATSUURA Shinya; KOMATSU Kenshi, The Japan Radiation Research Society
Journal of radiation research, Dec. 2001

Somatic Mutation Caused by Low Dose Rate Tritium Radiation : Studies Using A Hyper-sensitive DetectionSystem
TAUCHI Hiroshi; SHIRAISHI Takahiro; MORISHIMA Kenichi; MATSUURA Shinya; ICHIMASA Michiko; ICHIMASA Yusuke; KOMATSU Kenshi, The Japan Radiation Research Society
Journal of radiation research, Dec. 2001

Complementation studies of immortalized cell lines from infants with total PCS
ITO Emi; MATSUURA Shinya; SHINOHARA Miki; KOMATSU Kenshi; TAUCHI Hiroshi; IKEUCHI Tatsuro; KAJII Tadashi, The Japan Radiation Research Society
Journal of radiation research, Dec. 2001

Establishement of mouse Nbs1-deficient cell lines by gene targeting
MATSUURA Shinya; ITO Emi; ICHIKAWA Koji; NAKAMURA Asako; KOBAYASHI Junya; TAUCHI Hiroshi; KIMURA Akiro; WATANABE Hiromitsu; KOMATSU Kenshi, The Japan Radiation Research Society
Journal of radiation research, Dec. 2001

Association of DNA repair protein NBS1 with telomere maintenance
NAKAMURA Asako; TAUCHI Hiroshi; KOBAYASHI Junya; SHINOHARA Miki; MATSUURA Shinya; IDE Toshinori; KOMATSU Kenshi, The Japan Radiation Research Society
Journal of radiation research, Dec. 2001

The function of NBS1 and histone H2AX in the early process of DNA repair.
KOBAYASHI Junya; TAUCHI Hiroshi; SHINOHARA Miki; MATSUURA Shinya; TANIMOTO Keiji; KOMATSU Kenshi, The Japan Radiation Research Society
Journal of radiation research, Dec. 2001

Reversed dose-rate effect of high LET radiation in mutation induction
TAUCHI Hiroshi; SHIRAISHI Takahiro; EGUCHI-KASAI Kiyomi; FURUSAWA Yoshiya; ANDO Koichi; MATSUURA Shinya; KOMATSU Kenshi; ICHIMASA Yusuke, The Japan Radiation Research Society
Journal of radiation research, Dec. 2001

The Forkhead-associated domain of NBS1 is essential for nuclear foci formation after irradiation, but not essential for hRAD50/hMRE11/NBS1 complex DNA Repair activity
H Tauchi; J Kobayashi; K Morishima; S Matsuura; A Nakamura; T Shiraishi; E Ito; D Masnada; D Delia; K Komatsu, Lead
Journal of Biological Chemistry, 2001

Comparative genomic hybridization analysis suggests a gain of chromosome 7p associated with lymph node metastasis in non-small cell lung cancer
T Ubagai; S Matsuura; H Tauchi; K Itou; K Komatsu
Oncology Report, 2001

Expression of genes involved in repair of DNA double-strand breaks in normal and tumor tissues
KI Sakata; Y Matsumoto; H Tauchi; M Satoh; A Oouchi; H Nagakura; K Koito; Y Hosoi; N Suzuki; K Komatsu; M Hareyama
International Journal of Radiation Oncology and Bidogical Physics, 2001

Chk2 activation dependence on Nbsl after DNA damage
G Buscemi; C Savio; L Zannini; F Micciche; D Masnada; M Nakanishi; H Tauchi; K Komatsu; S Mizutani; K Khanna; P Chen; P Concannon; L Chessa; D Delia
Molecular and Cellular Biology, 2001

Chromosomal instability syndrome of total premature chromatid separation with mosaic variegated aneuploidy is defective in mitotic spindle checkpoint
MATSUURA Shinya; ITO Emi; TAUCHI Hiroshi; IKEUCHI Tatsuro; KAJII Tadashi; KOMATSU Kenshi, The Japan Radiation Research Society
Journal of radiation research, Dec. 2000

Screening of protein interacting with FANCG by Yeast two-hybrid system
MORISHIMA Ken-ichi; MATSUURA Shinya; NAKAMURA Asako; SHIRAISHI Takahiro; ITO Emi; KOBAYASHI Junya; TAUCHI Hiroshi; KOMATSU Kenshi, The Japan Radiation Research Society
Journal of radiation research, Dec. 2000

NBS1, the Nijmegen breakage syndrome protein, regulates the localization of DNA repair complex hRAD50/hMRE11/NBS1
SHIRAISHI Takahiro; TAUCHI Hiroshi; KOBAYASHI Junya; MORISHIMA Ken-ichi; NAKAMURA Asako; MATSUURA Shinya; KOMATSU Kenshi, The Japan Radiation Research Society
Journal of radiation research, Dec. 2000

Accelerated telomere shortening by disruption of DNA repair protein NBS1
NAKAMURA Asako; TAUCHI Hiroshi; MATSUURA Shinya; KOBAYASHI Jyunya; MORISHIMA Kenichi; SHIRAISHI Takahiro; ITO Emi; IDE Toshinori; KOMATSU Kenshi, The Japan Radiation Research Society
Journal of radiation research, Dec. 2000

Construction of Nbs1 knockout cell line using chicken DT40
TAUCHI Hiroshi; MORISHIMA Ken-ichi; KOBAYASHI Junya; YAMASHITA Yukiko; SONODA Eiichiro; TAKATA Minoru; TAKEDA Shunichi; MATSUURA Shinya; KOMATSU Kenshi, The Japan Radiation Research Society
Journal of radiation research, Dec. 2000

Function of NBS1 in Activation of ATM kinase in Response to IR.
KOBAYASHI Junya; TAUCHI Hiroshi; MATSUURA Shinya; OGAWA Akira; KOBAYASHI Toshiko; TANIMOTO Keiji; KOMATSU Kenshi, The Japan Radiation Research Society
Journal of radiation research, Dec. 2000

Activation of ATM kinase in NBS lymphoblastoid cells
Kobayashi Junya; Tauchi Hiroshi; Matsuura Shinya, Nagasaki University
Nagasaki Igakkai zasshi = Nagasaki medical journal, Sep. 2000

放射線高感受性遺伝病の原因遺伝子NBS1近傍の新規多型マーカーの単離と解析　　　　　　　　　　　　　　　
森島賢一; 松浦伸也; 田内広; 中村麻子; 小松賢志
広島医学, 01 Apr. 2000

機能的相補性試験によるDNA二重鎖切断修復遺伝子NBS1の重要ドメイン解析　　　　　　　　　　　　　　　
田内 広; 伊東淳; 小林; 純也; 森島; 賢一; 中村麻子; 松浦; 伸也; 小松 賢志
広島医学, 01 Apr. 2000

放射線高感受遺伝病NBS近傍の新規多型マーカーの単離と多型解析　　　　　　　　　　　　　　　
森島賢一; 田内広; 松浦伸也; 中村麻子; 小松賢志
広島医学, 01 Apr. 2000, [Reviewed]

ナイミーヘン染色体不安定症候群遺伝子のマウスホモログの単離　　　　　　　　　　　　　　　
松浦伸也; 田内広; 中村麻子; 森島賢一; 小松賢志
広島医学, 01 Apr. 2000

ナイミーヘン染色体不安定症候群(NBS)におけるテロメア維持機構　　　　　　　　　　　　　　　
中村麻子; 田内広; 小林純也; 松浦伸也; 井出利憲; 小松賢志
広島医学, 01 Apr. 2000

NBS細胞およびAT細胞におけるガンマ線誘導アポトーシス　　　　　　　　　　　　　　　
小林純也; 藤田和志; 田内広; 松浦伸也; 小松賢志; 谷本啓二
広島医学, 01 Apr. 2000

Positional cloning and functional analysis of the gene responsible for nijmegen breakage syndrome, NBS1
H Tauchi
JOURNAL OF RADIATION RESEARCH, Mar. 2000

Enhanced mutation of HPRT locus by ionizing radiation in combination with high gravity　　　　　　　　　　　　　　　
K. Komatsu; H. Tauchi; M. Ueda; S. Matsuura
Uchu seibutsu kagaku, 2000, [Reviewed]

Positional cloning and functional analysis of the gene for Nijmegen breakage syndrome,NBS1.
Tauchi; H., Japan Radiation Research Society
Journal of Radiation Ressearch, 2000

Altered splicing of the ATDC message in AT group D cells results in the absence of a functional protein.
Tauchi; H.; Green; C.; Knapp; M.; Laderoute; K.; Kapp; L.
Mutagenesis, 2000

Mutation spectrum of MSH3-deficient HHUA/chr.2 cells refrects in vivo activity of the MSH3 gene product in mismatch repair.
Tauchi; H.; Komatsu; K.; Ishizaki; K.; Yatagai; F.; Kato; T., Lead
Mutation Research, 2000

Heat-induced accumulation of p53 and hsp72 is suppressed in lung fibroblasts from SCID mouse
T Ohnishi; K Komatsu; H Tauchi; Wang, X; A Takahashi; K Ohnishi; A Shiba; H Matsumoto
International Journal of Radiation Biology, 2000

Chromosomal instability syndrome of total premature chromatid separation with mosaic variegated aneuploidy is defective in mitotic-spindle checkpoint
S Matsuura; E Ito; H Tauchi; K Komatsu; T Ikeuchi; T Kajii
American Journal of Human Genetics, 2000

Absence of mutation in the NBS1 gene in B-cell malignant lymphoma patients
S Hama; S Matsuura; H Tauchi; J Sawada; C Kato; F Yamasaki; H Yoshioka; K Sugiyama; K Arita; K Kurisu; N Kamada; Y Heike; K Komatsu
Anticancer Research, 2000

NBS1 Regulates Apoptosis induced by ɤ-irradiation in Lymphoblastoid
FUKAMI-KOBAYASHI Junya; FUJITA Kazushi; TAUCHI Hiroshi; MATSUURA Shinya; KOMATSU Kenshi; TANIMOTO Keiji, The Japan Radiation Research Society
Journal of radiation research, Dec. 1999

Mutation screening of the NBS1 gene in sporadic malignant lymphoma
MATSUURA Shinya; KATO Chikage; SAWADA Junko; TAUCHI Hiroshi; NAKAMURA Asako; MORISHIMA Ken-ichi; KAMADA Nanao; KOMATSU Kenshi, The Japan Radiation Research Society
Journal of radiation research, Dec. 1999

Functionally important domain analysis of the Nijimegen breakage syndrome gene. NBS1
TAUCHI Hiroshi; ITOH Atsushi; KOBAYASHI Junya; MORISHIMA Ken-ichi; NAKAMURA Asako; MATSUURA Shinya; KOMATSU Kenshi, The Japan Radiation Research Society
Journal of radiation research, Dec. 1999

Mapping of the underlying gene for rare genetic complementation group Fanconi anemia
MORISHIMA Ken-ichi; MATSUURA Shinya; TAUCHI Hiroshi; NAKAMURA Asako; TSUYAMA Naohiro; OSHIMURA Mitsuo; KOMATSU Kenshi, The Japan Radiation Research Society
Journal of radiation research, Dec. 1999

Development of a Radio-sensitive Mutation System for the Study of Dose Rate Effects of Space High LET Radiation
KOMATSU Kenshi; TAUCHI Hiroshi; NAKAMURA Asako; MORISHIMA Kenichi; UEDA Miki; KOBAYASHI Junya; KASAI Kiyomi E; ANDO Koichi; MATSUURA Shinya, The Japan Radiation Research Society
Journal of radiation research, Dec. 1999

LET, cell cycle dependence for mutation induction and spectrum in HPRT locus
TAUCHI Hiroshi; EGUCHI-KASAI Kiyomi; FRUSAWA Yoshiya; SUZUKI Masao; ANDO Koichi; ENDO Satoru; SAWADA Shozo; MATSUURA Shinya; KOMATSU Kenshi, The Japan Radiation Research Society
Journal of radiation research, Dec. 1999

High LET radiation-indcued cellular transformation and analysis of inversed dose rate effects by using(hamster x human X-chromosome) hybrid cells.
KOMATSU Kenshi; TAUCHI Hiroshi; UEDA Miki; NAKAMURA Asako; MORISHIMA Kenichi; KOBAYASHI Junnya; KASAI Kiyomi E; ANDO Koichi; MATSURA Shinya
Biological sciences in space, Sep. 1999

Mutations of a novel human RAD54 homologue, RAD54B, in primary cancer
T. Hiramoto; T. Nakanishi; T. Sumiyoshi; T. Fukuda; S. Matsuura; H. Tauchi; K. Komatsu; Y. Shibasaki; H. Inui; M. Watatani; M. Yasutomi; K. Sumii; G. Kajiyama; N. Kamada; K. Miyagawa; K. Kamiya
Oncogene, 1999, [Reviewed]

A polymorphic CA repeat marker at the human 27-kD calbindin (CALB1) locus
K.-I. Morishima; S. Matsuura; H. Tauchi; A. Nakamura; K. Komatsu
Journal of Human Genetics, 1999, [Reviewed]

Neutron generator (HIRRAC) and dosimetry study.
Endo, S; Hoshi, M; Takada, J; Tauchi, H; Matsuura, S; Takeoka, S; Kitagawa, K; Suga, S; Komatsu, K, Dosimetry studies have been made for neutrons from a neutron generator at Hiroshima University (HIRRAC) which is designed for radiobiological research. Neutrons in an energy range from 0.07 to 2.7 MeV are available for biological irradiations. The produced neutron energies were measured and evaluated by a 3He-gas proportional counter. Energy spread was made certain to be small enough for radiobiological studies. Dose evaluations were performed by two different methods, namely use of tissue equivalent paired ionization chambers and activation of method with indium foils. Moreover, energy deposition spectra in small targets of tissue equivalent materials, so-called lineal energy spectrum, were also measured and are discussed. Specifications for biological irradiation are presented in terms of monoenergetic beam conditions, dose rates and deposited energy spectra.
Journal of radiation research, 01 Jan. 1999

Sequence analysis of an 800-kb genomic DNA region on chromosome 8q21 that contains the Nijmegen breakage syndrome gene, NBS1
Tauchi; H.; Mastuura; S.; Isomura; M.; Kinjo; T.; Nakamura; A.; Sakamoto; S.; Kondo; N.; Endo; S.; Komatsu; K.; Nakamura Y, Lead
Genomics, 1999

Mutations of the Fanconi anemia group A gene(FAA)in Japanese patients
A Nakamura; S Matsuura; H Tauchi; R Hanada; H Ohashi; T Hasegawa; K Honda; M Masuno; K Imaizumi; K Sugita; T Ide; K Komatsu
Journal of Human Genetics, 1999

Cell cycle and LET dependence for radiation-induced mutation : A possible mechanism for reversed dose-rate effect.
Tauchi; H.; Endo; S.; Eguchi-Kasai; K.; Furusawa; Y.; Suzuki; M.; Matsuura; S.; Ando; K.; Nakamura; N.; Sawada; S.; Komatsu; K., Lead
Journal of Radiation Ressearch, 1999

Expression of full-length NBS1 protein restores normal radiation responses in cells from Nijmegen breakage syndrome patients.
A Ito; H Tauchi; J Kobayashi; K Morishima; A Nakamura; Y Hirokawa; S Matsuura; K Ito; K Komatsu
Biochemical and Biophysical Research Communications, 1999

Radiation-induced teratogenicity and embryo lethality in the scid mice.
SHOJI Shuneki; KOMATSU Kenshi; MATSUURA Shinya; TAUCHI Hiroshi; ENDO Satoru; ISHIMURA Yoshimasa; UESAKA Tosihiro; KATOH Osamu; WATANABE Hiromitsu, The Japan Radiation Research Society
Journal of radiation research, Dec. 1998

The relationship between NBS1 and cell death induced by ɤ-ray irradiation in lymphoblastoid
FUKAMI-KOBAYASHI Junya; FUJITA Kazushi; TAUCHI Hiroshi; MATSUURA Shinya; KOMATSU Kenshi; TANIMOTO Keiji, The Japan Radiation Research Society
Journal of radiation research, Dec. 1998

Nijmegen breakage syndrome : Sequence analysis of an 800-kb genomic region on chromosome 8q21.
TAUCHI Hiroshi; MATSUURA Shinya; MORISHIMA Kenichi; NAKAMURA Asako; SAKAMATO Shuichi; Kondo Noriko; ISOMURA Minoru; NAKAMURA Yusuke; KOMATSU Kenshi, The Japan Radiation Research Society
Journal of radiation research, Dec. 1998

Positional cloning of the gene for Nijmegen breakage syndrome
MATSUURA Shinya; TAUCHI Hiroshi; NAKAMURA Asako; KONDO Noriko; SAKAMOTO Shuichi; OSHIMURA Mitsuo; ISOMURA Minoru; NAKAMURA Yusuke; KOMATSU Kenshi, The Japan Radiation Research Society
Journal of radiation research, Dec. 1998

Nijmegen breakage syndrome : Analysis of an 800-kb genomic sequence
Tauchi H; Matsuura S; Morishima K; Nakamura A; Isomura M; Nakamura Y; Komatsu K
日本分子生物学会年会プログラム・講演要旨集, 01 Dec. 1998

Cloning of the NBS1 geng for Nijmegen breakage syndrome
Matsuura S; Tauchi H; Nakamura A; Kondo N; Sakamoto S; Oshimura M; Isomura M; Nakamura Y; Komatsu K
日本分子生物学会年会プログラム・講演要旨集, 01 Dec. 1998

マウスL5178Y細胞におけるHPRT欠損突然変異のLETおよび細胞周期依存性　　　　　　　　　　　　　　　
田内広; 遠藤暁; 松浦伸也; 笠井清美; 古澤佳也; 鈴木雅雄; 安藤興一; 澤田昭三; 小松賢志
広島医学, 01 Apr. 1998

A-T様電離放射線感受性を示すXRCC8相補性群の解析　　　　　　　　　　　　　　　
坂本修一; 中村麻子; 松浦伸也; 田内広; 遠藤暁; J.Thacher; 小松賢志
広島医学, 01 Apr. 1998

ナイミーヘン染色体不安定症候群(NBS)の家系分析によるマッピング　　　　　　　　　　　　　　　
近藤徳子; 松浦伸也; 遠藤暁; 田内広; C.Weemaes; 小松賢志
広島医学, 01 Apr. 1998

ナイミーヘン染色体不安定症候群：機能的相補性を応用したポジショナルクローニング　　　　　　　　　　　　　　　
松浦 伸也; 田内 広; 小松 賢志
放射線生物研究, 01 Apr. 1998

試験による染色体マッピング　　　　　　　　　　　　　　　
松浦伸也; 高見秀輝; 近藤徳子; 田内 広; 遠藤 暁; 押村光雄; C.Weemaes; 小松賢志
広島医学, 01 Apr. 1998

Comparative Genomic Hybridization(CGH)を用いた固形腫瘍における遺伝子増幅・欠失領域の検出　　　　　　　　　　　　　　　
松浦 伸也; 祖母井 努; 田内 広; 小松 賢志
放射線生物研究, 01 Apr. 1998

陽子線トラックストラクチャーコードの開発と陽子先W値の計算　　　　　　　　　　　　　　　
遠藤 暁; NIKJOO H; 星 正治; 高田 純; 上原 周三; 田内 広; 松浦 伸也; 小松 賢志; GOODHEAD D. T
放射線物理, 01 Apr. 1998

Radiation induction of p53 in cells from Nijmegen Breakage Syndrome and functional mapping of the underlying gene at 8q21.　　　　　　　　　　　　　　　
Komatsu K; Matsuura K; Matsuura S; Kondo N; Tauchi H; Oshimura M; Sweets D; Weemaes C
Disease Markers., 01 Apr. 1998

Estimation of Dose Absorbed Fraction for ¹³¹I-beta rays in Rat Thyroid
S. Endo; Y. Nitta; M. Ohtaki; J. Takada; V. Stepanenko; K. Komatsu; H. Tauchi; S. Matsuura; E. Iaskova; M. Hoshi
Journal of Radiation Research, 1998, [Reviewed]

Positional Cloning of the gene for Nijmegen Breakage Syndrome. (Jointly authored)
S Matsuura; H Tauchi; A Nakamura; N Kondo; S Sakamoto; S Endo; D Smeets; B Solder; BH Belohradsky; VMD Kaloustian; M Oshimura; M Isomura; Y Nakamura; K Komatsu
Nature Genetics, 1998

AT-like induction of p53 in cells from Nijmegen Breakage Syndrome and functional mapping of the gene at 8q21. (Jointly authored)　　　　　　　　　　　　　　　
Disease Markers, 1998

Radiation induction of p53 in cells from Nijmegen breakage syndrome is defective but not similar to ataxia-telangiectasia. (Jointly authored)
K Matsuura; T Balmukhanov; H Tauchi; C Weemaes; D Smeets; K Chrzanowska; S Endou; S Matsuura; K Komatsu
Biochemical and Biophysical Research Communications, 1998

Mutation Analysis of the Fanconi Anemia Genes in Japanese Patients
NAKAMURA Asako; MATSUURA Shinya; TAUCHI Hiroshi; HANADA Ryoji; OHASHI Hirofumi; HASEGAWA Tomonobu; HONDA Koujiro; MASUNO Mitsuo; IMAIZUMI Kiyoshi; SUGITA Katsuo; ENDO Satoru; KOMATSU Kenshi, The Japan Radiation Research Society
Journal of radiation research, Dec. 1997

Genetic Mapping of Nijmegen Breakage Syndrome using Functional Complementation Assays and Homozygosity Mapping
KONDO Noriko; MATSUURA Shinya; TAUCHI Hiroshi; SAKAMOTO Shuichi; NAKAMURA Asako; ENDO Satoru; OSHIMURA Mitsuo; WEEMAES Corry; SMEETS Dominique; KOMATSU Kenshi, The Japan Radiation Research Society
Journal of radiation research, Dec. 1997

Haplotype Analysis of Nijmegen Breakage Syndrome and Construction of Physical Map of Candidate Region.
MATSUURA Shinya; TAUCHI Hiroshi; KONDO Noriko; SAKAMOTO Shuichi; NAKAMURA Asako; ENDO Satoru; OSHIMURA Mitsuo; WEEMAES Corry; SMEETS Dominique; Concannon Patrick; KOMATSU Kenshi, The Japan Radiation Research Society
Journal of radiation research, Dec. 1997

Complementation Assay between Radiation-Sensitive irs2 Mutant and Ataxia-Telangiectasia Cell
SAKAMOTO Shuichi; NAKAMURA Asako; MATSUURA Shinya; TAUCHI Hiroshi; ENDO Satoru; OSHIMURA Mitsuo; THACKER John; KOMATSU Kenshi, The Japan Radiation Research Society
Journal of radiation research, Dec. 1997

Cell cycle and LET dependence for 6-thioguanine-resistant mutation induced by heavy ion beam in mouse L5178Y cells
Tauchi H; Eguchi -Kasai K; Matsura S; Endo S; Furusawa Y; Suzuki M; Ando K; Sawada S; Komatsu K, The Japan Radiation Research Society
Journal of radiation research, Dec. 1997

Complementation study and genetic mapping of nijmegen breakage syndrome　　　　　　　　　　　　　　　
S. Matsuura; H. Takami; N. Kondo; H. Tauchi; S. Endo; K. Komatsu; M. Oshimura; L. Weemaes
Japanese Journal of Human Genetics, 1997, [Reviewed]

Inhibitory action of (-)-epigallocatechin gallate on radiation-induced mouse oncogenic transformation.
K Komatsu; H Tauchi; N Yano; S Endo; S Matsuura; S Shoji
Cancer Letters, 1997

Genetic mapping using microcell-mediated chromosome transfer suggests a locus for Nijmegen Breakage Syndrome at chromosome 8q21-24. (Jointly authored)
S Matsuura; C Weemaes; D Smeets; H Takami; N Kondo; S Sakamoto; N Yano; A Nakamura; H Tauchi; S Endo; M Oshimura; K Komatsu
American Journal of Human Genetics, 1997

The Genetic Homogeneity of Nijmegen Breakage Syndrome V1 and V2.
MATSUURA Shinya; TAKAMI Hideki; KONDO Noriko; TAUCHI Hiroshi; ENDO Satoru; OSHIMURA Mitsuo; WEEMAES C; KOMATSU Kenshi, The Japan Radiation Research Society
Journal of radiation research, Dec. 1996

Radiation-induced HPRT mutation of a radiation sensitive hamster cell line irs1SF
YANO Nozomi; KONDO Noriko; MATSUURA Shinya; ENDO Satoru; TAUCHI Hiroshi; KOMATSU Kenshi, The Japan Radiation Research Society
Journal of radiation research, Dec. 1996

ハムスター電離放射線感受性細胞irs2とA-Tおよびそのバリアントとの遺伝的相補性
坂本修一; 松浦伸也; 田内 広; 遠藤; 暁; 城; 多恵子; THACKER J; 小松賢志
日本分子生物学会年会プログラム・講演要旨集, 01 Aug. 1996, [Reviewed]

ナイミーヘン染色体不安定症候群(NBS)線維芽細胞株の樹立と遺伝的均一性　　　　　　　　　　　　　　　
高見秀輝; 松浦伸也; 遠藤暁; 田内広; Weemaes C; 小松賢志
長崎医学会雑誌, 01 Apr. 1996

放射線高感受性マウスscid諸形質のヒト染色体8qll領域遺伝子による回復　　　　　　　　　　　　　　　
小松賢志; 田内広; 松浦伸也; 遠藤暁; 島崎達也; 奥村寛; 寺岡弘文
広島医学, 01 Apr. 1996

ハムスター放射線高感受性相補群XRCC3の原因遺伝子と機能　　　　　　　　　　　　　　　
矢野希; 松浦伸也; 遠藤暁; 田内広; 小松賢志
長崎医学会雑誌, 01 Apr. 1996, [Reviewed]

Establishment of new cell lines from patients with Nijmegen Breakage Syndrome and the genetic complementation group
KOMATSU Kenshi; MATSUURA Shinya; TAKAMI Hideki; TAUCHI Hiroshi; ENDO Satoru; OSHIMURA Mitsuo
Tissue culture research communications : the journal of experimental & applied cell culture research, 31 Mar. 1996

Accumulation of cells at G(2)/M stage by low dose-rate irradiation renders the cell population more susceptible to the subsequent induction of 6-thioguanine-resistant mutations by Cf-252 fission neutrons.
H Tauchi; N Nakamura; K Komatsu; S Sawada
JOURNAL OF RADIATION RESEARCH, Mar. 1996

The gene for Nijmegen Breakage Syndrome (V2) is not located on chromosome 11.
K Komatsu; S Matsuura; H Tauchi; S Endo; S Kodama; D Smeets; C Weemaes; M Oshimura
American Journal of Human Genetics, 1996

DNA-dependent protein kinase restores mouse scid mutation
TAUCHI Hiroshi; MATSUURA Shinya; ENDO Satoru; TERAOKA Hirofumi; KOMATSU Kenshi, The Japan Radiation Research Society
Journal of radiation research, Dec. 1995

Genetic heterogeneity of ataxia-telangiectasia-like hamster mutant irs2 with Nijmegen breakage syndrome.
SAKAMOTO Shuichi; KOMATSU Kenshi; TAUCHI Hiroshi; MATSUURA Shinya; ENDO Satoru; J. THACKER, The Japan Radiation Research Society
Journal of radiation research, Dec. 1995

The genetic complementation assay of Nijmegen breakage syndrome witit ataxia telangiectasia on the basis of radiation sensitivity to cell killing.
TAKAMI Hideki; MATSUURA Shinya; TAUCHI Hiroshi; ENDO Satoru; KODAMA Seiji; C. WEEMAES; KOMATSU Kenshi, The Japan Radiation Research Society
Journal of radiation research, Dec. 1995

Inhibition of radiation-induced oncogenic transformation in C3H10T1/2 cells by green tea component, (-)-epigallocatechin gal late.
YANO Nozomi; TAUCHI Hiroshi; MATSUURA Shinya; ENDO Satoru; KOMATSU Kenshi, The Japan Radiation Research Society
Journal of radiation research, Dec. 1995

Neutron Generator at Hiroshima University for Use in Radiobiology Study
S. Endo; M. Hoshi; H. Tauchi; S. Takeoka; K. Kitagawa; S. Suga; N. Maeda; K. Komatsu; S. Sawada; K. Takeyama; S. Sakamoto; M. Omura; E. Iwamoto
Journal of Radiation Research, 1995

Induction of somatic mutation and neoplastic transformation by neutrons : Reversed does - rate effect.　　　　　　　　　　　　　　　
Radiological Sciences, 1995

Expression of vascular endothelial growth factor (VEGF) receptor gene, KDR, in hematopoietic cells and inhibitory effect of VEGF on apoptotic cell death caused by ionizing radiation.
O KATOH; H TAUCHI; K KAWAISHI; A KIMURA; Y SATOW
Cancer Research, 1995

Suppressive effect of miso extract on radiation-induced in vitro carcinogenesis　　　　　　　　　　　　　　　
Journal of Hiroshima Medical Association, 1994

Analysis of mitotic cell death caused by radiation in mouse leukaemia L5178Y cells : apoptosis is the ultimate form of cell death following mitotic failure
H TAUCHI; S SAWADA
International Journal of Radiation Biology, 1994

CELL-CYCLE DEPENDENCE FOR THE INDUCTION OF 6-THIOGUANINE-RESISTANT MUTATIONS - G-2/M STAGE IS DISTINCTIVELY SENSITIVE TO CF-252 NEUTRONS BUT NOT TO CO-60 GAMMA-RAYS
H TAUCHI; N NAKAMURA; S SAWADA
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, Apr. 1993

Suppression of gamma-and neutron-induced neoplastic transformation by ascorbic acid in Balb/c 3T3 cells
H TAUCHI; S SAWADA
International Journal of Radiation Biology, 1993

Effect of TPA, okadaic acid and 1α, 25-dihydroxyvitamin D₃ on neoplastic transformation induced by ⁶⁰Co gamma-rays of ²⁵²Cf fission neutrons in Balb/c 3T3 cells
H TAUCHI; T ENOMOTO; S SAWADA
International Journal of Radiation Biology, 1992

低エネルギー中性子による細胞癌化　　　　　　　　　　　　　　　
広島医学, 1992

Induction of neoplastic transformation by low energy fission neutrons in Balb/c 3T3 cells　　　　　　　　　　　　　　　
Journal of Hiroshima Medical Association, 1992

Deficiency of a 90-kDa protein in S-150 fraction isolated from radiation sensitive mutants of mouse leukemia cells　　　　　　　　　　　　　　　
Korean Biochemical Journal, 1991

Production of carbon monoxide from aromatic amino acids by ┣DBMorganella(/)-┫DB ┣DBmorganii(/)-┫DB
S HINO; H TAUCHI
Archives of Microbiology, 1987

A history and perspectives of tritium biology in Japan　　　　　　　　　　　　　　　
Hiroshi Tauchi
ATOMOS 日本原子力学会誌, Nov. 2024, [Reviewed], [Invited]
Lead

トリチウムの生体影響に関するエビデンス　　　　　　　　　　　　　　　
田内 広
日本放射線技術学会 放射線防護部会誌, 13 Apr. 2023, [Invited]

トリチウム生体影響研究の現状とこれから ―UNSCEAR 2016 を越えて―　　　　　　　　　　　　　　　
増田 毅、長島明輝、田内 広
放射線生物研究, Apr. 2023, [Reviewed]

放射線の生体影響 −基礎研究データからー　　　　　　　　　　　　　　　
田内 広
大阪大学医学部 学友会会誌, Dec. 2019, [Invited]

放射線感受性の遺伝的個人差を規定する候補素因としてのNBS1遺伝子I171V多型の逆遺伝学的解析
冨岡啓太; 冨岡啓太; 阿久津シルビア夏子; 柳原啓見; 田内広; 山本卓; 小林正夫; 工藤美樹; 宮本達雄; 松浦伸也
日本分子生物学会年会プログラム・要旨集(Web), 2019

Exploration of genetic basis underlying individual differences in radiosensitivity within human populations using genome editing technology
Tatsuo Miyamoto; Silvia Natsuko Akutsu; Hiroshi Tauchi; Yoshiki Kudo; Satoshi Tashiro; Takashi Yamamoto; Shinya Matsuura
Journal of Radiation Research, 01 Apr. 2018, [Reviewed], [Invited]

ゲノム編集技術を用いたNBS1I171Vノックインマウスの作製
宮本達雄; 阿久津シルビア夏子; 田内広; 松浦伸也
日本放射線影響学会大会抄録(Web), 2018

Biological Effects of Tritium from the Cellular and Molecular Aspects
TACHIBANA Akira; KOBAYASHI Junya; TAUCHI Hiroshi
プラズマ・核融合学会誌 = Journal of plasma and fusion research, 25 Apr. 2012

RNF20-dependent H2B ubiquitination modulates repair of DNA double-strand breaks by homologous recombination.　　　　　　　　　　　　　　　
kihiro Kato; Kyosuke Nakamura; Junya Kobayashi; Hiromi Yanagihara; Shuichi Sakamoto; Hiroshi Tauchi; Satoshi Tashiro; Lee Zou; Kenshi Komatsu
日本放射線影響学会第55 回大会，2012 年9 月， 仙台, 2012, [Reviewed]

低線量放射線の生物影響とトリチウム研究　　　　　　　　　　　　　　　
田内 広; 馬田敏幸; 立花 章
プラズマ核融合学会誌, 2012, [Reviewed], [Invited]
Lead

放射線による細胞死を考える(その2) 治療戦略に向けて DNA損傷修復機構の治療戦略への応用　　　　　　　　　　　　　　　
田内 広; 船生 悠美; 大原 麻希; 坂田 耕一; 染谷 正則; 関 良太; 飯島 健太; 小松 賢志; 晴山 雅人
日本放射線影響学会大会講演要旨集, Nov. 2011

The roles of NBS1 in responses to radiation- and UV-induced DNA damage　　　　　　　　　　　　　　　
Kenshi Komatsu; Kyosuke Nalcamura; Akihiro Kato; Junya Kobayashi; Hiromi Yanagihara; Douglas V.N.P; Oliveira; Mikio Shimada; Satoshi Tashiro; Shinya Matsuura; Toshio Mori; Hiroshi Tauchi
The Sugahara Memorial International Symposium, Kyoto, January 25 ， 2011( 招待講演), 2011, [Reviewed]

DNA double-strand break repair via gene conversion is dependent on cell cycle.　　　　　　　　　　　　　　　
Kokuta Tetsuya; Ai Techigawara; naoki Hasegawa; Minora Takata; Kenshi Komatsu; Hiroshi Tauchi
第34 回日本分子生物学会年会 2011 年12 月 横浜, 2011, [Reviewed]

ナイミーヘン症候群における二本鎖DNA切断修復の異常　　　　　　　　　　　　　　　
Hiroshi Tauchi
Journal of Gastrointestinal Research, 01 Apr. 2010, [Invited]

「DNA 修復におけるRNF20 の役割」
中村恭介; 加藤晃弘; 坂本修一; 小林純也; 田内広; 田代聡; 小松賢志
日本放射線影響学会第51 回大会 2008 年11 月 北九州市, 2008, [Reviewed]

Current topics in DNA double-strand break repair
Kobayashi; J.; Iwabuchi; K.; Miyagawa; K.; Sonoda; E.; Suzuki; K.; Takata; M.; Tauchi; H.
Journal of Radiation Research, 2008, [Reviewed], [Invited]
Corresponding

Dancing on damaged chromatin: Functions of ATM and the RAD50/MRE11/NBS1 complex in cellular responses to DNA damage
Iijima; K.; Ohara; M.; Seki; R.; Tauchi; H.
Journal of Radiation Research, 2008, [Reviewed], [Invited]
Corresponding

AT the broken DNA end −ATMとNBS1を中心としたDNA損傷応答経路−
関良太; 江原俊介; 田中彩; 片吉健史; 飯島健太; 田内 広
放射線生物研究, Dec. 2007, [Invited]
Corresponding

「DNA 二重鎖切 断修復におけるNBS1 、ATM の役割」　　　　　　　　　　　　　　　
小林純也; 坂本修一; 飯島健太; 森島賢一; 中村恭介; 松浦伸也; 田内広; 小松賢志
第30 回日本分子生物学会年会 2007 年12 月, 2007, [Reviewed]

DNA の二重鎖 切断損傷におけるNBSl とヒストンH2AX の役割
小林純也; 坂本修一; 飯島健太; 森島賢一; 中村恭介; 松浦伸也; 田内広; 小松賢志
日本放射線影響学会第50 回大会2007 年11月, 2007, [Reviewed]

放射線被曝後に誘発されるTopBP1フォーカスとDNA修復機構
森島賢一; 小林純也; 坂本修一; 泉秀樹; 須田哲司; 松本祥幸; 田内広; 小松賢志; 松浦伸也
原子爆弾後障害研究会特集号, 2006

DNA 修復因子hMREll の相同組換えにおける役割
島田幹男; 小林純也; 田内広; 小松賢志
日本放射 線影響学会第49 回大会、北海道、2006 年9 月, 2006, [Reviewed]

DNA 損傷修復遺伝子NBS1 によるアポトーシス制御　　　　　　　　　　　　　　　
田内広; 小林純也; 小松賢志; 松浦伸也
第65 回二本癌学会学術総会、神奈川県、2006 年9 月, 2006, [Reviewed]

DNA 二重鎖切断修 復におけるTopBPl フォーカスの意義　　　　　　　　　　　　　　　
森島賢一; 小林純也; 坂本修一; 泉英樹; 須田哲司; 田内広; 小松賢志; 松浦伸也
第65 回二本癌学会学術総会、神奈川県、2006 年9 月, 2006, [Reviewed]

NBS1 によるATM 非依存的MRE11 局在を介した相同組換え修復の調節
中村恭介; 坂本修一; 飯島健太; 望月大輔; 勅使河原計介; 小林純也; 松浦伸也; 田内広; 小松賢志
日本放射線影響学会第49 回大会、北海道、2006 年9 月, 2006, [Reviewed]

NBS1 による放 射線誘発アポトーシスの制御
飯島健太; 村中千寿子; 小林純也; 坂本修一; 小松賢志; 松浦伸也; 一政祐輔; 田内広
日本放射線影響学会第49 回大会、北海道、2006 年9 月, 2006, [Reviewed]

DNA しゅうふくにおけるメ ディエータータンパクTopBP 1 の役割
森島賢一; 小林純也; 坂本修一; 須田哲司; 田内広; 小松賢志; 松浦伸也
日本放射線影響学会第49 回大会、北海道、2006 年9 月, 2006, [Reviewed]

ATM 依存性DNA 損傷応答の活性化におけるy-H2AX とNBS1 との協調的役割　　　　　　　　　　　　　　　
小林純也; 田内広; 森島賢一; 松浦伸也; 小松賢志
第65 回二本癌学会学術総会、神奈川県、2006 年9 月, 2006, [Reviewed]

「高LET 重イオン線による DNA 損傷に対するNBS1 の応答」　　　　　　　　　　　　　　　
富田雅典; 松本義久; 青木瑞穂; 古澤佳也; 矢野安重; 酒井一夫; 細井義夫; 小松賢志; 田内広
日本放射線影響学会第48 回大会、平成1 7 年11 月、広島市, 2005, [Reviewed]

「PCS 症候群7 家 系の遺伝子解析」　　　　　　　　　　　　　　　
松本祥幸; 泉秀樹; 森島賢一; 小林純也; 田内広; 小松賢志; 池内達郎; 梶井正; 松浦伸也
日本放射線影響学会第48 回大会、平成17 年11 月、広島市, 2005, [Reviewed]

「NBS1 が制御する損傷チェックポイントならびにアポトー シス経路」　　　　　　　　　　　　　　　
田内広; 小林純也; 坂本修一; 松浦伸也; 小松賢志
第64 回日本癌学会学術総会、平成17 年9 月、札幌市, 2005, [Reviewed]

「高発がん性を示す染色分 対早期解離(PCS) 症候群:BUB IB遺伝子変異とその機能解析」　　　　　　　　　　　　　　　
松浦伸也; 森島賢一; 泉秀樹; 小林純也; 田内広; 小松賢志; 池内達郎; 梶井正
第64 回日本癌学会学術総会、平成17 年9 月、札幌市, 2005, [Reviewed]

「D S B の相同組換え修復におけるNB S 1 の作用機構の解析」　　　　　　　　　　　　　　　
坂本修一; 田内広; 飯島健太; 勅使河原計介; 中村恭介; 小林純也; 松浦伸也; 小松賢志
組換えワークショップ、平成16 年12 月、兵庫県, 2004, [Reviewed]

「NBS 1 に依存したアポトーシス誘発経路の解析」　　　　　　　　　　　　　　　
望月大介; 尾形裕美; 村中千寿子; 小林純也; 坂本修一; 小松賢志; 一政祐輔; 窪田宣夫; 田内広
第47 回日本放射線影響学会、平成16 年 11 月、長崎県, 2004, [Reviewed]

「突然変異好感度検出系を用いた高LET 放射線の低線量率降下解析」　　　　　　　　　　　　　　　
田内広; 岩田佳之; 屋良早香; 小柳陽子; 奥村志乃; 和久弘幸; 笠井清美; 吉沢佳也; 小松賢志
第47 回日本放射線影響学会、 平成16 年11 月、長崎県, 2004, [Reviewed]

「NBS 1 によるDNA 二重鎖切断の修復とチェックポイント制御」　　　　　　　　　　　　　　　
Antoccia Antonio; 坂本修一; 松浦伸也; 小林純也; 田内広; 小松賢志
第27 回日本分子生物学会、平成16 年12 月、兵庫県, 2004, [Reviewed]

相同組換えを制御するNBS1タンパクにおける機能ドメイン解析　　　　　　　　　　　　　　　
飯島健太; 坂本修一; 小林純也; 松浦伸也; 小松 賢志; 田内広
第 27 回日本分子生物学会、平成16 年12 月、兵 庫県, 2004, [Reviewed]

放射 線高感受性を呈する日本人新規患者細胞の解析　　　　　　　　　　　　　　　
藤本浩子; 伊藤早織; 田内広; 小林純也; 山田雅 文; 小林邦彦; 松浦伸也; 小松賢志
第47 回日本放射線影響学会、平成16 年 11 月、長崎県, 2004, [Reviewed]

DNA 損傷認識におけるN BSI の機能について　　　　　　　　　　　　　　　
小林純也; 田内広; 坂本修一; 森島賢一; 松浦伸 也; 小松寶志
第63 回日本癌学会学術総会、平成 16 年9 月、福岡県．, 2004, [Reviewed]

DNA二重鎖切断修復の初期過程におけるNBS1とヒストンH2AXの機能　　　　　　　　　　　　　　　
小林 純也; 田内 広; 篠原 美紀; 松浦 伸也; 谷本 啓二; 小松 賢志
日本放射線影響学会大会講演要旨集, Oct. 2001

Developmental malformations and intrauterine deaths in gamma-ray-irradiated scid mouse embryos
S Shoji; H Watanabe; O Katoh; Y Masaoka; S Matsuura; H Tauchi; S Endo; K Komatsu
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, Jun. 1998

培養細胞を用いた放射線影響の研究　　　　　　　　　　　　　　　
広島大学原爆放射能医学研究所年報, 1991

放射線医科学の事典　　　　　　　　　　　　　　　
Contributor
朝倉書店, Dec. 2019
9784254301175

新版「放射線医科学」−生体と放射線・電磁波・超音波−　　　　　　　　　　　　　　　
Joint editor
医療科学社, Nov. 2016
9784860034818

本当のところを教えて！放射線のリスク　　　　　　　　　　　　　　　
日本放射線影響学会, Joint work
医療科学社, 22 Jan. 2015
9784860034542

「放射線医科学」−生体と放射線・電磁波・超音波−　　　　　　　　　　　　　　　
田内 広, Single work
学会出版センター, Mar. 2007

DNA損傷に対応する修復シグナルの概要．　　　　　　　　　　　　　　　
田内 広, Single work
キーワードで理解する「細胞周期イラストマップ」 羊土社, Feb. 2005

Suppresion of radiation-induced ┣DBin vitro(/)-┫DB carcinogenesis by ascorbic acid　　　　　　　　　　　　　　　
Radiation Carcinogenesis and its Control, 1993

食品中の放射性物質による内部被ばく　　　　　　　　　　　　　　　
田内 広
食の安全と安心フォーラム第28回「消費者のリスク認知バイアスを解消するための科学コミュニケーションとは」, 09 Mar. 2025, [Invited]

トリチウム内部被ばくは何が特殊なのか？　　　　　　　　　　　　　　　
田内 広
日本放射線影響学会第67回大会, 27 Sep. 2024, [Invited]

部位特異的DNA 二本鎖切断による突然変異誘発に対するDNA-PK キナーゼ活性阻害の影響　　　　　　　　　　　　　　　
今関桃花; 明道友希; 坂本裕貴; 佐藤圭汰; 飯島健太; 田内 広
日本放射線影響学会第67回大会, 25 Sep. 2024

DNA 二本鎖切断修復の経路選択における線量依存性が突然変異誘発に与える影響　　　　　　　　　　　　　　　
明道友希; 久野在世; 塩足敏士; 小松賢志; 田内 広
日本放射線影響学会第67回大会, 25 Sep. 2024

わが国におけるトリチウム生体影響研究の歴史と未解明の課題　　　　　　　　　　　　　　　
田内 広
アイソトープ・放射線研究発表会, 03 Jul. 2024, [Invited]

〔Major achievements〕A hyper-sensitive system for analysis of mutation induction by low dose or low dose-rate radiations: Comparison between HTO and gamma-rays　　　　　　　　　　　　　　　
Hiroshi TAUCHI
Biological Effects & Application of Radiation (BEAR2024), 15 Mar. 2024, BEAR2024 Organizing Committee, [Invited]
20240315, 20240317

ゲノム編集技術を用いた突然変異高感度検出系の改良　　　　　　　　　　　　　　　
明道友希、谷本早紀、長島明輝、坂本裕貴、坪田一希、宮本達雄、松浦伸也、田内 広
日本放射線影響学会第66回大会, 07 Nov. 2023, 一般社団法人 日本放射線影響学会
20231106, 20231108

Tritium biology in Japan: past and prospects for the future　　　　　　　　　　　　　　　
Hiroshi Tauchi; Masatoshi Suzuki; Tsuyoshi Masuda; Akira Tachibana
66th Annual Meeting of the Japanese Radiation Research Society, 06 Nov. 2023, Japanese Radiation Research Society, [Invited]
20231106, 20231108

Effect of PI3-kinase inhibitors on DNA double strand break repair pathways: An approach using a site specific DSB induction system　　　　　　　　　　　　　　　
Tomoki Myodo; Yuki Sakamoto; Honami Kobayashi; Kenta Iijima; Kenshi Komatsu; Shinya Matsuura; Hiroshi Tauchi
International Symposium on Natural and Artificial Radiation Exposures and Radiological Protection Studies (NARE2023), 20 Sep. 2023, NARE2023 Organising Committee
20230919, 20230922

Analysis of low-concentration tritiated water induced mutations using a hyper-sensitive assay system and understanding tritium disposition in the body using deuterium-labeled compounds　　　　　　　　　　　　　　　
Nagashima H; Komatsu K; Tauchi H
17th International Congress for Radiation Research (ICRR), Aug. 2023
20230827, 20230830

トリチウムの生体影響について：科学的な視点から　　　　　　　　　　　　　　　
田内 広
食のリスクコミュニケーション・フォーラム2023「消費者市民のリスクリテラシー向上につながるリスコミとは」、第２回トリチウム処理水のリスコミのあり方, 25 Jun. 2023, NPO法人 食の安全と安心を科学する会, [Invited]
20230625, 20230625

トリチウムの生体影響に関するエビデンス　　　　　　　　　　　　　　　
田内 広
第79回日本放射線技術学会総会学術大会, 14 Apr. 2023, 一般社団法人 日本ラジオロジー協会, [Invited]
20230413, 20230416

Analysis of factors which modulate DNA double strand break repair pathways　　　　　　　　　　　　　　　
明道友希、坂本裕貴、小林穂波、種田旭将、名倉莊一郎、飯島健太、小松賢志、松浦伸也、田内 広
日本放射線影響学会第65回大会, 15 Sep. 2022, 一般社団法人 日本放射線影響学会
20220915, 20220917

Dose and Dose-rate dependence of radiation-induced mutation: An approach using a hyper-sensitive cell system　　　　　　　　　　　　　　　
Nagashima H.; Hayashi Y.; Tanimoto S.; Shiraishi K.; Sakamoto Y.; Tauchi H.
The 6th International Symposium of the Network-type Joint Usage/ Research Center for Radiation Disaster Medical Science - Risk Communication in Radiation Disaster – During Crisis and Reconstruction -, 07 Feb. 2022, 放射線災害・医科学研究拠点, [Invited]
20220207, 20220207

ALPS処理水に含まれるトリチウムの生体影響　　　　　　　　　　　　　　　
田内 広
福島医学会学術研究集会シンポジウム「ALPS処理水を知る」, 19 Dec. 2021, 福島医学会, [Invited]
20211219

突然変異の高感度検出系における放射線誘発型変異の線量および線量率依存性解析　　　　　　　　　　　　　　　
田内 広
環境研セミナー, 05 Nov. 2021, （公財）環境科学技術研究所, [Invited]

Analysis of Dose and Dose-rate dependence of Radiation-Type mutation induced by tritiated water: An approach using a hyper-sensitive cell system.　　　　　　　　　　　　　　　
Nagashima H.; Hayashi Y.; Tanimoto S.; Shiraishi K.; Sakamoto Y.; Tauchi H.
Aomori (Online), 29 Sep. 2021, Institute of Environmental Science, [Invited]
20210927, 20210929

NBS1遺伝子 I171V 多型の放射線感受性に対する定量的評価　　　　　　　　　　　　　　　
Keita Tomioka1; Silvia Natsuko Akutsu; Hiromi Yanagihara; Hiroshi Tauchi; Takashi Yamamoto; Masao Kobayashi; Yoshiki Kudo; Tatsuo Miyamoto; Shinya Matsuura
日本放射線影響学会第62回大会, 15 Nov. 2019, 日本放射線影響学会

相同組換え修復の細胞周期依存性解析　　　　　　　　　　　　　　　
坂本 裕貴; 穀田 哲也; 勅使河原; 飯島 健太; 高田 穣; 小松 賢志; 田内 広
日本放射線影響学会第62回大会, 14 Nov. 2019, 日本放射線影響学会

高感度検出系を用いたトリチウム水による体細胞突然変異体の解析　　　　　　　　　　　　　　　
長島 明輝; 林 雄樹; 細江 一稀; 白石 久美子; 大川 沙織; 小松 賢志; 立花 章; 田内 広
日本放射線影響学会第62回大会, 14 Nov. 2019, 日本放射線影響学会

An approach for drug discovery targeting DNA double-strand break repair pathway　　　　　　　　　　　　　　　
Hiroshi Tauchi; Masaki Unno; Shinya Matsuura; Tatsuo Miyamoto; Keiji Suzuki
日本放射線影響学会第62回大会 シンポジウム, 16 Nov. 2019, 一般社団法人 日本放射線影響学会, [Invited]
201911, 201911

Analysis of somatic mutations induced by low-dose X-rays by using a hypersensitive system.　　　　　　　　　　　　　　　
Nagashima; H.; Hosoe; K.; Shiraishi; K.; Ohkawa; S.; Sakamoto; Y.; Komatsu; K.; Matsuura; S.; Tauchi; H.
The 3rd International Symposium of the Network-type Joint Usage/Research Center for Radiation Disaster Medical Science, 13 Jan. 2019

低線量X 線が誘発する体細胞突然変異体の解析　　　　　　　　　　　　　　　
長島明輝; 細江一稀; 白石久美子; 大川沙織; 小松賢志; 立花 章; 田内 広
日本放射線影響学会第61回大会, 08 Nov. 2018, 日本放射線影響学会

相同組換え修復効率の細胞周期に依存した変化　　　　　　　　　　　　　　　
坂本裕貴; 穀田哲也; 勅使河原愛; 飯島健太; 高田 穣; 小松賢志; 田内 広
日本放射線影響学会第61回大会, 08 Nov. 2018, 日本放射線影響学会

Analysis of somatic mutations induced by low-dose X-rays: an approach using hypersensitive system.　　　　　　　　　　　　　　　
Nagashima; H.; Shiraishi; K.; Ohkawa; S.; Sakamoto; Y.; Komatsu; K.; Matsuura; S.; Tachibana; A.; Tauchi; H.
8th International Society of Radiation neurobiology Conference, 10 Feb. 2018

Effect of serum derived from the mice bred in enriched environment on DNA damage repair kinetics　　　　　　　　　　　　　　　
Sakamoto; Y.; Ueki; Y.; Kanuka; Y.; Takayama; Y.; Nakamura; A.J.; Nishimura; M.; Morioka; T.; Kakinuma; S.; Shimada; S.; Tauchi; H.
8th International Society of Radiation neurobiology Conference, 08 Feb. 2018

DNA二重鎖切断の相同組換え修復に対する損傷応答キナーゼ活性の役割　　　　　　　　　　　　　　　
田部井由依; 佐藤圭汰; 小摩木里奈; 大橋由佳; 小林穂波; 坂本敬祥; 布施谷清香; 坂本裕貴; 小松賢志; 田内 広
生命科学系学会合同年次大会（日本分子生物学会年会）, 07 Dec. 2017

茨城大学大学院の取り組み：量子線科学専攻・環境放射線科学コースにおける人材養成　　　　　　　　　　　　　　　
田内 広; 中村麻子; 立花 章
日本放射線影響学会第60回大会, 27 Oct. 2017, 一般社団法人 日本放射線影響学会, [Invited]

飼育環境の異なるマウス血清がDNA損傷修復に与える影響.　　　　　　　　　　　　　　　
高山侑里; 植木優斗; 坂本裕貴; 鹿糠佑斗; 中村麻子; 西村まゆみ; 森岡孝満; 柿沼志津子; 島田義也; 田内 広
日本放射線影響学会第60回大会, 27 Oct. 2017

低線量率のトリチウムβ線照射が誘発する体細胞突然変異　　　　　　　　　　　　　　　
長島明輝; 白石久美子; 大川沙織; 菅谷紘太; 小松賢志; 立花 章; 田内 広
日本放射線影響学会第60回大会, 27 Oct. 2017

Tritium Biology in Japan: A search for a new approach　　　　　　　　　　　　　　　
Tauchi; H.
2nd Asia-Pacific Symposium on Tritium Science, 07 Sep. 2017, [Invited]

DNA二重鎖切断が誘発する体細胞突然変異におけるNBS1機能の役割　　　　　　　　　　　　　　　
田内 広
第39回日本分子生物学会年会, 01 Dec. 2016

高感度検出系を用いた低線量・低線量率照射による体細胞突然変異の解析　　　　　　　　　　　　　　　
長島明輝; 白石久美子; 大川沙織; 菅谷紘太; 小松賢志; 立花 章; 田内 広
日本放射線影響学会第59回大会, 26 Oct. 2016

部位特異的DSBで誘発される体細胞突然変異における修復機構の役割　　　　　　　　　　　　　　　
小摩木里奈; 小林穂波; 坂本敬祥; 小林健太; 本田千明; 布施谷清香; 飯島健太; 小林純也; 小松賢志; 田内 広
日本放射線影響学会第59回大会, 26 Oct. 2016

部位特異的 DNA 二重鎖切断により誘発される 体細胞 突然変異の解析　　　　　　　　　　　　　　　
坂本敬祥; 小林穂波; 小林健太; 本田千明; 飯島健太; 小林純也; 小松賢志; 立花 章; 田内 広
日本放射線影響学会ワークショップ, 16 Oct. 2015, 日本放射線影響学会

細胞周期による相同組換え修復効率の変化　　　　　　　　　　　　　　　
坂本裕貴; 大川沙織; 穀田哲也; 勅使河原愛; 飯島健太; 高田 穣; 小松賢志; 田内 広
日本放射線影響学会ワークショップ, 16 Oct. 2015, 日本放射線影響学会

Function of NBS1 protein in the pathways responding to DNA double strand breaks induced by ionizing radiation.　　　　　　　　　　　　　　　
Tauchi; H.
The 12th International Workshop on Microbeam Probes of Cellular Radiation Response, 31 May 2015, [Invited]

Analysis of mutation spectrum induced by a site specific DNA double strand break　　　　　　　　　　　　　　　
Sakamoto; K.; Kobayashi; H.; Kobayashi; K.; Honda; C.; Iijima; K.; kobayashi; J.; Komatsu; K.; Tachiban; A.; Tauchi; H.
15th International Congress of Radiation Research (ICRR2015), 28 May 2015

Induction of somatic mutation by low dose radiation: an approach by using a hyper-sensitive assay system　　　　　　　　　　　　　　　
Tabei; Y.; Shiraishi; K.; Okawa; S.; Sugaya; K.; Komatsu; K.; Tauchi; H
15th International Congress of Radiation Research (ICRR2015), 27 May 2015

Cell cycle dependence of DNA double strand break repair by homology-directed repair　　　　　　　　　　　　　　　
Sakamoto; Y.; Okawa; S.; Kokuta; T.; Teshigahara; A.; Iijima; K.; Takata; M.; Komatsu; K.; Tauch; H.
5th International Congress of Radiation Research (ICRR2015), 27 May 2015

An experimental approach for analysis of biological effect of low dose radiation and factors affecting DSB repair fidelity　　　　　　　　　　　　　　　
Hiroshi Tauchi
30th RBC-NIRS International Symposium, 20 Feb. 2015, Radiation Biology Center, Kyoto University, [Invited]

細胞周期とNBS1機能がDNA二重鎖切断修復効率と精度に与える影響　　　　　　　　　　　　　　　
田内 広; 坂本裕貴; 穀田哲也; 大川沙織; 小林健太; 小林純也; 飯島健太; 小松賢志
第37回日本分子生物学会年会, 26 Nov. 2014, 日本分子生物学会

相同組換え修復能の阻害による放射線感受性の変化と突然変異誘発　　　　　　　　　　　　　　　
田内 広; 穀田哲也; 大川沙織; 坂本裕貴; 江原俊介; 船生悠美; 小林健太; 小林純也; 飯島健太; 小松賢志
日本放射線影響学会第57回大会, 02 Oct. 2014, 日本放射線影響学会, [Invited]

Modification of camptothecin sensitivity by PARP inhibitor in DNA double strand break repair deficient cell lines　　　　　　　　　　　　　　　
Ohara; M; Tanaka; A.; Isaka; S.; Tomatsu; S.; Takata. M.; Komatsu; K.; Tatibana; A.; Tauchi; H.
RIRBM International Symposium, 13 Feb. 2014, RIRBM, Hiroshima University

Effect of ATM kinase inhibitor on radiosensitivity of various DNA double strand break repair deficient cells.　　　　　　　　　　　　　　　
Sakamoto; Y.; Fukasaku; N.; Abe; H.; Tanaka; A.; Tomatsu; S.; Ohara; M.; Takata; M.; Komatsu; K.; Tachibana; A.; Tauchi; H
29th RBC-NIRS International Symposium, Nov. 2013, Kyoto University

DNA損傷修復関連タンパクによるアポトーシス制御の二面性　　　　　　　　　　　　　　　
田内 広; 大原麻希; 田中 彩; 飯島健太; 高田 穣; 小林純也; 小松賢志
日本放射線影響学会第56回大会 シンポジウム, 20 Oct. 2013, 日本放射線影響学会, [Invited]

DNA二重鎖切断修復欠損細胞におけるATM阻害の影響　　　　　　　　　　　　　　　
坂本裕貴; 深作直子; 阿部紘子; 田中 彩; 戸松静香; 大原麻希; 高田 穣; 小松賢志; 立花 章; 田内 広
日本放射線影響学会第56回大会, 18 Oct. 2013, 日本放射線影響学会

Kinetics of Radiation-Induced DNA Double Strand Break Rejoining in DNA Repair Deficient Cells　　　　　　　　　　　　　　　
Maki Ohara; Yuki Sakamoto; Junko Fukasaku; Kenshi Komatsu; Shinya Matsuura; Hiroshi Tauchi
RIRBM International Symposium, 21 Feb. 2013, 広島大学原爆放射線医科学研究所

高感度検出系を用いた放射線感受性修飾効果の解析　　　　　　　　　　　　　　　
田内 広; 江原俊介; 船生悠美; 大原麻希; 宮本智弘; 関 良太; 小松賢志; 立花 章
日本放射線影響学会第55回大会, Sep. 2012, 日本放射線影響学会, [Invited]

Functional Link Between Nbs1 and Ku70 in DNA Damage Response　　　　　　　　　　　　　　　
H. Tauchi; M. Ohara; H. Abe; A. Tanaka; K. Iijima; J. Kobayashi; K.Komatsu; S. Matsuura
広島大学原爆放射線医科学研究所国際シンポジウム, Mar. 2011, 広島大学原爆放射線医科学研究所

Assessment of biological effect of tritiated water by using hypersensitive system　　　　　　　　　　　　　　　
H. Tauchi; H. Imamura; M. Inoue; K. Komatsu; and A. Tachibana
9th International Conference on Tritium Science and Technology, Oct. 2010, [Invited]

Functional relationship between Nbs1 and Ku70 in cellular responses to DNA damage　　　　　　　　　　　　　　　
Hiroshi Tauchi; Maki Ohara; Aya Tanaka; Kenta Iijima; Hiroko Abe; Kenshi Komatsu; Junya Kobayashi
Annual Meeting of RadiationResearch Sciety, Sep. 2010, Radiation Research Sciety

Interaction Between NBS1 and Ku70 Regulates Apoptosis Induction by Radiation　　　　　　　　　　　　　　　
Kenta Iijima; Chizuko Muranaka; Junya Kobayashi; Shuichi Sakamoto; Kenshi Komatsu; Shinya Matsuura and Hiroshi Tauchi
International Workshop on DNA damage, Jun. 2008

NBS1 regulates DNA-damage induced apoptosis through Bax activation　　　　　　　　　　　　　　　
Kenta Iijima; Chizuko Muranaka; Junya Kobayashi; Shuichi Sakamoto; Kenshi Komatsu; and Hiroshi Tauchi
Ataxia-telangiectasia International Workshop, Apr. 2008

NBS1 regulates the induction of apoptosis following radiation damage to DNA　　　　　　　　　　　　　　　
Kenta Iijima; Chizuko Muranaka; Junya Kobayashi; Shuichi Sakamoto; Kenshi Komatsu and Hiroshi Tauchi
13th International Congress on Radiation Research, Jul. 2007, International Association of Radiation Research

NBS1 regulates DNA-damage induced apoptosis independent of p53　　　　　　　　　　　　　　　
Kenta Iijima; Chizuko Muranaka; Junya Kobayashi; Kenshi Komatsu; Shinya Matsuura; Yusuke Ichimasa
20th IUBMB International Congress of Biochemistry and Molecular Biology, Jun. 2006

Human NBS1 regulates homology directed DNA repair through its N-terminal conserved domain　　　　　　　　　　　　　　　
Hiroshi Tauchi
Benzon Symposium No.52, Cellular Responces to DNA damage, 24 Aug. 2005, Alphred Benzon Faundation

DNA repair pathways mediated by Nijmegen breakage syndrome protein, Nbs1　　　　　　　　　　　　　　　
Hiroshi Tauchi
5th Japan-France Workshop on Radiaobiology and Medical Imaging, Jun. 2004, [Invited]

Nbs1, an essential factor for DNA damage response in vertebrate cells　　　　　　　　　　　　　　　
Hiroshi Tauchi
Kyoto University COE International Symbosium, Dec. 2003, [Invited]

Essential role of Nbs1 in DNA repair and damage response　　　　　　　　　　　　　　　
Hiroshi Tauchi
12th International Congress of Radiation Research, Aug. 2003, [Invited]

Apr. 2023 - Present
茨城大学大学院理工学研究科

Apr. 2016 - Present
茨城大学大学院理工学研究科

Oct. 2001 - Present
茨城大学理学部

Apr. 2001 - Present
茨城大学理学部

Apr. 2001 - Present
茨城大学理学部

Apr. 2002 - Mar. 2016
茨城大学大学院理工学研究科

茨城北西看護専門学校

Clinical Microbiology　　　　　　　　　　　　　　　
茨城北西看護専門学校

1996 - Dec. 2018, 米国人類遺伝学会(American Society of Human Genetics)

1990, 日本植物学会

日本宇宙生物科学会

日本分子生物学会

日本癌学会

米国放射線影響学会(Radiation Research Society)

日本放射線影響学会

DNA修復細胞集団の再分配に伴う低線量放射線リスクの上振れ　　　　　　　　　　　　　　　
挑戦的研究（萌芽）
Jul. 2022 - Mar. 2025

高感度検出系を用いた低濃度地リチウム水が誘発する突然変異の線量率依存性の解明　　　　　　　　　　　　　　　
基盤研究（C）
Apr. 2019 - Mar. 2022

Role of NBS1 C-terminal domain in genomic stability
Grant-in-Aid for Scientific Research (A)
Kyoto University
Apr. 2014 - Mar. 2018

Analysis of the relationship between DNA double strand break repair pathway and mutagenesis in response to ionizing radiation by using novel assay systems
Grant-in-Aid for Scientific Research (B)
Ibaraki University
Apr. 2012 - Mar. 2016

Analysis of radiation-induced DNA double strand break repair during cell cycle
Grant-in-Aid for Challenging Exploratory Research
Ibaraki University
Apr. 2013 - Mar. 2015

新規細胞系樹立による放射線DNA損傷修復シグナルと突然変異の関係解明
基盤研究(B)
茨城大学
2010 - 2012

Induction of DNA double strand break by environmental genotoxic and carcinogenic agents
Grant-in-Aid for Scientific Research (S)
Kyoto University
2006 - 2010

DNA損傷に応答した修復遺伝子の修飾と発現制御による発がん抑制機構の解明
特定領域研究
茨城大学
2008 - 2009

Study on DNA repair mechanism and mutagenesis using novel cell lines
Grant-in-Aid for Scientific Research (B)
Ibaraki University
2007 - 2009

Analysis of radiation-induced somatic mutation by using a gene knockout
Grant-in-Aid for Scientific Research (B)
Ibaraki University
2004 - 2006

DNA損傷修復遺伝子異常とアポトーシス制御機構
特定領域研究
茨城大学
2005 - 2005

発がん抑制に機能するDNA修復タンパクにおける相同組換え制御ドメイン
特定領域研究
茨城大学
2004 - 2004

発がん抑制に機能するDNA修復タンパクにおける相同組換え活性ドメイン
特定領域研究
茨城大学
2003 - 2003

Study on repair mechanism of DMA double-strand breaks induced by ionizing radiation using a gene targeting technique
Grant-in-Aid for Scientific Research (C)
IBARAKI UNIVERSITY
2002 - 2003

Role of NBS1 in Repair of DNA damage Induced by Ionizing Radiation
Grant-in-Aid for Scientific Research (C)
2000 - 2001

核分裂中性子における逆線量率効果の発生機序の解明に関する研究
奨励研究(A)
広島大学
1993 - 1993

水戸市防災会議 委員　　　　　　　　　　　　　　
others
水戸市, 02 Apr. 2018 - Present

原子力と放射線なんでもQ&A　　　　　　　　　　　　　　
appearance
茨城県原子力安全対策課, 茨城放送, 03 Feb. 2025 - 20 Feb. 2025

原子力と放射線 なんでもQ&A　　　　　　　　　　　　　　
appearance
茨城県原子力安全対策課, 茨城放送, 12 Feb. 2024 - 29 Feb. 2024

「放射線教育コアティーチャー研修」廃炉に向けた課題、トリチウムと放射線生体影響　　　　　　　　　　　　　　
lecturer
科学技術振興財団, 放射線教育コアティーチャー研修会, 26 Dec. 2023

トリチウムの生体影響について：科学的な視点から　　　　　　　　　　　　　　
contribution
NPO法人 食の安全と安心を科学する会, 食の安全と安心通信 Vol.51, 01 Dec. 2023

アインシュタインスクール「放射線・原子力の基礎講座」放射線の基礎と生体影響　　　　　　　　　　　　　　
lecturer
ひたちなか市、および（公社）茨城原子力協議会, 10 Sep. 2023

Opinion: ,Fukushima water release must be judged on scientific evidence: Concentrations of radiation in the Pacific will not rise significantly.
contribution
日本経済新聞社, Nikkei Asia, 28 Jul. 2023

原子力と放射線、なんでもQ&A　　　　　　　　　　　　　　
appearance
茨城県、茨城放送, 茨城放送, Feb. 2023 - Mar. 2023

原子力と放射線、なんでもQ&A　　　　　　　　　　　　　　
appearance
茨城県、茨城放送, 茨城放送, Feb. 2022

日本国際放送のアジア向け番組出演　　　　　　　　　　　　　　
appearance
日本国際放送, Jan. 2022

アインシュタインスクール「原子力と放射線の基礎講座」：放射線の基礎　　　　　　　　　　　　　　
appearance
（公社）茨城原子力協議会, 30 Oct. 2021

アインシュタインスクール「原子力と放射線の基礎講座」第1回　　　　　　　　　　　　　　
appearance
（公社）茨城原子力協議会, 19 Sep. 2020

大人のための科学教室 講師　　　　　　　　　　　　　　
lecturer
日立シビックセンター, 2017 - 2018

サイエンスアゴラ参加企画「私たちは福島原発事故から何を学んだか」　　　　　　　　　　　　　　
panelist
科学技術振興機構, サイエンスアゴラ2017, 26 Nov. 2017 - 26 Nov. 2017

原子力と放射線の基礎知識普及啓発講座 講師　　　　　　　　　　　　　　
lecturer
公益社団法人 茨城原子力協議会, 2015

放射線影響に関する基礎事項解説　　　　　　　　　　　
茨城放送, 原子力と放射線 なんでもQ&A, Feb. 2024, Media report

Fukushima water release must be judged on scientific evidence: Concentrations of radiation in the Pacific will not rise significantly.　　　　　　　　　　　
Nikkei Asia, Jul. 2023, Paper

福島第一原発の処理水に関する論考　　　　　　　　　　　
産経新聞社, 産経新聞, 14 Mar. 2021, Paper

放射線とその健康影響に関する解説　　　　　　　　　　　
茨城放送, 原子力と放射線なんでもQ&A, Feb. 2021, Media report

トリチウムに関する解説　　　　　　　　　　　
福島民友新聞, 14 Feb. 2020, Paper